Bas ter Braak
Onderzoeker
- Naam
- Dr. S.J. ter Braak
- Telefoon
- 071 5272727
- s.j.ter.braak@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-7290-4119
Voor meer informatie zie de Engelse profielpagina
Promovendi
Onderzoeker
- Faculteit der Wiskunde en Natuurwetenschappen
- LACDR
- Divisie Cell systems and Drug Safety
- Meijer T., Braak S.J. ter, Wolters L., Kunnen S.J., Islam B., Suciu I., Gardner I., Hatley O., Currie R., Hardy B., Leist M., Water B. van de, Jennings P. & Wilmes A. (2025), Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models, Toxicology In Vitro 104: 106010.
- Sharma R.P., Loonstra-Wolters L., Braak S.J. ter, Niemeijer M.C., White A., Water B. van de, Middleton A.M. & Beltman J.B. (2025), Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling, Toxicology 519: 154284.
- Niemeijer M.C., Danilyuk T.Y., Hagens T.M.S. Bahtiri S., Wijaya L.S., Davidse S.C., Kunnen S.J., Sinke L.J., Hochane M., Berk L. van den, Snijders K.E., Braak S.J. ter, Callegaro G., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2025), Human hiPSC-derived hepatocyte-like cell stress response fluorescent protein reporter imaging platform for chemical screening, Toxicology Letters 411: 39.
- Danilyuk T.Y., Niemeijer M.C., Wijaya L.S., Snijders K., Berk L. van der, Braak S.J. ter, Callegaro G., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Human-induced pluripotent stem cell reporters for high-content screening of stress response activation identifying target organ-specific toxicities, Toxicology Letters 384: S192.
- Braak S.J. ter, Niemeijer M.C., Wolters L., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2022), Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters, Mutagenesis 37(2): 130-142.
- Braak S.J. ter, Klip J.E., Wink S., Hiemstra S.W., Cooper S.L., Middleton A., White A. & Water B. van de (2022), Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses, Toxicology In Vitro 84: 105419.
- Gupta R., Schrooders Y., Hauser D., Herwijnen M. van, Albrecht W., Braak B. ter, Brecklinghaus T., Castell J.V., Elenschneider L., Escher S., Guye P., Hengstler J.G., Ghallab A., Hansen T., Leist M., Maclennan R., Moritz W., Tolosa L., Tricot T., Verfaillie C., Walker P., Water B. van de, Kleinjans J. & Caiment F. (2021), Comparing in vitro human liver models to in vivo human liver using RNA-Seq, Archives of Toxicology 95: 573-589.
- Braak B. ter, Niemeijer M., Boon R., Parmentier C., Baze A., Richert. L., Huppelschoten S., Wink S., Verfaillie C. & Water B. van de (2021), Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes, Toxicology In Vitro 73: 105107.
- Liu T., Berk L. van den, Wondergem J.A.J., Tong C., Kwakernaak M.C., Braak B. ter, Heinrich D., Water B. van de & Kieltyka R.E. (2021), Squaramide‐based supramolecular materials Drive hepG2 spheroid differentiation, Advanced Healthcare Materials 10(11): 2001903.
- Tolosa L., Martínez-Sena T., Schimming J.P., Moro E., Escher S.E., Braak S.J. ter, Water B. van de, Miranda M.A., Vugt-Lussenburg B.M.A. van & Castell J.V. (2021), The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example, Archives of Toxicology 95(6): 2109-2121.
- Krebs A. Vugt-Lussenburg B.M.A. van Waldmann T. Albrecht W. Boei J. Braak B. ter Brajnik M. Braunbeck T. Brecklinghaus T. Busquet F. Dinnyes A. Dokler J. Dolde X. Exner T.E. Fisher C. Fluri D. Forsby A. Hengstler J.G. Holzer A.K. Janstova Z. Jennings P. Kisitu J. Kobolak J. Kumar M. Limonciel A. Lundqvist J. Mihalik B. Moritz W. Pallocca G. Ulloa A.P.C. Pastor M. Rovida C. Sarkans U. Schimming J.P. Schmidt B.Z. Stöber R. Strassfeld T. Water B. van de Wilmes A. Burg B. van der Verfaillie C.M. von Hellfeld R. Vrieling H. Vrijenhoek N.G. Leist M. (2020), The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods, Archives of Toxicology 94(7): 2435-2461.
