Eline Slagboom
Professor Molecular Epidemiology
- Name
- Prof.dr. P. Slagboom
- Telephone
- +31 71 526 9731
- p.slagboom@lumc.nl
P. Eline Slagboom is professor of molecular epidemiology. She is head of the section of Molecular Epidemiology within the department of Biomedical Data Sciences. She is chair of the LUMC Medical Research Profile on Ageing and of the DUSRA – Dutch Society for Research on Ageing. Slagboom is PI of the Leiden Longevity Study and Fellow at the Max Planck Institute for Biology of Ageing in Cologn, Germany. She is board member of BBMRI-NL (Biobanking and Biomolecular Resources Research Infrastructure) steering national studies in metabolomics. Slagboom is member of the organising committee of various prestigious international conferences (such as the Welcome Trust, UK).
More information about Eline Slagboom
P. Eline Slagboom is professor of molecular epidemiology. She is head of the section of Molecular Epidemiology within the department of Biomedical Data Sciences. She is chair of the LUMC Medical Research Profile on Ageing and of the DUSRA – Dutch Society for Research on Ageing. Slagboom is PI of the Leiden Longevity Study and Fellow at the Max Planck Institute for Biology of Ageing in Cologn, Germany. She is board member of BBMRI-NL (Biobanking and Biomolecular Resources Research Infrastructure) steering national studies in metabolomics. Slagboom is member of the organising committee of various prestigious international conferences (such as the Welcome Trust, UK).
Molecular Epidemiology
In the past 25 years I have been inspired by the fact that the ageing process in humans is fundamental to all major diseases, is heterogeneous and malleable. The studies of my group into the molecular epidemiology of ageing includes studies into the biology of the genome, the aetiology and biomarkers of age-related disease and longevity/healthy ageing. My chair and our work relate to various Dutch Research Agendas (Big data, prevention and health, precision medicine) and precipitated in over 400 scientific publications and graduation of over 20 young PhDs. Since recently we study heterogeneity of responses of elderly to health promoting intervention studies (Growing Old Together Study).
I teach with passion and developed for High School, Graduate students and Biology teachers a MOOC and training program, to creative and logical thinking in science. I give the same training in the Master Vitality and Ageing at LUMC.
Academic career
Professor P. Eline Slagboom had a MSc in biology om 1985 and obtained her PhD at the Leiden University on 11-30-1993 on the doctoral thesis ‘Genomic instability and aging”. Between ‘93 and 2000 she was group leader at the TNO Institute for applied sciences (Gaubius Institute) in Leiden and was appointed in 2000 as professor of Molecular Epidemiology at the Leiden University Medical Center (LUMC). Her Inaugural lecture on 03-21-2003 was entitled: ‘Van het concert des levens…’
Slagboom attracted many talented researchers and the group expanded over the years through the grants she obtained and collaborations with industry. The largest projects she coordinated sofar include a NWO supported genotyping facility, a large scale FP7-EU project (IDEAL: Integrated research on DEvelopmental determinants of Aging and Longevity) and the Netherlands Consortium for Healthy Ageing.
Prizes and honourable appointments
- Designers and Artists 4 Genomics Award (2011)
- Fellow at the Max Planck Institute for Biology of Ageing in Cologn, Germany
Professor Molecular Epidemiology
- Faculteit Geneeskunde
- Divisie 4
- Biomedical Data Sciences
- Pelsma, I.C.M.; Claessen, K.M.J.A.; Slagboom, P.E.; Heemst, D. van; Pereira, A.M.; Kroon, H.; Ramos, Y.F.M.; Kloppenburg, M.; Biermasz, N.R. & Meulenbelt, I.M. (2021), Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis, European Journal of Endocrinology 184(1): 29-39.
- Akker, E.B. van den; Makrodimitris, S.; Hulsman, M.; Brugman, M.H.; Nikolic, T.; Bradley, T.; Waisfisz, Q.; Baas, F.; Jakobs, M.E.; Jong, D. de; Slagboom, P.E.; Staal, F.J.T.; Reinders, M.J.T. & Holstege, H. (2020), Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian.
- Akker, E.B. van den; Trompet, S.; Wolf, J.J.H.B.; Beekman, M.; Suchiman, H.E.D.; Deelen, J.; Asselbergs, F.W.; Boersma, E.; Cats, D.; Elders, P.M.; Geleijnse, J.M.; Ikram, M.A.; Kloppenburg, M.; Mei, H.; Meulenbelt, I.; Mooijaart, S.P.; Nelissen, R.G.H.H.; Netea, M.G.; Penninx, B.W.J.H.; Slofstra, M.; Stehouwer, C.D.A.; Swertz, M.A.; Teunissen, C.E.; Terwindt, G.M.; Hart, L.M. 't; Maagdenberg, A.M.J.M. van den; Harst, P. van der; Horst, I.C.C. van der; Kallen, C.J.H. van der; Greevenbroek, M.M.J. van; Spil, W.E. van; Wijmenga, C.; Zhernakova, A.; Zwinderman, A.H.; Sattar, N.; Jukema, J.W.; Duijn, C.M. van; Boomsma, D.I.; Reinders, M.J.T. & Slagboom, P.E. (2020), Metabolic Age Based on the BBMRI-NL H-1-NMR Metabolomics Repository as Biomarker of Age-related Disease, Circulation: Genomic and Precision Medicine 13(5): 541-547.
- Giacconi, R.; Maggi, F.; Macera, L.; Spezia, P.G.; Pistello, M.; Provinciali, M.; Piacenza, F.; Basso, A.; Burkle, A.; Moreno-Villanueva, M.; Dolle, M.E.T.; Jansen, E.; Grune, T.; Stuetz, W.; Gonos, E.S.; Schon, C.; Bernhardt, J.; Grubeck-Loebenstein, B.; Sikora, E.; Dudkowska, M.; Janiszewska, D.; Toussaint, O.; Debacq-Chainiaux, F.; Franceschi, C.; Capri, M.; Hervonen, A.; Hurme, M.; Slagboom, E.; Breusing, N.; Mocchegiani, E. & Malavolta, M. (2020), Prevalence and Loads of Torquetenovirus in the European MARK-AGE Study Population, Journal of Gerontology: Medical Sciences 75(10): 1838-1845.
- Rutten, J.W.; Hack, R.J.; Duering, M.; Gravesteijn, G.; Dauwerse, J.G.; Overzier, M.; Akker, E.B. van den; Slagboom, E.; Holstege, H.; Nho, K.; Saykin, A.; Dichgans, M.; Malik, R. & Oberstein, S.A.J.L. (2020), Broad phenotype of cysteine-alteringNOTCH3variants in UK Biobank CADASIL to nonpenetrance, Neurology 95(13): E1835-E1843.
- Meessen, J.M.T.A.; Saberi-Hosnijeh, F.; Bomer, N.; Hollander, W. den; Bom, J.G. van der; Hilten, J.A. van; Spil, W.E. van; So-Osman, C.; Uitterlinden, A.G.; Kloppenburg, M.; Nelissen, R.G.H.H.; Duijn, C.M. van; Slagboom, P.E.; Meurs, J.B.J. van & Meulenbelt, I. (2020), Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI, Scientific Reports 10(1).
- Sijp, M.P.L. van der; Suchiman, H.E.D.; Eijk, M.; Vojinovic, D.; Niggebrugge, A.H.P.; Blauw, G.J.; Achterberg, W.P. & Slagboom, P.E. (2020), The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture, Geriatric Orthopaedic Surgery and Rehabilitation 11.
- Hop, P.J.; Luijk, R.; Daxinger, L.; Iterson, M. van; Dekkers, K.F.; Jansen, R.; Meurs, J.B.J. van; Hoen, P.A.C. 't; Ikram, M.A.; Greevenbroek, M.M.J. van; Boomsma, D.I.; Slagboom, P.E.; Veldink, J.H.; Zwet, E.W. van; Heijmans, B.T. & BIOS Consortium (2020), Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference, Genome Biology 21(1).
- Mourits, R.J.; Berg, N. van den; Rodriguez-Girondo, M.; Mandemakers, K.; Slagboom, P.E.; Beekman, M. & Janssens, A.A.P.O. (2020), Intergenerational transmission of longevity is not affected by other familial factors:evidence from 16,905 Dutch families from Zeeland, 1812-1962, HISTORY OF THE FAMILY 25(3): 484-526.
- Benedetti, E.; Gerstner, N.; Pucic-Bakovic, M.; Keser, T.; Reiding, K.R.; Ruhaak, L.R.; Stambuk, T.; Selman, M.H.J.; Rudan, I.; Polasek, O.; Hayward, C.; Beekman, M.; Slagboom, E.; Wuhrer, M.; Dunlop, M.G.; Lauc, G. & Krumsiek, J. (2020), Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference, Metabolites 10(7).
- Paraschiakos, S.; Cachucho, R.; Moed, M.; Heemst, D. van; Mooijaart, S.; Slagboom, E.P.; Knobbe, A. & Beekman, M. (2020), Activity recognition using wearable sensors for tracking the elderly, User Modeling and User-Adapted Interaction.
- Pool R., Hagenbeek F.A., Hendriks A.M., Dongen J. van, Willemsen G., Geus E. de, Dijk K.W. van, Verhoeven A., Suchiman H.E., Beekman M., Slagboom P.E., Harms A.C., Hankemeier T., Boomsma D.I., Beekman M., Suchiman H.E.D., Amin N., Beulens J.W., Bom J.A. van der, Bomer N., Demirkan A., Hilten J.A., Meessen J.M.T.A., Pool R., Moed M.H., Fu J., Onderwater G.L.J., Rutters F., So-Osman C., Flier W.M. van der, Heijden A.A.W.A. van der, Spek A. van der, Asselbergs F.W., Boersma E., Elders P.M., Geleijnse J.M., Ikram M.A., Kloppenburg M., Meulenbelt I., Mooijaart S.P., Nelissen R.G.H.H., Netea M.G., Penninx B.W.J.H., Stehouwer C.D.A., Teunissen C.E., Terwindt G.M., Hart L.M. 't, Maagdenberg A.M.J.M. van den, Harst P. van der, Horst I.C.C. van der, Kallen C.J.H. van der, Greevenbroek M.M.J. van, Spil W.E. van, Wijmenga C., Zwinderman A.H., Zhernikova A., Jukema J.W., Wolf J.J.H.B., Cats D., Mei H., Slofstra M., Swertz M., Akker E.B. van den, Deelen J., Reinders M.J.T., Boomsma D.I., Duijn C.M. van & Slagboom P.E. (2020), Genetics and not shared environment explains familial resemblance in adult metabolomics data, Twin Research and Human Genetics 23(3): 145-155.
- Pool, R.; Hagenbeek, F.A.; Hendriks, A.M.; Dongen, J. van; Willemsen, G.; Geus, E. de; Dijk, K.W. van; Verhoeven, A.; Suchiman, H.E.; Beekman, M.; Slagboom, P.E.; Harms, A.C.; Hankemeier, T.; Boomsma, D.I.; Beekman, M.; Suchiman, H.E.D.; Amin, N.; Beulens, J.W.; Bom, J.A. van der; Bomer, N.; Demirkan, A.; Hilten, J.A. van; Meessen, J.M.T.A.; Pool, R.; Moed, M.H.; Fu, J.; Onderwater, G.L.J.; Rutters, F.; So-Osman, C.; Flier, W.M. van der; Heijden, A.A.W.A. van der; Spek, A. van der; Asselbergs, F.W.; Boersma, E.; Elders, P.M.; Geleijnse, J.M.; Ikram, M.A.; Kloppenburg, M.; Meulenbelt, I.; Mooijaart, S.P.; Nelissen, R.G.H.H.; Netea, M.G.; Penninx, B.W.J.H.; Stehouwer, C.D.A.; Teunissen, C.E.; Terwindt, G.M.; Hart, L.M. 't; Maagdenberg, A.M.J.M. van den; Harst, P. van der; Horst, I.C.C. van der; Kallen, C.J.H. van der; Greevenbroek, M.M.J. van; Spil, W.E. van; Wijmenga, C.; Zwinderman, A.H.; Zhernikova, A.; Jukema, J.W.; Wolf, J.J.H.B.; Cats, D.; Mei, H.; Slofstra, M.; Swertz, M.; Akker, E.B. van den; Deelen, J.; Reinders, M.J.T.; Boomsma, D.I.; Duijn, C.M. van; Slagboom, P.E. & BBMRI Metabol Consortium (2020), Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data, Twin Research and Human Genetics 23(3): 145-155.
- Berg, N. van den; Rodriguez-Girondo, M.; Mandemakers, K.; Janssens, A.A.P.O.; Beekman, M. & Slagboom, P.E. (2020), Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies, Aging Cell.
- Beekman, M.; Schutte, B.A.M.; Akker, E.B. van den; Noordam, R.; Dibbets-Schneider, P.; Geus-Oei, L.F. de; Deelen, J.; Rest, O.V. van de; Heemst, D. van; Feskens, E.J.M. & Slagboom, P.E. (2020), Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter, Molecular Nutrition and Food Research 64(10).
