Universiteit Leiden

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Electroextraction approaches for preconcentration of metabolites

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

Oedit, A.
22 maart 2023
Thesis in Leiden Repository

We wanted to make EE more practical and easy to use for extracting different types of molecules. We tackled three main challenges: making EE work seamlessly with other techniques, avoiding the need to dilute small samples, and making EE more robust and user-friendly. To do this, we used automation and made use of existing analysis systems. This allowed us to fully take advantage of EE without needing manual processing or dilution. As a result, we were able to expand the range of compounds and types of molecules that EE can extract, and even extract both positively and negatively charged molecules at the same time.


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