The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
- Chung Sing Wong
- 10 December 2015
- Thesis in Leiden Repository
Bioconjugates are involved in many biological processes. Glycoconjugates can bind to lectin receptors based on their specific carbohydrate structure. The mannose receptor, a C-type lectin, makes an interesting target to induce selective uptake by dendritic cells and macrophages. This thesis focus on the design and synthesis glycoconjugates linked with oligomannosides and artificial mannose clusters as homing device for the mannose receptor and other mannose binding lectins.