Matthijs van Haren
Onderzoeker
- Naam
- Dr. M.J. van Haren Ph.D.
- Telefoon
- +31 71 527 6592
- m.j.van.haren@biology.leidenuniv.nl
.
Supervisor(s)
Onderzoeker
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Buijs N., Vlaming H.C., Haren M.J. van & Martin N.I. (2022), Synthetic studies with bacitracin A and preparation of analogues containing alternative zinc binding groups, ChemBioChem 23(24): e202200547.
- Zhang Y., Haren M.J. van, Marechal N., Troffer-Charlier N., Cura V., Cavarelli J. & Martin N.I. (2022), A direct assay for measuring the activity and inhibition of coactivator-associated arginine methyltransferase 1, Biochemistry 61(11): 1055-1063.
- Zhang Y., Marechal N., Haren M.J. van, Troffer-Charlier N., Cura V., Cavarelli J. & Martin N.I. (2021), Structural studies provide new insights into the role of lysine acetylation on substrate recognition by CARM1 and inform the design of potent peptidomimetic inhibitors, ChemBioChem 22(24): 3469-3476.
- Wade N., Tehrani K.H.M.E., Brüchle N.C., Haren M.J. van, Mashayekhi Vi. & Martin N.I. (2021), Mechanistic investigations of metallo‐β‐lactamase inhibitors: strong zinc binding Is not required for potent enzyme inhibition, ChemMedChem 16(10): 1651-1659.
- Haren M.J. van, Zhang Y., Thijssen V., Buijs N.P., Gao Y., Mateuszuk L., Fedak F.A., Kij A., Campagna R., Sartini D., Emanuelli M., Chlopicki S., Jongkees S.A.K. & Martin N.I. (2021), Macrocyclic peptides as allosteric inhibitors of nicotinamide n-methyltransferase (NNMT), RSC Chemical Biology 2(5): 1546-1555.
- Tehrani K.H.M.E., Wade N., Mashayekhi V., Brüchle N., Jespers W., Voskuil K., Pesce D., Haren M.J. van, Westen G.J.P. van & Martin N.I. (2021), Novel Cephalosporin conjugates display potent and selective inhibition of Imipenemase-type Metallo-β-Lactamases, Journal of Medicinal Chemistry 64(13): 9141–9151.
- Haren M.J. van, Tehrani K.H.M.E., Kotsogianni I., Wade N., Brüchle N., Mashayekhi V. & Martin N.I. (2021), Cephalosporin prodrug inhibitors overcome metallo-β-lactamase driven antibiotic resistance, Chemistry: a European Journal 27(11): 3806-3811.
- Gao Y., Haren M.J., Buijs N., Innocent I., Zhang Y., Sartini D., Campagna R., Emanuelli M., Parsons R.B., Jespers W., Gutiérrez-de-Terán H., Westen G.J.P. van & Martin N.I. (2021), Potent inhibition of nicotinamide N-Methyltransferase by alkene-linked bisubstrate mimics bearing electron deficient aromatics, Journal of Medicinal Chemistry 64(17): 12938-12963.
- Haren M.J. van, Tehrani K.H.M.E., Kotsogianni Teftsoglou A.I., Wade N., Brüchle N.C., Mashayekhi V. & Martin N.I. (2021), Cephalosporin prodrug inhibitors overcome metallo‐β‐lactamase driven antibiotic resistance, Chemistry: a European Journal 27(11): 3806-3811.
- Gao Y., Martin N.I. & Haren M.J. van (2021), Nicotinamide N-Methyl Transferase (NNMT): an emerging therapeutic target, Drug Discovery Today 26(11): 2699-2706.
- Tehrani K.H.M.E., Wade N., Mashayekhi V., Brüchle N.C., Jespers W., Voskuil K., Pesce D., Haren. M.J. van, Westen G.J.P. van & Martin N.I. (2021), Novel cephalosporin conjugates display potent and selective inhibition of imipenemase-type metallo-β-lactamases, Journal of Medicinal Chemistry 64(13): 9141-9151.
- Haren M.J. van, Gao Y., Buijs N., Campagna R., Sartini D., Emanuelli M., Mateuszuk L., Kij A., Chlopicki S., Martinez de Castilla P.E., Schiffelers R. & Martin N.I. (2021), Esterase-sensitive prodrugs of a potent bisubstrate inhibitor of Nicotinamide N-Methyltransferase (NNMT) display cellular activity, Biomolecules 11(9): 1357.
- Tehrani K.H.M.E., Fu H., Brüchle N.C., Mashayekhi V., Prats Luján A., Haren M.J. van, Poelarends G.J. & Martin N.I. (2020), Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1, Chemical Communications 56(20): 3047-3049.
- Zhang Y., Haren M.J. van & Martin N.I. (2020), Peptidic transition state analogues as PRMT inhibitors, Methods 175: 24-29.
- Tehrani K.H.M.E., Brüchle N.C., Wade N., Mashayekhi V., Pesce D., Haren M.J. van & Martin N.I. (2020), Small molecule carboxylates inhibit metallo-β-lactamases and resensitize carbapenem-resistant bacteria to meropenem, ACS Infectious Diseases 6(6): 1366-1371.
- Haren M.J. van & Martin N.I. (2019), PRMT Inhibitors. Topics in Medicinal Chemistry. Berlin: Springer. 1-38.
- Gao Y., Haren M.J. van, Moret E.E., Rood J.J.M., Sartini D., Salvucci A., Emanuelli M., Craveur P., Babault N., Jin J. & Martin N.I. (2019), Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity, Journal of Medicinal Chemistry 62(14): 6597-6614.
- Haren M.J. van, Thomas M.G., Sartini D., Barlow D.J., Ramsden D.B., Emanuelli M., Klamt F., Martin N.I. & Parsons R.B. (2018), The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition, International Journal of Biochemistry and Cell Biology 98: 127-136.
- Cura V., Marechal N., Troffer-Charlier N., Strub J-M., Haren M.J. van, Martin N.I., Cianferani S., Bonnefond L. & Cavarelli J. (2017), Functional insights from structural studies of protein arginine methyltransferase 2, FEBS Journal 284(1): 77-96.
- Haren M.J. van, Taig R., Kuppens J., Sastre Toraño J., Moret E.E., Parsons R.B., Sartini D., Emanuelli M. & Martin N.I. (2017), Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state, Organic and Biomolecular Chemistry 15(31): 6656-6667.
- Haren M.J. van, Marechal N., Troffer-Charlier N., Cianciulli A., Sardella G., Cavarelli J. & Martin N.I. (2017), Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1, Proceedings of the National Academy of Sciences 114(14): 3625-3630.
- Thomas M.G., Sartini D., Emanuelli M., Haren M.J. van, Martin N.I., Mountford D.M., Barlow D.J., Klamt F., Ramsden D.B., Reza M. & Parsons R.B. (2016), Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway, Biochemical Journal 473(19): 3253–3267.
- Haren M.J. van, Sastre Toraño J., Sartini D., Emanuelli M., Parsons R.B. & Martin N.I. (2016), A rapid and efficient assay for the characterization of substrates and inhibitors of nicotinamide N-methyltransferase, Biochemistry 55(37): 5307-5315.
- Haren M.J. van, Quarles Ufford L. van, Moret E.E. & Martin N.I. (2015), Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites, Organic and Biomolecular Chemistry 13(2): 549.
- Koopmans T., Haren M. van, Quarles Ufford L. van, Beekman J. & Martin N.I. (2013), A concise preparation of the fluorescent amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis, Bioorganic & Medicinal Chemistry 21(2): 533.