Universiteit Leiden

nl en

Promotie

Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment

  • A.L. Cabral De Sá Leitão Oliveira
Datum
donderdag 24 maart 2022
Tijd
Locatie
Academiegebouw
Rapenburg 73
2311 GJ Leiden

Promotor(en)

  • Prof.dr. LF de Geus-Oei

Samenvatting:

The objective of this thesis was the development and biological investigation of three drug delivery systems for the treatment of colorectal cancer (CRC). The feasibility of therapy based on drug delivery systems targeted at tumor cells was studied, thus reducing drug resistance and side effects of existing drugs on the market. New treatments were formulated and evaluated for anti-inflammatory and antitumor activity in in vitro and in vivo models. The results showed that treatment with NPs decreased inflammation and had antioxidant properties, decreases the size of tumors, and potentiated the antitumor activity of chemotherapeutic agents. These promising data will significantly contribute to the progress of cancer research. In the clinic, nanomedicine-based therapy is closely linked to improving patient prognosis, which is an important research program. This work being has great importance in the field of colorectal cancer therapy.

Proefschriften

Ongeveer een week na de promotie zijn proefschriften van Leidse promovendi digitaal beschikbaar via het Leids Repositorium. De proefschriften op deze site zijn vrij toegankelijk. Alleen in sommige gevallen rust er een tijdelijk embargo op een proefschrift en wordt het proefschrift pas later volledig beschikbaar gesteld.

Persvragen (alleen journalisten)

pers@lumc.nl

Algemene informatie

Bureau Pedel
pedel@bb.leidenuniv.nl
071 527 7211

Deze website maakt gebruik van cookies.  Meer informatie.