- Raz, Y.; Akker, E.B. van den; Roest, T.; Riaz, M.; Rest, O. van de; Suchiman, H.E.D.; Lakenberg, N.; Stassen, S.A.; Putten, M. van; Feskens, E.J.M.; Reinders, M.J.T.; Goeman, J.; Beekman, M.; Raz, V. & Slagboom, P.E. (2020), A data-driven methodology reveals novel myofiber clusters in older human muscles, FASEB Journal 34(4): 5525-5537.
- Spoel, E. van der; Roelfsema, F.; Akintola, A.A.; Jansen, S.W.; Slagboom, P.E.; Westendorp, R.G.J.; Blauw, G.J.; Pijl, H. & Heemst, D. van (2020), Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects, Journal of Clinical Endocrinology and Metabolism 105(4).
- Tilburg, J.; Slieker, R.C.; Suchiman, H.E.D.; Heath, A.; Heemst, D. van; Slagboom, P.E.; Gruijl, F.R. de; Gunn, D.A. & Heijmans, B.T. (2020), Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response, Epigenomics 12(7): 563-573.
- Bos, M.M.; Noordam, R.; Bennett, K.; Beekman, M.; Mook-Kanamori, D.O.; Dijk, K.W. van; Slagboom, P.E.; Lundstedt, T.; Surowiec, I. & Heemst, D. van (2020), Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity, Metabolomics 16(3).
- Bot, M.; Milaneschi, Y.; Al-Shehri, T.; Amin, N.; Garmaeva, S.; Onderwater, G.L.J.; Pool, R.; Thesing, C.S.; Vijfhuizen, L.S.; Vogelzangs, N.; Arts, I.C.W.; Demirkan, A.; Duijn, C. van; Greevenbroek, M. van; Kallen, C.J.H. van der; Kohler, S.; Ligthart, L.; Maagdenberg, M.J.M. van den; Mook-Kanamori, D.O.; Mutsert, R. de; Tiemeier, H.; Schram, M.T.; Stehouwer, C.D.A.; Terwindt, G.M.; Dijk, K.W. van; Fu, J.Y.; Zhernakova, A.; Beekman, M.; Slagboom, P.E.; Boomsma, D.I.; Penninx, B.W.J.H. & BBMRI-NL Metabol Consortium (2020), Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls, Biological Psychiatry 87(5): 409-418.
- Meessen JMTA, Fiocco M, Tordoir RL, Sjer A, Verdegaal SHM, Slagboom PE, Vlieland TPMV & Nelissen RGHH (2020), Association of handgrip strength with patient-reported outcome measures after total hip and knee arthroplasty, Rheumatology International 40(4): 565-571.
- Munn-Chernoff, M.A.; Johnson, E.C.; Chou, Y.L.; Coleman, J.R.I.; Thornton, L.M.; Walters, R.K.; Yilmaz, Z.; Baker, J.H.; Hubel, C.; Gordon, S.; Medland, S.E.; Watson, H.J.; Gaspar, H.A.; Bryois, J.; Hinney, A.; Leppa, V.M.; Mattheisen, M.; Ripke, S.; Yao, S.Y.; Giusti-Rodriguez, P.; Hanscombe, K.B.; Adan, R.A.H.; Alfredsson, L.; Ando, T.; Andreassen, O.A.; Berrettini, W.H.; Boehm, I.; Boni, C.; Perica, V.B.; Buehren, K.; Burghardt, R.; Cassina, M.; Cichon, S.; Clementi, M.; Cone, R.D.; Courtet, P.; Crow, S.; Crowley, J.J.; Danner, U.N.; Davis, O.S.P.; Zwaan, M. de; Dedoussis, G.; Degortes, D.; DeSocio, J.E.; Dick, D.M.; Dikeos, D.; Dina, C.; Dmitrzak-Weglarz, M.; Docampo, E.; Duncan, L.E.; Egberts, K.; Ehrlich, S.; Escaramis, G.; Esko, T.; Estivill, X.; Farmer, A.; Favaro, A.; Fernandez-Aranda, F.; Fichter, M.M.; Fischer, K.; Focker, M.; Foretova, L.; Forstner, A.J.; Forzan, M.; Franklin, C.S.; Gallinger, S.; Giegling, I.; Giuranna, J.; Gonidakis, F.; Gorwood, P.; Mayora, M.G.; Guillaume, S.; Guo, Y.R.; Hakonarson, H.; Hatzikotoulas, K.; Hauser, J.; Hebebrand, J.; Helder, S.G.; Herms, S.; Herpertz-Dahlmann, B.; Herzog, W.; Huckins, L.M.; Hudson, J.I.; Imgart, H.; Inoko, H.; Janout, V.; Jimenez-Murcia, S.; Julia, A.; Kalsi, G.; Kaminska, D.; Karhunen, L.; Karwautz, A.; Kas, M.J.H.; Kennedy, J.L.; Keski-Rahkonen, A.; Kiezebrink, K.; Kim, Y.R.; Klump, K.L.; Knudsen, G.P.S.; Via, M.C. la; Hellard, S. le; Levitan, R.D.; Li, D.; Lilenfeld, L.; Lin, B.D.; Lissowska, J.; Luykx, J.; Magistretti, P.J.; Maj, M.; Mannik, K.; Marsal, S.; Marshall, C.R.; Mattingsdal, M.; McDevitt, S.; McGuffin, P.; Metspalu, A.; Meulenbelt, I.; Micali, N.; Mitchell, K.; Monteleone, A.M.; Monteleone, P.; Nacmias, B.; Navratilova, M.; Ntalla, I.; O'Toole, J.K.; Ophoff, R.A.; Padyukov, L.; Palotie, A.; Pantel, J.; Papezova, H.; Pinto, D.; Rabionet, R.; Raevuori, A.; Ramoz, N.; Reichborn-Kjennerud, T.; Ricca, V.; Ripatti, S.; Ritschel, F.; Roberts, M.; Rotondo, A.; Rujescu, D.; Rybakowski, F.; Santonastaso, P.; Scherag, A.; Scherer, S.W.; Schmidt, U.; Schork, N.J.; Schosser, A.; Seitz, J.; Slachtova, L.; Slagboom, P.E.; Landt, M.C.T.S.O.; Slopien, A.; Sorbi, S.; Swiatkowska, B.; Szatkiewicz, J.P.; Tachmazidou, I.; Tenconi, E.; Tortorella, A.; Tozzi, F.; Treasure, J.; Tsitsika, A.; Tyszkiewicz-Nwafor, M.; Tziouvas, K.; Elburg, A.A. van; Furth, E.F. van; Wagner, G.; Walton, E.; Widen, E.; Zeggini, E.; Zerwas, S.; Zipfel, S.; Bergen, A.W.; Boden, J.M.; Brandt, H.; Crawford, S.; Halmi, K.A.; Horwood, L.J.; Johnson, C.; Kaplan, A.S.; Kaye, W.H.; Mitchell, J.; Olsen, C.M.; Pearson, J.F.; Pedersen, N.L.; Strober, M.; Werge, T.; Whiteman, D.C.; Woodside, D.B.; Grove, J.; Henders, A.K.; Larsen, J.T.; Parker, R.; Petersen, L.V.; Jordan, J.; Kennedy, M.A.; Birgegard, A.; Lichtenstein, P.; Norring, C.; Landen, M.; Mortensen, P.B.; Polimanti, R.; McClintick, J.N.; Adkins, A.E.; Aliev, F.; Bacanu, S.A.; Batzler, A.; Bertelsen, S.; Biernacka, J.M.; Bigdeli, T.B.; Chen, L.S.; Clarke, T.K.; Degenhardt, F.; Docherty, A.R.; Edwards, A.C.; Foo, J.C.; Fox, L.; Frank, J.; Hack, L.M.; Hartmann, A.M.; Hartz, S.M.; Heilmann-Heimbach, S.; Hodgkinson, C.; Hoffmann, P.; Hottenga, J.J.; Konte, B.; Lahti, J.; Lahti-Pulkkinen, M.; Lai, D.B.; Ligthart, L.; Loukola, A.; Maher, B.S.; Mbarek, H.; McIntosh, A.M.; McQueen, M.B.; Meyers, J.L.; Milaneschi, Y.; Palviainen, T.; Peterson, R.E.; Ryu, E.; Saccone, N.L.; Salvatore, J.E.; Sanchez-Roige, S.; Schwandt, M.; Sherva, R.; Streit, F.; Strohmaier, J.; Thomas, N.; Wang, J.C.; Webb, B.T.; Wedow, R.; Wetherill, L.; Wills, A.G.; Zhou, H.; Boardman, J.D.; Chen, D.F.; Choi, D.S.; Copeland, W.E.; Culverhouse, R.C.; Dahmen, N.; Degenhardt, L.; Domingue, B.W.; Frye, M.A.; Gabel, W.; Hayward, C.; Ising, M.; Keyes, M.; Kiefer, F.; Koller, G.; Kramer, J.; Kuperman, S.; Lucae, S.; Lynskey, M.T.; Maier, W.; Mann, K.; Mannisto, S.; Muller-Myhsok, B.; Murray, A.D.; Nurnberger, J.I.; Preuss, U.; Raikkonen, K. & Reyn (2020), Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies, Addiction Biology.
- Ouwens, K.G.; Jansen, R.; Nivard, M.G.; Dongen, J. van; Frieser, M.J.; Hottenga, J.J.; Arindrarto, W.; Claringbould, A.; Iterson, M. van; Mei, H.L.; Franke, L.; Heijmans, B.T.; Hoen, P.A.C. 't; Meurs, J. van; Brooks, A.I.; Penninx, B.W.J.H.; Boomsma, D.I.; Isaacs, A.; Pool, R.; Hottenga, J.J.; Greevenbroek, M.M.J. van; Stehouwer, C.D.A.; Kallen, C.J.H. van der; Schalkwijk, C.G.; Wijmenga, C.; Zhernakova, S.; Tigchelaar, E.F.; Slagboom, P.E.; Beekman, M.; Deelen, J.; Heemst, D. van; Veldink, J.H.; Berg, L.H. van den; Duijn, C.M. van; Hofman, B.A.; Uitterlinden, A.G.; Jhamai, P.M.; Verbiest, M.; Suchiman, H.E.D.; Verkerk, M.; Breggen, R. van der; Rooij, J. van; Lakenberg, N.; Galen, M. van; Bot, J.; Zhernakova, D.V.; van't Hof, P.; Deelen, P.; Nooren, I.; Moed, M.; Vermaat, M.; Luijk, R.; Bonder, M.J.; Dijk, F. van; Kielbasa, S.M.; Swertz, M.A.; Zwet, E.W. van; Hoen, P.B. 't & BIOS Consortium (2020), A characterization of cis- and trans-heritability of RNA-Seq-based gene expression, European Journal of Human Genetics 28(2): 253-263.
- Beenakker, K.G.M.; Westendorp, R.G.J.; Craen, A.J.M. de; Chen, S.J.; Raz, Y.; Ballieux, B.E.P.B.; Nelissen, R.G.H.H.; Later, A.F.L.; Huizinga, T.W.; Slagboom, P.E.; Boomsma, D.I. & Maier, A.B. (2020), Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations, Journal of Innate Immunity 12(2): 142-153.
- Hagenbeek, F.A.; Pool, R.; Dongen, J. van; Draisma, H.H.M.; Hottenga, J.J.; Willemsen, G.; Abdellaoui, A.; Fedko, I.O.; Braber, A. den; Visser, P.J.; Geus, E.J.C.N. de; Dijk, K.W. van; Verhoeven, A.; Suchiman, H.E.; Beekman, M.; Slagboom, P.E.; Duijn, C.M. van; Harms, A.C.; Hankemeier, T.; Bartels, M.; Nivard, M.G.; Boomsma, D.I.; Wolf, J.J.H.B.; Cats, D.; Amin, N.; Beulens, J.W.; Bom, J.A. van der; Bomer, N.; Demirkan, A.; Hilten, J.A. van; Meessen, J.M.T.A.; Moed, M.H.; Fu, J.; Onderwater, G.L.J.; Rutters, F.; So-Osman, C.; Flier, W.M. van der; Heijden, A.A.W.A. van der; Spek, A. van der; Asselbergs, F.W.; Boersma, E.; Elders, P.M.; Geleijnse, J.M.; Ikram, M.A.; Kloppenburg, M.; Meulenbelt, I.; Mooijaart, S.P.; Nelissen, R.G.H.H.; Netea, M.G.; Penninx, B.W.J.H.; Stehouwer, C.D.A.; Teunissen, C.E.; Terwindt, G.M.; Hart, L.M. 't; Maagdenberg, A.M.J.M. van den; Harst, P. van der; Horst, I.C.C. van der; Kallen, C.J.H. van der; Greevenbroek, M.M.J. van; Spil, W.E. van; Wijmenga, C.; Zwinderman, A.H.; Zhernikova, A.; Jukema, J.W.; Mei, H.; Slofstra, M.; Swertz, M.; Akker, E.B. van den; Deelen, J.; Reinders, M.J.T. & BBMRI Metabolomics Consortium (2020), Heritability estimates for 361 blood metabolites across 40 genome-wide association studies, Nature Communications 11(1).
