Hans van den Elst
Analist
- Naam
- Ing. H. van den Elst
- Telefoon
- 071 5274275
- elst_h@chem.leidenuniv.nl
Analist
- Faculteit der Wiskunde en Natuurwetenschappen
- LIC
- Chemistry for Human Health
- Bio-organic Synthesis
- Wintermans S.E.L., Hoffmann J.S., Kuijk V. van, Durmus Y., Tacoma M.D., Broekhuizen I., Janssen A.P.A., Elst H. van den, Doodewaerd B.R. van, Geurink P.P., Artola M. & Olsthoorn R.C.L. (2025), High-throughput competitive binding assay for targeting RNA tertiary structures with small molecules: application to pseudoknots and G-quadruplexes, Nucleic Acids Research 53(16): gkaf819.
- Peterse E., Meeuwenoord N.J., Elst H. van den, Marel G.A. van der, Overkleeft H.S. & Filippov D.V. (2022), Solid-phase synthesis of macrocyclic peptides via side-chain anchoring of the ornithine delta-amine, European Journal of Organic Chemistry 2022(11): e202101341.
- Gagestein B., von Hegedus J.H., Kwekkeboom J.C., Heijink M., Blomberg N., Wel T. van der, Florea B.I., Elst H. van der, Wals K., Overkleeft H.S., Giera M., Toes R.E.M., Ioan-Facsinay A. & Stelt M. van der (2022), Comparative photoaffinity profiling of omega-3 signaling lipid probes reveals prostaglandin reductase 1 as a metabolic hub in human macrophages, Journal of the American Chemical Society 144(41): 18938–18947.
- Marneth K., Elst H. van den, Cramer-Blok A.J., Codee J.D.C., Overkleeft H.S., Aerts J.M.F.G., Ubbink M. & Ben Bdira F. (2021), Tuning the transglycosylation reaction of a GH11 xylanase by a delicate enhancement of its thumb flexibility, ChemBioChem 22(10): 1743-1749.
- Koenders S.T.A., Rooden E.J. van, Elst H. van den, Florea B.I., Overkleeft H.S. & Stelt M. van der (2020), STA-55, an Easily Accessible, Broad-Spectrum, Activity-Based Aldehyde Dehydrogenase Probe, ChemBioChem 21: 1911-1917.
- Li R.E., Hogervorst T.P., Achilli S., Bruijns S.C., Arnoldus T., Vivès C., Wong C.C., Thépaut M., Meeuwenoord N.J., Elst H Van den, Overkleeft H.S., Marel G.A. van der, Filippov D.V., Vliet S.J. van, Fieschi F., Codee J.D.C. & Kooyk Y. van (2019), Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen, Frontiers in Chemistry 7: 650.
- Koenders S.T.A., Wijaya L.S., Erkelens M.N., Bakker A.T., Noord V.E. van der, Rooden E.J. van, Burggraaff L., Putter P.C., Botter E., Wals K., Elst H. van den, Dulk H. den, Florea B.I., Water B. van de, Westen G.J.P. van, Mebius R.E., Overkleeft H.S., Le Dévédec S.E. & Stelt M. van der (2019), Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells, ACS Central Science 5(12): 1965-1974.
- Artola M., Kuo C.L., McMahon S.A., Oehler V., Hansen T., Lienden M.J.C. van der, He X., Elst H. van den, Florea B.I., Kermode A.R., Marel G.A. van der, Gloster T.M., Codée J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2018), New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes, Chemistry: a European Journal 24(71): 19081-19088.
- Hoogendoorn S., Mock E.D., Strijland A., Donker-Koopman W.E., Elst H. van den, Berg R.J.B.H.N. van den, Aerts J.M.F.G., Marel G.A. van der & Overkleeft H.S. (2015), Ortho-Carborane-modified N-substituted Deoxynojirimycins, European Journal of Organic Chemistry 2015(20): 4437-4446.
