Universiteit Leiden

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Dissertation

Determining the most appropriate dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Author
J. Hua
Date
03 September 2015
Links
Thesis in Leiden Repository

Nanoparticles (NPs) exhibit special physicochemical properties compared to bulk particles. The difference in properties could, in principle, produce different effects on organisms. It is therefore important to determine the relationship between the physicochemical characteristics of NPs and their toxicity profile, by means of experimental testing. Experimental toxicity testing data can also be used to find the best dose metric for the responses induced by NPs, which was the purpose of the research presented in this thesis. Furthermore, this thesis aims to move forward from toxicity testing primarily in animal models to computational dose metric modeling.

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