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- Noordam, R.; Jansen, S.W.M.; Akintola, A.A.; Oei, N.Y.L.; Maier, A.B.; Pijl, H.; Slagboom, P.E.; Westendorp, R.G.J.; Grond, J. van der; Craen, A.J.M. de; Heemst, D. van & Leiden Longevity Study Grp (2012), Familial Longevity Is Marked by Lower Diurnal Salivary Cortisol Levels: The Leiden Longevity Study, PLoS ONE 7(2): -.
- Wijsman, C.A.; Westendorp, R.G.J.; Slagboom, P.E.; Heemst, D. van & Mooijaart, S.P. (2012), 24-HOUR GLUCOSE RHYTHMS IN AGEING AND LONGEVITY, Age and Ageing 41: 2-2.
- Rius-Ottenheim, N.; Craen, A.J.M. de; Geleijnse, J.M.; Slagboom, P.E.; Kromhout, D.; Mast, R.C. van der; Zitman, F.G.; Westendorp, R.G. & Giltay, E.J. (2012), C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects., Inflammation Research 61(1): 43-51.
- Rius-Ottenheim, N.; Craen, A.J.M. de; Geleijnse, J.M.; Slagboom, P.E.; Kromhout, D.; Mast, R.C. van der; Zitman, F.G.; Westendorp, R.G. & Giltay, E.J. (2012), C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects, Inflammation Research 61(1): 43-51.
- Postmus, I.; Trompet, S.; Craen, A.J.M. de; Slagboom, P.E.; Westendorp, R.G.J. & Jukema, J.W. (2012), GENOME WIDE ASSOCIATION STUDY OF LDL-CHOLESTEROL. THE FIRST RESULTS OF THE PROSPER/PHASE STUDY, Age and Ageing 41: 8-8.
- Raz, Y.; Craen, A.J.M. de; Heemst, D. van; Slagboom, P.E.; Westendorp, R.G.J. & Maier, A.B. (2012), INNATE IMMUNITY IN FAMILIAL LONGEVITY - THE LEIDEN LONGEVITY STUDY, Age and Ageing 41: 36-36.
- Soerensen, M.; Dato, S.; Tan, Q.H.; Thinggaard, M.; Kleindorp, R.; Beekman, M.; Suchiman, H.E.D.; Jacobsen, R.; McGue, M.; Stevnsner, T.; Bohr, V.A.; Craen, A.J.M. de; Westendorp, R.G.J.; Schreiber, S.; Slagboom, P.E.; Nebel, A.; Vaupel, J.W.; Christensen, K. & Christiansen, L. (2012), Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity., AGE.
- Passtoors, W.M.; Boer, J.M.; Goeman, J.J.; Akker, E.B. van den; Deelen, J.; Zwaan, B.J.; Scarborough, A.; Breggen, R. van der; Vossen, R.H.A.M.; Houwing-Duistermaat, J.J.; Ommen, G.J.B. van; Westendorp, R.G.J.; Heemst, D. van; Craen, A.J.M. de; White, A.J.; Gunn, D.A.; Beekman, M. & Slagboom, P.E. (2012), Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R, PLoS ONE 7(1): -.
- Uh HW, Deelen J, Beekman M, Helmer Q, Rivadeneira F, Hottenga JJ, Boomsma DI, Hofman A, Uitterlinden AG, Slagboom PE, Böhringer S & Houwing-Duistermaat JJ (2012), How to deal with the early GWAS data when imputting and combining different arrays is necessary, European Journal of Human Genetics.
- Brandsma M, Baas F, de Bakker PIW, Beem EP, Boomsma DI, Bovenberg J, Bueno-de-Mesquita B, van Duijn C, Kiemeney LA, Klungel O, de Leeuw FE, van Leeuwen FE, Ridder-Numan J, Stolk RP, Slagboom PE, Swertz M, Wijmenga C, van Ommen GJB & on behalf of BBMRI-NL (2012), How to kickstart a national biobanking infrastructure - experiences and prospects of BBMRI-NL, Norsk Epidemiologi.
- Noordam, R.; Craen, A.J.M. de; Pedram, P.; Maier, A.B.; Mooijaart, S.P.; Pelt, J. van; Feskens, E.J.; Streppel, M.T.; Slagboom, P.E.; Westendorp, G.J.; Beekman, M. & Heemst, D. van (2012), Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study, CMAJ.
- Zhang, Y.J.; Lameijer, E.W.; Hoen, P.A.C. 't; Ning, Z.M.; Slagboom, P.E. & Ye, K. (2012), PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data, Bioinformatics 28(4).
- Yusuf, E.; Bijsterbosch, J.; Slagboom, P.E.; Kroon, H.M.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Association between Several Clinical and Radiological Determinants with Long-Term Clinical Progression and Good Prognosis of Lower Limb Osteoarthritis., PLoS ONE 6(10): e25426.
- Trompet, S.; Pons, D.; Kanse, S.M.; Craen, A.J. de; Ikram, M.A.; Verschuren, J.J.; Zwinderman, A.H.; Doevendans, P.A.; Tio, R.A.; Winter, R.J. de; Slagboom, P.E.; Westendorp, R.G. & Jukema, J.W. (2011), Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality., Stroke Research and Treatment 2011: 424759.
- Derhovanessian, E.; Maier, A.B.; Hahnel, K.; Beck, R.; Craen, A.J.M. de; Slagboom, E.P.; Westendorp, R.G.J. & Pawelec, G. (2011), Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4(+) and CD8(+) T-cells in humans.
- van den Akker EB, Verbruggen B, Heijmans BT, Beekman M, Kok JN, Slagboom PE & Reinders MJ (2011), Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis., Journal of Integrative Bioinformatics 8(2): 188.
- Trompet, S.; Craen, A.J.M. de; Postmus, I.; Ford, I.; Sattar, N.; Caslake, M.; Stott, D.J.; Buckley, B.M.; Sacks, F.; Devlin, J.J.; Slagboom, P.E.; Westendorp, R.G.J.; Jukema, J.W. & PROSPER Study Grp (2011), Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses., BMC Medical Genetics 12: 131.
- Uh, H.W.; Deelen, J.; Beekman, M.; Helmer, Q.; Rivadeneira, F.; Hottenga, J.J.; Boomsma, D.I.; Hofman, A.; Uitterlinden, A.G.; Slagboom, P.E.; Bohringer, S. & Houwing-Duistermaat, J.J. (2011), How to deal with the early GWAS data when imputing and combining different arrays is necessary., European Journal of Human Genetics.
- Sampietro, M.L.; Trompet, S.; Verschuren, J.J.W.; Talens, R.P.; Deelen, J.; Heijmans, B.T.; Winter, R.J. de; Tio, R.A.; Doevendans, P.A.F.M.; Ganesh, S.K.; Nabel, E.G.; Westra, H.J.; Franke, L.; Akker, E.B. van den; Westendorp, R.G.J.; Zwinderman, A.H.; Kastrati, A.; Koch, W.; Slagboom, P.E.; Knijff, P. de & Jukema, J.W. (2011), A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention., Human Molecular Genetics 20(23): 4748-57.
- Martella, F.; Vermunt, J.K.; Beekman, M.; Westendorp, R.G.J.; Slagboom, P.E. & Houwing-Duistermaat, J.J. (2011), A mixture model with random-effects components for classifying sibling pairs, Statistics in Medicine 30(27): 3252-3264.
- Skytthe, A.; Valensin, S.; Jeune, B.; Cevenini, E.; Balard, F.; Beekman, M.; Bezrukov, V.; Blanche, H.; Bolund, L.; Broczek, K.; Carru, C.; Christensen, K.; Christiansen, L.; Collerton, J.C.; Cotichini, R.; Craen, A.J.M. de; Dato, S.; Davies, K.; Benedictis, G. de; Deiana, L.; Flachsbart, F.; Gampe, J.; Gilbault, C.; Gonos, E.S.; Haimes, E.; Hervonen, A.; Hurme, M.A.; Janiszewska, D.; Jylha, M.; Kirkwood, T.B.L.; Kristensen, P.; Laiho, P.; Leon, A.; Marchisio, A.; Masciulli, R.; Nebel, A.; Passarino, G.; Pelicci, G.; Peltonen, L.; Perola, M.; Poulain, M.; Rea, I.M.; Remade, J.; Robine, J.M.; Schreiber, S.; Scurti, M.; Sevini, F.; Sikora, E.; Skouteri, A.; Slagboom, P.E.; Spazzafumo, L.; Stazi, M.A.; Toccaceli, V.; Toussaint, O.; Tornwall, O.; Vaupel, J.W.; Voutetakis, K.; Franceschi, C. & GEHA Consortium (2011), Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project, Experimental Gerontology 46(11): 934-945.
- Geus, E. de; Snieder, H.; Kupper, N.; Suchiman, E.; Slagboom, E.; Bartels, M.; Willemsen, G. & Boomsma, D. (2011), Heritability of cardiac sympathetic control at rest and during stress and the contribution of the Gln27Glu beta-2-adrenergic receptor polymorphism, Behavior Genetics 41(6): 899-899.
- Deelen, J.; Uh, H.W.; Monajemi, R.; Heemst, D. van; Thijssen, P.E.; Bohringer, S.; Akker, E.B. van den; Craen, A.J.M. de; Rivadeneira, F.; Uitterlinden, A.G.; Westendorp, R.G.J.; Goeman, J.J.; Slagboom, P.E.; Houwing-Duistermaat, J.J. & Beekman, M. (2011), Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways., AGE.
- Noordam, R.; Gunn, D.A.; Tomlin, C.C.; Maier, A.B.; Mooijaart, S.P.; Slagboom, P.E.; Westendorp, R.G.J.; Craen, A.J.M. de; Heemst, D. van & Leiden Longevity Study Grp (2011), High serum glucose levels are associated with a higher perceived age., AGE.
- Talens, R.P.; Jukema, J.W.; Trompet, S.; Kremer, D.; Westendorp, R.G.J.; Lumey, L.H.; Sattar, N.; Putter, H.; Slagboom, P.E.; Heijmans, B.T. & PROSPER Grp (2011), Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction., International Journal of Epidemiology.
- Dekker, P.; Baalen, L.M. van; Dirks, R.W.; Slagboom, P.E.; Heemst, D. van; Tanke, H.J.; Westendorp, R.G.J. & Maier, A.B. (2011), Chronic Inhibition of the Respiratory Chain in Human Fibroblast Cultures: Differential Responses Related to Subject Chronological and Biological Age., Journals of Gerontology, Series A.
- Finken, M.J.J.; Meulenbelt, I.; Dekker, F.W.; Frolich, M.; Walther, F.J.; Romijn, J.A.; Slagboom, P.E.; Wit, J.M. & Dutch POPS-19 Collaborative Study (2011), Abdominal Fat Accumulation in Adults Born Preterm Exposed Antenatally to Maternal Glucocorticoid Treatment Is Dependent on Glucocorticoid Receptor Gene Variation, Journal of Clinical Endocrinology and Metabolism 96(10): E1650-E1655.
- Ling, C.H.Y.; Craen, A.J.M. de; Slagboom, P.E.; Gunn, D.A.; Stokkel, M.P.M.; Westendorp, R.G.J. & Maier, A.B. (2011), Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population., Clinical Nutrition 30(5): 610-5.
- Yusuf, E.; Bijsterbosch, J.; Slagboom, P.E.; Kroon, H.M.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Association between Several Clinical and Radiological Determinants with Long-Term Clinical Progression and Good Prognosis of Lower Limb Osteoarthritis, PLoS ONE 6(10): -.
- Yusuf, E.; Bijsterbosch, J.; Slagboom, P.E.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Body mass index and alignment and their interaction as risk factors for progression of knees with radiographic signs of osteoarthritis, Osteoarthritis and Cartilage 19(9): 1117-1122.
- Obermann-Borst, S.A.; Slagboom, P.E.; Eilers, P.H.C.; Tobi, E.W.; Jong, F.H. de; Steegers, E.A.P.; Heijmans, B.T. & Steegers-Theunissen, R.P.M. (2011), Duration of Breastfeeding Is Associated with the Methylation of LEP in Young Children, Journal of Developmental Origins of Health and Disease 2: S118-S119.
- Waaijer, M.E.C.; Gunn, D.A.; Catt, S.D.; Ginkel, M. van; Craen, A.J.M. de; Hudson, N.M.; Heemst, D. van; Slagboom, P.E.; Westendorp, R.G.J. & Maier, A.B. (2011), Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study., AGE.
- Deelen, J.; Beekman, M.; Uh, H.W.; Helmer, Q.; Kuningas, M.; Christiansen, L.; Kremer, D.; Breggen, R. van der; Suchiman, H.E.D.; Lakenberg, N.; Akker, E.B. van den; Passtoors, W.M.; Tiemeier, H.; Heemst, D. van; Craen, A.J. de; Rivadeneira, F.; Geus, E.J. de; Perola, M.; Ouderaa, F.J. van der; Gunn, D.A.; Boomsma, D.I.; Uitterlinden, A.G.; Christensen, K.; Duijn, C.M. van; Heijmans, B.T.; Houwing-Duistermaat, J.J.; Westendorp, R.G.J. & Slagboom, P.E. (2011), Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited, Aging Cell 10(4): 686-698.
