Meindert Lamers
Directeur NeCEN / Hoogleraar Structuurbiologie
- Naam
- Prof. dr. M.H. Lamers
- Telefoon
- 071 5271413
- m.h.lamers@lumc.nl
- ORCID iD
- null
Voor meer informatie, zie de Engelse pagina.
Directeur NeCEN / Hoogleraar Structuurbiologie
- IBL
- NeCEN
Contact
Hoogleraar Cel en Chemische Biologie
- LUMC
- Ren M.R., Li D., Addison H., Noteborn W.E.M., Andeweg E.H., Glatter T., Winde J.H. de, Rebelein J.G., Lamers M.H. & Schada von Borzyskowski L. (2025), NAD-dependent dehydrogenases enable efficient growth of Paracoccus denitrificans on the PET monomer ethylene glycol, Nature Communications 16: 5845.
- Kuin R.C.M., Lamers M.H. & Westen G.J.P. van (2025), PyVADesign: a python-based cloning tool for one-step generation of large mutant libraries, Bioinformatics 41(9): btaf433.
- Kuin R.C.M., Westen G.J.P. van & Lamers M.H. (2025), Identification of determinants of high-fidelity DNA synthesis in mycobacterium smegmatis DnaE1 through in silico and in vivo approaches, Nucleic Acids Research 53(21): gkaf1274.
- Ren, M.R.; Li, D.N.; Addison, H.; Noteborn, W.E.M.; Andeweg, E.H.; Glatter, T.; Winde, J.H. de; Rebelein, J.G.; Lamers, M.H. & Borzyskowski, L.S. von (2025), NAD-dependent dehydrogenases enable efficient growth of Paracoccus denitrificans on the PET monomer ethylene glycol, Nature Communications 16(1).
- Kuin, R.C.M.; Lamers, M.H. & Westen, G.J.P. van (2025), PyVADesign, Bioinformatics 41(9).
- Fountain, A.J.; Böhning, J.; McLaughlin, S.H.; Morgan, T.E.; Edelstein, P.H.; Troll, M.; Lamers, M.H.; Bharat, T.A.M.; Luisi, B. & Ramakrishnan, L. (2025), Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance, Proceedings of the National Academy of Sciences 122(39).
- Xu, L.F.; Jin, S.K.; Urem, M.; Lee, S.J.; Lamers, M.H.; Chen, X.; Wolynes, P.G. & Wuite, G.J.L. (2025), DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins, Nature Communications 16(1).
- Kuin, R.C.M.; Westen, G.J.P. van & Lamers, M.H. (2025), Identification of determinants of high-fidelity DNA synthesis in Mycobacterium smegmatis DnaE1 through in silico and in vivo approaches, Nucleic Acids Research 53(21).
- Urem, M.; Friggen, A.H.; Musch, N.; Silverman, M.H.; Swain, C.J.; Barbachyn, M.R.; Mortin, L.I.; Yu, X.; Deluccia, R.J.; Lamers, M.H. & Smits, W.K. (2025), A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens, Nature Communications 16(1).
- Santos, J.A.; Timinskas, K.; Ramudzuli, A.A.; Lamers, M.H.; Venclovas, C.; Warner, D.F. & Gessner, S.J. (2025), The RecA-NT homology motif in ImuB mediates the interaction with ImuA0, which is essential for DNA damage-induced mutagenesis, Journal of Biological Chemistry 301(2).
- Fernow, J.; Olliver, M.; Couet, W.; Lagrange, S.; Lamers, M.H.; Olesen, O.F.; Orrling, K.; Pieren, M.; Sloan, D.J.; Vaquero, J.J.; Miles, T.J. & Karlen, A. (2025), The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships, Nature Reviews Drug Discovery 24(1): 1-2.
- Kemps, P.G.; Baelde, H.J.; Vorderman, R.H.P.; Stelloo, E.; Swennenhuis, J.F.; Szuhai, K.; Lamers, M.H.; Kenkhuis, B.; Al-Hussaini, M.; Briaire-de Bruijn, I.H.; Lam, S.W.; Bovée, J.V.M.G.; Cleven, A.H.G.; Verdijk, R.M.; Noesel, C.J.M.; Dijk, M.R.; Scheijde-Vermeulen, M.A.; Bruggink, A.H.; Laar, J.A.M.; Vries, A.C.H.; Tissing, W.J.E.; Bos, C. van den; Deimling, A. von; Wezel, T. van; Halteren, A.G.S. & Hogendoorn, P.C.W. (2024), Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue, Blood 144(23): 2439-2455.
- Lippai, Z.; Péterfia, B.; Papp, G.; Dezso, K.; Bedics, G.; Pápai, Z.; Lamers, M.H.; Kuin, R.C.M.; Szuhai, K. & Sápi, Z. (2024), A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas, European Journal of Cancer 202.
- Botto, M.M.; Borsellini, A. & Lamers, M.H. (2023), A four-point molecular handover during Okazaki maturation, Nature Structural and Molecular Biology 30(10): 1505-+.
