Rongfang Liu
Labmanager
- Naam
- Dr. R. Liu
- Telefoon
- +31 71 527 4607
- r.liu@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0003-0136-8811
Labmanager
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Dilweg M.A., Gorostiola González M., Ruiter M.D. de, Meijboom N.J., Veldhoven J.P.D. van, Liu R., Jespers W., Westen G.J.P. van, Heitman L.H., IJzerman A.P. & Es D. van der (2025), Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools, Purinergic Signalling : .
- Zhou X., Abyar S., Carbo-Bague I., Wang L., Türck S., Siegler M.A., Basu U., Ott I., Liu R., IJzerman A.P. & Bonnet S.A. (2024), Multitarget thiol-activated tetrapyridyl gold(III) complexes for hypoxic cancer therapy, CCS Chemistry 63(3): 783-797.
- Beerkens B.L.H., Andrianopoulou V., Wang X., Liu R., Westen G.J. P. van, Jespers W., IJzerman A.P., Heitman L.H. & Es D. van der (2024), N-Acyl-N-alkyl sulfonamide probes for ligand-directed covalent labeling of GPCRs: the adenosine A2B receptor as case study, ACS Chemical Biology 19(7): 1554-1562.
- Feng C., Liu R., Brooks R.D.B., Wang X., Jespers W., Gorostiola González M., Westen G.J. P. van, Danen E.H.J. & Heitman L.H. (2024), The effect of cancer-associated mutations on ligand binding and receptor function: a case for the 5-HT2C receptor, European Journal of Pharmacology 985: 177081.
- Beerkens B.L.H., Snijders I.M., Snoeck J., Liu R., Tool A.T.J., Le Dévédec S.E., Jespers W., Kuijpers T.W., Westen G.J.P. van, Heitman L.H., IJzerman A.P. & Es D. van der (2023), Development of an affinity-based probe to profile endogenous human adenosine A3 receptor expression, Journal of Medicinal Chemistry 66(16): 11399-11413.
- Gorostiola Gonzalez M., Sijben H.J., Dall' Acqua L., Liu R., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2023), Molecular insights into disease-associated glutamate transporter (EAAT1 / SLC1A3) variants using in silico and in vitro approaches, Frontiers in Molecular Biosciences 10: 1286673.
- Siutkina A.I.: Kalinina S., Liu R., Heitman L.H., Junker A., Daniliuc C.G. & Kalinin D.V. (2023), Microwave-assisted synthesis, structure, and preliminary biological evaluation of novel 6-methoxy-5,6-dihydro-5-azapurines, ACS Omega 8(15): 14097-14112.
- Sijben H.J., Dall’ Acqua L., Liu R., Jarret A., Christodoulaki E., Onstein S., Wolf G., Verburgt S.J., Le Dévédec S.E., Wiedmer T., Superti-Furga G., IJzerman A.P. & Heitman L.H. (2022), Impedance-based phenotypic readout of transporter function: a case for glutamate transporters, Frontiers in Pharmacology 13: 872335.
- Lemmerhirt J.P., Isaak A., Liu R., Kock M., Daniliuc C.G., Jacobson K.A., Heitman L.H. & Junker A. (2022), Development of Bicyclo[3.1.0]hexane-based A3 receptor ligands: closing the gaps in the structure–affinity relationships, Molecules 27(7): 2283.
- Beerkens B.L.H., Wang X., Avgeropoulou M., Adistia L.N., Veldhoven J.P.D. van, Jespers W., Liu R., Heitman L.H., IJzerman A.P. & Es D. van der (2022), Development of subtype-selective covalent ligands for the adenosine A2B receptor by tuning the reactive group, RSC Medicinal Chemistry 13(7): 850-856.
- Feng C.L., Wang X., Jespers W., Liu R., Zamarbide Losada S.D., Gorostiola Gonzalez M., Westen G.J.P. van, Danen E.H.J. & Heitman L.H. (2022), Cancer-associated mutations of the adenosine A2A receptor have diverse influences on ligand binding and receptor functions, Molecules 27(15): 4676.
