Sacha Goultiaev
Gast
- Naam
- Dr. A.P. Goultiaev
- Telefoon
- +31 71 527 2727
- a.p.goultiaev@liacs.leidenuniv.nl
Alexander P. Gultyaev (Goultiaev) is een computationeel bioloog. Hij werkt aan bio-informatica onderzoeksprojecten. Zijn voornaamste interesses zijn structuren, functies en evolutie van RNA moleculen.
Alexander P. Gultyaev (Goultiaev) is een computationeel bioloog. Hij werkt aan bio-informatica onderzoeksprojecten. Zijn voornaamste interesses zijn structuren, functies en evolutie van RNA moleculen. In het bijzonder werkt hij aan voorspellingen van functioneel belangrijke RNA-structuren in RNA-virussen. Deze theoretische modellen worden getest in experimenten uitgevoerd door virologen; naast zijn werk bij LIACS heeft Alexander Gultyaev een aanstelling bij de afdeling Virowetenschap van het Erasmus Medisch Centrum in Rotterdam.
Gast
- Wiskunde en Natuurwetenschappen
- Leiden Inst of Advanced Computer Science
- Dilweg I.W., Savina A., Köthe S., Goultiaev A.P., Bredenbeek P.J. & Olsthoorn R.C.L. (2021), All genera of Flaviviridae host a conserved Xrn1-resistant RNA motif, RNA Biology 18(12): 2321-2329.
- Goultiaev A.P., Spronken M., Funk M., Fouchier R.A.M. & Richard M. (2021), Insertions of codons encoding basic amino acids in H7 hemagglutinins of influenza A viruses occur by recombination with RNA at hotspots near snoRNA binding sites, RNA 27(2): 123-132.
- Goultiaev A.P., Olsthoorn R.C.L., Spronken M. & Richard M. (2021), Structural Bioinformatics of Influenza Virus RNA Genomes: Virus Bioinformatics. In: Frishman D. & Marz M. (red.), Virus Bioinformatics. Boca Raton: Chapman and Hall/CRC.
- Martorelli I., Helwerda L.S., Kerkvliet J., Gomes S.I.F., Nuytinck J., Werff C.R.A. van der, Ramackers G.J., Goultiaev A.P., Merckx V.S.F.T. & Verbeek F.J. (2020), Fungal metabarcoding data integration framework for the MycoDiversity DataBase (MDDB), Journal Integrative Bioinformatics 17(1): 20190046.
- Dilweg I.W., Bouabda A., Dalebout T., Goultiaev A.P., Bredenbeek P.J. & Olsthoorn R.C.L. (2020), Xrn1-resistant RNA structures are well-conserved within the genus flavivirus, RNA Biology 18(5): 709-717.
- Zammit A., Helwerda L.S., Olsthoorn R.C.L., Verbeek F.J. & Goultiaev A.P. (2020), A database of flavivirus RNA structures with a search algorithm for pseudoknots and triple base interactions, Bioinformatics 37(7): 956-962.
- Goultiaev A.P., Richard M., Spronken M., Olsthoorn R.C.L. & Fouchier R.A.M. (2019), Conserved structural RNA domains in regions coding for cleavage site motifs in hemagglutinin genes of influenza viruses, Virus Evolution 5(2): vez034.
- Dilweg I.W., Goultiaev A.P. & Olsthoorn R.C.L. (2019), Structural features of an Xrn1-resistant plant virus RNA, RNA Biology 16(6): 838-845.
- Spronken M.I., Sandt C.E. van de, Jongh E.P. de, Vuong O., Vliet S. van der, Bestebroer T.M., Olsthoorn R.C.L., Rimmelzwaan G.F., Fouchier R.A.M. & Goultiaev A.P. (2017), A compensatory mutagenesis study of a conserved hairpin in the M gene segment of influenza A virus shows its role in virus replication, RNA Biology 14(11): 1606-1616.
- Goultiaev A.P., Spronken M.I., Richard M., Schrauwen E.J.A., Olsthoorn R.C.L. & Fouchier R.A.M. (2016), Subtype-specific structural constraints in the evolution of influenza A virus hemagglutinin genes, Scientific Reports 6: 38892.
