Division of BioTherapeutics

Key publications

Selected publications of the Cardiovascular and Metabolic Therapeutics group.

Hoekstra M, Nahon JE, de Jong LM, Kröner MJ, de Leeuw LR, Van Eck M. Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1402-1409.
Ouweneel AB, Hoekstra M, van der Wel EJ, Schaftenaar FH, Snip OSC, Hassan J, Korporaal SJA, Van Eck M. Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice. Atherosclerosis. 2019 Mar;282:176-182.
van der Sluis RJ, Verwilligen RAF, Lendvai Z, Wever R, Hoekstra M, Van Eck M. HDL is essential for atherosclerotic lesion regression in Apoe knockout mice by bone marrow Apoe reconstitution. Atherosclerosis. 2018 Nov;278:240-249.
Nahon JE, Hoekstra M, Havik SR, Van Santbrink PJ, Dallinga-Thie GM, Kuivenhoven JA, Geerling JJ, Van Eck M. Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model. Atherosclerosis. 2018 Jul;274:120-127.
Ouweneel A.B., Heestermans M., Verwilligen R.A., Gijbels M.J., Reitsma P.H., van Eck M., van Vlijmen B.J., Silencing of Anticoagulant Protein C Evokes Low Incident but Spontaneous Atherothrombosis in Apolipoprotein E-Deficient Mice. Arterioscler Thromb Vasc Biol. 2017 37(5): 782-785
Louwe M.C., Lammers B., Frias M.A., Foks A.C., de Leeuw L.R., Hildebrand R.B., Kuiper J., Smit J.W.A., Van Berkel T.J.C., James R.W., Geerling J.J., Rensen P.C.N., Van Eck M., Abca1 deficiency protects the heart against myocardial infarction-induced injury. Atherosclerosis. 2016; 251: 159-163
Hoekstra M., Van Eck M., HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile. J Lipid Res. 2016; 57: 631-7
van der Stoep M., Li Z., Calpe-Berdiel L., van der Sluis R.J., Saleh P., McKinnon H.J., Smit M.J., Korporaal S.J., Van Berkel T.J., Van Eck M., Hoekstra M., Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development. Biochem Pharmacol. 2013; 86: 1594-1602
Korporaal S.J.A., Meurs I., Hauer A.D., Hildebrand R.B., Hoekstra M., Ten Cate H., Praticò D., Akkerman J.W.N., Van Berkel T.J.C., Kuiper J., Van Eck M., Deletion of the HDL receptor SR-BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol. Arterioscler Thromb Vasc Biol. 2011; 31: 34-42.
Vergeer M., Korporaal S.J.A., Franssen R., Meurs I., Out R., Hovingh G.K., Hoekstra M., Sierts J.A., Dallinga-Thie G.M., Motazacker M.M., Holleboom A.G., Van Berkel T.J.C., Kastelein J.J.P., Van Eck M., Kuivenhoven J.A., A Genetic Variant of the Scavenger Receptor BI in Humans. N Engl J Med. 2011; 364: 136-145
Zhao Y., Pennings M., Hildebrand R.B., Ye D., Calpe-Berdiel L., Out R., Kjerrulf M., Hurt-Camejo E., Groen A.K., Hoekstra M., Jessup W., Chimini G., Van Berkel T.J., Van Eck M., Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet. Circ Res. 2010; 107: e20-e31
Out R., Jessup W., Le Goff W., Hoekstra M., Gelissen I.C., Zhao Y., Kritharides L., Chimini G., Kuiper J., Chapman M.J., Huby T., Van Berkel T.J.C., Van Eck M., Coexistence of foam cells and hypocholesterolemia in mice lacking ABC transporters A1 and G1. Circ Res. 2008; 102: 113-120.
Van Eck M., Bos I.S.T., Kaminski W.E., Orsó E., Rothe G., Twisk J., Böttcher A., Van Amersfoort E.S., Christiansen-Weber T.A., Fung-Leung W.-P., Van Berkel Th.J.C., Schmitz G., Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Nat Acad Sci USA. 2002; 99: 6298-303.