Universiteit Leiden

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Inverse design of curvature-sensing antiviral peptides

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

N. van Hilten
14 september 2023
Thesis in Leiden Repository

In this thesis, we used a combination of molecular dynamics simulations and an evolutionary algorithm to inverse design such curvature-sensing antiviral peptides, purely from physical principles.

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