Wilhelmina Mesker
- Naam
- W.E. Mesker
- Telefoon
- +31 71 526 2987
- w.e.mesker@lumc.nl
- Faculteit Geneeskunde
- LUMC - Medische Faculteit Leiden
- Divisie 1
- Heelkunde
- Diederiks, N.; Ravensbergen, C.J.; Treep, M.; Wezel, M. van; Kuruc, M.; Ruhaak, L.R.; Tollenaar, R.A.E.M.; Cobbaert, C.M.; Burgt, Y.E.M. van der & Mesker, W.E. (2023), Development of Tier 2 LC-MRM-MS protein quantification methods for liquid biopsies, JOURNAL OF MASS SPECTROMETRY AND ADVANCES IN THE CLINICAL LAB 27: 49-55.
- Weerd, S. van de; Smit, M.A.; Roelands, J.; Mesker, W.E.; Bedognetti, D.; Kuppen, P.J.K.; Putter, H.; Tollenaar, R.A.E.M.; Roodhart, J.M.L.; Hendrickx, W.; Medema, J.P. & Krieken, J.H.J.M. van (2022), Correlation of immunological and histopathological features with gene expression-based classifiers in colon cancer patients, International Journal of Molecular Sciences 23(20).
- Hagenaars, S.C.; Dekker, L.J.M.; Ravesteijn, B.; Vlierberghe, R.L.P. van; Romijn, F.P.H.T.M.; Verhoeff, L.; Witkamp, A.J.; Schenk, K.E.; Keymeulen, K.B.I.M.; Menke-Pluijmers, M.B.E.; Dassen, A.E.; Kortmann, B.A.; Vries, J. de; Rutgers, E.J.T.; Burgt, Y.E.M. van der; Kranenbarg, E.M.K.; Cobbaert, C.M.; Luider, T.M.; Mesker, W.E. & Tollenaar, R.A.E.M. (2022), Longitudinal serum protein analysis of women with a high risk of developing breast cancer reveals large interpatient versus small intrapatient variations, International Journal of Molecular Sciences 23(20).
- Levink, I.J.M.; Klatte, D.C.F.; Hanna-Sawires, R.G.; Vreeker, G.C.M.; Ibrahim, I.S.; Burgt, Y.E.M. van der; Overbeek, K.A.; Koopmann, B.D.M.; Cahen, D.L.; Fuhler, G.M.; Wuhrer, M.; Bonsing, B.A.; Tollenaar, R.A.E.M.; Vleggaar, F.P.; Vasen, H.F.A.; Leerdam, M.E. van; Bruno, M.J. & Mesker, W.E. (2022), Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals, Pancreatology 22(4): 497-506.
- Polack, M.; Hagenaars, S.C.; Couwenberg, A.; Kool, W.; Tollenaar, R.A.E.M.; Vogel, W.V.; Snaebjornsson, P. & Mesker, W.E. (2022), Characteristics of tumour stroma in regional lymph node metastases in colorectal cancer patients, Clinical and Translational Oncology 24(9): 1776-1784.
- Hagenaars, S.C.; Vangangelt, K.M.H.; Pelt, G.W. van; Karancsi, Z.; Tollenaar, R.A.E.M.; Green, A.R.; Rakha, E.A.; Kulka, J. & Mesker, W.E. (2022), Standardization of the tumor-stroma ratio scoring method for breast cancer research, Breast Cancer Research and Treatment 193(3): 545-553.
- Hoorn, S. ten; Waasdorp, C.; Oijen, M.G.H. van; Damhofer, H.; Trinh, A.; Zhao, L.; Smits, L.J.H.; Bootsma, S.; Pelt, G.W. van; Mesker, W.E.; Mol, L.; Goey, K.K.H.; Koopman, M.; Medema, J.P.; Tuynman, J.B.; Zlobec, I.; Punt, C.J.A.; Vermeulen, L. & Bijlsma, M.F. (2022), Serum-based measurements of stromal activation through ADAM12 associate with poor prognosis in colorectal cancer, BMC Cancer 22(1).
