Meindert Lamers
Co-director NeCEN & Associate professor (LUMC)
- Naam
- Prof.dr. M.H. Lamers
- Telefoon
- 071 5272727
- m.h.lamers@biology.leidenuniv.nl
- ORCID iD
- null
Voor meer informatie, zie de Engelse pagina.
Co-director NeCEN & Associate professor (LUMC)
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Algemeen
Hoogleraar Cel en Chemische Biologie, in het bijzonder Structuurbiologie
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
- Ren M.R., Li D., Addison H., Noteborn W.E.M., Andeweg E.H., Glatter T., Winde J.H. de, Rebelein J.G., Lamers M.H. & Schada von Borzyskowski L. (2025), NAD-dependent dehydrogenases enable efficient growth of Paracoccus denitrificans on the PET monomer ethylene glycol, Nature Communications 16: 5845.
- Fernow, J.; Olliver, M.; Couet, W.; Lagrange, S.; Lamers, M.H.; Olesen, O.F.; Orrling, K.; Pieren, M.; Sloan, D.J.; Vaquero, J.J.; Miles, T.J. & Karlen, A. (2025), The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships, Nature Reviews Drug Discovery 24(1): 1-2.
- Santos, J.A.; Timinskas, K.; Ramudzuli, A.A.; Lamers, M.H.; Venclovas, C.; Warner, D.F. & Gessner, S.J. (2025), The RecA-NT homology motif in ImuB mediates the interaction with ImuA0, which is essential for DNA damage-induced mutagenesis, Journal of Biological Chemistry 301(2).
- Lippai, Z.; Péterfia, B.; Papp, G.; Dezso, K.; Bedics, G.; Pápai, Z.; Lamers, M.H.; Kuin, R.C.M.; Szuhai, K. & Sápi, Z. (2024), A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas, European Journal of Cancer 202.
- Kemps, P.G.; Baelde, H.J.; Vorderman, R.H.P.; Stelloo, E.; Swennenhuis, J.F.; Szuhai, K.; Lamers, M.H.; Kenkhuis, B.; Al-Hussaini, M.; Briaire-de Bruijn, I.H.; Lam, S.W.; Bovée, J.V.M.G.; Cleven, A.H.G.; Verdijk, R.M.; Noesel, C.J.M.; Dijk, M.R.; Scheijde-Vermeulen, M.A.; Bruggink, A.H.; Laar, J.A.M.; Vries, A.C.H.; Tissing, W.J.E.; Bos, C. van den; Deimling, A. von; Wezel, T. van; Halteren, A.G.S. & Hogendoorn, P.C.W. (2024), Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue, Blood 144(23): 2439-2455.
- Botto, M.M.; Borsellini, A. & Lamers, M.H. (2023), A four-point molecular handover during Okazaki maturation, Nature Structural and Molecular Biology 30(10): 1505-+.
- Gessner, S.; Martin, Z.A.M.; Reiche, M.A.; Santos, J.A.; Dinkele, R.; Ramudzuli, A.; Dhar, N.; Wet, T.J. de; Anoosheh, S.; Lang, D.M.; Aaron, J.; Chew, T.L.; Herrmann, J.; Müller, R.; McKinney, J.D.; Woodgate, R.; Mizrahi, V.; Venclovas, C.; Lamers, M.H. & Warner, D.F. (2023), Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome, eLife 12.
- Botto, M.M.; Murthy, S. & Lamers, M.H. (2023), High-throughput exonuclease assay based on the fluorescent base Analogue 2-aminopurine, ACS Omega 8(9).
- Chengalroyen, M.D.; Mason, M.K.; Borsellini, A.; Tassoni, R.; Abrahams, G.L.; Lynch, S.; Ahn, Y.M.; Ambler, J.; Young, K.; Crowley, B.M.; Olsen, D.B.; Warner, D.F.; Barry, C.E.; Boshoff, H.I.M.; Lamers, M.H. & Mizrahi, V. (2022), DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis, ACS Infectious Diseases 8(3): 612-625.
- Borsellini, A.; Kunetsky, V.; Friedhoff, P. & Lamers, M.H. (2022), Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair, Nature Structural and Molecular Biology 29(1): 59-+.
- Borsellini, A.; Lebbink, J.H.G. & Lamers, M.H. (2022), MutL binds to 3 ' resected DNA ends and blocks DNA polymerase access, Nucleic Acids Research 50(11): 6224-6234.
- Xiao, X.S.; Willemse, J.; Voskamp, P.; Li, X.M.; Prota, A.E.; Lamers, M.; Pannu, N.; Abrahams, J.P. & Wezel, G.P. van (2021), Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces, Open Biology 11(2).
- Fernandez-Leiro, R.; Bhairosing-Kok, D.; Kunetsky, V.; Laffeber, C.; Winterwerp, H.H.; Groothuizen, F.; Fish, A.; Lebbink, J.H.G.; Friedhoff, P.; Sixma, T.K. & Lamers, M.H. (2021), The selection process of licensing a DNA mismatch for repair, Nature Structural and Molecular Biology 28(4): 373-+.
- Singh, J.K.; Smith, R.; Rother, M.B.; Groot, A.J.L. de; Wiegant, W.W.; Vreeken, K.; D'Augustin, O.; Kim, R.Q.; Qian, H.B.; Krawczyk, P.M.; Gonzalez-Prieto, R.; Vertegaal, A.C.O.; Lamers, M.; Huet, S. & Attikum, H. van (2021), Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining, Nature Communications 12(1).
- Dodd, T.; Botto, M.; Paul, F.; Fernandez-Leiro, R.; Lamers, M.H. & Ivanov, I. (2020), Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path, Nature Communications 11(1).
- Santos, J.A. & Lamers, M.H. (2020), Novel antibiotics targeting bacterial replicative DNA polymerases, Antibiotics 9(11).
- Gahlon, H.L.; Walker, A.R.; Cisneros, G.A.; Lamers, M.H. & Rueda, D.S. (2018), Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant, Physical Chemistry Chemical Physics 20(42): 26892-26902.
- Lamers, M.; Berlin, I. & Neefjes, J. (2018), Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck, Current Biology 28(2): R83-R86.
- Lamers, M.H.; Gerogijevic, D.; Lebbink, J.H.; Winterwerp, H.H.K.; Agianian, B.; Wind, N. de & Sixma, T.K. (2004), ATP increases the affinity between MutS ATPase domains - Implications for atp hydrolysis and conformational changes, Journal of Biological Chemistry 279(42).
- Lamers, M.H.; Perrakis, A.; Enzlin, J.H.; Winterwerp, H.H.K.; Wind, N. de & Sixma, T.K. (2000), The crystal structure of DNA mismatch repair protein MutS binding to a G center dot T mismatch, Nature 407(6805).