Vlad Lysenko
Onderzoeker
- Naam
- V. Lysenko MSc
- Telefoon
- 071 5276592
- v.lysenko@biology.leidenuniv.nl
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Onderzoeker
- IBL
- Microbial Sciences
- Machushynets N.V., Elsayed S.S., Du C., Lysenko V., Cruz M. de la, Sanchez P., Genilloud O., Martin N.I., Liles M.R. & Wezel G.P. van (2026), Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated Paenibacillus species, mSystems 11(3): e01496-25.
- Lysenko V., Theriault M.E., Sterk F.A.C., Choudhari P., Son S., Lewis K. & Martin N.I. (2026), Structure–activity studies on the antitubercular natural product evybactin, ACS Medicinal Chemistry Letters 17(2): 503-509.
- Lysenko V. (21 mei 2026), Natural Product Antibiotics: Synthesis and Next Generation Analogues [Natural Product Antibiotics: Synthesis and Next Generation Analogues] (Dissertatie. IBL, Faculteit der Wiskunde en Natuurwetenschappen, Leiden University). Promotor(en) en copromotor(en): Martin N., Hacker S.M.
- Lysenko V., Son S., Theriault M.E., Slingerland C.J., Hauk G., Cleenewerk L., Speer A., Berger J.M., Lewis K. & Martin N.I. (2025), Total synthesis and structural reassignment of the antitubercular natural product evybactin, Chemistry: a European Journal 31(1): e202403767.
- Machushynets N.V., Lysenko V., Du C., Slingerland C.J., Elsayed S.S., Liles M.R., Martin N.I. & Wezel G.P. van (2025), Exploring the chemicals space of Paenibacillus NRPs and discovery of Paenilipoheptin B, Organic Letters 27(12): 2821-2825.
- Lysenko V., Machushynets N.V., Dam J.L. de, Sterk F.A.C., Speer A., Ram A.F.J., Slingerland C.J., Wezel G.P. van & Martin N.I. (2025), Total synthesis, structure elucidation, and bioactivity evaluation of the cyclic lipopeptide natural product paenilipoheptin A, Organic Letters 27(12): 2826-2831.
- Cleenewerk L., Otto A., Wouters W., Willemse J.J., Gao M., Lysenko V., Punt J.M., Stelt M. van der, Martin N.I., Ulsen P. van & Luirink J. (2025), An Rcs stress-based high-throughput screen reveals novel gyrase inhibitors as indirect inducers of cell envelope stress in gram-negative bacteria, ACS infectious diseases 11(9): 2577-2592.
- Lysenko V., Gao M., Sterk F.A.C., Innocenti P., Slingerland C.J. & Martin N.I. (2025), Design, synthesis, and antibacterial evaluation of rifampicin–siderophore conjugates, ACS infectious diseases 11(8): 2301-2309.
- Groesen E. van, Mons E., Kotsogianni A.I., Arts M., Tehrani K.H.M.E., Wade N., Lysenko V., Stel F.M., Zwerus J.T., De Benedetti S., Bakker A.T., Chakraborty P., Stelt M. van der, Scheffers D.-J., Gooskens J., Smits W.K., Holden K., Gilmour P., Willemse J.J., Hitchcock C.A., Hasselt J.G.C. van, Schneider T. & Martin N.I. (2024), Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity, Science Translational Medicine 16(759): eabo4736.
- Slingerland C.J., Lysenko V., Chaudhuri S., Wesseling C.M.J., Barnes D., Masereeuw R. & Martin N.I. (2023), Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity, RSC Medicinal Chemistry 14(11): 2417-2425.