Rolf Boot
Universitair docent
- Naam
- Dr. R.G. Boot
- Telefoon
- +31 71 527 4771
- r.g.boot@lic.leidenuniv.nl
- ORCID iD
- 0000-0002-7031-3390
Universitair docent
- Wiskunde en Natuurwetenschappen
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Kuo C.L., Su Q., Nieuwendijk A.M.C.H. van den, Beenakker T.J.M., Offen W.A., Willems L.I., Boot R.G., Sarris A.J.C., Rosa Alcalde Marques A.R.A., Codée J.D.C., Marel G.A. van der, Florea B.I., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2023), The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe, Organic and Biomolecular Chemistry 21(38): 7813-7820.
- Su Q., Schroder S.P., Lelieveld L.T., Guimaraes Da Lomba Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola Perez de Azanza M.E. & Kuo C.L. (2023), Corrigendum: xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 24(3): e202300728.
- Lienden M.J.C. van der, Aten J., Boot R.G., Eijk M.C. van, Aarts J.M.F.G. & Kuo C.L. (2022), HEPES‐buffering of bicarbonate‐containing culture medium perturbs lysosomal glucocerebrosidase activity, Journal of Cellular Biochemistry 123(5): 893-905.
- Lelieveld L.T., Gerhardt S., Maas S., Zwiers K.C., Wit C. de, Beijk E.H., Guimaraes Da Lomba Ferraz M.J., Artola Perez de Azanza M.E., Meijer A.H., Tudorache C., Salvatori D., Boot R.G. & Aerts J.M.F.G. (2022), Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish, Journal of Lipid Research 63(5): 100199.
- Su Q., Schröder S.P., Lelieveld L.T., Ferraz M.J., Verhoek M., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., Artola M. & Kuo C.L. (2021), Xylose-configured cyclophellitols as selective inhibitors for glucocerebrosidase, ChemBioChem 22(21): 3090-3098.
- Boer D.E., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.C.P., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2021), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions, Journal of Lipid Research 62: 100018.
- Kok K., Zwiers K.C., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2021), Fabry disease: molecular basis, pathophysiology, diagnostics and potential therapeutic directions, Biomolecules 11(2): 271.
- Boer D.E.C., Mirzaian M., Ferraz M.J., Zwiers K.C., Baks M.V., Hazeu M.D., Ottenhoff R., Marques A.R.A., Meijer R., Roos J.P.C., Cox T.M., Boot R.G., Pannu N., Overkleeft H.S., Artola M. & Aerts J.M.F.G. (2020), Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions, Journal of Lipid Research 61(12): jlr.RA120001043.
- Eijk M. van, Ferraz M.J., Boot R.G. & Aerts J.M.F.G. (2020), Lyso-glycosphingolipids: presence and consequences, Essays in Biochemistry 64(3): 565-578.
- Armstrong Z., Kuo C.L., Lahav D., Liu B., Johnson R., Beenakker T.J.M., Boer C. de, Wong C.S., Rijssel E.R. van, Debets M.F., Florea B.I., Hissink C., Boot R.G., Geurink P.P., Ovaa H., Stelt M. van der, Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Wu L., Overkleeft H.S. & Davies G.J. (2020), Manno-epi-cyclophellitols enable activity-based protein profiling of human α-mannosidases and discovery of new golgi mannosidase II inhibitors, Journal of the American Chemical Society 142(30): 13021-13029.
- Aerts J.M.F.G., Artola M.E., Eijk M.C. van, Ferraz M.J. & Boot R.G. (2019), Glycosphingolipids and infection. Potential new therapeutic avenues, Frontiers in Cell and Developmental Biology 7: 324.
- Lelieveld L.T., Mirzaian M., Kuo C.L., Artola Perez de Azanza M.E., Guimaraes da Lomba Ferraz M.J., Peter R.E.A., Akiyama H., Greimel P., Berg R.J.B.H.N. van den, Overkleeft H.S., Boot R.G., Meijer A. & Aerts J.M.F.G. (2019), Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish, Journal of Lipid Research 60(11): 1851-1867.
- Moro Chao D.H., Wang Y., Foppen E., Ottenhoff R., Roomen C. van, Parlevliet E.T., Eijk M.C. van, Verhoek M., Boot R.G., Marques A.R., Scheij S., Mirzaian M., Kooijman S., Jansen K., Wang D., Mergen C., Seeley R.J., Tschöp M.H., Overkleeft H.S., Rensen P.C.N., Kalsbeek A., Aerts J.M.F.G. & Yi C.X. (2019), The iminosugar AMP-DNM improves satiety and activates brown adipose tissue through GLP1, Diabetes 68(12): 2223-2234.
- Artola M., Kuo C.L., Lelieveld L.T., Rowland R.J., Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2019), Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish, Journal of the American Chemical Society 141(10): 4214-4218.
- Lienden M.J.C. van der, Gaspar P., Boot R.G., Aerts J.M.F.G. & Eijk M.C. van (2018), Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages, International Journal of Molecular Sciences 20(1): 66.
