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PhD defence

Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment

  • A.L. Cabral De Sá Leitão Oliveira
Thursday 24 March 2022
Academy Building
Rapenburg 73
2311 GJ Leiden


  • Prof. LF de Geus-Oei


The objective of this thesis was the development and biological investigation of three drug delivery systems for the treatment of colorectal cancer (CRC). The feasibility of therapy based on drug delivery systems targeted at tumor cells was studied, thus reducing drug resistance and side effects of existing drugs on the market. New treatments were formulated and evaluated for anti-inflammatory and antitumor activity in in vitro and in vivo models. The results showed that treatment with NPs decreased inflammation and had antioxidant properties, decreases the size of tumors, and potentiated the antitumor activity of chemotherapeutic agents. These promising data will significantly contribute to the progress of cancer research. In the clinic, nanomedicine-based therapy is closely linked to improving patient prognosis, which is an important research program. This work being has great importance in the field of colorectal cancer therapy.


PhD dissertations

Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.

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