- Ling, C.H.Y.; Craen, A.J.M. de; Slagboom, P.E.; Westendorp, R.G.J. & Maier, A.B. (2011), Handgrip strength at midlife and familial longevity : The Leiden Longevity Study., AGE.
- Yusuf, E.; Ioan-Facsinay, A.; Bijsterbosch, J.; Klein-Wieringa, I.; Kwekkeboom, J.; Slagboom, P.E.; Huizinga, T.W.J. & Kloppenburg, M. (2011), Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis, Annals of the Rheumatic Diseases 70(7): 1282-1284.
- Panoutsopoulou, K.; Southam, L.; Elliott, K.S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N.K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W.E.R.; Ralston, S.H.; Spector, T.D.; Valdes, A.M.; Wallis, G.A.; Wilkinson, J.M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.J.; Bumpstead, S.; Cupples, L.A.; Day-Williams, A.G.; Dixon, K.; Doherty, S.A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J.J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B.V.; Hauksson, V.B.; Hofman, A.; Hunt, S.E.; Ioannidis, J.P.A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H.J.M.; Kloppenburg, M.G.; Koller, N.; Lakenberg, N.; Lane, N.E.; Lee, A.T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M.C.; O'Neill, F.; Parimi, N.; Potter, S.C.; Rego-Perez, I.; Riancho, J.A.; Sherburn, K.; Slagboom, P.E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A.G.; Meurs, J.B.J. van; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J.M.; Zeggini, E.; Loughlin, J. & arcOGEN Consortium (2011), Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study, Annals of the Rheumatic Diseases 70(5): 864-867.
- Waarsing, J.H.; Kloppenburg, M.; Slagboom, P.E.; Kroon, H.M.; Houwing-Duistermaat, J.J.; Weinans, H. & Meulenbelt, I. (2011), Osteoarthritis Susceptibility Genes Influence the Association Between Hip Morphology and Osteoarthritis, Arthritis and Rheumatism 63(5): 1349-1354.
- Smith, N.L.; Huffman, J.E.; Strachan, D.P.; Huang, J.; Dehghan, A.; Trompet, S.; Lopez, L.M.; Shin, S.Y.; Baumert, J.; Vitart, V.; Bis, J.C.; Wild, S.H.; Rumley, A.; Yang, Q.; Uitterlinden, A.G.; Stott, D.J.; Davies, G.; Carter, A.M.; Thorand, B.; Polasek, O.; McKnight, B.; Campbell, H.; Rudnicka, A.R.; Chen, M.H.; Buckley, B.M.; Harris, S.E.; Peters, A.; Pulanic, D.; Lumley, T.; Craen, A.J.M. de; Liewald, D.C.; Gieger, C.; Campbell, S.; Ford, I.; Gow, A.J.; Luciano, M.; Porteous, D.J.; Guo, X.Q.; Sattar, N.; Tenesa, A.; Cushman, M.; Slagboom, P.E.; Visscher, P.M.; Spector, T.D.; Illig, T.; Rudan, I.; Bovill, E.G.; Wright, A.F.; McArdle, W.L.; Tofler, G.; Hofman, A.; Westendorp, R.G.J.; Starr, J.M.; Grant, P.J.; Karakas, M.; Hastie, N.D.; Psaty, B.M.; Wilson, J.F.; Lowe, G.D.O.; O'Donnell, C.J.; Witteman, J.C.M.; Jukema, J.W.; Deary, I.J.; Soranzo, N.; Koenig, W. & Hayward, C. (2011), Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults, Circulation 123(17): 1864+.
- Saviouk, V.; Hottenga, J.J.; Slagboom, E.P.; Distel, M.A.; Geus, E.J.C. de; Willemsen, G. & Boomsma, D.I. (2011), ADHD in Dutch Adults: Heritability and Linkage Study, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(3): 352-362.
- Rius-Ottenheim, N.; Kromhout, D.; Craen, A.J.M. de; Geleijnse, J.M.; Mast, R.C. van der; Zitman, F.G.; Westendorp, R.G.; Slagboom, P.E. & Giltay, E.J. (2011), Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects., AGE.
- Landt, M.C.T.S.O. 't; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; Trier, J. van; Onkenhout, E.J.; Vink, J.M.; Beijsterveldt, C.E.M. van; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M. de; Herpertz, S.; Ehrlich, S.; Elburg, A.A. van; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; Furth, E.F. van & Slagboom, P.E. (2011), Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting, Genes, Brain and Behavior 10(2): 236-243.
- Kerkhof, H.J.M.; Doherty, M.; Arden, N.K.; Abramson, S.B.; Attur, M.; Bos, S.D.; Cooper, C.; Dennison, E.M.; Doherty, S.A.; Evangelou, E.; Hart, D.J.; Hofman, A.; Javaid, K.; Kerna, I.; Kisand, K.; Kloppenburg, M.; Krasnokutsky, S.; Maciewicz, R.A.; Meulenbelt, I.; Muir, K.R.; Rivadeneira, F.; Samuels, J.; Sezgin, M.; Slagboom, E.; Smith, A.J.P.; Spector, T.D.; Tamm, A.; Tamm, A.; Uitterlinden, A.G.; Wheeler, M.; Zhai, G.; Zhang, W.; Meurs, J.B.J. van & Valdes, A.M. (2011), Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis, Osteoarthritis and Cartilage 19(3): 265-271.
- Kerkhof, H.J.M.; Meulenbelt, I.; Akune, T.; Arden, N.K.; Aromaa, A.; Bierma-Zeinstra, S.M.A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S.A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D.J.; Hauksson, V.B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U.M.; Lane, N.E.; Leino-Arjas, P.; Lohmander, L.S.; Luyten, F.P.; Malizos, K.N.; Nakajima, M.; Nevitt, M.C.; Pols, H.A.P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T.D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A.E.; Tsezou, A.; Uchida, A.; Uitterlinden, A.G.; Wilkinson, J.M.; Yoshimura, N.; Valdes, A.M. & Meurs, J.B.J. van (2011), Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium, Osteoarthritis and Cartilage 19(3): 254-264.
- Wijsman, C.A.; Heemst, D. van; Rozing, M.P.; Slagboom, P.E.; Beekman, M.; Craen, A.J.M. de; Maier, A.B.; Westendorp, R.G.J.; Blom, H.J. & Mooijaart, S.P. (2011), Homocysteine and Familial Longevity: The Leiden Longevity Study, PLoS ONE 6(3).
- Wijsman, C.A.; Rozing, M.P.; Streefland, T.C.M.; Cessie, S. le; Mooijaart, S.P.; Slagboom, P.E.; Westendorp, R.G.J.; Pijl, H.; Heemst, D. van & Leiden Longevity Study Grp (2011), Familial longevity is marked by enhanced insulin sensitivity., Aging Cell 10(1): 114-21.
- Evangelou, E.; Valdes, A.M.; Kerkhof, H.J.M.; Styrkarsdottir, U.; Zhu, Y.Y.; Meulenbelt, I.; Lories, R.J.; Karassa, F.B.; Tylzanowski, P.; Bos, S.D.; Akune, T.; Arden, N.K.; Carr, A.; Chapman, K.; Cupples, L.A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B.V.; Hammond, C.L.; Hart, D.J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U.M.; Lohmander, L.S.; Loughlin, J.; Luyten, F.P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P.M.; Nishida, N.; Ollier, W.E.R.; Panoutsopoulou, K.; Putte, T. van de; Ralston, S.H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.Q.; Slagboom, P.E.; Sudo, A.; Tamm, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G.A.; Wilkinson, J.M.; Yoshimura, N.; Zeggini, E.; Zhai, G.J.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A.G.; Felson, D.T.; Meurs, J.B. van; Stefansson, K.; Ioannidis, J.P.A.; Spector, T.D.; ArcOGEN Consortium & Translation Res Europe Appl (2011), Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22, Annals of the Rheumatic Diseases 70(2): 349-355.
- Tobi, E.W.; Heijmans, B.T.; Kremer, D.; Putter, H.; Delemarre-van de Waal, H.A.; Finken, M.J.J.; Wit, J.M. & Slagboom, P.E. (2011), DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age., Epigenetics 6(2).
- Pons, D.; Trompet, S.; Craen, A.J.M. de; Thijssen, P.E.; Quax, P.H.A.; Vries, M.R. de; Wierda, R.J.; Elsen, P.J. van den; Monraats, P.S.; Ewing, M.M.; Heijmans, B.T.; Slagboom, P.E.; Zwinderman, A.H.; Doevendans, P.A.F.M.; Tio, R.A.; Winter, R.J. de; Maat, M.P.M. de; Iakoubova, O.A.; Sattar, N.; Shepherd, J.; Westendorp, R.G.J.; Jukema, J.W.; PROSPER Study Grp; WOSCOPS Study Grp & GENDER Study Grp (2011), Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies, Heart 97(2): 143-150.
- Beijsterveldt, C.E.M. van; Middeldorp, C.M.; Landt, M.C.T.S.O.; Bartels, M.; Hottenga, J.J.; Suchiman, H.E.D.; Slagboom, P.E. & Boomsma, D.I. (2011), Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study, Behavior Genetics 41(1): 155-164.
- Meulenbelt, I.; Bos, S.D.; Chapman, K.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kremer, D.; Kloppenburg, M.; Carr, A.; Tsezou, A.; Gonzalez, A.; Loughlin, J. & Slagboom, E. (2011), Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility, Annals of the Rheumatic Diseases 70(1): 164-167.
- Rozing, M.P.; Mooijaart, S.P.; Beekman, M.; Wijsman, C.A.; Maier, A.B.; Bartke, A.; Westendorp, R.G.J.; Slagboom, E.P. & Heemst, D. van (2011), C-reactive protein and glucose regulation in familial longevity., AGE.
- Slagboom, P.E.; Beekman, M.; Passtoors, W.M.; Deelen, J.; Vaarhorst, A.A.M.; Boer, J.M.; Akker, E.B. van den; Heemst, D. van; Craen, A.J.M. de; Maier, A.B.; Rozing, M.; Mooijaart, S.P.; Heijmans, B.T. & Westendorp, R.G.J. (2011), Genomics of human longevity, Philosophical Transactions B: Biological Sciences 366(1561): 35-42.
- Slagboom, P.E.; Beekman, M.; Passtoors, W.M.; Deelen, J.; Vaarhorst, A.A.M.; Boer, J.M.; Akker, E.B. van den; Heemst, D. van; Craen, A.J.M. de; Maier, A.B.; Rozing, M.; Mooijaart, S.P.; Heijmans, B.T. & Westendorp, R.G.J. (2011), Genomics of human longevity., Philosophical Transactions B: Biological Sciences 366(1561): 35-42.
- Middeldorp, C.M.; Geus, E.J.C. de; Willemsen, G.; Hottenga, J.J.; Slagboom, P.E. & Boomsma, D.I. (2010), The Serotonin Transporter Gene Length Polymorphism (5-HTTLPR) and Life Events: No Evidence for an Interaction Effect on Neuroticism and Anxious Depressive Symptoms, Twin Research and Human Genetics 13(6): 544-549.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Hokke, C.H.; Westendorp, R.G.J.; Houwing-Duistermaat, J.; Wuhrer, M.; Deelder, A.M. & Sagboom, P.E. (2010), Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health., Journal of Proteome Research.
- Mooijaart, S.P.; Heemst, D. van; Noordam, R.; Rozing, M.P.; Wijsman, C.A.; Craen, A.J.M. de; Westendorp, R.G.J.; Beekman, M. & Slagboom, P.E. (2010), Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study., Aging.
- Callegaro, A.; Meulenbelt, I.; Kloppenburg, M.; Slagboom, P.E. & Houwing-Duistermaat, J.J. (2010), Allele-Sharing Statistics Using Information on Family History, Annals of Human Genetics 74: 547-554.
- Lu, Y.C.; Feskens, E.J.M.; Boer, J.M.A.; Imholz, S.; Verschuren, W.M.M.; Wijmenga, C.; Vaarhorst, A.; Slagboom, E.; Muller, M. & Dolle, M.E.T. (2010), Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study, Atherosclerosis 213(1): 200-205.
- Rozing, M.P.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M.; Frolich, M.; Craen, A.J.M. de; Westendorp, R.G.J. & Heemst, D. van (2010), Familial Longevity Is Associated with Decreased Thyroid Function, Journal of Clinical Endocrinology and Metabolism 95(11): 4979-4984.
- Kerkhof, H.J.M.; Meulenbelt, I.; Carr, A.; Gonzalez, A.; Hart, D.; Hofman, A.; Kloppenburg, M.; Lane, N.E.; Loughlin, J.; Nevitt, M.C.; Pols, H.A.P.; Rivadeneira, F.; Slagboom, E.P.; Spector, T.D.; Stolk, L.; Tsezou, A.; Uitterlinden, A.G.; Valdes, A.M. & Meurs, J.B.J. van (2010), Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis, BMC Medical Genetics 11.