- Rooden E.J. van, Esbroeck A.C.M. van, Baggelaar M.P., Deng H., Florea B.I., Rosa Alcalde Marques A., Ottenhoff R., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Stelt M. van der (2018), Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain, Frontiers in Neuroscience 12: 440.
- Kallemeijn W.W., Scheij S., Hoogendoorn S., Witte M.D., Herrera Moro Chao D., Roomen C.P.A.A. van, Ottenhoff R., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2017), Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes, PLoS ONE 12(2): e0170268.
- Kytidou K., Beenakker T.J.M., Westerhof L.B., Hokke C.H., Moolenaar G.F., Goosen N., Mirzaian M., Guimaraes da Lomba Ferraz M.J., Geus M.A.R. de, Kallemeijn W.W., Overkleeft H.S., Boot R.G., Schots A., Bosch D. & Aerts J.M.F.G. (2017), Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease, Frontiers in Plant Science 8: 1026.
- Ben Bdira F., Kallemeijn W.W., Oussoren S.V., Scheij S., Bleijlevens B., Florea B.I., Roomen C.P.A.A. van, Ottenhoff R., Kooten M.J.F.M. van, Walvoort M.T.C., Witte M.D., Boot R.G., Ubbink M., Overkleeft H.S. & Aerts J.M.F.G. (2017), Stabilization of Glucocerebrosidase by Active Site Occupancy, ACS Chemical Biology 12(7): 1830-1841.
- Jiang J., Kuo C.L., Wu L., Franke C., Kallemeijn W.W., Florea B.I., Meel H.M.M. van, Marel G.A. van der, Codee J.D.C., Boot R.G., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2017), Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes", ACS Central Science 3(6): 673.
- Aerts J.M.F.G., Guimaraes da Lomba Ferraz M.J., Mirzaian M., Gaspar P., Oussoren S.V., Wisse P., Kuo C.L., Lelieveld L.T., Kytidou K., Hazeu M.D., Boer D.E.C., Meijer R., Lienden M.J.C. van der, Herrera D., Gabriel T.L., Aten J., Overkleeft H.S., Eijk M.C. van, Boot R.G. & Rosa Alcalde Marques A. (2017), Lysosomal Storage Diseases. For Better or Worse: Adapting to Defective Lysosomal Glycosphingolipid Breakdown. In: , eLS. eLS: John Wiley & Sons, Ltd.. 1-13.
- Marques A.R., Willems L.I., Herrera Moro D., Florea B.I., Scheij S., Ottenhof R., Roomen C. van, Verhoek M., Nelson J.K., Kallemeijn W.W., Biela-Banas A., Martin O.R., Cachón-González M.B., Kim N.N., Cox T.M., Boot R.G., Overkleeft H.S. & Aerts J.M.F.G. (2017), A specific activity-based probe to monitor family GH59 galactosylceramidase - the enzyme deficient in Krabbe disease, ChemBioChem 18(4): 402-412.
- Lahav D., Liu B., Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Wennekes T., Ghisaidoobe A.T., Breen I., Ferraz M.J., Kuo C.L., Wu L., Geurink P.P., Ovaa H., Marel G.A. van der, Stelt M. van der, Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2017), A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase, Journal of the American Chemical Society 138(40): 14192-14197.
- James A.J., Reinius L.E., Verhoek M., Gomes A., Kupczyk M., Hammar U., Ono J., Ohta S., Izuhara K., Bel E., Kere J., Soderhall C., Dahlen B., Boot R.G. & Dahlen S.-E. (2016), Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease, American Journal of Respiratory and Critical Care Medicine 193(2): 131-142.
- Herrera Moro Chao D., Argmann C., Eijk M. van, Boot R.G., Ottenhoff R., Roomen C. van, Foppen E., Siljee J.E., Unmehopa U.A., Kalsbeek A. & Aerts J.M.F.G. (2016), Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem, Scientific Reports 6: 29094.
- Ben Bdira F., Jiang J., Kallemeijn W.W., Haan A. de, Florea B.I., Bleijlevens B., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Ubbink M. (2016), Hydrophobic interactions contribute to conformational stabilization of endoglycoceramidase II by mechanism-based probes, Biochemistry 55(34): 4823-4835.
- Guimaraes da Lomba Ferraz M.J., Marques A.R., Appelman M.D., Verhoek M., Strijland A., Mirzaian M., Scheij S., Ouairy C.M.J., Lahav D., Wisse P., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2016), Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases, FEBS Letters 590(6): 716-725.
- Jiang J., Kuo C.L., Wu L., Franke C., Kallemeijn W.W., Florea B.I., Meel H.M.M. van, Marel G.A. van der, Codée J.D.C., Boot R.G., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2016), Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes, ACS Central Science 2(5): 351-358.
- Kramer G., Wegdam W., Donker-Koopman W., Ottenhoff R., Gaspar P., Verhoek M., Nelson J., Gabriel T., Kallemeijn W.W., Boot R.G., Laman J.D., Vissers J.P., Cox T., Pavlova E., Moran M.T., Aerts J.M.F.G. & Eijk M.C. van (2016), Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models, FEBS Open Bio 6(9): 902-913.
