Ine Tijdens
Arbo- en milieucoördinator
- Naam
- R.B. Tijdens
- Telefoon
- +31 6 2785 2348
- tijdens@lacdr.leidenuniv.nl
Arbo- en milieucoördinator
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Algemeen
- Miltenburg M.H. van, Nimwegen M.J. van, Tijdens R.B., Lalai R.A., Kuiper R., Klarenbeek S., Schouten P.C., Vries A. de, Jonkers J.M.M. & Water B. van de (2014), Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation, British Journal of Cancer 110(11): 2747-2755.
- Hendriks G., Atallah M., Raamsman M., Morolli B., Putten H. van der, Jaadar H., Tijdens R.B., Esveldt-Van Lange R., Mullenders L., Water B. van de & Vrieling H. (2011), Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 709-710: 49-59.
- Graauw M. de, Tijdens I., Smeets M.B., Hensbergen P.J., Deelder A.M. & Water B. van de (2008), Annexin A2 Phosphorylation Mediates Cell Scattering and Branching Morphogenesis via Cofilin Activation, Molecular and Cellular Biology 28(3): 1029-1040.
- Graauw M. de, Le Devedec S., Tijdens R.B., Smeets M.B., Deelder A.M. & Water B. van de (2007), Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary rat renal proximal tubular cells, Journal of Pharmacology and Experimental Therapeutics 322(1): 89-100.
- Nimwegen M.J. van, Huigsloot M., Camier A., Tijdens R.B. & Water B. van de (2006), Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells, Molecular Pharmacology 70(4): 1330-1339.
- Graauw M. de, Tijdens R.B., Cramer R., Corless S. & Timms J.F. (2005), Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis, Journal of Biological Chemistry 280(33): 29885-29898.
- Huigsloot M., Tijdens R.B. & Water B. van de (2003), Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2, Molecular Pharmacology 64(4): 965-973.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2002), Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary (MTLn3) cells, Journal of Biological Chemistry 277(39): 35869-35879.
- Water B. van de, Houtepen F., Huigsloot M. & Tijdens R.B. (2001), Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury, Journal of Biological Chemistry 276(39): 36183-36193.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2001), Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells, Biochemical Pharmacology 62(8): 1087-1097.
- Water B. van de, Tijdens R.B., Verbrugge A., Huigsloot M., Dihal A.A., Stevens J.L., Jaken S. & Mulder G.J. (2000), Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells, Journal of Biological Chemistry 275(33): 25805-25813.
- Haas R.R. de, Gijlswijk R.P.M. van, Tol E.B. van der, Veuskens J., Gijssel H.E. van, Tijdens R.B. & Bonnet J. (1999), Phosphorescent platinum/palladium coproporphyrins for time-resolved luminescence microscopy, Journal of Histochemistry and Cytochemistry 47(2): 183-196.
- Beerendonk G.J.M. van, Klein J.C., Tijdens R.B., Lichtenauer-Kaligis E.G.R., Tasseron-de Jong J.G. & Meerman J.H.N. (1998), Lack of mammalian mutagenicity of the potent bacterial mutagen tris (2,3-dibromopropyl) phosphate and its metabolite 2-bromoacrolein, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 415: 201-211.
- Bol S.A.M., Groot A.J.L. de, Tijdens R.B., Meermans J.H.N., Mullenders L.H.F. & Zeeland A.A. van (1997), Electrochemical detection and quantification of the acetylated and deacetylated C8-deoxyguanosine DNA-adducts induced by 2-acetylaminofluroence, Analytical Biochemistry 251: 24-31.