The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate large scale metabolic, transcriptomic and genetic data from these models, in order to systematically identify, characterise and validate novel targets for therapeutic intervention and bioinfomatic models for predictive diagnostics.
- 2013 - 2018
- Thomas Hankemeier
Leiden’s Objectives: Large scale metabolic profiling of in vitro and in vivo models of pancreatic cancer
- Customising and miniaturising of available metabolomics platforms for in vivo and in vitro pancreatic cancer samples of CAM-PaC
- Defining the metabolic phenotype of human pancreatic cancer
- Identifying key metabolic pathways in in vitro and in vivo pancreatic cancer models
- Validating key metabolic pathways of pancreatic cancer to identify new possible drug targets