Rongfang Liu
Analist
- Naam
- Dr. R. Liu
- Telefoon
- +31 71 527 4607
- r.liu@lacdr.leidenuniv.nl
Analist
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Siutkina A.I.: Kalinina S., Liu R., Heitman L.H., Junker A., Daniliuc C.G. & Kalinin D.V. (2023), Microwave-assisted synthesis, structure, and preliminary biological evaluation of novel 6-methoxy-5,6-dihydro-5-azapurines, ACS Omega 8(15): 14097-14112.
- Beerkens B.L.H., Koc C., Liu R., Florea B.I., Le Dévédec S.E., Heitman L.H., IJzerman A.P. & Es D. van der (2022), A chemical biological approach to study G protein-coupled receptors: labeling the adenosine A1 receptor using an electrophilic covalent probe, ACS Chemical Biology 17(11): 3131-3139.
- Feng C.L., Wang X., Jespers W., Liu R., Zamarbide Losada S.D., Gorostiola Gonzalez M., Westen G.J.P. van, Danen E.H.J. & Heitman L.H. (2022), Cancer-associated mutations of the adenosine A2A receptor have diverse influences on ligand binding and receptor functions, Molecules 27(15): 4676.
- Sijben H.J., Dall’ Acqua L., Liu R., Jarret A., Christodoulaki E., Onstein S., Wolf G., Verburgt S.J., Le Dévédec S.E., Wiedmer T., Superti-Furga G., IJzerman A.P. & Heitman L.H. (2022), Impedance-based phenotypic readout of transporter function: a case for glutamate transporters, Frontiers in Pharmacology 13: 872335.
- Lemmerhirt J.P., Isaak A., Liu R., Kock M., Daniliuc C.G., Jacobson K.A., Heitman L.H. & Junker A. (2022), Development of Bicyclo[3.1.0]hexane-based A3 receptor ligands: closing the gaps in the structure–affinity relationships, Molecules 27(7): 2283.
- Beerkens B.L.H., Wang X., Avgeropoulou M., Adistia L.N., Veldhoven J.P.D. van, Jespers W., Liu R., Heitman L.H., IJzerman A.P. & Es D. van der (2022), Development of subtype-selective covalent ligands for the adenosine A2B receptor by tuning the reactive group, RSC Medicinal Chemistry 13(7): 850-856.
- Amelia T., Veldhoven J.P.D. van, Falsini M., Liu R., Heitman L.H., Westen G.J.P. van, Segala E., Verdon G., Cheng R.K.Y., Cooke R.M., Es D. van der & IJzerman A.P. (2021), Crystal structure and subsequent ligand design of a nonriboside partial agonist bound to the adenosine A2A receptor, Journal of Medicinal Chemistry 64(7): 3827-3842.
- Zhou X., Carbo-Bague I., Siegler M.A., Hilgendorf J., Basu U., Ott I., Liu R., Zhang L., Vadde R., IJzerman A.P. & Bonnet S.A. (2021), Rollover cyclometalation vs nitrogen coordination in Tetrapyridyl Anticancer Gold(III) complexes: effect on protein interaction and toxicity, JACS AU 1(4): 380-395.
- Burggraaff L. Lenselink E.B. Jespers W. Engelen J. van Bongers B.J. Gorostiola Gonzalez M. Liu R. Hoos H.H. Vlijmen H. van IJzerman A.P. Westen G.J.P. van (2020), Successive statistical and structure-based modeling to identify chemically novel kinase inhibitors, Journal of Chemical Information and Modeling 60(9): 4283-4295.
- Ruano‑Ordás D., Burggraaff L., Liu R., Horst C. van der, Heitman L.H., Emmerich M.T.M., Mendez J.R., Yevseyeva I. & Westen G.J.P. van (2019), A multiple classifier system identifies novel cannabinoid CB2 receptor ligands, Journal of Cheminformatics 11: 66.
- Yun Y., Chen J., Liu R., Chen W., Liu C., Wang R., Hou Z., Yu Z., Sun Y., IJzerman A.P., Heitman L.H., Yin X. & Guo D. (2019), Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes, Biochemical Pharmacology 164: 45-52.
- Liu R. (8 december 2016), The activation mechanisms of G protein-coupled receptors : the case of the adenosine A2B and HCA2/3 receptors (Dissertatie. Leiden Academic Centre for Drug Researc (LACDR), Science, Leiden University). Promotor(en): IJzerman A.P.
- Liu R., Wong W. & IJzerman A.P. (2016), Human G protein-coupled receptor studies in Saccharomyces cerevisiae, Biochemical Pharmacology 114: 103-115.
- Guo D., Pan A.C., Dror R.O., Mocking T., Liu R., Heitman L.H., Shaw D.E. & IJzerman A.P. (2016), Molecular Basis of Ligand Dissociation from the Adenosine A(2A) Receptor, Molecular Pharmacology 89(5): 485-491.
- Liu R., Veldhoven J.P.D. van & IJzerman A.P. (2016), The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells, European Journal of Pharmacology 2016(770): 70-77.
- Veldhoven J.P.D. van, Liu R., Thee S.A., Wouters Y., Verhoork S.J.M., Mooiman C., Louvel J. & IJzerman A.P. (2015), Affinity and kinetics study of anthranilic acids as HCA(2) receptor agonists, Bioorganic & Medicinal Chemistry 23(14): 4013-4025.
- Liu R., Nahon D., Roy B. le, Lenselink E.B. & IJzerman A.P. (2015), Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling, Biochemical Pharmacology 95(4): 290-300.
- Liu R., Groenewoud N.J.A., Peeters M.C., Lenselink E.B. & IJzerman A.P. (2014), A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits, Purinergic Signalling 10(3): 441-453.
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