Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
|Links||Thesis in Leiden Repository|
Nanoparticles (NPs) exhibit special physicochemical properties compared to bulk particles. The difference in properties could, in principle, produce different effects on organisms. It is therefore important to determine the relationship between the physicochemical characteristics of NPs and their toxicity profile, by means of experimental testing. Experimental toxicity testing data can also be used to find the best dose metric for the responses induced by NPs, which was the purpose of the research presented in this thesis. Furthermore, this thesis aims to move forward from toxicity testing primarily in animal models to computational dose metric modeling.