- Marques A.R., Mirzaian M., Akiyama H., Wisse P., Ferraz M.J., Gaspar P., Ghauharali-Van der Vlugt K., Meijer R., Giraldo P., Alfonso P., Irún P., Dahl M., Karlsson S., Pavlova E.V., Cox T.M., Scheij S., Verhoek M., Ottenhoff R., Roomen C.P. van, Pannu N.S., Van Eijk M., Dekker N., Boot R.G., Overkleeft H.S., Blommaart E., Hirabayashi Y. & Aerts J.M. (2016), Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases, 57: 451-463.
- Kallemeijn W.W., Scheij S., Voorn-Brouwer T.M., Witte M.D., Verhoek M., Overkleeft H.S., Boot R.G. & Aerts J.M. (2016), Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement, ChemBioChem 17(18): 1698-1704.
- Marques A.R.A., Aten J., Ottenhoff R., Roomen C.P.A.A. van, Moro D.H., Claessen N., Veloz M.F.V., Zhou K., Lin Z., Mirzaian M., Boot R.G., Zeeuw C.I. de, Overkleeft H.S., Yildiz Y. & Aerts J.M.F.G. (2015), Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice, PLoS ONE 10(8): e0135889.
- Ouairy C.M.J., Ferraz M.J., Boot R.G., Baggelaar M.P., Stelt M. van der, Appelman M., Marel G.A. van der, Florea B.I., Aerts J.M.F.G. & Overkleeft H.S. (2015), Development of an acid ceramidase activity-based probe, Chemical Communications 51(28): 6161-6163.
- Chao D.H.M., Kallemeijn W.W., Marques A.R.A., Orre M., Ottenhoff R., Roomen C. van, Foppen E., Renner M.C., Moeton M., Eijk M. van, Boot R.G., Kamphuis W., Hol E.M., Aten J., Overkleeft H.S., Kalsbeek A. & Aerts J.M.F.G. (2015), Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes, PLoS ONE 10(9): e0138107.
- Mirzaian M., Wisse P., Ferraz M.J., Gold H., Donker-Koopman W.E., Verhoek M., Overkleeft H.S., Boot R.G., Kramer G., Dekker N. & Aerts J.M.F.G. (2015), Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard, Blood Cells, Molecules and Diseases 54(4): 307-314.
- Jiang J., Kallemeijn W.W., Wright D.W., Nieuwendijk A.M.C.H. van den, Coco Rohde V., Folch E.C., Elst H. van den, Florea B.I., Scheij S., Donker-Koopman W.E., Verhoek M., Li N., Schürmann M., Mink D., Boot R.G., Codée J.D.C., Marel G.A. van der, Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2015), In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 alpha-L-fucosidases, Chemical Science 6(5): 2782-2789.
- Jebbink J.M., Boot R.G., Keijser R., Moerland P.D., Aten J., Veenboer G.J.M., Wely M. van, Buimer M., Ver Loren van Themaat E., Aerts J.M.F.G., Post J.A.M. van der, Afink G.B. & Ris-Stalpers C. (2015), Increased glucocerebrosidase expression and activity in preeclamptic placenta, Placenta 36(2): 160-169.
- Kallemeijn W.W., Witte M.D., Voorn-Brouwer T.M., Walvoort M.T.C., Li K.Y., Codee J.D.C., Marel G.A. van der, Boot R.G., Overkleeft H.S. & Aerts J.M.F.G. (2014), A Sensitive Gel-Based Method Combining Distinct Cyclophellitol-Based Probes for the Identification of Acid/Base Residues in Human Retaining Beta-Glucosidases, Journal of Biological Chemistry 289(51): 35351-35362.
- Li K.-Y., Kallemeijn W.W., Jiang J., Walvoort M.T.C., Willems L.I., Beenakker T., Elst H. van den, Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Florea B.I., Boot R.G., Witte M.D. & Overkleeft H.S. (2014), Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. In: Waldmann H. & Janning P. (red.), Concepts and Case Studies in Chemical Biology: Wiley. 191-206.
- Dussen L. van, Hendriks E.J., Groener J.E.M., Boot R.G., Hollak C.E.M. & Aerts J.M.F.G. (2014), Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy, Journal of Inherited Metabolic Disease 37(6): 991-1001.
- Guimaraes da Lomba Ferraz M.J., Kallemeijn W.W., Mirzaian M., Herrera Moro D., Marques A., Wisse P., Boot R.G., Willems L.I., Overkleeft H.S. & Aerts J.M.F.G. (2014), Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1841(5): 811-825.
- Willems L.I., Beenakker T.J.M., Murray B., Scheij S., Kallemeijn W.W., Boot R.G., Verhoek M., Donker-Koopman W.E., Guimaraes da Lomba Ferraz M.J., Rijssel E.R. van, Florea B.I., Codee J.D.C., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2014), Potent and Selective Activity-Based Probes for GH27 Human Retaining alpha-Galactosidases, Journal of the American Chemical Society 136(33): 11622-11625.
