Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
- Jelle Jurjen Goeman
- 08 maart 2006
- Thesis in Leiden Repository
In this thesis novel statistical methods are developed for the analysis of high dimensional microarray data. In short: Chapter 1 gives an overview of the most important research methods developed so far. Chapter 2 describes a method for testing association of the expression of gene sets (pathways) with a patient level response variable, which can be continuous or two-valued. Chapter 3 extends the methodology of chapter 2 to survival as a response variable. Chapter 4 presents a goodness-of-fit test for the multinomial regression model, which can be used to extend the methodology of chapter 2 to multi-valued outcomes. Chapter 5 presents a general theoretical framework in for the tests of chapters 2-4 and derives optimality properties for these tests. Chapter 6 presents a method for predicting a response variable from high dimensional data, based on latent variables. Chapter 7 presents a visualization tool for improved presentation of scatterplots with many thousands of dots.