- Jiang J., Beenakker T.J.M., Kallemeijn W.W., Marel G.A. van der, Elst H. van der, Codee J.D.C., Aerts J.M.F.G. & Overkleeft H.S. (2015), Comparing Cyclophellitol N-Alkyl and N-Acyl Cyclophellitol Aziridines as Activity-Based Glycosidase Probes, Chemistry: a European Journal 21(30): 10861-10869.
- Jiang J., Kallemeijn W.W., Wright D.W., Nieuwendijk A.M.C.H. van den, Coco Rohde V., Folch E.C., Elst H. van den, Florea B.I., Scheij S., Donker-Koopman W.E., Verhoek M., Li N., Schürmann M., Mink D., Boot R.G., Codée J.D.C., Marel G.A. van der, Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2015), In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 alpha-L-fucosidases, Chemical Science 6(5): 2782-2789.
- Wisse P., Gold H., Mirzaian M., Guimaraes Da Lomba Ferraz M.J., Lutteke G., Berg R.J.B.H.N. van den, Elst H. van den, Lugtenburg J., Marel G.A. van der, Aerts J.M.F.G., Codee J.D.C. & Overkleeft H.S. (2015), Synthesis of a panel of carbon-13-labelled (glyco)sphingolipids, European Journal of Organic Chemistry 2015(12): 2661-2677.
- Li K.-Y., Kallemeijn W.W., Jiang J., Walvoort M.T.C., Willems L.I., Beenakker T., Elst H. van den, Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Florea B.I., Boot R.G., Witte M.D. & Overkleeft H.S. (2014), Rational Design of Activity-Based Retaining β-Exoglucosidase Probes. In: Waldmann H. & Janning P. (red.), Concepts and Case Studies in Chemical Biology: Wiley. 191-206.
- Willems Lianne I., Beenakker Thomas J.M., Murray Benjamin, Gagestein Berend, Van den Elst Hans, Van Rijssel Erwin R., Codee Jeroen D.C., Kallemeijn Wouter W., Aerts Johannes M.F.G., Van der Marel Gijsbert A. & Overkleeft Herman S. (2014), Synthesis of alpha- and beta-Galactopyranose-Configured Isomers of Cyclophellitol and Cyclophellitol Aziridine, (27): 6044-6056.
- Mueller Sebastian, Garcia-Gonzalez Eva, Mainz Andi, Hertlein Gillian, Heid Nina C., Moesker Eva, Van den Elst Hans, Overkleeft Herman S., Genersch Elke & Suessmuth Roderich D. (2014), Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae, 53(40): 10821-10825.
- Li Kah-Yee, Jiang Jianbing, Witte Martin D., Kallemeijn Wouter W., Van den Elst Hans, Wong Chung-Sing, Chander Sharina D., Hoogendoorn Sascha, Beenakker Thomas J.M., Codee Jeroen D.C., Aerts Johannes M.F.G., Van der Marel Gijs A. & Overkleeft Herman S. (2014), Synthesis of Cyclophellitol, Cyclophellitol Aziridine, and Their Tagged Derivatives, (27): 6030-6043.
- De Jong Ana R., Volbeda Anne G., Hagen Bas, Van den Elst Hans, Overkleeft Herman S., Van der Marel Gijsbert A. & Codee Jeroen D.C. (2013), A Second-Generation Tandem Ring-Closing Metathesis Cleavable Linker for Solid-Phase Oligosaccharide Synthesis, European Journal of Organic Chemistry 2013(29): 6644-6655.
- Baggelaar M.P., Janssen F.J., Esbroeck A.C.M. van, Dulk J. den, Allara M., Hoogendoorn S., McGuire R., Florea B.I., Meeuwenoord N.J., Elst H. van den, Marel G.A. van der, Brouwer J., Marzo V. di, Overkleeft H.S. & Stelt M. van der (2013), Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-alpha in Brain, Angewandte Chemie (International Edition) 52(46): 12081-12085.
- Li N., Kuo C.L., Paniagua G., Elst H. van der, Verdoes M., Willems L.I., Linden W.A. van der, Ruben M., Genderen E. van, Gubbens J., Wezel G.P. van, Overkleeft H.S. & Florea B.I. (2013), Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS, Nature Physics 8(6): 1155-1168.
