Unravelling cancer drug resistance mechanisms
Mechanisms fro drug resistance
- Bob van de Water
Unraveling cancer drug resistance mechanisms. For sarcoma and triple negative breast cancer, large RNAi and drug screens have been performed to identify candidate mechanisms for drug resistance. Clinical relevance of identified pathways and candidate targets to break resistance is done together with hospitals. Such clinically relevant mechanisms and candidate targets and drugs to intervene are further unraveled in 3D in vitro and in vivo models.