Jara Bouma
Promovendus
- Naam
- Dr. J. Bouma
- Telefoon
- +31 71 527 2727
- j.bouma@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-6572-6158
For more information look at the English website
Promovendus
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Borrega-Roman L., Hoare B.L., KosarM., Sarott R.C., Patej K.J., Bouma J., Scott-Dennis M., Koers E.J., Gazzi T., Mach L., Barrondo S., Sallés J., Guba W., Kusznir E., Nazaré M., Rufer A.C., Grether U., Heitman L.H., Carreira E.M., Sykes D.A. & Veprintsev D.B. (2025), A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay, Frontiers in Pharmacology 16: 1469986.
- Vlachodimou A., Bouma J., Cleyn M. de, Berthelot D., Pype S., Bosmans J.P., Vlijmen H. van, Wroblowski B., Heitman L.H. & IJzerman A.P. (2024), Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors, Purinergic Signalling 20: 193-205.
- Bouma J. (11 september 2024), It's about time: novel drug discovery concepts for the molecular pharmacological characterization fo the cannabinoid CB2 receptor (Dissertatie. Leiden Academic Centre for Drug Research (LADCR), Faculty of Science, Leiden University). Promotor(en): Heitman L.H. & Stelt M. van de.
- Mach L., Omran A., Bouma J., Radetzki S., Sykes D.A., Guba W., Li X., Höffelmeyer C., Hentsch A., Gazzi T., Mostinski Y., Wasinska-Kalwa M., Molnier F. de, Horst C. van der, Kries J.P. von, Vendrell M., Hua T., Veprintsev D.B., Heitman L.H., Grether U. & Nazare M. (2024), Highly selective drug-derived fluorescent probes for the cannabinoid receptor type 1 (CB1R), Journal of Medicinal Chemistry 67(14): 11841-11867.
- Wąsińska-Kałwa M., Omran A., MachL., Scipioni L., Bouma J., Li X., Radetzki S., Mostinski Y., Schippers M, Gazzi T., Horst C. van der, Brennecke B., Hanske A., Kolomeets Y., Guba W., Sykes D., Kries J.P. von, Broichhagen J., Hua T., Veprintsev D., Heitman L.H., Oddi S., Maccarrone M., Grether U. & Nazare M. (2024), Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs, Chemical Science 15(44): 18443-18454.
- Bouma, J., Broekhuis J.D., Horst C. van der, Kumar P., Ligresti A., Stelt M. van der & Heitman L.H. (2023), Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor, Biochemical Pharmacology 218: 115924.
- Li X., Chang H., Bouma J., Paus L.V. de, Mukhopadhyay P., Paloczi J., Mustafa M., Horst C. van der, Kumar S.S., Wu L., Yu Y., Berg R.J.B.H.N. van den, Janssen A.P.A., Lichtman A., Liu Z.J., Pacher P., Stelt M. van der, Heitman L.H. & Hua T. (2023), Structural basis of selective cannabinoid CB2 receptor activation, Nature Communications 14(1): 1447.
- Bouma J., Soethoudt M., Gils N. van, Xia L., Stelt M van der & Heitman L.H. (2022), Cellular assay to study β-arrestin recruitment by the cannabinoid receptors 1 and 2. In: Maccarrone M. (red.), Endocannabinoid Signaling. Methods in Molecular Biology nr. 2576. New York, U.S.A.: Humana. 189-199.