- Kallemeijn W.W., Li K.Y., Witte M.D., Marques A.R.A., Aten J., Scheij S., Jiang J., Willems L.I., Voorn-Brouwer T.M., Roomen C.P.A.A. van, Ottenhoff R., Boot R.G., Elst H. van den, Walvoort M.T.C., Florea B.I., Codee J.D.C., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie (International Edition) 51(50): 12529-12533.
- Berg R.J.B.H.N. van den., Elst H. van den., Korevaar C.G.N., Aerts J.M.F.G., Marel G.A. van der. & Overkleeft H.S. (2011), A Rapid and Efficient Synthesis of D-erythro-Sphingosine from D-ribo-Phytosphingosine, European Journal of Organic Chemistry 2011(33): 6685-6689.
- Kriek N.M.A.J., Meeuwenoord N.J., Elst H. van den, Heus H.A., Marel G.A. van der & Filippov D.V. (2006), Chemical synthesis of picornaviral protein primers of RNA replication, ORGANIC & BIOMOLECULAR CHEMISTRY 4: 3576-3586.
- El Oualid F., Elst H. van den, Leroy I.M., Pieterman E., Cohen L.H., Burm B.E.A., Overkleeft H.S., Marel G.A. van der & Overhand M. (2005), A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1, Journal Of Combinatorial Chemistry 7: 703-713.
- El Oualid F., Baktawar J., Leroy I.M., Elst H. van den, Cohen L.H., Marel G.A. van der, Overkleeft H.S. & Overhand M. (2005), Synthesis and biological evaluation of lipophilic Ca1a2L analogues as potential bisubstrate inhibitors of protein: geranylgeranyl transferase-1, Bioorganic & Medicinal Chemistry 13: 1463-1475.
- Koning M.C. de, Knaap M.S. van der, Petersen L., Elst H. van den, Marel G.A. van der, Overhand M. & Filippov D.V. (2005), Reactivity of PNA thioesters in chemical ligation reactions, SYNLETT 6: 595-598.
- Kriek N.M.A.J., Filippov D.V., Elst H. van den, Meeuwenoord N.J., Tesser G.I., Boom J.H. van & Marel G.A. van der (2003), Stepwise solid phasae synthesis of uridylylated viral genome-linked peptides using uridylylated amino acid building blocks, Tetrahedron 59: 1589-1597.
- Robillard M.S., Bacac M., Elst H. van den, Flamigni A., Marel G.A. van der, Boom J.H. van & Reedijk J. (2003), Automated parallel solid-phase synthesis and anticancer screening of a library of peptide-tethered platinum (II) complexes, Journal Of Combinatorial Chemistry 5(6): 821-825.
- Rossenberg S.M.W. van, Sliedregt-Bol K.M., Koning G., Elst H. van den, Berkel T.J.C. van, Boom J.H. van, Marel G.A. van der & Biessen E.A.L. (2003), Improvement of hepatocyte-specific gene expression by a targeted colchicine prodrug, ChemBioChem 4: 633-639.
- Kriek N.M.A.J., Filippov D.V., Elst H. van den, Meeuwenoord N.J., Tesser G.I., Boom J.H. van & Marel G.A. van der (2003), Stepwise solid phase synthesis of uridylylated viral genome-linked peptides using uridylylated amino acid building blocks, Tetrahedron 59(9): 1589-1597.
- Ippel H.H., Elst H. van den, Marel G.A. van der, Boom J.H. van & Altona C. (1998), Structural similarities and differences between H1- and H2-family DNA minihairpin loops: NMR studies of octameric minihairpins, Biopolymers 46: 375-383.
- Garderen C.J. van, Elst H. van den, Boom J.H. van, Reedijk J. & Houte L.P.A. van (1989), A double stranded DNA fragment shows a significant decrease in double-helix stability after binding of monofunctional platinum amine compounds, Journal of the American Chemical Society 111(11): 4123-4125.