Anne Wentink
Assistant Professor
- Name
- Dr. A.S. Wentink
- Telephone
- +31 71 527 4534
- a.s.wentink@lic.leidenuniv.nl
The research of Anne Wentink is focused on understanding the role of chaperone mediated disaggregation of protein aggregates in the context of neurodegenerative disease.
Biography
Dr. Anne S Wentink (09-05-1990) studied Biochemistry at University College London (UCL) from 2007-2010. She obtained a BBSRC scholarship to pursue a PhD in the lab of Prof John Christodoulou at UCL (2010-2015). Here she used solution-state NMR spectroscopy to study the structure and dynamics of the ribosome associated bacterial chaperone Trigger Factor and its interaction with nascent polypeptide chains.
Her postdoctoral research with Prof Bernd Bukau at Heidelberg University (since 2015) on the molecular mechanism of amyloid fibre disaggregation by the human Hsp70 chaperone cumulated in two back-to-back publications in Nature in 2020. In January 2022, she started her own research group as assistant professor within the division of Macromolecular Biochemistry focused on understanding the role of chaperone mediated disaggregation of protein aggregates in the context of neurodegenerative disease.
Assistant Professor
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Macromolecular Biochemistry
- Beton J.G., Monistrol J., Wentink A.S., Johnston E.C., Roberts A.J., Bukau B.G., Hoogenboom B.W. & Saibil H.R. (2022), Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase, The EMBO Journal 41(16): e110410.
- Faust O., Abayev-Avraham M., Wentink A.S., Maurer M., Nillegoda N.B., London N., Bukau B. & Rosenzweig R. (2020), HSP40 proteins use class-specific regulation to drive HSP70 functional diversity, Nature 587(7834): 489-+.
- Wentink A.S., Nillegoda N.B., Feufel J., Ubartaite G., Schneider C.P., De Los Rios P., Hennig J., Barducci A. & Bukau B. (2020), Molecular dissection of amyloid disaggregation by human HSP70, Nature 587(7834): 483-+.
- Nachman E., Wentink A.S., Madiona K., Bousset L., Katsinelos T., Allinson K., Kampinga H., McEwan W.A., Jahn T.R., Melki R., Mogk A., Bukau B. & Nussbaum-Krammer C. (2020), Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species, J BIOL CHEM 295(28): 9676-9690.
- Serlidaki D., Waarde M.A.W.H. van, Rohland L., Wentink A.S., Dekker S.L., Kamphuis M.J., Boertien J.M., Brunsting J.F., Nillegoda N.B., Bukau B., Mayer M.P., Kampinga H.H. & Bergink S. (2020), Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones, J BIOL CHEM 295(21): 7301-7316.
- De Mattos EP Wentink A Nussbaum-Krammer C Hansen C Bergink S Melki R Kampinga HH (2020), Protein Quality Control Pathways at the Crossroad of Synucleinopathies, J PARKINSON DIS 10(2): 369-382.
- Wentink A., Nussbaum-Krammer C. & Bukau B. (2019), Modulation of Amyloid States by Molecular Chaperones, Cold Spring Harbor Perspectives in Biology 11(7): a033969.
- Waudby C.A., Wlodarski T., Karyadi M.E., Cassaignau A.M.E., Chan S.H.S., Wentink A.S., Schmidt-Engler J.M., Camilloni C., Vendruscolo M., Cabrita L.D. & Christodoulou J. (2018), Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis, Proceedings of the National Academy of Sciences of the United States of America 115(39): 9744-9749.
- Nillegoda N.B., Wentink A.S. & Bukau B. (2018), Protein Disaggregation in Multicellular Organisms, TRENDS BIOCHEM SCI 43(4): 285-300.
- Mashaghi A., Bezrukavnikov S., Minde D.P., Wentink A.S., Kityk R., Zachmann-Brand B., Mayer M.P., Kramer G., Bukau B. & Tans S.J. (2016), Alternative modes of client binding enable functional plasticity of Hsp70, Nature 539(7629): 448-451.
- Deckert A., Waudby C.A., Wlodarski T., Wentink A.S., Wang X.L., Kirkpatrick J.P., Paton J.F.S., Camilloni C., Kukic P., Dobson C.M., Vendruscolo M., Cabrita L.D. & Christodoulou J. (2016), Structural characterization of the interaction of alpha-synuclein nascent chains with the ribosomal surface and trigger factor, Proceedings of the National Academy of Sciences of the United States of America 113(18): 5012-5017.
- Cabrita L.D., Cassaignau A.M.E., Launay H.M.M., Waudby C.A., Wlodarski T., Camilloni C., Karyadi M.E., Robertson A.L., Wang X.L., Wentink A.S., Goodsell L.S., Woolhead C.A., Vendruscolo M., Dobson C.M. & Christodoulou J. (2016), A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding, NAT STRUCT MOL BIOL 23(4): 278-285.
No relevant ancillary activities