Universiteit Leiden

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LED3 Lecture: Organoids to model human health and disease in vitro

Thursday 28 March 2024
Niels Bohrweg 2
2333 CA Leiden

Prof. Clevers is a molecular geneticist and stem cell researcher. He is the head of Pharma, Research and Early Development of Hoffmann-La Roche (Basel, Switzerland). He is also a distinguished professor in molecular genetics at Utrecht University. He studied the biology of Wnt detection in tissue renewal and in cancer. The discovery of Lgr5 as a marker for Wnt-dependent stem cells in various matured types of tissue led to the development of a technology that lets stem cells grow into expanding epithelial organoids. These organoids share very many characteristics with the original tissue. This makes them suitable for use in the studying of physiological and pathological processes, including drug treatment. Organoids grown from the patient's own cells can, for example, be used to predict the tissue's response to them (personalized medicine).

After the talk, there will be a borrel outside the lecture hall.

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