Universiteit Leiden

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Research project

Unravelling cancer drug resistance mechanisms

Mechanisms fro drug resistance

Bob van de Water


Unraveling cancer drug resistance mechanisms. For sarcoma and triple negative breast cancer, large RNAi and drug screens have been performed to identify candidate mechanisms for drug resistance. Clinical relevance of identified pathways and candidate targets to break resistance is done together with hospitals. Such clinically relevant mechanisms and candidate targets and drugs to intervene are further unraveled in 3D in vitro and in vivo models.

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