Sebastian Geibel
Associate Professor
- Name
- Dr. S.R.J. Geibel
- Telephone
- +31 71 527 4544
- s.r.j.geibel@lic.leidenuniv.nl
- ORCID iD
- 0000-0003-0068-680X
Pathogenic mycobacteria have evolved sophisticated mechanisms to subvert the human immune defence. Sebastian Geibel aims to understand one of their most important mechanisms: the secretion of proteins by the type VII secretion system.
More information about Sebastian Geibel
PhD candidates
News
Curriculum Vitae
Personal information
Nationality: German
Education
2010 PhD, Institute of Chemistry and Biochemistry, Free University Berlin, Germany, 10 September, 2010. Thesis title: “Structure and function of primase RepB’ encoded by the broad host range plasmid RSF1010”
Supervisor: Prof. W. Saenger
2006 Diploma in Biochemistry, Institute of Chemistry and Biochemistry, Free University Berlin, Germany
Current and previous research positions
2022 – now Associate Professor (tenured), Leiden Institute of Chemistry, Leiden University, The Netherlands
2014 – 2021 Junior Research Group Leader, Elite Network Bavaria, Center for Infectious Diseases, University of Würzburg, Germany
2010 – 2014 Postdoctoral fellow, Dept. of Biological Science, Birkbeck College, United Kingdom (Prof. G. Waksman)
2006 – 2010 Graduate student, Institute of Chemistry and Biochemistry, Free University Berlin, Germany (Prof. W. Saenger)
Grants, awards, recognitions
2022 LIC 1e GS (1 PhD position)
Contribution to teaching and supervision
- Course for MSc Chemistry: Macromolecular Crystallography
- Course for BSc Chemistry: Bioinformatics- Structural Analysis
Supervision of 3 PhD students and 1 MSc student.
Other current responsibilities
- Reviewer for Nature, Nature Communications, American Chemical Society Omega, eLife, ReviewCommons, Federation of American Societies For Experimental Biology Journal, Journal of Medical Microbiology and Immunology
- Reviewer for Welcome Trust, Biotechnology and Biological Sciences Research Council, The French National Academy of Sciences, German Research Foundation
Publication record including five recent representative publications
21 papers with >1100 citations, H-index 13 (Web of Science)
Full publication record: Leiden University
- N. Famelis, S. Geibel, D. van Tol, Mycobacterial type VII secretion systems. Biological Chemistry, 2023, 404 (7), 691-702. DOI: 10.1515/hsz-2022-0350
- S. Banchenko, C. Weise, E. Lanka, W. Saenger, S. Geibel, Helix Bundle Domain of Primase RepB′ Is Required for Dinucleotide Formation and Extension. ACS Omega, 2021, 6 (43), 28903-28911. DOI: 10.1021/acsomega.1c03881
- A. Rivera-Calzada, N. Famelis, O. Llorca, S. Geibel, Type VII secretion systems: structure, functions and transport models. Nature Reviews Microbiology, 2021, 19 (9), 567-584. DOI: 10.1038/s41579-021-00560-5
- N. Famelis, A. Rivera-Calzada, G. Degliesposti, M. Wingender, N. Mietrach, J. Skehel, R. Fernandez-Leiro, B. Böttcher, A. Schlosser, O. Llorca, S. Geibel, Architecture of the mycobacterial secretion system. Nature, 2019, 576 (7786), 321-325. DOI: 10.1038/s41586-019-1633-1
- B. Mielich-Süss, R.M. Wagner, N. Mietrach, T. Hertlein, G. Marincola, N. Mietrach, T. Hertlein, G. Marincola, K. Ohlsen, S. Geibel, D. Lopez, Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus. PLoS pathogens, 2017, 13 (11), e1006728. DOI: 10.1371/journal.ppat.1006728
Presentations including five presentations at international conferences
~20 invited presentations at universities and institutes since 2010
- ISMB Symposium, London (07-08.01.2021)
- Transport Colloquium, Rauischholzhausen, Germany (22-24.04.2020)
Associate Professor
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Biophysical Structural Chemistry
No relevant ancillary activities