Universiteit Leiden

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Alireza Mashaghi Tabari

Associate professor

Name
Dr. A. Mashaghi Tabari
Telephone
+31 71 527 4425
E-mail
a.mashaghi.tabari@lacdr.leidenuniv.nl
ORCID iD
0000-0002-2157-1211

Alireza Mashaghi is a principal investigator at the LACDR Division of Systems Pharmacology and Pharmacy, Leiden University, since 2016. He leads the Medical Systems Biophysics and Bioengineering group. His lab conducts experimental and computational research at the interface of physics, engineering, and biomedicine.

More information about Alireza Mashaghi Tabari

News

Alireza Mashaghi is a Principal Investigator at the LACDR Division of Systems Pharmacology and Pharmacy, Leiden University. He leads the Medical Systems Biophysics and Bioengineering (MSBB) group, which conducts research at the interface of physics, engineering, and biomedicine. These studies are primarily directed towards understanding biological heterogeneity in human diseases, at the molecular, cellular, organ, and/or organism scales.

The lab develops and uses experimental and computational approaches to address basic and applied research problems in pharmaceutical sciences. Fundamental research is focused on the single-molecule analysis of biomolecular structure and dynamics. In particular, how interacting molecules (e.g., chaperones or drugs) assist or interfere with conformational search of biomolecules and how fold topology defines dynamics of biomolecules. Other areas of interest are systems biophysics and complex biological networks. The lab develops tools to analyse topology of interactions in complex systems (e.g. 3D genome, biochemical reaction networks, and human disease networks). The hope is to demonstrate how these topology analyses help solving biomedical problems such as molecular (mis)folding puzzles and medical diagnostic problems.

The MSBB lab also applies engineering analyses and design approaches to problems in virology, immunology and hematology using single-cell and chip-based approaches. The lab co-pioneered the development of organ chips for viral studies and was the first to develop organ chips for viral hemorrhagic syndromes, including Ebola virus disease. Sample from such disease models are then subjected to high resolution physicochemical analysis of disease and drug effect. By combining single cell chemical analysis tools and single cell physical/mechanical manipulation approaches, the lab explores critical links between mechanics and metabolism in human disease biology.

 

Mashaghi lab homepage

Associate professor

  • Science
  • Leiden Academic Centre for Drug Research
  • LACDR/Pharmacology

Work address

Gorlaeus Building
Einsteinweg 55
2333 CC Leiden
Room number GE1.01

Contact

Publications

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