Universiteit Leiden

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Chromatin organization & dynamics (Dr. Remus Dame)

Our approach

In order to gain an understanding of bacterial chromatin organization and its interplay with transcription, we employ a multi-disciplinary molecular approach which includes, but is not limited to:

  • bulk-biochemical techniques
  • computer modelling
  • scanning force microscopy
  • bulk and single molecule fluorescence
  • magnetic and optical tweezers

In addition, we collaborate with theoretical physicists to develop theoretical frameworks for the quantitative interpretation of our results.

Occasionally we address other interesting questions (e.g. related to DNA topology, protein-DNA interactions, functional protein aggregation) outside the direct field of interest with the above techniques.

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