Coert Margadant
Universitair hoofddocent
- Naam
- Dr. C. Margadant
- Telefoon
- 071 5274916
- c.margadant@biology.leidenuniv.nl
Head of the Cell Adhesion and Migration Lab, a biomedical lab investigating the regulation of cell adhesion and migration in human health and disease. We use several approaches including cell biology, biochemistry, quantitative (live) imaging, and in vivo models to study how cells interact with their environment and move.
In the Cell Adhesion and Migration lab we perform research into the mechanisms underlying human disease, using a variety of approaches including cell biology, structural biology and quantitative imaging.
Universitair hoofddocent
- IBL
- Animal Sciences
- Stam W., Broekhuis J.D., Meer F.W.T. van der, Pirée R.P., Oosterhoff J.J., Pereda J.M. de, Schoot E. van der, Vidarsson G. & Margadant C. (2026), Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity, Blood 148(3): 300-316.
- de Pereda J.M., Stam W., Gragera M., Meer F.W.T. van der, Chichón F.J., Zarkadas E., Schoot E. van der, Vidarsson G., Takagi J. & Margadant C. (2026), High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation, Science Advances 12(29): eaed9833.
- Oosterhoff J.J., Stam W., Brummelen S.R. van, Bentlage A.E.H., Vos T. de, Pereda J. M. de, Porcelijn L., Kapur R., Haas M. de, Schoot C.E. van der, Vidarsson G. & Margadant C. (2025), HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins, Blood 146(18): 2189-2202.
- Stam W., Wachholz G.E., Perede J.M. de, Kapur R., Schoot E. van der & Margadant C. (2023), Fetal and neonatal alloimmune thrombocytopenia: current pathophysiological insights and perspectives for future diagnostics and treatment, Blood Review 59: 101038.
- Stalborch A.M.D. van, Clark A.G., Sonnenberg A. & Margadant C. (2023), Imaging and quantitative analysis of integrin-dependent cell-matrix adhesions, STAR Protocols 4(3): 102473.
- Aman J. & Margadant C. (2023), Integrin-dependent cell–matrix adhesion in endothelial health and disease, Circulation Research 132(3): 355-378.