Anne-Charlotte Dubbelman
Onderzoeker / gast
- Naam
- Dr.ir. A.C. Dubbelman
- Telefoon
- +31 71 527 2727
- a.c.dubbelman@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-5295-7758
Onderzoeker / gast
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Analytical Biosciences
- Leygeber S., Grossmann J.L., Diez-Simon C., Karu N., Dubbelman A.C., Harms A.C., Westerhuis J.A., Jacobs D.M., Lindenburg P.W., Hendriks M.M.W.B., Ammerlaan B.C., Berg M.A. van den, Doorn R. van, Mumm R., Hall R.D., Smilde A.K. & Hankemeier T. (2022), Flavor profiling using comprehensive mass spectrometry analysis of metabolites in tomato soups, Metabolites 12(12): 1194.
- Laan T. van der, Elfrink H.L., Azadi-Chegeni F., Dubbelman A.C., Harms A.C., Jacobs D.M., Braumann U., Velders A.H., Duynhoven J. & Hankemeier T. (2021), Fractionation platform for target identification using off-line directed two-dimensional chromatography, mass spectrometry and nuclear magnetic resonance, Analytica Chimica Acta 1142: 28-37.
- Hosseinkhani F., Dubbelman A.C., Karu N., Harms A.C. & Hankemeier T. (2021), Towards standards for human fecal sample preparation in targeted and untargeted LC-HRMS studies, Metabolites 11(6): 364.
- Laan T. van der, Dubbelman A.C., Duisters K.L.W., Kindt A.S.D., Harms A.C. & Hankemeier T. (2020), High-throughput fractionation coupled to mass spectrometry for improved quantitation in metabolomics, Analytical Chemistry 92(21): 14330-14338.
- Laan T. van der, Boom I., Maliepaard J., Dubbelman A.C., Harms A.C. & Hankemeier T. (2020), Data-independent acquisition for the quantification and identification of metabolites in plasma, Metabolites 10(12): 514.
- Laan T. van der, Kloots T.N., Beekman M., Kindt A.S.D., Dubbelman A.C., Harms A.C., Duijn C.M. van, Slagboom P.E. & Hankemeier T. (2019), Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum, Scientific Reports 9: 12370.
- Miggiels P., Wouters B., Westen G.J.P van, Dubbelman A.-C. & Hankemeier T. (2019), Novel technologies for metabolomics: More for less, Trends in Analytical Chemistry 120: 115323.
- Dubbelman A.C., Cuyckens F., Dillen L., Gross G., Vreeken R.J. & Hankemeier T. (2018), Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry, Analytica Chimica Acta 1020: 62-75.
- Dubbelman A.C., Cuyckens F., Dillen L., Gross G., Hankemeier T. & Vreeken R.J. (2014), Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity, Journal of Chromatography A 1374: 122-133.
- Dubbelman A.C., Rosing H., Nijenhuis C., Huitema A.D.R., Mergui-Roelvink M., Gupta A., Verbel D., Thompson G., Shumaker R., Schellens J.H.M. & Beijnen J. (2014), Pharmacokinetics and excretion of 14C-lenvatinib in patients with advanced solid tumors or lymphomas, Investigational New Drugs 33: 233-240.
- Dubbelman Anne-Charlotte, Rosing Hilde, Mergui-Roelvink Marja, Gupta Anubha, Verbel David, Sellecchia Rita, Fan Jean, Thompson Gary A., Shumaker Robert, Huitema Alwin D.R., Beijnen Jos H. & Schellens Jan H.M. (2013), A MASS BALANCE STUDY OF C-14-LENVATINIB (E7080) IN PATIENTS WITH ADVANCED SOLID TUMOURS OR LYMPHOMAS, British Journal of Clinical Pharmacology 76(5): 831-831.
- Hendrikx J.J.M.A., Dubbelman A.C., Rosing H., Schinkel A.H., Schellens J.H.M. & Beijnen J.H. (2013), Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry, Rapid Communications in Mass Spectrometry 27(17): 1925-1934.
- Dubbelman Anne-Charlotte, Jansen Robert S., Rosing Hilde, Darwish Mona, Hellriegel Edward, Robertson , Philmore Jr. , Schellens Jan H.M. & Beijnen Jos H. (2012), Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [C-14]Bendamustine, Drug Metabolism and Disposition 40(7): 1297-1307.
- Dubbelman A.C., Rosing H., Thijssen B., Gebretensae A., Lucas L., Chen H., Shumaker R., Schellens J.H.M. & Beijnen J.H. (2012), Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 887: 25-34.
- Dubbelman Anne-Charlotte, Rosing Hilde, Jansen Robert S., Mergui-Roelvink Marja, Huitema Alwin D.R., Koetz Barbara, Lymboura Margarita, Reyderman Larisa, Lopez-Anaya Arturo, Schellens Jan H.M. & Beijnen Jos H. (2012), Mass Balance Study of [C-14]Eribulin in Patients with Advanced Solid Tumors, Drug Metabolism and Disposition 40(2): 313-321.
- Dubbelman A.C., Tibben M., Rosing H., Gebretensae A., Nan L., Gorman S.H., Robertson Jr. P., Schellens J.H.M. & Beijnen J.H. (2012), Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 893: 92-100.
- Dubbelman Anne-Charlotte, Upthagrove Alana, Beijnen Jos H., Marchetti Serena, Tan Eugene, Krone Kimberly, Anand Suraj & Schellens Jan H.M. (2012), Disposition and metabolism of C-14-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors, Cancer Chemotherapy and Pharmacology 70(5): 653-663.
- Dubbelman Anne-Charlotte, Rosingi Hilde, Schellens Jan H.M. & Beijnen Jos H. (2011), Bioanalytical aspects of clinical mass balance studies in oncology, Bioanalysis 3(23): 2637-2655.
- Dubbelman Anne-Charlotte, Rosing Hilde, Darwish Mona, D'Andrea Denise, Bond Mary, Hellriegel Edward T., Beijnen Jos H. & Schellens Jan H.M. (2011), An Open-Label Phase I Pharmacokinetic Study of [(14)c] Bendamustine in Patients with Relapsed or Refractory Malignancy, Blood 118(21): 1061-1061.
- Dubbelman A.C., Rosing H., Thijssen B., Lucas L., Copalu W., Wanders J., Schellens J.H.M. & Beijnen J.H. (2011), Validation of high-performance liquid chromatography-tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 879(15-16): 1149-1155.