- Middeldorp, C.M.; Slof-Op 't Landt, M.C.T.; Medland, S.E.; Beijsterveldt, C.E.M. van; Bartels, M.; Willemsen, G.; Hottenga, J.J.; Geus, E.J.C. de; Suchiman, H.E.D.; Dolan, C.V.; Neale, M.C.; Slagboom, P.E. & Boomsma, D.I. (2010), Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?, Genes, Brain and Behavior 9(7): 808-816.
- Beekman, M.; Nederstigt, C.; Suchiman, H.E.D.; Kremer, D.; Breggen, R. van der; Lakenberg, N.; Alemayehu, W.G.; Craen, A.J.M. de; Westendorp, R.G.J.; Boomsma, D.I.; Geus, E.J.C. de; Houwing-Duistermaat, J.J.; Heijmans, B.T. & Slagboom, P.E. (2010), Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity, Proceedings of the National Academy of Sciences 107(42): 18046-18049.
- Derhovanessian, E.; Maier, A.B.; Beck, R.; Jahn, G.; Hahnel, K.; Slagboom, P.E.; Craen, A.J.M. de; Westendorp, R.G.J. & Pawelec, G. (2010), Hallmark Features of Immunosenescence Are Absent in Familial Longevity, Journal of Immunology 185(8): 4618-4624.
- Derhovanessian, E.; Maier, A.B.; Beck, R.; Jahn, G.; Hahnel, K.; Slagboom, P.E.; Craen, A.J.M. de; Westendorp, R.G.J. & Pawelec, G. (2010), Hallmark Features of Immunosenescence Are Absent in Familial Longevity, Journal of Immunology 185(8): 4618-4624.
- Landt, M.C.T.S.O. 't; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; Trier, J. van; Onkenhout, E.J.; Vink, J.M.; Beijsterveldt, C.E.M. van; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M. de; Herpertz, S.; Ehrlich, S.; Elburg, A.A. van; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; Furth, E.F. van & Slagboom, P.E. (2010), Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting., Genes, Brain and Behavior.
- Talens, R.P.; Boomsma, D.I.; Tobi, E.W.; Kremer, D.; Jukema, J.W.; Willemsen, G.; Putter, H.; Slagboom, P.E. & Heijmans, B.T. (2010), Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology, FASEB Journal 24(9): 3135-3144.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Koeleman, C.A.M.; Hokke, C.H.; Westendorp, R.G.J.; Wuhrer, M.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Deelder, A.M. (2010), Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity, PLoS ONE 5(9).
- Vaarhorst, A.A.M.; Beekman, M.; Suchiman, E.H.D.; Heemst, D. van; Houwing-Duistermaat, J.J.; Westendorp, R.G.J.; Slagboom, P.E.; Heijmans, B.T.; Project Grp & Leiden Longevity Study LLS Grp (2010), Lipid metabolism in long-lived families: the Leiden Longevity Study., AGE.
- Bos, S.D.; Lakenberg, N.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kloppenburg, M.; Craen, A.J.M. de; Beekman, M.; Meulenbelt, I. & Slagboom, P.E. (2010), A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels, European Journal of Human Genetics 18(8): 953-959.
- Bos, S.D.; Lakenberg, N.; Breggen, R. van der; Houwing-Duistermaat, J.J.; Kloppenburg, M.; Craen, A.J.M. de; Beekman, M.; Meulenbelt, I. & Slagboom, P.E. (2010), A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels, European Journal of Human Genetics 18(8): 953-959.
- Bijsterbosch, J.; Wassenaar, M.J.E.; Cessie, S. le; Slagboom, P.E.; Rosendaal, F.R.; Huizinga, T.W.J. & Kloppenburg, M. (2010), Doyle Index is a valuable additional pain measure in osteoarthritis, Osteoarthritis and Cartilage 18(8): 1046-1050.
- Caliebe, A.; Kleindorp, R.; Blanche, H.; Christiansen, L.; Puca, A.A.; Rea, I.M.; Slagboom, E.; Flachsbart, F.; Christensen, K.; Rimbach, G.; Schreiber, S. & Nebel, A. (2010), No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis, Ageing Research Reviews 9(3): 238-244.
- Terracciano, A.; Sanna, S.; Uda, M.; Deiana, B.; Usala, G.; Busonero, F.; Maschio, A.; Scally, M.; Patriciu, N.; Chen, W.M.; Distel, M.A.; Slagboom, E.P.; Boomsma, D.I.; Villafuerte, S.; Sliwerska, E.; Burmeister, M.; Amin, N.; Janssens, A.C.J.W.; Duijn, C.M. van; Schlessinger, D.; Abecasis, G.R. & Costa, P.T. (2010), Genome-wide association scan for five major dimensions of personality, Molecular Psychiatry 15(6): 647-656.
- Willemsen, G.; Geus, E.J.C. de; Bartels, M.; Beijsterveldt, C.E.M.T. van; Brooks, A.I.; Estourgie-van Burk, G.F.; Fugman, D.A.; Hoekstra, C.; Hottenga, J.J.; Kluft, K.; Meijer, P.; Montgomery, G.W.; Rizzu, P.; Sondervan, D.; Smit, A.B.; Spijker, S.; Suchiman, H.E.D.; Tischfield, J.A.; Lehner, T.; Slagboom, P.E. & Boomsma, D.I. (2010), The Netherlands Twin Register Biobank: A Resource for Genetic Epidemiological Studies, Twin Research and Human Genetics 13(3): 231-245.
- Newman, A.B.; Walter, S.; Lunetta, K.L.; Garcia, M.E.; Slagboom, P.E.; Christensen, K.; Arnold, A.M.; Aspelund, T.; Aulchenko, Y.S.; Benjamin, E.J.; Christiansen, L.; D'Agostino, R.B.; Fitzpatrick, A.L.; Franceschini, N.; Glazer, N.L.; Gudnason, V.; Hofman, A.; Kaplan, R.; Karasik, D.; Kelly-Hayes, M.; Kiel, D.P.; Launer, L.J.; Marciante, K.D.; Massaro, J.M.; Miljkovic, I.; Nalls, M.A.; Hernandez, D.; Psaty, B.M.; Rivadeneira, F.; Rotter, J.; Seshadri, S.; Smith, A.V.; Taylor, K.D.; Tiemeier, H.; Uh, H.W.; Uitterlinden, A.G.; Vaupel, J.W.; Walston, J.; Westendorp, R.G.J.; Harris, T.B.; Lumley, T.; Duijn, C.M. van & Murabito, J.M. (2010), A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Journals of Gerontology, Series A 65(5): 478-487.
- Meulenbelt, I.; Bos, S.D.; Kloppenburg, M.; Lakenberg, N.; Houwing-Duistermaat, J.J.; Watt, I.; Craen, A.J. de; Duijn, C.M. van & Slagboom, P.E. (2010), Interleukin-1 Gene Cluster Variants With Innate Cytokine Production Profiles and Osteoarthritis in Subjects From the Genetics, Osteoarthritis and Progression Study, Arthritis and Rheumatism 62(4): 1119-1126.
- Rozing, M.P.; Westendorp, R.G.J.; Craen, A.J.M. de; Frolich, M.; Heijmans, B.T.; Beekman, M.; Wijsman, C.; Mooijaart, S.P.; Blauw, G.J.; Slagboom, P.E.; Heemst, D. van & LLS Grp (2010), Low Serum Free Triiodothyronine Levels Mark Familial Longevity: The Leiden Longevity Study, Journals of Gerontology, Series A 65(4): 365-368.
- May, L.; Bodegom, D. van; Frolich, M.; Lieshout, L. van; Slagboom, P.E.; Westendorp, R.G.J. & Kuningas, M. (2010), Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana, European Journal of Human Genetics 18(4): 490-495.
- Rozing, M.P.; Westendorp, R.G.J.; Craen, A.J.M. de; Frolich, M.; Goeij, M.C.M. de; Heijmans, B.T.; Beekman, M.; Wijsman, C.A.; Mooijaart, S.P.; Blauw, G.J.; Slagboom, P.E.; Heemst, D. van & Leiden Longevity Study Grp (2010), Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study, Journal of the American Geriatrics Society 58(3): 564-569.
- Kerkhof, H.J.M.; Lories, R.J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A.M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.J.; Zhang, F.; Zhu, Y.Y.; Breggen, R. van der; Carr, A.; Doherty, M.; Doherty, S.; Felson, D.T.; Gonzalez, A.; Halldorsson, B.V.; Hart, D.J.; Hauksson, V.B.; Hofman, A.; Ioannidis, J.P.A.; Kloppenburg, M.; Lane, N.E.; Loughlin, J.; Luyten, F.P.; Nevitt, M.C.; Parimi, N.; Pols, H.A.P.; Rivadeneira, F.; Slagboom, E.P.; Styrkarsdottir, U.; Tsezou, A.; Putte, T. van de; Zmuda, J.; Spector, T.D.; Stefansson, K.; Uitterlinden, A.G. & Meurs, J.B.J. van (2010), A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22, Arthritis and Rheumatism 62(2): 499-510.
- Kuningas, M.; Bodegom, D. van; May, L.; Meij, J.J.; Slagboom, P.E. & Westendorp, R.G.J. (2010), Common CFTR gene variants influence body composition and survival in rural Ghana.
- May, L.; Kuningas, M.; Bodegom, D. van; Meij, H.J.; Frolich, M.; Slagboom, P.E.; Mantovani, A. & Westendorp, R.G.J. (2010), Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women.
- Moxley, G.; Meulenbelt, I.; Chapman, K.; Diujn, C.M. van; Slagboom, P.E.; Neale, M.C.; Smith, A.J.P.; Carr, A.J. & Loughlin, J. (2010), Interleukin-1 region meta-analysis with osteoarthritis phenotypes, Osteoarthritis and Cartilage 18(2): 200-207.
- Hart, L.M. 't; Simonis-Bik, A.M.; Nijpels, G.; Haeften, T.W. van; Schafer, S.A.; Houwing-Duistermaat, J.J.; Boomsma, D.I.; Groenewoud, M.J.; Reiling, E.; Hove, E.C. van; Diamant, M.; Kramer, M.H.H.; Heine, R.J.; Maassen, J.A.; Kirchhoff, K.; Machicao, F.; Haring, H.U.; Slagboom, P.E.; Willemsen, G.; Eekhoff, E.M.; Geus, E.J. de; Dekker, J.M. & Fritsche, A. (2010), Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.
- Reiling, E.; Jafar-Mohammadi, B.; van't Riet, E.; Weedon, M.N.; Vliet-Ostaptchouk, J.V. van; Hansen, T.; Saxena, R.; Haeften, T.W. van; Arp, P.A.; , S. das; Nijpels, G.; Groenewoud, M.J.; Hove, E.C. van; Uitterlinden, A.G.; Smit, J.W.A.; Morris, A.D.; Doney, A.S.F.; Palmer, C.N.A.; Guiducci, C.; Hattersley, A.T.; Frayling, T.M.; Pedersen, O.; Slagboom, P.E.; Altshuler, D.M.; Groop, L.; Romijn, J.A.; Maassen, J.A.; Hofker, M.H.; Dekker, J.M.; McCarthy, M.I. & Hart, L.M. 't (2010), Genetic association analysis of LARS2 with type 2 diabetes, Diabetologia 53(1): 103-110.
- Reiling, E.; Jafar-Mohammadi, B.; van't Riet, E.; Weedon, M.N.; Vliet-Ostaptchouk, J.V. van; Hansen, T.; Saxena, R.; Haeften, T.W. van; Arp, P.A.; , S. das; Nijpels, G.; Groenewoud, M.J.; Hove, E.C. van; Uitterlinden, A.G.; Smit, J.W.A.; Morris, A.D.; Doney, A.S.F.; Palmer, C.N.A.; Guiducci, C.; Hattersley, A.T.; Frayling, T.M.; Pedersen, O.; Slagboom, P.E.; Altshuler, D.M.; Groop, L.; Romijn, J.A.; Maassen, J.A.; Hofker, M.H.; Dekker, J.M.; McCarthy, M.I. & Hart, L.M. 't (2010), Genetic association analysis of LARS2 with type 2 diabetes., Diabetologia 53(1): 103-10.
- Trompet, S.; Craen, A.J.M. de; Jukema, J.W.; Pons, D.; Slagboom, P.E.; Kremer, D.; Bonen, E.L.E.M. & Westendorp, R.G.J. (2010), Variation in the CBP gene involved in epigenetic control associates with cognitive function.
- Rozing MP, Westendorp RG, Frölich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D & Group OB (2009), Human insulin/IGF-1 and familial longevity at middle age., Aging 1(8): 714-22.
- Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom PE & Heijmans BT (2009), Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child., PLoS ONE 4(11): e7845.
- Kuningas M, May L, Tamm R, van Bodegom D, van den Biggelaar AH, Meij JJ, Frölich M, Ziem JB, Suchiman HE, Metspalu A, Slagboom PE & Westendorp RG (2009), Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population., PLoS ONE 4(11): e7795.
- Slof-Op 't Landt MCT, van Furth EF, Rebollo-Mesa I, Bartels M, van Beijsterveldt CEM, Slagboom PE, Boomsma DI, Meulenbelt I & Dolan CV (2009), Sex Differences in Sum Scores May Be Hard to Interpret The Importance of Measurement Invariance, Assessment 16(4): 415-423.