- Gessner, S.; Martin, Z.A.M.; Reiche, M.A.; Santos, J.A.; Dinkele, R.; Ramudzuli, A.; Dhar, N.; Wet, T.J. de; Anoosheh, S.; Lang, D.M.; Aaron, J.; Chew, T.L.; Herrmann, J.; Müller, R.; McKinney, J.D.; Woodgate, R.; Mizrahi, V.; Venclovas, C.; Lamers, M.H. & Warner, D.F. (2023), Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome, eLife 12.
- Botto, M.M.; Murthy, S. & Lamers, M.H. (2023), High-throughput exonuclease assay based on the fluorescent base Analogue 2-aminopurine, ACS Omega 8(9).
- Borsellini, A.; Lebbink, J.H.G. & Lamers, M.H. (2022), MutL binds to 3 ' resected DNA ends and blocks DNA polymerase access, Nucleic Acids Research 50(11): 6224-6234.
- Chengalroyen, M.D.; Mason, M.K.; Borsellini, A.; Tassoni, R.; Abrahams, G.L.; Lynch, S.; Ahn, Y.M.; Ambler, J.; Young, K.; Crowley, B.M.; Olsen, D.B.; Warner, D.F.; Barry, C.E.; Boshoff, H.I.M.; Lamers, M.H. & Mizrahi, V. (2022), DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis, ACS Infectious Diseases 8(3): 612-625.
- Borsellini, A.; Kunetsky, V.; Friedhoff, P. & Lamers, M.H. (2022), Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair, Nature Structural and Molecular Biology 29(1): 59-+.
- Xiao, X.S.; Willemse, J.; Voskamp, P.; Li, X.M.; Prota, A.E.; Lamers, M.; Pannu, N.; Abrahams, J.P. & Wezel, G.P. van (2021), Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces, Open Biology 11(2).
- Fernandez-Leiro, R.; Bhairosing-Kok, D.; Kunetsky, V.; Laffeber, C.; Winterwerp, H.H.; Groothuizen, F.; Fish, A.; Lebbink, J.H.G.; Friedhoff, P.; Sixma, T.K. & Lamers, M.H. (2021), The selection process of licensing a DNA mismatch for repair, Nature Structural and Molecular Biology 28(4): 373-+.
- Singh, J.K.; Smith, R.; Rother, M.B.; Groot, A.J.L. de; Wiegant, W.W.; Vreeken, K.; D'Augustin, O.; Kim, R.Q.; Qian, H.B.; Krawczyk, P.M.; Gonzalez-Prieto, R.; Vertegaal, A.C.O.; Lamers, M.; Huet, S. & Attikum, H. van (2021), Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining, Nature Communications 12(1).
- Santos, J.A. & Lamers, M.H. (2020), Novel antibiotics targeting bacterial replicative DNA polymerases, Antibiotics 9(11).
- Dodd, T.; Botto, M.; Paul, F.; Fernandez-Leiro, R.; Lamers, M.H. & Ivanov, I. (2020), Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path, Nature Communications 11(1).
- Lemmers, R.J.L.F.; Stoep, N. van der; Vliet, P.J. van der; Moore, S.A.; Granado, D.S.; Johnson, K.; Topf, A.; Straub, V.; Evangelista, T.; Mozaffar, T.; Kimonis, V.; Shaw, N.D.; Selvatici, R.; Ferlini, A.; Voermans, N.; Engelen, B. van; Sacconi, S.; Tawil, R.; Lamers, M. & Maarel, S.M. van der (2019), SMCHD1 mutation spectrum for facioscapulohumeral muscular dystrophy type 2 (FSHD2) and Bosma arhinia microphthalmia syndrome (BAMS) reveals disease-specific localisation of variants in the ATPase domain, Journal of Medical Genetics 56(10): 693-700.
- Gahlon, H.L.; Walker, A.R.; Cisneros, G.A.; Lamers, M.H. & Rueda, D.S. (2018), Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant, Physical Chemistry Chemical Physics 20(42): 26892-26902.
- Lamers, M.; Berlin, I. & Neefjes, J. (2018), Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck, Current Biology 28(2): R83-R86.
- Zhao, G.J.; Gleave, E.S. & Lamers, M.H. (2017), Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis, eLife 6.
- Banos-Mateos, S.; Roon, A.M.M. van; Lang, U.F.; Maslen, S.L.; Skehel, J.M. & Lamers, M.H. (2017), High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center, Nature Communications 8.
- Fernandez-Leiro, R.; Conrad, J.; Yang, J.C.; Freund, S.M.V.; Scheres, S.H.W. & Lamers, M.H. (2017), Self-correcting mismatches during high-fidelity DNA replication, Nature Structural & Molecular Biology 24(2): 140-+.
- Gahlon, H.L.; Zhao, G.; Fernandez-Leiro, R.; Lamers, M.H. & Rueda, D. (2017), Dynamic proofreading in bacterial DNA polymerase III, European Biophysics Journal with Biophysics Letters 46: S142-S142.