- Spronken M.I., Short K.R., Herfst S., Bestebroer T.M., Vaes V.P., Hoeven B. van der, Koster A.J., Kremers G.J., Scott D.P., Goultiaev A.P., Sorell E.M., Graaf M. de, Bárcena M., Rimmelzwaan G.F. & Fouchier R.A. (2015), Optimisations and Challenges Involved in the Creation of Various Bioluminescent and Fluorescent Influenza A Virus Strains for In Vitro and In Vivo Applications, PLoS ONE 10(8): e0133888.
- Goultiaev A.P., Tsyganov-Bodounov A., Spronken M.I., Kooij S. van der, Fouchier R.A.M. & Olsthoorn R.C.L. (2014), RNA structural constraints in the evolution of the influenza A virus genome NP segment, RNA Biology 11(7): 942-952.
- Gultyaev A.P., Olsthoorn R.C.L., Spronken M.I.J. & Fouchier R.A.M. (2014), Detection of structural constraints and conformational transitions in the influenza virus RNA genome using structure predictions and mutual information calculations. Ortuno F. & Rojas I. (red.), Proceedings IWBBIO 2014, International Work-Conference on Bioinformatics and Biomedical Engineering. IWBBIO 2014, International Work-Conference on Bioinformatics and Biomedical Engineering 7 april 2014 - 9 april 2014. Granada: Copicentro Granada S.L. 273-284.
- Hoogen B.G. van den, Boheemen S. van, Rijck J. de, Nieuwkoop S. van, Smith D.J., Laksono B., Goultiaev A.P., Osterhaus A.D. & Fouchier R.A. (2014), Excessive production and extreme editing of human metapneumovirus defective interfering RNA is associated with type I IFN induction, Journal of General Virology 95(8): 1625-1633.
- Goultiaev A.P., Redchuk T., Korolova A. & Kozeretska I. (2014), P element temperature-specific transposition: a model for possible regulation of mobile elements activity by pre-mRNA secondary structure, Cytology and Genetics 48(6): 378-382.
- Clabbers M.T.B., Olsthoorn R.C.L. & Goultiaev A.P. (2014), Tospovirus ambisense genomic RNA segments use almost complete repertoire of stable tetraloops in the intergenic region, Bioinformatics 30(13): 1800-1804.
- Goultiaev A.P., Olsthoorn R.C.L., Pleij C.W.A. & Westhof E. (2012), RNA Structure: Pseudoknots. In: , Encyclopedia of Life Sciences. Encyclopedia of Life Sciences (eLS): Wiley.
- Girard G.A.O., Goultiaev A.P. & Olsthoorn R.C.L. (2011), Upstream start codon in segment 4 of North American H2 avian influenza A viruses, Infection, Genetics and Evolution 11(2): 489-495.
- Goultiaev A.P., Fouchier R.A.M. & Olsthoorn R.C.L. (2010), Influenza virus RNA structure: unique and common features, International Reviews of Immunology 29(6): 533-556.
- Goultiaev A.P. & Olsthoorn R.C.L. (2010), A family of non-classical pseudoknots in influenza A and B viruses, RNA Biology 7(2): 125-129.
- Chen S.C., Goultiaev A.P., Pleij C.W.A. & Olsthoorn R.C.L. (2009), A Secondary Structure Model for the 3'-Untranslated Region of Ilarvirus RNAs. In: Feng Z. & Long M. (red.), Viral Genomes: Diversity, Properties and Parameters: Nova Science Publishers, Inc.. 65-83.
- Goultiaev A.P., Heus H.A. & Olsthoorn R.C.L. (2007), An RNA conformational shift in recent H5N1 influenza A viruses, Bioinformatics 23(3): 272-276.
- Goultiaev A.P., Heus H.A. & Olsthoorn R.C.L. (2007), An RNA conformational shift in recent H5N1 influenza A viruses, Bioinformatics 23(3): 272-276.
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