Universiteit Leiden

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Peptide-based probes for protein N-Methyltransferases

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Zhang, Y.
02 juni 2022
Thesis in Leiden Repository

The thesis not only describes the extended application to produce peptide-based transition states mimicking PRMT inhibitors but builds an LC-MS/MS method to evaluate CARM1 inhibition and activity.

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