Proefschrift
Metabolomics approaches for unravelling host-gut microbiota changes in different stages of cognitive impairment
The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.
- Auteur
- F. Hosseinkhani
- Datum
- 05 december 2024
- Links
- Thesis in Leiden Repository
Recognizing the metabolic flexibility of the gut microbiota and its ability to respond to environmental shifts, this thesis goes beyond underestimated metabolites such as SCFAs. The hypothesis underlying this research is that the composition of the gut microbiota intertwines with broader metabolic processes in the host. Therefore, this thesis, aims to explore the alterations observed in metabolites linked to immune signalling pathways in both fecal and blood specimens. The primary objective is to unravel the correlation between these alterations and variations in the composition of gut microbiota, particularly within the context of cognitive impairment. In addition, since metabolomics methods are often optimized for blood analysis rather than fecal samples, developing of a sample preparation technique for comprehensively extracting metabolites from the complex fecal matrix, as well as analysing global metabolites, comprise significant focus of this thesis.