- Li K.Y., Jiang J., Witte M.D., Kallemeijn W.W., Donker-Koopman W.E., Boot R.G., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2014), Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors, ORGANIC & BIOMOLECULAR CHEMISTRY 12(39): 7786-7791.
- Duivenvoorden B.A., Ghauharali K., Scheij S., Boot R.G., Aerts J.M.F.G., Marel G.A. van der, Overkleeft H.S. & Codee J.D.C. (2014), Design and synthesis of 4 '-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates, Carbohydrate Research 399: 26-37.
- Konradsen J.R., James A., Nordlund B., Reinius L.E., Söderhäll C., Melén E., Wheelock A.M., Lödrup C.K.C., Lidegran M., Verhoek M., Boot R.G., Dahlén B., Dahlén S.E. & Hedlin G. (2013), The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma, Journal of Allergy and Clinical Immunology 132(2): 328-35.e5.
- Aerts J.M.F.G., Guimaraes da Lomba Ferraz M.J., Boot R.G., Breemen M.J. van, Dekker N., Kramer G., Hollak C.E.M., Maas M., Linthorst G.E., Smid B., Rombach S.M., Dussen L. van, Poorthuis B. & Groener J.E.M. (2013), Biomarkers for lysosomal storage disorders. In: Surendran S. (red.), Neurochemistry of metabolic diseases: lysosomal storage diseases, phenylketonuria, and Canavan disease. Hauppage, NY: Nova Science Publishers. 169-202.
- Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruben M., Witte M.D., Brussee J., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin, European Journal of Organic Chemistry 2012(18): 3437-3446.
- Lo S.M., Choi M., Liu J., Jain D., Boot R.G., Kallemeijn W.W., Aerts J.M.F.G., Pashankar F., Kupfer G.M., Mane S., Lifton R.P. & Mistry P.K. (2012), Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis, Blood 119(20): 4731-4740.
- Aureli M., Bassi R., Loberto N., Regis S., Prinetti A., Chigorno V., Aerts J.M.F.G., Boot R.G., Filocamo M. & Sonnino S. (2012), Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts, Journal of Inherited Metabolic Disease 35(6): 1081-1091.
- Kallemeijn W.W., Li K.Y., Witte M.D., Marques A.R.A., Aten J., Scheij S., Jiang J., Willems L.I., Voorn-Brouwer T.M., Roomen C.P.A.A. van, Ottenhoff R., Boot R.G., Elst H. van den, Walvoort M.T.C., Florea B.I., Codee J.D.C., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie (International Edition) 51(50): 12529-12533.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance. In: Cowart L.A. (red.), Sphingolipids and Metabolic Disease. Advances in Experimental Medicine and Biology nr. 721. New York, NY, U.S.A.: Springer. 20-41.
- Dekker N., Dussen L. van, Hollak C.E.M., Overkleeft H., Scheij S., Ghauharali K., Breemen M.J. van, Ferraz M.J., Groener J.E.M., Maas M., Wijburg F.A., Speijer D., Tylki-Szymanska A., Mistry P.K., Boot R.G. & Aerts J.M.F.G. (2011), Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response, Blood 118(16): e118-27.
- Dekker N., Voorn-Brouwer T., Verhoek M., Wennekes T., Narayan R.S., Speijer D., Hollak C.E.M., Overkleeft H.S., Boot R.G. & Aerts J.M.F.G. (2011), The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation, Blood Cells, Molecules and Diseases 46(1): 19-26.
- Berg R.J.B.H.N. van den, Wennekes T., Ghisaidoobe A., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2011), Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors, Acs Medicinal Chemistry Letters 2(7): 519-522.
- Gold H., Boot R.G., Aerts J.M.F.G., Overkleeft H.S., Codee J.D.C. & Marel G.A. van der (2011), A Concise Synthesis of Globotriaosylsphingosine, European Journal of Organic Chemistry (9): 1652-1663.
- Witte M.D., Walvoort M.T.C., Li K.Y., Kallemeijn W.W., Donker-Koopman W.E., Boot R.G., Aerts J.M.F.G., Codee J.D.C., Marel G.A. van der & Overkleeft H.S. (2011), Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study, ChemBioChem 12(8): 1263-1269.
- Aerts J.M.F.G., Kallemeijn W.W., Wegdam W., Joao Ferraz M., Van Breemen M.J., Dekker N., Kramer G., Poorthuis B.J., Groener J.E.M., Cox-Brinkman J., Rombach S.M., Hollak C.E.M., Linthorst G.E., Witte M.D., Gold H., Marel G.A. van der, Overkleeft H.S. & Boot R.G. (2011), Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies, Journal of Inherited Metabolic Disease 34(3): 605-619.
- Ghisaidoobe A., Bikker P., Bruijn A.C.J. de, Godschalk F.D., Rogaar E., Guijt M.C., Hagens P., Halma J.M., Hart S.M. van 't, Luitjens S.B., Rixel V.H.S. van, Wijzenbroek M., Zweegers T., Donker-Koopman W.E., Strijland A., Boot R.G., Marel G.A. van der, Overkleeft H.S., Aerts J.M.F.G. & Berg R.J.B.H.N. van den (2011), Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars, Acs Medicinal Chemistry Letters 2(2): 119-123.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance, Advances in Experimental Medicine and Biology 721: 99-119.