- Beerkens B.L.H., Koc C., Liu R., Florea B.I., Le Dévédec S.E., Heitman L.H., IJzerman A.P. & Es D. van der (2022), A chemical biological approach to study G protein-coupled receptors: labeling the adenosine A1 receptor using an electrophilic covalent probe, ACS Chemical Biology 17(11): 3131-3139.
- Amelia T., Veldhoven J.P.D. van, Falsini M., Liu R., Heitman L.H., Westen G.J.P. van, Segala E., Verdon G., Cheng R.K.Y., Cooke R.M., Es D. van der & IJzerman A.P. (2021), Crystal structure and subsequent ligand design of a nonriboside partial agonist bound to the adenosine A2A receptor, Journal of Medicinal Chemistry 64(7): 3827-3842.
- Zhou X., Carbo-Bague I., Siegler M.A., Hilgendorf J., Basu U., Ott I., Liu R., Zhang L., Vadde R., IJzerman A.P. & Bonnet S.A. (2021), Rollover cyclometalation vs nitrogen coordination in Tetrapyridyl Anticancer Gold(III) complexes: effect on protein interaction and toxicity, JACS Au 1(4): 380-395.
- Burggraaff L. Lenselink E.B. Jespers W. Engelen J. van Bongers B.J. Gorostiola Gonzalez M. Liu R. Hoos H.H. Vlijmen H. van IJzerman A.P. Westen G.J.P. van (2020), Successive statistical and structure-based modeling to identify chemically novel kinase inhibitors, Journal of Chemical Information and Modeling 60(9): 4283-4295.
- Yun Y., Chen J., Liu R., Chen W., Liu C., Wang R., Hou Z., Yu Z., Sun Y., IJzerman A.P., Heitman L.H., Yin X. & Guo D. (2019), Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes, Biochemical Pharmacology 164: 45-52.
- Ruano‑Ordás D., Burggraaff L., Liu R., Horst C. van der, Heitman L.H., Emmerich M.T.M., Mendez J.R., Yevseyeva I. & Westen G.J.P. van (2019), A multiple classifier system identifies novel cannabinoid CB2 receptor ligands, Journal of Cheminformatics 11: 66.
- Liu R., Veldhoven J.P.D. van & IJzerman A.P. (2016), The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells, European Journal of Pharmacology 2016(770): 70-77.
- Liu R. (8 december 2016), The activation mechanisms of G protein-coupled receptors : the case of the adenosine A2B and HCA2/3 receptors (Dissertatie. Leiden Academic Centre for Drug Researc (LACDR), Science, Leiden University). Promotor(en): IJzerman A.P.
- Liu R., Wong W. & IJzerman A.P. (2016), Human G protein-coupled receptor studies in Saccharomyces cerevisiae, Biochemical Pharmacology 114: 103-115.
- Guo D., Pan A.C., Dror R.O., Mocking T., Liu R., Heitman L.H., Shaw D.E. & IJzerman A.P. (2016), Molecular Basis of Ligand Dissociation from the Adenosine A(2A) Receptor, Molecular Pharmacology 89(5): 485-491.
- Veldhoven J.P.D. van, Liu R., Thee S.A., Wouters Y., Verhoork S.J.M., Mooiman C., Louvel J. & IJzerman A.P. (2015), Affinity and kinetics study of anthranilic acids as HCA(2) receptor agonists, Bioorganic & Medicinal Chemistry 23(14): 4013-4025.
- Liu R., Nahon D., Roy B. le, Lenselink E.B. & IJzerman A.P. (2015), Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling, Biochemical Pharmacology 95(4): 290-300.
- Liu R., Groenewoud N.J.A., Peeters M.C., Lenselink E.B. & IJzerman A.P. (2014), A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits, Purinergic Signalling 10(3): 441-453.