Proefschrift
Antibiotic Conjugates and Natural Products as Next-Generation Strategies Against Antimicrobial Resistance
This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.
- Auteur
- M. Gao
- Datum
- 17 december 2025
- Links
- Thesis in Leiden Repository
It combines chemical synthesis, structural optimization, and biological evaluation to overcome resistance mechanisms. The first part focuses on antibiotic conjugates, including carbapenem/MBL inhibitor and rifampicin–siderophore conjugates. Results show that linker design critically affects potency, with certain rifampicin–chlorocatechol conjugates showing up to 32-fold improved activity. The second part investigates natural products, notably poriolide, for antibacterial and anticancer potential and as payloads in antibody–drug conjugates. Overall, the work advances strategies for next-generation therapeutics against AMR.