- Lescai F, Blanche H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G & Franceschi C (2009), Human longevity and 11p15.5: a study in 1321 centenarians, European Journal of Human Genetics 17(11): 1515-1519.
- Kettunen J, Perola M, Martin NG, Cornes BK, Wilson SG, Montgomery GW, Benyamin B, Harris JR, Boomsma D, Willemsen G, Hottenga JJ, Slagboom PE, Christensen K, Kyvik KO, Sorensen TIA, Pedersen NL, Magnusson PKE, Andrew T, Spector TD, Widen E, Silventoinen K, Kaprio J, Palotie A & Peltonen L (2009), Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci, International Journal of Obesity 33(11): 1235-1242.
- Uh HW, Beekman M, Slagboom PE & Houwing-Duistermaat JJ (2009), Testing for genetic association using family data: incorporating phenotypic information of un-genotyped relatives, Annals of Human Genetics 73: 662-662.
- Heijmans BT, Tobi EW, Lumey LH & Slagboom PE (2009), The epigenome: archive of the prenatal environment., Epigenetics 4(8): 526-31.
- Heijmans BT, Tobi EW, Lumey LH & Slagboom PE (2009), The epigenome Archive of the prenatal environment, Epigenetics 4(8): 526-531.
- Kuningas M, May L, Tamm R, van Bodegom D, van den Biggelaar AHJ, Meij JJ, Frolich M, Ziem JB, Suchiman HED, Metspalu A, Slagboom PE & Westendorp RGJ (2009), Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population, PLoS ONE 4(11): A174A180.
- Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE & Heijmans BT (2009), DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific., Human Molecular Genetics 18(21): 4046-53.
- Tobi EW, Lumey L, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE & Heijmans BT (2009), DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific, Human Molecular Genetics 18(21): 4046-4053.
- Zhai G, van Meurs JBJ, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards JB, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A & Spector TD (2009), A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium, Journal of Medical Genetics 46(9): 614-616.
- Westendorp RGJ, van Heemst D, Rozing MP, Frolich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJM & Slagboom PE (2009), Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study, Journal of the American Geriatrics Society 57(9): 1634-1637.
- Westendorp RG, van Heemst D, Rozing MP, Frölich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE & (2009), Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study., Journal of the American Geriatrics Society 57(9): 1634-7.
- Reiling E, van Vliet-Ostaptchouk JV, van't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC & Romijn JA (2009), Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study, European Journal of Human Genetics 17(8): 1056-1062.
- Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA, Smit JW, Nijpels G, Heine RJ, Uitterlinden AG, Pedersen O, Slagboom PE, Maassen JA, Hofker MH, 't Hart LM & Dekker JM (2009), Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study., European Journal of Human Genetics 17(8): 1056-62.
- Botha-Scheepers S, Riyazi N, Watt I, Rosendaal FR, Slagboom E, Bellamy N, Breedveld FC & Kloppenburg M (2009), Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study, Annals of the Rheumatic Diseases 68(8): 1260-1264.
- Botha-Scheepers S, Riyazi N, Watt I, Rosendaal FR, Slagboom E, Bellamy N, Breedveld FC & Kloppenburg M (2009), Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study., Annals of the Rheumatic Diseases 68(8): 1260-4.
- Sampietro ML, Pons D, de Knijff P, Slagboom PE, Zwinderman A & Jukema JW (2009), A genome wide association analysis in the GENDER study., Netherlands Heart Journal 17(6): 262-4.
- Kerkhof HJM, Jonsdottir I, Meulenbelt I, Stolk L, Valdes AM, Zhai G, Zhu Y, Doherty M, Doherty S, Tsezou A, Gonzalez A, Carr A, Felson DT, Styrkarsdottir U, Slagboom EP, Loughlin J, Rivadeneira F, Hofman A, Pols HAP, Spector TD, Uitterlinden AG & van Meurs JBJ (2009), A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis, BONE 44(2): S224S224.
- Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gomez-Reino JJ & Gonzalez A (2009), Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand, Arthritis and Rheumatism 60(6): 1710-1721.
- Dieguez-Gonzalez R, Calaza M, Shi D, Meulenbelt I, Loughlin J, Tsezou A, Dai J, Malizos KN, Slagboom EP & Kloppenburg M (2009), Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections, Annals of the Rheumatic Diseases 68(6): 1017-1021.
- Bos SD, Kloppenburg M, Suchiman E, van Beelen E, Slagboom PE & Meulenbelt I (2009), The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA, Osteoarthritis and Cartilage 17(5): 621-626.
- Bos SD, Kloppenburg M, Suchiman E, van Beelen E, Slagboom PE & Meulenbelt I (2009), The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA., Osteoarthritis and Cartilage 17(5): 621-6.
- Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi DQ, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A & Nakajima M (2009), Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations, Human Molecular Genetics 18(8): 1518-1523.
- Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi D, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A, Nakajima M, van der Breggen R, Lakenberg N, Gomez-Reino JJ, Jiang Q, Ikegawa S, Gonzalez A, Loughlin J & Slagboom EP (2009), Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations., Human Molecular Genetics 18(8): 1518-23.
- Middeldorp CM, Sullivan PF, Wray NR, Hottenga JJ, de Geus EJC, van den Berg M, Montgomery GW, Coventry WL, Statham DJ, Andrews G, Slagboom PE, Boomsma DI & Martin NG (2009), Suggestive Linkage on Chromosome 2, 8, and 17 for Lifetime Major Depression.
- Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, Slagboom PE, Valdes AM, Spector TD & Gomez-Reino JJ (2009), Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes, Osteoarthritis and Cartilage 17(3): 321-327.
- Albers HM, Kurreeman FAS, Stoeken-Rijsbergen G, Brinkman DMC, Kamphuis SSM, van Rossum MAJ, Girschick HJ, Wouters C, Saurenmann RK, Hoppenreijs E, Slagboom P, Houwing-Duistermaat JJ, Verduijn W, Huizinga TWJ, ten Cate R, Toes REM & Schilham MW (2009), Association of the Autoimmunity Locus 4q27 With Juvenile Idiopathic Arthritis, Arthritis and Rheumatism 60(3): 901-904.
- Albers HM, Kurreeman FA, Stoeken-Rijsbergen G, Brinkman DM, Kamphuis SS, van Rossum MA, Girschick HJ, Wouters C, Saurenmann RK, Hoppenreijs E, Slagboom P, Houwing-Duistermaat JJ, Verduijn W, Huizinga TW, Ten Cate R, Toes RE & Schilham MW (2009), Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis., Arthritis and Rheumatism 60(3): 901-4.
- Kuningas M, Mooijaart SP, Jolles J, Slagboom PE, Westendorp RGJ & van Heemst D (2009), VDR gene variants associate with cognitive function and depressive symptoms in old age, Neurobiology of Aging 30(3): 466-473.
- Vink JM, Smit AB, de Geus EJC, Sullivan P, Willemsen G, Hottenga JJ, Smit JH, Hoogendijk WJ, Zitman FG, Peltonen L, Kaprio J, Pedersen NL, Magnusson PK, Spector TD, Kyvik KO, Morleyis KI, Heath AC, Martin NG, Westendorp RGJ, Slagboom PE, Tiemeier H, Hofman A, Uitterlinden AG, Aulchenko YS, Amin N, van Duijn C, Penninx BW & Boomsma DI (2009), Genome-wide Association Study of Smoking Initiation and Current Smoking, American Journal of Human Genetics 84(3): 367-379.
- Houwing-Duistermaat JJ, Callegaro A, Beekman M, Westendorp RG, Slagboom PE & van Houwelingen JC (2009), Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study., Statistics in Medicine 28(1): 140-51.
- Houwing-Duistermaat JJ, Callegaro A, Beekman M, Westendorp RG, Slagboom PE & van Houwelingen JC (2009), Weighted statistics for aggregation and linkage analysis of human longevity in selected families: The Leiden Longevity Study, Statistics in Medicine 28(1): 140-151.
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Slagboom PE & Kok JN (2008), A comparison of two methods for finding groups using heat maps and model based clustering, APPLICATIONS AND INNOVATIONS IN INTELLIGENT SYSTEMS XV: 119-131.
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Kloppenburg M, Watt I, van Rooden SA, Visser M, Marinus J, Cannon EO, Bender A, van Hilten JJ, Slagboom PE & Kok JN (2008), A Scenario Implementation in R for SubtypeDiscovery Examplified on Chemoinformatics Data, LEVERAGING APPLICATIONS OF FORMAL METHODS, VERIFICATION AND VALIDATION, PROCEEDINGS 17: 669-683.
- Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Kloppenburg M, Watt I, van Rooden SM, Visser M, Marinus J, van Hilten JJ, Slagboom PE & Kok JN (2008), Reliability of Cluster Results for Different Types of Time Adjustments in Complex Disease Research, 2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8: 4601-4604.
- Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, Slagboom PE & Lumey LH (2008), Persistent epigenetic differences associated with prenatal exposure to famine in humans, Proceedings of the National Academy of Sciences 105(44).
- Macgregor S, Hottenga JJ, Lind PA, Suchiman HED, Willemsen G, Slagboom PE, Montgomery GW, Martin NG, Visscher PM & Boomsma DI (2008), Vitamin D Receptor Gene Polymorphisms Have Negligible Effect on Human Height, Twin Research and Human Genetics 11(5).
- Bos SD, Slagboom PE & Meulenbelt I (2008), New insights into osteoarthritis: early developmental features of an ageing-related disease, Current Opinion in Rheumatology 20(5).
- Botha-Scheepers S, Watt I, Slagboom E, de Craen AJM, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2008), Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis, Annals of the Rheumatic Diseases 67(8).
- Trompet S, de Craen AJM, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen ELEM, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RGJ & Jukema JW (2008), Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study, Experimental Gerontology 43(8).
- Bos SD, Suchiman HED, Kloppenburg M, Houwing-Duistermaat JJ, le Graverand MPH, Seymour AB, Kroon HM, Slagboom PE & Meulenbelt I (2008), Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study, Annals of the Rheumatic Diseases 67(6).
- Wray NR, Middeldorp CM, Birley AJ, Gordon SD, Sullivan PF, Visscher PM, Nyholt DR, Willemsen G, de Geus EJC, Slagboom PE, Montgomery GW, Martin NG & Boomsma DI (2008), Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands, Archives of General Psychiatry 65(6).
- Riyazi N, Rosendaal FR, Slagboom E, Kroon HM, Breedveld FC & Kloppenburg M (2008), Risk factors in familial osteoarthritis: the GARP sibling study, Osteoarthritis and Cartilage 16(6).
- Meulenbelt I, Min JL, Bos S, Riyazi N, Houwing-Duistermaat JJ, van der Wijk HJ, Kroon HM, Nakajima M, Ikegawa S, Uitterlinden AG, van Meurs JBJ, van der Deure WM, Visser TJ, Seymour AB, Lakenberg N, van der Breggen R, Kremer D, van Duijn CM, Kloppenburg M, Loughlin J & Slagboom PE (2008), Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis, Human Molecular Genetics 17(12).
- 't Landt MCTSO, Bartels M, van Furth EF, van Beijsterveldt CEM, Meulenbelt I, Slagboom PE & Boomsma DI (2008), Genetic influences on disordered eating behaviour are largely independent of body mass index.
- Chapman K, Takahashi A, Meulenbelt I, Watson C, Rodriguez-Lopez J, Egli R, Tsezou A, Malizos KN, Kloppenburg M, Shi DQ, Southam L, van der Breggen R, Donn R, Qin JH, Doherty M, Slagboom PE, Wallis G, Kamatani N, Jiang Q, Gonzalez A, Loughlin J & Ikegawa S (2008), A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility, Human Molecular Genetics 17(10).
- Kuningas M, Mooijaart SP, van Heemst D, Zwaan BJ, Slagboom PE & Westendorp RGJ (2008), Genes encoding longevity: from model organisms to humans, Aging Cell 7(2).
- Trompet S, de Craen AJM, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen ELEM, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Jukema JW & Westendorp RGJ (2008), Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study, Brain 131.
- Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG, Hettema JM, An SS, Neale MC, Van den Oord EJCG, Kendler KS, Chen X, Boomsma DI, Middeldorp CM, Hottenga JJ, Slagboom PE & Flint J (2008), A whole genome association study of neuroticism using DNA pooling, Molecular Psychiatry 13(3).
- Passtoors WM, Beekman M, Gunn D, Boer JM, Heijmans BT, Westendorp RGJ, Zwaan BJ & Slagboom PE (2008), Genomic studies in ageing research: the need to integrate genetic and gene expression approaches, Journal of Internal Medicine 263(2).
- Middeldorp CM, Hottenga JJ, Slagboom PE, Sullivan PF, de Geus EJC, Posthuma D, Willemsen G & Boomsma DI (2008), Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype, Molecular Psychiatry 13(1).
- Bakaysa SL, Mucci LA, Slagboom PE, Boomsma DI, McClearn GE, Johansson B & Pedersen NL (2007), Telomere length predicts survival independent of genetic influences, Aging Cell 6(6).
- Finken MJJ, Meulenbelt I, Dekker FW, Frolich M, Romijn JA, Slagboom PE & Wit JM (2007), The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth, Journal of Clinical Endocrinology and Metabolism 92(12).
