Universiteit Leiden

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Research project

Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a systems microscopy-based approach and apply this for drug target and drug lead discovery in pathogen-mediated inflammatory response signalling.

Duration
2017  -   2021
Contact
Bob van de Water

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