- Smid B.E., Aerts J.M.F.G., Boot R.G., Linthorst G.E. & Hollak C.E. (2011), Pharmacological small molecules for the treatment of lysosomal storage disorders, Expert Opinion on Investigational Drugs 19(11): 1367-1379.
- Nieuwendijk A.M.C.H. van, Ruben M., Engelsma S.E., Risseeuw M.D.P., Berg R.J.B.H.N. van den, Boot R.G., Aerts J.M.F.G., Brussee J., Marel G.A. van der & Overkleeft H.S. (2010), Synthesis of L-altro-1-Deoxynoprimycin, D-allo-1-Deoxynoprimycin, and D-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin, 12(17): 3957-3959.
- Boot R.G., Hollak C.E.M., Verhoek M., Alberts C., Jonkers R.E. & Aerts J.M.F.G. (2010), Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis, Clinica Chimica Acta 411(1-2): 31-36.
- Witte M.D., Kallemeijn W.W., Aten J., Li K.Y., Strijland A., Donker-Koopman W.E., Nieuwendijk A.M.C.H. van den, Bleijlevens B., Kramer G., Florea B.I., Hooibrink B., Hollak C.E.M., Ottenhoff R., Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology 6(12): 907-913.
- Wennekes T., Meijer A.J., Groen A.K., Boot R.G., Groener J.E., Eijk M.C. van, Ottenhoff R., Bijl N., Ghauharali K., Song H., O'Shea T.J., Liu H., Yew N., Copeland D., Berg R.J.B.H.N. van den, Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry 53(2): 689-698.
- Dinkelaar J., Duivenvoorden B.A., Wennekes T., Overkleeft H.S., Boot R.G., Aerts J.M.F.G., Codee J.D.C. & Van der Marel G.A. (2010), A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4'-Deoxychitobiosyl)-4-methylumbelliferone, European Journal of Organic Chemistry (13): 2565-2570.
- Smid B.E., Aerts J. M.F.G., Boot R.G., Linthorst G.E. & Hollak C.E.M. (2010), Pharmacological small molecules for the treatment of lysosomal storage disorders, Expert Opinion on Investigational Drugs 19(11): 1367-1379.
- Eijk M.C. van, Aust G., Brouwer M.S.M., Meurs M. van, Voerman J.S.A., Dijke I.E., Pouwels W., Saendig I., Wandel E., Aerts J.M.F.G., Boot R.G., Laman J.D. & Hamann J. (2010), Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease, Immunology Letters 129(2): 64-71.
- Eijk M.C. van, Voorn-Brouwer T., Scheij S.S., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2010), Curdlan-mediated regulation of human phagocyte-specific chitotriosidase, FEBS Letters 584(14): 3165-3169.
- Aerts J.M.F.G. & Boot R.G. (2009), The Gaucher cell and chitotriosidase, the phagocyte chitinase. In: Musumeci S. & Paoletti M.G. (red.), Binomium Chitin-Chitinase: recent issues. Hauppage, NY: Nova Science Publishers. 113-128.
- Boot R.G., Speijer D., Bussink A.P. & Aerts J.M.F.G. (2009), The origin and genetics of human chitinases. In: Musumeci S. & Paoletti M.G. (red.), Binomium chitin-chitinase : recent issues. Hauppage, NY: Nova Science Publishers. 77-99.
- Seibold M.A., Reese T.A., Choudhry S., Salam M.T., Beckman K., Eng C., Atakilit A., Meade K., Lenoir M., Watson H.G., Thyne S., Kumar R., Weiss K.B., Grammer L.C., Avila P., Schleimer R.P., Fahy J.V., Rodriguez-Santana J., Rodriguez-Cintron W., Boot R.G., Sheppard D., Gilliland F.D., Locksley R.M. & Burchard E.G. (2009), Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein, Journal of Biological Chemistry 284(29): 19650-19658.
- Wennekes T., Berg R.J.B.H.N. van den, Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2009), Glycosphingolipids-Nature, Function, and Pharmacological Modulation, Angewandte Chemie (International Edition) 48(47): 8848-8869.
- Ghauharali-Van der Vlugt K., Bussink A.P., Groener J.E.M., Boot R.G. & Aerts J.M.F.G. (2009), Detection of chitinase activity by 2-aminobenzoic acid labeling of chito-oligosaccharides, Analytical Biochemistry 384(1): 191-193.
- Bussink A.P., Verhoek M., Vreede J., Ghauharali-Van der Vlugt K., Donker-Koopman W.E., Sprenger R.R., Hollak C.E., Aerts J.M.F.G. & Boot R.G. (2009), Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates, FEBS Journal 276(19): 5678-5688.
