Jurriaan Heming
Promovendus
- Naam
- Ing. J.J.A. Heming MSc
- Telefoon
- 071 5272727
- j.j.a.heming@lic.leidenuniv.nl
- ORCID iD
- 0000-0002-9217-3616
Promovendus
- Faculteit der Wiskunde en Natuurwetenschappen
- LIC
- Chemistry for Human Health
- Bio-organic Synthesis
- Heming J.J.A. (16 januari 2026), Substrates and inhibitors to study and modulate ER-I α-glucosidase activity (Dissertatie. Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University). Promotor(en): Overkleeft H.S. & Artola M.E.
- Vieira Da Cruz A., Perraudin V., Minopoli N., Iacono R., Roig-Zamboni V., Bossio A., Tangara S., Fayolle M., Kanazawa A., Philouze C., Tarallo A., Heming J.J.A., Artola Perez de Azanza M.E., Behr J.-B., Overkleeft H.S., Moracci M., Sulzenbacher G., Parenti G. & Py S. (2025), C-branched iminosugars as selective pharmacological chaperones of lysosomal α-glucosidase for the treatment of pompe disease, Journal of Medicinal Chemistry 68(18): 19269-19286.
- Ofman T.P., Heming J.J.A., Nin-Hill A., Küllmer F., Moran E., Bennett M., Steneker R., Klein A.M., Ruijgrok G., Kok K., Armstrong Z.W.B., Aerts J.M.F.G., Marel G.A. van der, Rovira C., Davies G.J., Artola M.E., Codée J.D.C. & Overkleeft H.S. (2024), Conformational and electronic variations in 1,2‐ and 1,5a‐Cyclophellitols and their impact on retaining α‐glucosidase inhibition, Chemistry: a European Journal 30(31): e202400723.
- Thaler M., Ofman T.P., Kok K., Heming J.J.A., Moran E., Pickles I., Leijs A.A., Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruijgrok G., Armstrong Z.W.B., Salgado-Benvindo C., Ninaber D.K., Snijder E.J., Boeckel C.A.A. van, Artola Perez de Azanza M.E., Davies G.J., Overkleeft H.S. & Hemert M.J. van (2024), Epi-Cyclophellitol cyclosulfate, a mechanism-based endoplasmic reticulum α-Glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses, ACS Central Science 10(8): 1594-1608.