- Margarita, C.T.; Landt, S.O.T.; Bartels, M.; Furth, E.F. van; Meulenbelt, I.; Slagboom, E. & Boomsma, D.I. (2007), Genetic influences on disordered eating behavior are largely independent of BMI, Behavior Genetics 37(6): 794-794.
- Alizadeh BZ, Njajou OT, Hazes JMW, Hofman A, Slagboom PE, Pols HAP & van Duijn CM (2007), The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis, Annals of the Rheumatic Diseases 66(11).
- Hottenga JJ, Suchiman E, Willemsen G, Slagboom E & Boomsma DI (2007), The vitamin D receptor gene is not strongly associated with stature: Results from the Netherlands twin register, Behavior Genetics 37(6): 763-763.
- Sahiratmadja E, Wieringa FT, van Crevel R, de Visser AW, Adnan I, Alisjahbana B, Slagboom E, Marzuki S, Ottenhoff THM, van de Vosse E & Marx JJA (2007), Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3/UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population, British Journal of Nutrition 98(4).
- Slagboom PE, Heijmans BT, Beekman M & Meulenbelt I (2007), Molecular epidemiology, candidate genes versus genome-wide scans, Genes and Nutrition 2(1).
- Lambert JC, Ferreira S, Gussekloo J, Christiansen L, Brysbaert G, Slagboom E, Cottel D, Petit T, Hauw J, DeKosky ST, Richard F, Berr C, Lendon C, Kamboh MI, Mann D, Christensen K, Westendorp R & Amouyel P (2007), Evidence for the association of the S100 beta gene with low cognitive performance and dementia in the elderly, Molecular Psychiatry 12(9).
- Min JL, Meulenbelt I, Kloppenburg M, van Duijn CM & Slagboom PE (2007), Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis, European Journal of Human Genetics 15(7).
- Thabet MM, Wesoly J, Slagboom PE, Toes REM & Huizinga TWJ (2007), FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians, Annals of the Rheumatic Diseases 66(6).
- Kuningas M, de Rijk RH, Westendorp RGJ, Jolles J, Slagboom PE & van Heemst D (2007), Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors, Neuropsychopharmacology 32(6).
- Botha-Scheepers SA, Watt I, Slagboom E, Meulenbelt I, Rosendaal FR, Breedveld FC & Kloppenburg M (2007), Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: A prospective longitudinal cohort study, Arthritis and Rheumatism 57(4).
- Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Hellio-Le Graverand MP, DeGroot J & Slagboom PE (2007), Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study, Osteoarthritis and Cartilage 15(4).
- Trompet S, Pons D, DE Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Hyland M, Gaw A, Macfarlane PW, Packard CJ, Norrie J, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG & Jukema JW (2007), Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study., Annals of the New York Academy of Sciences 1100: 189-98.
- Mooijaart SP, Kuningas M, Westendorp RGJ, Houwing-Duistermaat JJ, Slagboom PE, Rensen PCN & van Heemst D (2007), Liver X receptor alpha associates with human life span, Journals of Gerontology, Series A 62(4).
- Ali S, Vollaard AM, Kremer D, de Visser AW, Martina CAE, Widjaja S, Surjadi C, Slagboom E, van de Vosse E & Van Dissel JT (2007), Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever, Journal of Interferon and Cytokine Research 27(4).
- Middeldorp CM, de Geus EJC, Beem AL, Lakenberg N, Hottenga JJ, Slagboom PE & Boomsma DI (2007), Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression, Behavior Genetics 37(2).
- Kuningas M, Magi R, Westendorp RGJ, Slagboom PE, Remm M & van Heemst D (2007), Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age, European Journal of Human Genetics 15(3).
- Heijmans BT, Kremer D, Tobi EW, Boomsma DI & Slagboom PE (2007), Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus, Human Molecular Genetics 16(5).
- Loughlin J, Meulenbelt I, Min J, Mustafa Z, Sinsheimer JS, Carr A & Slagboom PE (2007), Genetic association analysis of RHOB and TXNDC3 in osteoarthritis, American Journal of Human Genetics 80(2).
- Trompet S, Pons D, De Craen AJM, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen ELEM, Buckley BM, Ford I, Hyland M, Gaw A, Macfarlane PW, Packard CJ, Norrie J, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RGJ & Jukema JW (2007), Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events - The PROSPER study, Annals of the New York Academy of Sciences 1100.
- Heijmans BT, Beekman M, Houwing-Duistermaat JJ, Cobain MR, Powell J, Blauw GJ, van der Ouderaa F, Westendorp RGJ & Slagboom PE (2006), Lipoprotein particle profiles mark familial and sporadic human longevity, PLoS Medicine 3(12): 2317-2323.
- Meulenbelt I, Min JL, van Duijn CM, Kloppenburg M, Breedveld FC & Slagboom PE (2006), Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes, European Journal of Human Genetics 14(12).
- Botha-Scheepers S, Riyazi N, Kroon HM, Scharloo M, Houwing-Duistermaat JJ, Slagboom E, Rosendaal FR, Breedveld FC & Kloppenburg M (2006), Activity limitations in the lower extremities in patients with osteoarthritis: the modifying effects of illness perceptions and mental health, Osteoarthritis and Cartilage 14(11).
- Min J, Meulenbelt I & Slagboom E (2006), Replication in genetic association studies: comment on the editorial by Spector et al, Arthritis and Rheumatism 54(9).
- Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, van Duijn CM & Slagboom PE (2006), Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand, Annals of the Rheumatic Diseases 65(8).
- Kuningas M, Mooijaart SP, Slagboom PE, Westendorp RGJ & Van Heemst D (2006), Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study, Biogerontology 7(4).
- Min JL, Lakenberg N, Bakker-Verweij M, Suchiman E, Boomsma DI, Slagboom PE & Meulenbelt I (2006), High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes, Twin Research and Human Genetics 9(4).
- Meulenbelt I, Kloppenburg M, Houwing-Duistermaat JJ, Garnero P, Le Graverand MH, DeGroot J & Slagboom PE (2006), Biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial oa at multiple sites. The GARP study, Annals of the Rheumatic Diseases 65: 589-589.
- Min JL, Meulenbelt I, Riyazi N, Putter H, Seymour A, Lakenberg N, Van Duijn C, Kloppenburg M & Slagboom E (2006), Genetic linkage analysis of osteoarthritis at multiple joint sites in Dutch sibpairs, Annals of the Rheumatic Diseases 65: 75-75.
- Dahaghin S, Alizadeh B, Bierma-Zeinstra S, Koes B, Slagboom P, Pols H, Van Duijn C, Njajou O & Hazes J (2006), Should patients with osteoarthritis of the metacarpophalangeal joints be screened for hereditary hemochromatosis gene (HFE) mutations?, Annals of the Rheumatic Diseases 65: 228-228.
- Mooijaart SP, Berbee JFP, van Heemst D, Havekes LM, de Craen AJM, Slagboom PE, Rensen PCN & Westendorp RGJ (2006), ApoE plasma levels and risk of cardiovascular mortality in old age, PLoS Medicine 3(6): 874-883.
- Valle A, O'Connor DT, Taylor P, Zhu G, Montgomery GW, Slagboom PE, Martin NG & Whitfield JB (2006), Butyrylcholinesterase: Association with the metabolic syndrome and identification of 2 gene loci affecting activity, Clinical Chemistry 52(6).
- Beekman M, Blauw GJ, Houwing-Duistermaat JJ, Brandt BW, Westendorp RGJ & Slagboom PE (2006), Chromosome 4q25, microsomal transfer protein gene, and human longevity: Novel data and a meta-analysis of association studies, Journals of Gerontology, Series A 61(4).
- Wessels JAM, de Vries-Bouwstra JK, Heijmans BT, Slagboom PE, Goekoop-Ruiterman YPM, Allaart CF, Kerstens PJSM, van Zeben D, Breedveld FC, Dijkmans BAC, Huizinga TWJ & Guchelaar HJ (2006), Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes, Arthritis and Rheumatism 54(4).
- Kuningas M, Slagboom PE, Westendorp RGJ & van Heemst D (2006), Impact of genetic variations in the WRN gene on age related pathologies and mortality, Mechanisms of Ageing and Development 127(3).
- Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Le Graverand MPH, DeGroot J & Slagboom PE (2006), Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study, Annals of the Rheumatic Diseases 65(3).
- Pons D, Monraats PS, de Vries FR, Zwinderman AH, de Maat MPM, Slagboom PE, Agema WRR, Doevendans PAFM, de Winter RJ, Tio RA, Waltenberger J, Frants RR, van der Laarse A, van der Wall EE & Jukema JW (2006), Different genetic make-up of the anti-inflammatory II10-gene contributes to the development of restenosis after PCI, Journal of the American College of Cardiology 47(4): 317A-317A.
- Beem AL, de Geus EJC, Hottenga JJ, Sullivan PF, Willemsen G, Slagboom PE & Boomsma DI (2006), Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression, Behavior Genetics 36(1).
- Schoenmaker M, de Craen AJM, de Meijer PHEM, Beekman M, Blauw GJ, Slagboom PE & Westendorp RGJ (2006), Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study, European Journal of Human Genetics 14(1).
- Boomsma DI, Cacioppo JT, Slagboom PE & Posthuma D (2006), Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24, Behavior Genetics 36(1).
- Posthuma D, Visscher PM, Willemsen G, Zhu G, Martin NG, Slagboom PE, de Geus EJC & Boomsma DI (2006), Replicated linkage for eye color on 15q using comparative ratings of sibling pairs, Behavior Genetics 36(1).
- Posthuma D, Gosso F, Luciano M, de Geus EJC, Wright MJ, Montgomery GW, van Belzen M, Heutink P, Slagboom PE, Boomsma DI & Martin NG (2005), Gene finding for intelligence, Behavior Genetics 35(6): 817-818.
- Boomsma DI, Beem AL, Willemsen G, Hottenga JJ, de Geus EJC, Middeldor CM, Sullivan P, Suchiman E, Lakenberg N & Slagboom PE (2005), Genetic association tests of RGS genes on chromosome 1q for depression and correlated traits in the Netherlands Twin-family Study of Anxious Depression (NETSAD), Behavior Genetics 35(6): 794-795.
- Slof-Op 't Landt MCT, van Furth EF, Meulenbelt I, Slagboom RE, Bartels M, Boomsma DI & Bulik CM (2005), Eating disorders: From twin studies to candidate genes and beyond, Twin Research and Human Genetics 8(5).
- Heijmans BT, Beekman M, Putter H, Lakenberg N, van der Wijk HJ, Whitfield JB, Posthuma D, Pedersen NL, Martin NG, Boomsma DI & Slagboom PE (2005), Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions, European Journal of Human Genetics 13(10).
- Monraats PS, de Vries FR, Slagboom EP, Zwinderman AH, de Maat MP, Agema WR, Hart LMT, de Winter R, Doevendans PA, Waltenberger J, Frants RR, van der Laarse A, Vandewall E & Jukema JW (2005), Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention, Circulation 112(17): U57-U57.
- Monraats PS, Sewgobind VD, de Vries FR, Zwinderman AH, de Maat MP, Agema WR, Slagboom EP, Doevendans PA, de Winter R, Tio R, Waltenberger J, Frants RR, van der Laarse A, Vandewall E & Jukema JW (2005), MMP9, an important mediator of vascular remodelling, and risk of restenosis after percutaneous coronary intervention, Circulation 112(17): U166-U166.
- Wesoly J, Toes REM, Slagboom PE & Huizinga TWJ (2005), RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians, Rheumatology 44(9).
- Legraverand MPH, Pickering E, Redifer P, Totterman S, Tamez J, Slagboom E, Kornaat P, Riyazi N, Sheepers S & Kloppenburg M (2005), The prevalence of bone marrow edema in sibling pairs with familial osteoarthritis at multiple sites. The GARP study., Arthritis and Rheumatism 52(9): S69-S70.
- Posthuma D, Luciano M, de Geus EJC, Wright MJ, Slagboom PE, Montgomery GW, Boomsma DI & Martin NG (2005), A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p, American Journal of Human Genetics 77(2).
- Mooijaart SP, Brandt BW, Baldal EA, Pijpe J, Kuningas M, Beekman M, Zwaan BJ, Slagboom PE, Westendorp RGJ & van Heemst D (2005), C-elegans DAF-12, nuclear hormone receptors and human longevity and disease at old age, Ageing Research Reviews 4(3).
- Mooijaart SP, Brandt BW, Baldal EA, Pijpe J, Kuningas M, Beekman M, Zwaan BJ, Slagboom PE, Westendorp RG & van Heemst D (2005), C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age., Ageing Research Reviews 4(3): 351-71.
- Vink JM, Willemsen G, Posthuma D, Slagboom PE, Chen X, Neale M, Kendler K & Boonasma DL (2005), Genetics of smoking and nicotine dependence, Nicotine and Tobacco Research 7(4): 655-656.
- Leroi AM, Bartke A, De Benedictis G, Franceschi C, Gartner A, Gonos ES, Fedei ME, Kivisild T, Lee S, Kartaf-Ozer N, Schumacher M, Sikora E, Slagboom E, Tatar M, Yashin AI, Vijg J & Zwaan B (2005), What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? (vol 126, pg 421, 2005), Mechanisms of Ageing and Development 126(8): 906-906.