- Boot R.G., Breemen M.J. van, Wegdam W., Sprenger R.R., Jong S. de, Speijer D., Hollak C.E.M., Dussen L. van, Hoefsloot H.C.J., Smilde A.K., Koster C.G. de, Vissers J.P.C. & Aerts J.M.F.G. (2009), Gaucher disease: a model disorder for biomarker discovery, 6(4): 411-419.
- Bijl N., Sokolovic M., Vrins C., Langeveld M., Moerland P.D., Ottenhoff R., Roomen C.P.A.A. van, Claessen N., Boot R.G., Aten J., Groen A.K., Aerts J.M.F.G. & Eijk M.C. van (2009), Modulation of Glycosphingolipid Metabolism Significantly Improves Hepatic Insulin Sensitivity and Reverses Hepatic Steatosis in Mice, Hepatology 50(5): 1431-1441.
- Breemen M.J. van, Fost M. de, Maas M., Wiersma M.G., Hollak C.E.M., Poll L.W., Vom Dahl S., Boot R.G. & Aerts J.M.F.G. (2009), Different dose-dependent correction of MIP-1 beta and chitotriosidase during initial enzyme replacement therapy, Journal of Inherited Metabolic Disease 32(2): 274-279.
- Bijl N., Roomen C.P.A.A. van, Triantis V., Sokolovic M., Ottenhoff R., Scheij S., Eijk M. van, Boot R.G., Aerts J.M.F.G. & Groen A.K. (2009), Reduction of Glycosphingolipid Biosynthesis Stimulates Biliary Lipid Secretion In Mice, Hepatology 49(2): 637-645.
- Bussink A.P., Vreede J., Aerts J.M.F.G. & Boot R.G. (2008), A single histidine residue modulates enzymatic activity in acidic mammalian chitinase, FEBS Letters 582(6): 931-935.
- Aerts J.M.F.G., Groener J.E., Kuiper S., Donker-Koopman W.E., Strijland A., Ottenhoff R., Roomen C. van, Mirzaian M., Wijburg F.A., Linthorst G.E., Vedder A.C., Rombach S.M., Cox-Brinkman J., Somerharju P., Boot R.G., Hollak C.E., Brady R.O. & Poorthuis B.J. (2008), Elevated globotriaosylsphingosine is a hallmark of Fabry disease, Proceedings of the National Academy of Sciences 105(8): 2812-2817.
- Seibold M.A., Donnelly S., Solon M., Innes A., Woodruff P.G., Boot R.G., Burchard E.G. & Fahy J.V. (2008), Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit, Journal of Allergy and Clinical Immunology 122(5): 944-950.
- Bijl N., Scheij S., Houten S., Boot R.G., Groen A.K. & Aerts J.M.F.G. (2008), The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells, Journal of Pharmacology and Experimental Therapeutics 326(3): 849-855.
- Aerts J.M.F.G., Breemen M.J. van, Bussink A.P., Ghauharali K., Sprenger R., Boot R.G., Groener J.E., Hollak C.E., Maas M., Smit S., Hoefsloot H.C., Smildel A.K., Vissers J.P.C., Jong S. de, Speijer D. & Koster C.G. de (2008), Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease, Acta Paediatrica 97(s457): 7-14.
- Fost M. de, Out T.A., Wilde F.A. de, Tjin E.P.M., Pals S.T., Oers M.H.J. van, Boot R.G., Aerts J.F.M.G., Maas M., Dahl S. vom & Hollak C.E.M. (2008), Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature, Annals of Hematology 87(6): 439-449.
- Breemen M.J. van, Fost M. de, Voerman J.S.A., Laman J.D., Boot R.G., Maas M., Hollak C.E.M., Aerts J.M.F.G. & Rezaee F. (2007), Increased plasma macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta levels in type 1 Gaucher disease, Biochimica et Biophysica Acta: Molecular Basis of Disease 1772(7): 788-796.
- Bussink A.P., Swieten P.F. van, Ghauharali K., Scheij S., Eijk M.C. van, Wennekes T., Marel G.A. van der, Boot R.G., Aerts J.M.F.G. & Overkleeft H.S. (2007), N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides, Journal of Lipid Research 48(6): 1417-1421.
- Bussink A.P., Speijer D., Aerts J.M.F.G. & Boot R.G. (2007), Evolution of mammalian chitinase (-like) members of family 18 glycosyl hydrolases, Genetics 177(2): 959-970.
- Aerts J.M.F.G. & Boot R.G. (2007), Beyond the primary biochemical defect in type 1 Gaucher disease, Clinical Therapeutics 29(Supplement C): S77-S78.
- Eijk M.C. van, Scheij S.S., Roomen C.P.A.A. van, Speijer D., Boot R.G. & Aerts J.M.F.G. (2007), TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase, FEBS Letters 581(28): 5389-5395.
- Boot R.G., Verhoek M., Donker-Koopman W., Strijland A., Marle J. van, Overkleeft H.S., Wennekes T. & Aerts J.M.F.G. (2007), Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2, Journal of Biological Chemistry 282(2): 1305-1312.
