Development of nanoparticulate adjuvants based on aluminium salts
The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.
- H. Vrieling
- 21 september 2023
- Thesis in Leiden Repository
Compared to traditional aluminium salt-based adjuvants, nanoparticles may improve vaccine efficacy and reduce encountered side effects. Nanoparticles were synthesised and their physicochemical properties were investigated. Their immunostimulating properties were investigated in vitro and in vivo and compared to traditional aluminium salt-based adjuvants.