Le Zhang
Technicus onderwijs en onderzoek
- Naam
- Dr. L. Zhang
- Telefoon
- +31 71 527 4395
- l.zhang@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-0641-2383
.
Technicus onderwijs en onderzoek
- Wiskunde en Natuurwetenschappen
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Uiterweerd M.T., Nuñez Santiago I., Cunha A.V., Havenith R.W.A., Du C., Zhang L., Heul H.U. van der, Elsayed S.S.M.A., Minnaard A.J. & Wezel G.P. van (2025), Biomimetic total synthesis and paired omics identify an intermolecular diels–alder reaction as the key step in lugdunomycin biosynthesis, Journal of the American Chemical Society 147(16): 13764-13774.
- Bakker A.T., Kotsogianni I., Avalos Garcia M., Punt J.M., Liu B., Piermarini D., Gagestein B., Slingerland C.J., Zhang L., Willemse J.J., Ghimire L.B., Berg Richard J.H.B.N. van den, Janssen A.P.A., Ottenhoff T.H.M., Boeckel C.A.A. van, Wezel G.P. van, Ghilarov D., Martin N.I. & Stelt M. van der (2024), Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria, Nature Chemistry 16: 1462-1472.
- Hulst M.B., Zhang L., Heul H.U. van der, Du C., Elsayed S.S.M.A., Koroleva A., Grocholski T., Wander D.P.A., Metsä-Ketelä M., Neefjes J.J.C. & Wezel G.P. (2024), Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines, Frontiers in Bioengineering and Biotechnology 12: 1363803.
- Augustijn H.E., Reitz Z.L., Zhang L., Boot J.A., Elsayed S.S.M.A., Challis G.L., Medema M.H. & Wezel G.P. van (2024), Prediction of gene cluster function based on transcriptional regulatory networks uncovers a novel locus required for desferrioxamine B biosynthesis. bioRxiv. [working paper].
- Li C, Urem M., Du C., Zhang L. & Wezel G.P. van (2023), Systems-wide analysis of the ROK-family regulatory gene rokL6 and its role in the control of glucosamine toxicity in Streptomyces coelicolor, 89(12): e01674-23.
- Yague P., Willemse J., Xiao X.S., Zhang L., Manteca A. & Wezel G.P. van (2023), FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor, Antonie van Leeuwenhoek 116(1): 1-19.
- Bergeijk D.A. van, Elsayed S.S.M.A., Du C., Nuñez Santiago I., Roseboom A.M., Zhang L., Carrion Bravo V.J., Spaink H.P. & Wezel G.P. van (2022), The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces, Communications Chemistry 5: 14.
- Kapteijn R., Shitut S.S., Aschmann D., Zhang L., Beer M. de, Daviran D., Roverts R., Akiva A., Wezel G.P. van, Kros A. & Claessen D. (2022), Endocytosis-like DNA uptake by cell wall-deficient bacteria, Nature Communications 13(1): 5524.
- Zhong X., Zhang L., Wezel G.P. van, Vijgenboom E. & Claessen D. (2022), Role for a lytic polysaccharide monooxygenase in cell wall remodeling in streptomyces coelicolor, mBio 13(2): e00456-22.
- Ultee E., Aart L.T. van der, Zhang L., Dissel M.D. van, Diebolder C.A., Wezel G.P. van, Claessen D. & Briegel A. (2020), Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium, Communications Biology 3: 314.
- Zhang L., Willemse J.J., Hoskisson P.A. & Wezel G.P. van (2018), Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD, Scientific Reports 8(1): 7328.
- Wu C., Medema M.H., Läkamp R.M., Zhang L., Dorrestein P.C., Choi Y.H. & Wezel G.P. van (2016), Leucanicidin and endophenasides result from methyl-rhamnosylation by the same tailoring enzymes in Kitasatospora sp. MBT66, ACS Chemical Biology 11(2): 478-490.
- Zhang L. (27 mei 2015), Identification and characterization of developmental genes in streptomyces (Dissertatie. Institute of Biology, Faculty of Science, Leiden University). Promotor(en): Wezel G.P. van.
- Drabsch Y.S., He S., Zhang L., Snaar-Jagalska B.E. & Dijke P. ten (2013), Transforming growth factor-ß signalling controls human breast cancer metastasis in a zebrafish xenograft model, Breast Cancer Research 15: R106.