- Boven L.A., Meurs M. van, Zwam M. van, Wierenga-Wolf A., Hintzen R.Q., Boot R.G., Aerts J.M.F.G., Amor S., Nieuwenhuis E.E. & Laman J.D. (2006), Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis, Brain 129((Part 2)): 517-526.
- Boot R.G., Verhoek M., Langeveld M., Renkema G.H., Hollak C.E.M., Weening J.J., Donker-Koopman W.E., Groener J.E. & Aerts J.M.F.G. (2006), CCL18: A urinary marker of Gaucher cell burden in Gaucher patients, Journal of Inherited Metabolic Disease 29(4): 564-571.
- Aerts J.M.F.G., Hollak C.E.M., Boot R.G., Groener J.E.M. & Maas M. (2006), Substrate reduction therapy of glycosphingolipid storage disorders, Journal of Inherited Metabolic Disease 29(2-3): 449-456.
- Bussink A.P., Eijk M. van, Renkema G.H., Aerts J.M.F.G. & Boot R.G. (2006), The biology of the Gaucher cell: The cradle of human chitinases, International Review of Cytology 252: 71-128.
- Deegan P.B., Moran M.T., McFarlane I., Schofield J.P., Boot R.G., Aerts J.M.F.G. & Cox T.M. (2005), Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease, Blood Cells, Molecules and Diseases 35(2): 259-267.
- Eijk M.C. van, Roomen C.P.A.A. van, Renkema G.H., Bussink A.P., Andrews L., Blommaart E.F.C., Sugar A., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2005), Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity, International Immunology 17(11): 1505-1512.
- Hollak C.E.M., Boot R.G., Poorthuis B.J.H.M. & Aerts J.M.F.G. (2005), Van gen naar ziekte; de ziekte van Gaucher, Nederlands Tijdschrift voor Geneeskunde 149: 2163-2166.
- Boot R.G., Bussink A.P., Verhoek M., Boer P.A.J. de, Moorman A.F.M. & Aerts J.M.F.G. (2005), Marked differences in tissue-specific expression of chitinases in mouse and man, Journal of Histochemistry and Cytochemistry 53(10): 1283-1292.
- Aerts J.M.F.G., Hollak C.E.M., Breemen M. van, Maas M., Groener J.E.M. & Boot R.G. (2005), Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases, Acta Paediatrica 94(s447): 43-46.
- Boot R.G., Bussink A.P. & Aerts J.M.F.G. (2005), Human acidic mammalian chitinase erroneously known as eosinophil chemotactic cytokine is not the ortholog of mouse YM1, Journal of Immunology 175(4): 2041-2042.
- Rao F.V., Houston D.R., Boot R.G., Aerts J.M.F.G., Hodkinson M., Adams D.J., Shiomi K., Omura S. & Aalten D.M.F. van (2005), Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases, Chemistry & Biology 12(1): 65-76.
- Dimitriou E., Verhoek M., Altun S., Karabatsos F., Moraitou M., Youssef J., Boot R.G., Sarafidou J., Karagiorga M., Aerts J.M.F.G. & Michelakakis H. (2005), Elevated plasma chemokine CCL18/PARC in beta-thalassemia, Blood Cells, Molecules and Diseases 35(3): 328-331.
- Brinkman J., Wijburg F.A., Hollak C.E., Groener J.E., Verhoek M., Scheij S., Aten J., Boot R.G. & Aerts J.M.F.G. (2005), Plasma chitotriosidase and CCL18: Early biochemical surrogate markers in type B Niemann-Pick disease, Journal of Inherited Metabolic Disease 28(1): 13-20.
- Boven L.A., Meurs M. van, Boot R.G., Mehta A., Boon L., Aerts J.M.F.G. & Laman J.D. (2004), Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages, American Journal of Clinical Pathology 122(3): 359-369.
- Boot R.G., Verhoek M., Fost M. de, Hollak C.E.M., Maas M., Bleijlevens B., Breemen M.J. van, Meurs M. van, Boven L.A., Laman J.D., Moran M.T., Cox T.M. & Aerts J.M.F.G. (2004), Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention, Blood 103(1): 33-39.
- Rao F.V., Houston D.R., Boot R.G., Aerts J.M.F.G., Sakuda S. & Aalten D.M.F. van (2003), Crystal structures of allosamidin derivatives in complex with human macrophage chitinase, Journal of Biological Chemistry 278(22): 20110-20116.
- Groener J.E.M., Hollak C.E.M., Bakker H.D., Boot R.G. & Aerts J.M.F.G. (2003), Behandeling van patiënten met de ziekte van Gaucher aan de hand van chemische ziektemarkers, Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde 28: 352-355.
- Aerts J.M.F.G., Hollak C.E.M., Boot R.G. & Groener A. (2003), Macrophages as therapeutic targets in lysosomal storage disorders. In: Gordon S. (red.), The macrophage as therapeutic target. Handbook of Experimental Pharmacology nr. 158. Berlin, Heidelberg: Springer. 193-208.
- Aerts J.M.F.G., Hollak C., Boot R.G. & Groener A. (2003), Biochemistry of glycosphingolipid storage disorders: implications for therapeutic intervention, Philosophical Transactions of the Royal Society B: Biological Sciences 358(1433): 905-914.