- Gräpel R., Braak B. ter, Escher S.E., Fisher C., Gardner I., Kamp H., Kroese D., Leist M., Moné M.J., Pastor M. & Water B. van de (2019), Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy, Current Opinion in Toxicology 15: 33-39.
- Schimming J.P., Braak B. ter, Niemeijer M., Wink S. & Water B. van de (2019), System Microscopy of Stress Response Pathways in Cholestasis Research. In: Vinken M. (red.), Experimental Cholestasis Research. Methods in Molecular Biology nr. 1981. New York, NY, U.S.A.: Humana Press. 187-202.
- Bischoff L.J.M., Kuijper I.A., Schimming J.P., Wolters L., Braak B. ter, Langenberg J.P., Noort D., Beltman J.B. & Water B. van de (2019), A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure, Archives of Toxicology 93(2): 435-451.
- Niemeijer M.C., Hiemstra S.W., Wink S., Hollander W. den, Braak S.J. ter & Water B. van de (2018), Systems microscopy approaches in unraveling and predicting Drug-Induced Liver Injury (DILI). In: Chen M. & Will Y. (red.), Drug-Induced Liver Toxicity. Methods in Pharmacology and Toxicology. New York: Humana Press. 611-625.
- Bronsveld H.K., Bruin M.L. de, Wesseling J., Sanders J., Hofland I., Jensen V., Bazelier M.T., Braak S.J. ter, Boer A. de, Vestergaard P. & Schmidt M.K. (2018), The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors, BMC Cancer 18(1): 224.
- Braak S.J. ter, Siezen C.L., Lee J.S., Rao P., Voorhoeve C., Ruppin E., Laan J.W. van der & Water B. van de (2017), Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production, Breast cancer research 19: 14.
- Braak S.J. ter, Siezen C.L.E., Speksnijder E.N., Koedoot E., Steeg H. ter, Salvatori D.C.F., Water B. van de & Laan J.W. van der (2015), Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model, Breast cancer research 17: 14.
- Dempster M., Siezen K., Braak S.J. ter, Brink W.J. van den, Emerenciana A., Bellanti F., Duijnhoven R.G., Kwa M. & Laan J.W. van der (2015), Carcinogenicity of Biopharmaceuticals. In: Graziano M.J. & Jacobson-Kram D. (red.), Genotoxicity and Carcinogenicity Testing of Pharmaceuticals. Cham: Springer International Publishing. 125-157.
- Bronsveld H.K., Braak B. ter, Karlstad O., Vestergaard P., Starup-Linde J., Bazelier M.T., Bruin M.L. de, Boer A. de, Siezen C.L.E., Water B. van de, Laan J.W. van der & Schmidt M.K. (2015), Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence, Breast cancer research 17: 100.
- Braak B. ter, Wink S., Koedoot E., Pont C., Siezen C., Laan J.W. van der & Water B. van de (2015), Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells, Breast cancer research 17: 97.
- Braak S.J. ter, Siezen C.L.E., Kannegieter N., Koedoot E., Water B. van de & Laan J.W. van der (2014), Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel, Archives of Toxicology 88(4): 953-966.
- Braak S.J. ter, Laughton A.M., Altincicek B., Parker B.J. & Gerardo N.M. (2013), Exposure to bacterial signals does not alter pea aphids' survival upon a second challenge or investment in production of winged offspring, 8(8): e73600.
- De La Vega J., Braak S.J. ter, Azzoni A.R., Monteiro G.A. & Prazeres D.M. (2013), Impact of plasmid quality on lipoplex-mediated transfection, Journal of Pharmaceutical Sciences 102(11): 3932-3941.