Anne Charlotte Dubbelman
Senior Research Scientist and Quality Manager
- Naam
- Dr.ir. A.C. Dubbelman
- Telefoon
- +31 71 527 1869
- a.c.dubbelman@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-5295-7758
Senior Research Scientist and Quality Manager
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Analytical Biosciences
- Laan T. van der, Kloots T.N., Beekman M., Kindt A.S.D., Dubbelman A.C., Harms A.C., Duijn C.M. van, Slagboom P.E. & Hankemeier T. (2019), Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum, Scientific Reports 9: 12370.
- Miggiels P., Wouters B., Westen G.J.P van, Dubbelman A.-C. & Hankemeier T. (2019), Novel technologies for metabolomics: More for less, TrAC Trends in Analytical Chemistry 120: 115323.
- Dubbelman A.C., Cuyckens F., Dillen L., Gross G., Vreeken R.J. & Hankemeier T. (2018), Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry, Analytica Chimica Acta 1020: 62-75.
- Dubbelman A.C., Cuyckens F., Dillen L., Gross G., Hankemeier T. & Vreeken R.J. (2014), Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity., Journal of Chromatography A 1374: 122-133.
- Dubbelman A.C., Rosing H., Nijenhuis C., Huitema A.D.R., Mergui-Roelvink M., Gupta A., Verbel D., Thompson G., Shumaker R., Schellens J.H.M. & Beijnen J. (2014), Pharmacokinetics and excretion of 14C-lenvatinib in patients with advanced solid tumors or lymphomas, Investigational New Drugs 33: 233-240.
- Dubbelman Anne-Charlotte, Rosing Hilde, Mergui-Roelvink Marja, Gupta Anubha, Verbel David, Sellecchia Rita, Fan Jean, Thompson Gary A., Shumaker Robert, Huitema Alwin D. R., Beijnen Jos H. & Schellens Jan H. M. (2013), A MASS BALANCE STUDY OF C-14-LENVATINIB (E7080) IN PATIENTS WITH ADVANCED SOLID TUMOURS OR LYMPHOMAS, British Journal of Clinical Pharmacology 76(5): 831-831.
- Hendrikx J. J. M. A., Dubbelman A. C., Rosing H., Schinkel A. H., Schellens J. H. M. & Beijnen J. H. (2013), Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY 27(17): 1925-1934.
- Dubbelman Anne-Charlotte, Upthagrove Alana, Beijnen Jos H., Marchetti Serena, Tan Eugene, Krone Kimberly, Anand Suraj & Schellens Jan H. M. (2012), Disposition and metabolism of C-14-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors, Cancer Chemotherapy and Pharmacology 70(5): 653-663.
- Dubbelman Anne-Charlotte, Jansen Robert S., Rosing Hilde, Darwish Mona, Hellriegel Edward, Robertson, Philmore Jr., Schellens Jan H. M. & Beijnen Jos H. (2012), Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [C-14]Bendamustine, Drug Metabolism and Disposition 40(7): 1297-1307.
- Dubbelman A. C., Tibben M., Rosing H., Gebretensae A., Nan L., Gorman S. H., Robertson, P. Jr., Schellens J. H. M. & Beijnen J. H. (2012), Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine, Journal of Chromatography B 893: 92-100.
- Dubbelman A. C., Rosing H., Thijssen B., Gebretensae A., Lucas L., Chen H., Shumaker R., Schellens J. H. M. & Beijnen J. H. (2012), Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices, Journal of Chromatography B 887: 25-34.
- Dubbelman Anne-Charlotte, Rosing Hilde, Jansen Robert S., Mergui-Roelvink Marja, Huitema Alwin D. R., Koetz Barbara, Lymboura Margarita, Reyderman Larisa, Lopez-Anaya Arturo, Schellens Jan H. M. & Beijnen Jos H. (2012), Mass Balance Study of [C-14]Eribulin in Patients with Advanced Solid Tumors, Drug Metabolism and Disposition 40(2): 313-321.
- Dubbelman Anne-Charlotte, Rosingi Hilde, Schellens Jan H. M. & Beijnen Jos H. (2011), Bioanalytical aspects of clinical mass balance studies in oncology, Bioanalysis 3(23): 2637-2655.
- Dubbelman Anne-Charlotte, Rosing Hilde, Darwish Mona, D'Andrea Denise, Bond Mary, Hellriegel Edward T., Beijnen Jos H. & Schellens Jan H. M. (2011), An Open-Label Phase I Pharmacokinetic Study of [(14)c] Bendamustine in Patients with Relapsed or Refractory Malignancy, Blood (ASH Annual Meeting Abstracts) - print 118(21): 1061-1061.
- Dubbelman A. C., Rosing H., Thijssen B., Lucas L., Copalu W., Wanders J., Schellens J. H. M. & Beijnen J. H. (2011), Validation of high-performance liquid chromatography-tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices, Journal of Chromatography B 879(15-16): 1149-1155.
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