- Aguilera B., Ghauharali-Van der Vlugt K., Helmond M.T.J., Out J.M.M., Donker-Koopman W.E., Groener J.E.M., Boot R.G., Renkema G.H., Marel G.A. van der, Boom J.H. van, Overkleeft H.S. & Aerts J.M.F.G. (2003), Transglycosidase activity of chitotriosidase - Improved enzymatic assay for the human macrophage chitinase, Journal of Biological Chemistry 278(42): 40911-40916.
- Fusetti F., Moeller H. von, Houston D., Rozeboom H.J., Dijkstra B.W., Boot R.G., Aerts J.M.F.G. & Aalten D.M.F. van (2002), Structure of human chitotriosidase - Implications for specific inhibitor design and function of mammalian chitinase-like lectins, Journal of Biological Chemistry 277(28): 25537-25544.
- Boot R.G., Blommaart E.F.C., Swart E., Ghauharali-Van der Vlugt K., Bijl N., Moe C., Place A. & Aerts J.M.F.G. (2001), Identification of a novel acidic mammalian chitinase distinct from chitotriosidase, Journal of Biological Chemistry 276(9): 6770-6778.
- Boot R.G., Achterberg T.A.E. van, Aken B.E. van, Renkema G.H., Jacobs M.J.H.M., Aerts J.M.F.G. & Vries C.J.M. de (1999), Strong induction of members of the chitinase family of proteins in atherosclerosis - Chitotriosidase and human cartilage gp-39 expressed in lesion macrophages, Arteriosclerosis, Thrombosis, and Vascular Biology 19(3): 687-694.
- Renkema G.H., Boot R.G., Au F.L., Donker-Koopman W.E., Strijland A., Muijsers A.O., Hrebicek M. & Aerts J.M.F.G. (1998), Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages, European Journal of Biochemistry 251(1-2): 504-509.
- Boot R.G., Renkema G.H., Verhoek M., Strijland A., Bliek J., Meulemeester T.M.A.M.O. de, Mannens M.M.A.M. & Aerts J.M.F.G. (1998), The human chitotriosidase gene - Nature of inherited enzyme deficiency, Journal of Biological Chemistry 273(40): 25680-25685.
- Boot R.G., Hollak C.E.M., Verhoek M., Sloof P., Poorthuis B.J.H.M., Kleijer W.J., Wevers R.A., Oers M.H.J. van, Mannens M.M.A.M., Aerts J.M.F.G. & Weely S. van (1997), Glucocerebrosidase genotype of Gaucher patients in The Netherlands: Limitations in prognostic value, Human Mutation 10(5): 348-358.
- Renkema G.H., Boot R.G., Strijland A., Donker-Koopman W.E., Berg M. van den, Muijsers A.O. & Aerts J.M.F.G. (1997), Synthesis, sorting, and processing into distinct isoforms of human macrophage chitotriosidase, European Journal of Biochemistry 244(2): 279-285.
- Aerts J.M.F.G., Boot R.G., Renkema G.H., Weely S. van, Hollak C.E.M., Donker-Koopman W.E., Strijland A. & Verhoek M. (1996), Chitotriosidase: a human macrophage chitinase that is a marker for Gaucher disease manifestation. Muzzarelli R.A.A. (red.), Chitin Enzymology. 2nd International Symposium on Chitin Enzymology 8 mei 1996 - 11 mei 1996 nr. 2. Ancona: Atec. 3-10.
- Renkema G.H., Boot R.G., Muijsers A.O., Donker-Koopman W.E. & Aerts J.M.F.G. (1995), Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins, Journal of Biological Chemistry 270(5): 2198-2202.
- Aerts J.M.F.G., Boot R.G., Renkema G.H., Weely S. van, Jones S., Hollak C.E.M. & Oers M.H.J. van (1995), Molecular and biochemical abnormalities of Gaucher disease. Chitotriosidase, a newly identified biochemical marker, Seminars in Hematology 32: 10-13.
- Michelakakis H., Dimitriou E., Weely S. van, Boot R.G., Mavridou I., Verhoek M. & Aerts J.M.F.G. (1995), Characterization of glucocerebrosidase in Greek Gaucher disease patients - mutation analysis and biochemical studies, Journal of Inherited Metabolic Disease 18(5): 609-615.
- Boot R.G., Renkema G.H., Strijland A., Zonneveld A.J. van & Aerts J.M.F.G. (1995), Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages, Journal of Biological Chemistry 270(44): 26252-26256.
- Aerts J.M.F.G., Weely S. van, Boot R., Hollak C.E.M. & Tager J.M. (1993), Pathogenesis of lysosomal storage disorders as illustrated by Gaucher disease, Journal of Inherited Metabolic Disease 16(2): 288-291.
- Leij I. van der, Berg M. van den, Boot R.G., Franse M., Distel B. & Tabak H.F. (1992), Isolation of peroxisome assembly mutants from Saccharomyces cereviseae with differnt morphologies using a novel positive selection procedure, Journal of Cell Biology 119(1): 153-162.