- Riyazi N, Rosendaal FR, Slagboom E, Breedveld FC & Kloppenburg M (2005), Risk factors in familial osteoarthritis. The GARP Sibling Study, Annals of the Rheumatic Diseases 64: 67-67.
- Riyazi N, Slagboom E, de Craen AJ, Meulenbelt I, Houwing-Duistermaat JJ, Kroon HM, van Schaardenburg D, Rosendaal FR, Breedveld FC, Huizinga TW & Kloppenburg M (2005), Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation., Arthritis and Rheumatism 52(5): 1443-50.
- Riyazi N, Slagboom E, de Craen AJM, Meulenbelt I, Houwing-Duistermaat JJ, Kroon HM, van Schaardenburg D, Rosendaal FR, Breedveld FC, Huizinga TWJ & Kloppenburg M (2005), Association of the risk of osteoarthritis with high innate production of interleukin-1 beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation, Arthritis and Rheumatism 52(5).
- Alizadeh BZ, Njajou OT, Bijkerk C, Meulenbelt I, De Wildt SC, Hofman A, Pols HAP, Slagboom PE & van Duijn CM (2005), Evidence for a role of the genomic region of the gene encoding for the alpha 1 chain of type IX collagen (COL9A1) in hip osteoarthritis - A population-based study, Arthritis and Rheumatism 52(5).
- Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, Pols HA, van Duijn CM & Slagboom PE (2005), Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites, Arthritis and Rheumatism 52(4).
- Posthuma D, Meulenbelt I, de Craen AJM, de Geus EJC, Slagboom PE, Boomsma DI & Westendorp RGJ (2005), Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors, Twin Research and Human Genetics 8(2).
- van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE & Westendorp RGJ (2005), Reduced insulin/IGF-1 signalling and human longevity, Aging Cell 4(2).
- Riyazi N, Meulenbelt I, Kroon HM, Ronday KH, le Graverand MPH, Rosendaal FR, Breedveld FC, Slagboom PE & Kloppenburg M (2005), Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study, Annals of the Rheumatic Diseases 64(3).
- Brandt BW, Zwaan BJ, Beekman M, Westendorp RGJ & Slagboom PE (2005), Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?, BioEssays 27(3).
- Brandt BW, Zwaan BJ, Beekman M, Westendorp RG & Slagboom PE (2005), Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?, BioEssays 27(3): 339-46.
- Leroi AM, Bartke A, De Benedictis G, Franceschi C, Gartner A, Gonos E, Feder ME, Kivisild T, Lee S, Kartal-Ozer N, Schumacher M, Sikora E, Slagboom E, Tatar M, Yashin AI, Vijg J & Zwaan B (2005), What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?, Mechanisms of Ageing and Development 126(3).
- Meulenbelt I, Slagboom PE & van Duijn CM (2005), Accuracy of haplotype association studies is enhanced by increasing number of polymorphic loci examined: comment on the article by Meulenbelt et al - Reply, Arthritis and Rheumatism 52(2).
- van Heemst D, Mooijaart SP, Beekman M, Schreuder J, de Craen AJM, Brandt BW, Slagboom PE & Westendorp RGJ (2005), Variation in the human TP53 gene affects old age survival and cancer mortality, Experimental Gerontology 40(1-2).
- de Geus EJC, Posthuma D, Kupper N, van den Berg M, Willemsen G, Beem AL, Slagboom PE & Boomsma DI (2005), A whole-genome scan for 24-hour respiration rate: A major locus at 10q26 influences respiration during sleep, American Journal of Human Genetics 76(1).
- Meulenbelt I, Kloppenburg G, Min J, Pickering E, Le Graverand MPH, Groot J & Slagboom PE (2004), Cross sectional evaluation of biochemical markers of bone and cartilage metabolism in sibling pairs with familial OA at multiple sites. The GARP study, Osteoarthritis and Cartilage 12: S92-S93.
- Riyazi N, Rosendaal FR, Slagboom E, Breedveld FC & Kloppenburg M (2004), Risk factors in familial osteoarthritis. The GARP sibling study, Osteoarthritis and Cartilage 12: S112-S112.
- Willemsen G, Boomsma DI, Beem AL, Vink JM, Slagboom PE & Posthuma D (2004), QTLs for height: results of a full genome scan in Dutch sibling pairs, European Journal of Human Genetics 12(10).
- Meulenbelt I, Min J, Kloppenburg M, Van Duijn CM & Slagboom E (2004), Genome wide scan in early onset generalized OA; Mutation analysis of a candidate gene, Annals of the Rheumatic Diseases 63: 120-120.
- Min J, Meulenbelt I, Kloppenburg M, Van Duijn CM & Slagboom E (2004), Genome wide scan in early onset generalized OA; Mutation and association analysis of candidate genes within the region of linkage, Annals of the Rheumatic Diseases 63: 120-120.
- Alizadeh BZ, Njajou OT, Hazes JMW, Hofman A, Slagboom PE, Pols HAR & van Duijn CM (2004), The H63D mutation in the HFE gene predisposes to arthralgia, chondrocalcinosis, and osteoarthritis, Annals of the Rheumatic Diseases 63: 71-71.
- Beekman M, Posthuma D, Heijmans BT, Lakenberg N, Suchiman HED, Snieder H, de Knijff P, Frants RR, van Ommen GJB, Kluft C, Vogler GP, Slagboom PE & Boomsma DI (2004), Combined association and linkage analysis applied to the APOE locus, Genetic Epidemiology 26(4).
- Zhai G, Rivadeneira F, Houwing-Duistermat JJ, Meulenbelt I, Bijkerk C, Hofman A, van Meurs JBJ, Uitterlinden AG, Pols HAP, Slagboom PE & van Duijn CM (2004), Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha 1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study, Annals of the Rheumatic Diseases 63(5).
- Meulenbelt I, Seymour AB, Nieuwland M, Huizinga TWJ, van Duijn CM & Slagboom PE (2004), Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip, Arthritis and Rheumatism 50(4).
- Heijmans BT, Beem AL, Willemsen G, Posthuma D, Slagboom PE & Boomsma DI (2004), Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families, Twin Research 7(2).
- Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Slagboom PE & Westendorp RGJ (2004), Variation in the SHC1 gene and longevity in humans, Experimental Gerontology 39(2).
- Vink JM, Beem AL, Posthuma D, Neale MC, Willemsen G, Kendler KS, Slagboom PE & Boomsma DI (2004), Linkage analysis of smoking initiation and quantity in Dutch sibling pairs, Pharmacogenomics Journal 4(4).
- Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, Snieder H, Lakenberg N, Eka H, Suchiman D, de Knijff P, Frants RR, van Ommen GJB, Kluft C, Vogler GP, Boomsma DI & Slagboom PE (2003), Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population, European Journal of Human Genetics 11(11).
- Houwing-Duistermaat JJ, Bijkerk C, Hsu L, Stijnen T, Slagboom EP & van Duijn CM (2003), A unified approach to modelling linkage to quantitative and qualitative traits, Annals of Human Genetics 67.
- Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, Snieder H, Lakenberg N, Knijff PC, Frants RR, van Ommen GJB, Kluft C, Vogler GR, Slagboom RE & Boomsma DI (2003), Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels, Twin Research 6(4).
- Heijmans BT, Boer JMA, Suchiman HED, Cornelisse CJ, Westendorp RGJ, Kromhout D, Feskens EJM & Slagboom PE (2003), A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer, Cancer Research 63(6).
- Meulenbelt I, Seymour A, Nieuwland M, Bijkerk C, Gabel CA, Huizinga T, van Duijn CM & Slagboom PE (2002), Interleukin-1 polymorphism significantly associated with increased risk for hip osteoarthritis in females., American Journal of Human Genetics 71(4): 347-347.
- van Aken MO, de Craen AJM, Gussekloo J, Moghaddam PH, Vandenbroucke JP, Heijmans BT, Slagboom PE & Westendorp RGJ (2002), No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus Study, European Journal of Clinical Investigation 32(10).
- Slagboom PE & Meulenbelt I (2002), Organisation of the human genome and our tools for identifying disease genes, Biological Psychology 61(1-2).
- Heijmans BT, Westendorp RGJ, Droog S, Kluft C, Knook D & Slagboom PE (2002), Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort, Genes and Immunity 3(4).
- Beekman M, Heijmans BT, Martin NG, Pedersen NL, Whitfield JB, DeFaire U, van Baal GCM, Snieder H, Vogler GP, Slagboom PE & Boomsma DI (2002), Heritabilities of apolipoprotein and lipid levels in three countries, Twin Research 5(2).
- Heijmans BT, Slagboom PE, Gussekloo J, Droog S, Lagaay AM, Kluft C, Knook DL & Westendorp RGJ (2002), Association of APOE epsilon 2/epsilon 3/epsilon 4 and promoter gene variants with dementia but not cardiovascular mortality in old age, American Journal of Medical Genetics 107(3).
- Duffy D, Montgomery G, Treloar S, Birley A, Kirk K, Boomsma D, Beem L, de Geus E, Slagboom E, Knighton J, Reed P & Martin N (2001), IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers, Nature Genetics 28(4).
- Feskens EJM, Heijmans BT, Slagboom PE & Kromhout D (2001), Insulin gene VNTR associated with type 2 diabetes: Interactions with age, body fatness and height, Diabetologia 44: A87-A87.
- Beekman M, Lakenburg N, Cherny SS, De Knijff P, Kluft CC, Van Ommen GJB, Vogler GP, Frants RR, Boomsma DI & Slagboom PE (2001), A powerful and rapid approach to human genome scanning using small quantities of genomic DNA, Genetics Research 77(2).
- van Meurs JBJ, Arp PP, Fang Y, Slagboom PE, Meulenbelt I, van Leeuwen JPTM, Pols HAP & Uitterlinden AG (2000), Detection of sequence variability of the collagen type II alpha 1 3 ' variable number of tandem repeat, ELECTROPHORESIS 21(17).
- Heijmans BT, Westendorp RGJ & Slagboom PE (2000), Common gene variants, mortality and extreme longevity in humans, Experimental Gerontology 35(6-7).
- Meulenbelt I, Slagboom PE & van Duijn C (2000), Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: comment on the article by Meulenbelt et al - Reply.
- Heijmans BT, Westendorp RGJ, Lagaay AM, Knook DL, Kluft C & Slagboom PE (2000), Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects.
- Slagboom PE, Heijmans BT, Beekman M, Westendorp RGJ & Meulenbelt I (2000), Genetics of human aging - The search for genes contributing to human longevity and diseases of the old.
- Heijmans BT, Westendorp RGJ, Knook DL, Kluft C & Slagboom PE (1999), Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: Risk of mortality and fatal cardiovascular disease in an elderly population-based cohort, Journal of the American College of Cardiology 34(4): 1176-1183.
- Meulenbelt I, Bijkerk C, Houwing-Duistermaat JJ, Breedveld FC, van Duijn CM & Slagboom PE (1999), Genetic studies on osteoarthritis., American Journal of Human Genetics 65(4): A435-A435.
- Beekman M, Boomsma DI, De Knijff P, Vogler GP, Kluft CC, Van Ommen GJB, Frants RR & Slagboom PE (1999), Genome scan for quantitative traits involved in cardiovascular disease., American Journal of Human Genetics 65(4): A243-A243.
- Meulenbelt I, Bijkerk C, De Wildt SCM, Miedema HS, Breedveld FC, Pols HAP, Hofman A, Van Duijn CM & Slagboom PE (1999), Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis.
- Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HAP, van Duijn CM & Slagboom PE (1999), Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine, Arthritis and Rheumatism 42(8): 1729-1735.
- Westendorp RGJ, Hottenga JJ & Slagboom PE (1999), Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock, Lancet 354(9178): 561-563.
- Gussekloo J, Heijmans BT, Lagaay AM, Slagboom PE, Knook DL & Westendorp RGJ (1999), A common Methylenetetrahydrofolate Reductase polymorphism and cognitive decline in the oldest old., Zeitschrift f�r Gerontologie und Geriatrie 32(2): 120-120.
- Slagboom PE, Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HAP & van Duijn CM (1999), Heritability and candidate gene studies in Osteoarthritis, Zeitschrift f�r Gerontologie und Geriatrie 32(2): 127-127.
- Heiimans BT, Gussekloo J, Kluft C, Droog S, Lagaay AM, Knook DL, Westendorp RGJ & Slagboom PE (1999), Increased risk of mortality associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR), Zeitschrift f�r Gerontologie und Geriatrie 32(2): 146-146.
- Westendorp RGJ, Knook DL & Slagboom PE (1999), Saving time to reveal determinants of disease at old age, Zeitschrift f�r Gerontologie und Geriatrie 32(2): 47-47.
- Heijmans BT, Westendorp RGJ, Knook DL, Kluft C & Slagboom PE (1999), Paraoxonase Met-55/Leu and Gln-192/Arg polymorphisms and the risk of mortality and fatal cardiovascular events in elderly subjects, Atherosclerosis 144: 18-18.