Universiteit Leiden

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Sebastian Geibel

Associate Professor

Dr. S.R.J. Geibel
+31 71 527 4544

Pathogenic mycobacteria have evolved sophisticated mechanisms to subvert the human immune defence. Sebastian Geibel aims to understand one of their most important mechanisms: the secretion of proteins by the type VII secretion system.

More information about Sebastian Geibel

Curriculum Vitae

Personal information

Nationality:   German


2010   PhD, Institute of Chemistry and Biochemistry, Free University Berlin, Germany, 10 September, 2010. Thesis title: “Structure and function of primase RepB’ encoded by the broad host range plasmid RSF1010”
Supervisor: Prof. W. Saenger
2006   Diploma in Biochemistry, Institute of Chemistry and Biochemistry, Free University Berlin, Germany

Current and previous research positions

2022 – now    Associate Professor (tenured), Leiden Institute of Chemistry, Leiden University, The Netherlands
2014 – 2021   Junior Research Group Leader, Elite Network Bavaria, Center for Infectious Diseases, University of Würzburg, Germany
2010 – 2014   Postdoctoral fellow, Dept. of Biological Science, Birkbeck College, United Kingdom (Prof. G. Waksman)
2006 – 2010   Graduate student, Institute of Chemistry and Biochemistry, Free University Berlin, Germany (Prof. W. Saenger)

Grants, awards, recognitions

2022    LIC 1e GS (1 PhD position)

Contribution to teaching and supervision

  • Course for MSc Chemistry: Macromolecular Crystallography
  • Course for BSc Chemistry: Bioinformatics- Structural Analysis

Supervision of 3 PhD students and 1 MSc student.

Other current responsibilities

  • Reviewer for Nature, Nature Communications, American Chemical Society Omega, eLife, ReviewCommons, Federation of American Societies For Experimental Biology Journal, Journal of Medical Microbiology and Immunology
  • Reviewer for Welcome Trust, Biotechnology and Biological Sciences Research Council, The French National Academy of Sciences, German Research Foundation

Publication record including five recent representative publications

21 papers with >1100 citations, H-index 13 (Web of Science)

Full publication record: Leiden University

  • N. Famelis, S. Geibel, D. van Tol, Mycobacterial type VII secretion systems. Biological Chemistry, 2023, 404 (7), 691-702. DOI: 10.1515/hsz-2022-0350
  • S. Banchenko, C. Weise, E. Lanka, W. Saenger, S. Geibel, Helix Bundle Domain of Primase RepB′ Is Required for Dinucleotide Formation and Extension. ACS Omega, 2021, 6 (43), 28903-28911. DOI: 10.1021/acsomega.1c03881
  • A. Rivera-Calzada, N. Famelis, O. Llorca, S. Geibel, Type VII secretion systems: structure, functions and transport models. Nature Reviews Microbiology, 2021, 19 (9), 567-584. DOI: 10.1038/s41579-021-00560-5
  • N. Famelis, A. Rivera-Calzada, G. Degliesposti, M. Wingender, N. Mietrach, J. Skehel, R. Fernandez-Leiro, B. Böttcher, A. Schlosser, O. Llorca, S. Geibel, Architecture of the mycobacterial secretion system. Nature, 2019, 576 (7786), 321-325. DOI: 10.1038/s41586-019-1633-1
  • B. Mielich-Süss, R.M. Wagner, N. Mietrach, T. Hertlein, G. Marincola, N. Mietrach, T. Hertlein, G. Marincola, K. Ohlsen, S. Geibel, D. Lopez, Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus. PLoS pathogens, 2017, 13 (11), e1006728. DOI: 10.1371/journal.ppat.1006728

Presentations including five presentations at international conferences

~20 invited presentations at universities and institutes since 2010

  • ISMB Symposium, London (07-08.01.2021)
  • Transport Colloquium, Rauischholzhausen, Germany (22-24.04.2020)

Associate Professor

  • Science
  • Leiden Institute of Chemistry
  • LIC/Chemical Biology
  • LIC/CB/Biophysical Structural Chemistry

Work address

Gorlaeus Building
Einsteinweg 55
2333 CC Leiden
Room number DM2.14


  • No relevant ancillary activities
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