- Fernandez-Leiro, R.; Conrad, J.; Scheres, S.H.W. & Lamers, M.H. (2015), cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and tau, eLife 4.
- Rock, J.M.; Lang, U.F.; Chase, M.R.; Ford, C.B.; Gerrick, E.R.; Gawande, R.; Coscolla, M.; Gagneux, S.; Fortune, S.M. & Lamers, M.H. (2015), DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader, Nature Genetics 47(6): 677-681.
- Aibara, S.; Valkov, E.; Lamers, M. & Stewart, M. (2015), Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface, Nucleic Acids Research 43(3): 1927-1936.
- Aibara, S.; Valkov, E.; Lamers, M.H.; Dimitrova, L.; Hurt, E. & Stewart, M. (2015), Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum, Acta Crystallographica Section F: Structural Biology Communications 71: 876-888.
- Vidangos, N.K.; Heideker, J.; Lyubimov, A.; Lamers, M.; Huo, Y.X.; Pelton, J.G.; Ton, J.; Gralla, J.; Berger, J. & Wemmer, D.E. (2014), DNA Recognition by a sigma(54) Transcriptional Activator from Aquifex aeolicus, Journal of Molecular Biology 426(21): 3553-3568.
- Rego, A.T.; Holding, A.N.; Kent, H. & Lamers, M.H. (2013), Architecture of the Pol III-clamp-exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair, The EMBO Journal 32(9): 1334-1343.
- Barros, T.; Guenther, J.; Kelch, B.; Anaya, J.; Prabhakar, A.; O'Donnell, M.; Kuriyan, J. & Lamers, M.H. (2013), A structural role for the PHP domain in E. coli DNA polymerase III, {BMC} Structural Biology 13.
- Holding, A.N.; Lamers, M.H.; Stephens, E. & Skehel, J.M. (2013), Hekate: Software Suite for the Mass Spectrometric Analysis and Three-Dimensional Visualization of Cross-Linked Protein Samples, Journal of Proteome Research 12(12): 5923-5933.
- Hadders, M.A.; Agromayor, M.; Obita, T.; Perisic, O.; Caballe, A.; Kloc, M.; Lamers, M.H.; Williams, R.L. & Martin-Serrano, J. (2012), ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes, Proceedings of the National Academy of Sciences 109(43): 17424-17429.
- Jura, N.; Endres, N.F.; Engel, K.; Deindl, S.; , R. das; Lamers, M.H.; Wemmer, D.E.; Zhang, X.W. & Kuriyan, J. (2009), Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment, Cell 137(7): 1293-1307.
- Lamers, M.H. & O'Donnell, M. (2008), A consensus view of DNA binding by the C family of replicative DNA polymerases, Proceedings of the National Academy of Sciences 105(52): 20565-20566.
- Batchelor, J.D.; Doucleff, M.; Lee, C.J.; Matsubara, K.; Carlo, S. de; Heideker, J.; Lamers, M.H.; Pelton, J.G. & Wemmer, D.E. (2008), Structure and Regulatory Mechanism of Aquifex aeolicus NtrC4: Variability and Evolution in Bacterial Transcriptional Regulation, Journal of Molecular Biology 384(5): 1058-1075.
- Winger, J.A.; Derbyshire, E.R.; Lamers, M.H.; Marletta, M.A. & Kuriyan, J. (2008), The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase, {BMC} Structural Biology 8.
- Lamers, M.H.; Georgescu, R.E.; Lee, S.G.; O'Donnell, M. & Kuriyan, J. (2006), Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III, Cell 126(5): 881-892.
- Lamers, M.H.; Gerogijevic, D.; Lebbink, J.H.; Winterwerp, H.H.K.; Agianian, B.; Wind, N. de & Sixma, T.K. (2004), ATP increases the affinity between MutS ATPase domains - Implications for atp hydrolysis and conformational changes, Journal of Biological Chemistry 279(42).
- Wu, S.Y.; Culligan, K.; Lamers, M. & Hays, J. (2003), Dissimilar mispair-recognition spectra of Arabidopsis DNA-mismatch-repair proteins MSH2.MSH6 (MutS alpha) and MSH2.MSH7 (MutS gamma), Nucleic Acids Research 31(20): 6027-6034.
- Natrajan, G.; Lamers, M.H.; Enzlin, J.H.; Winterwerp, H.H.K.; Perrakis, A. & Sixma, T.K. (2003), Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates, Nucleic Acids Research 31(16): 4814-4821.
- Lamers, M.H.; Winterwerp, H.H.K. & Sixma, T.K. (2003), The alternating ATPase domains of MutS control DNA mismatch repair, The EMBO Journal 22(3): 746-756.
- Lamers, M.H.; Perrakis, A.; Enzlin, J.H.; Winterwerp, H.H.K.; Wind, N. de & Sixma, T.K. (2000), The crystal structure of DNA mismatch repair protein MutS binding to a G center dot T mismatch, Nature 407(6805).