- Strous, M.T.A.; Faes, T.K.E.; Gubbels, A.L.H.M.; Linden, R.L.A. van der; Mesker, W.E.; Bosscha, K.; Bronkhorst, C.M.; Janssen-Heijnen, M.L.G.; Vogelaar, F.J. & Bruine, A.P. de (2022), A high tumour-stroma ratio (TSR) in colon tumours and its metastatic lymph nodes predicts poor cancer-free survival and chemo resistance, Clinical and Translational Oncology 24.
- Huang, Y.S.; Liu, S.J.; Shan, M.J.; Hagenaars, S.C.; Mesker, W.E.; Cohen, D.; Wang, L.; Zheng, Z.; Devilee, P.; Tollenaar, R.A.E.M.; Li, Z.F.; Song, Y.M.; Zhang, L.; Li, D. & Dijke, P. ten (2022), RNF12 is regulated by AKT phosphorylation and promotes TGF-beta driven breast cancer metastasis, Cell Death and Disease 13(1).
- Ravensbergen, C.J.; Kuruc, M.; Polack, M.; Crobach, S.; Putter, H.; Gelderblom, H.; Roy, D.; Tollenaar, R.A.E.M. & Mesker, W.E. (2022), The Stroma Liquid Biopsy panel contains a stromal-epithelial gene signature ratio that is associated with the histologic tumor-stroma ratio and predicts survival in colon cancer, Cancers 14(1).
- Ravensbergen, C.J.; Polack, M.; Roelands, J.; Crobach, S.; Putter, H.; Gelderblom, H.; Tollenaar, R.A.E.M. & Mesker, W.E. (2021), Combined assessment of the tumor-stroma ratio and tumor immune cell infiltrate for immune checkpoint inhibitor therapy response prediction in colon cancer, Cells 10(11).
- Hanna-Sawires, R.G.; Groen, J.V.; Hamming, A.; Tollenaar, R.A.E.M.; Mesker, W.E.; Luelmo, S.A.C.; Vahrmeijer, A.L.; Bonsing, B.A.; Versteeg, H.H.; Klok, F.A. & Mieog, J.S.D. (2021), Incidence, timing and risk factors of venous thromboembolic events in patients with pancreatic cancer, Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis 207: 134-139.
- Smit, M.A.; Pelt, G.W. van; Terpstra, V.; Putter, H.; Tollenaar, R.A.E.M.; Mesker, W.E. & Krieken, J.H.J.M. van (2021), Tumour-stroma ratio outperforms tumour budding as biomarker in colon cancer, International Journal of Colorectal Disease 36.
- Hagenaars, S.C.; Groot, S. de; Cohen, D.; Dekker, T.J.A.; Charehbili, A.; Kranenbarg, E.M.K.; Carpentier, M.D.D.; Pijl, H.; Putter, H.; Tollenaar, R.A.E.M.; Kroep, J.R.; Mesker, W.E. & Dutch Breast Can (2021), Tumor-stroma ratio is associated with Miller-Payne score and pathological response to neoadjuvant chemotherapy in HER2-negative early breast cancer, International Journal of Cancer 149(5).
- Vreeker, G.C.M.; Vangangelt, K.M.H.; Bladergroen, M.R.; Nicolardi, S.; Mesker, W.E.; Wuhrer, M.; Burgt, Y.E.M. van der & Tollenaar, R.A.E.M. (2021), Serum N-glycan profiles differ for various breast cancer subtypes, Glycoconjugate Journal 38(3): 387-395.
- Hanna-Sawires, R.G.; Schiphuis, J.H.; Wuhrer, M.; Vasen, H.F.A.; Leerdam, M.E. van; Bonsing, B.A.; Mesker, W.E.; Burgt, Y.E.M. van der & Tollenaar, R.A.E.M. (2021), Clinical perspective on proteomic and glycomic biomarkers for diagnosis, prognosis, and prediction of pancreatic cancer, International Journal of Molecular Sciences 22(5).
- Patuleia, S.I.S.; Hagenaars, S.C.; Moelans, C.B.; Ausems, M.G.E.M.; Gils, C.H. van; Tollenaar, R.A.E.M.; Diest, P.J. van; Mesker, W.E. & Wall, E. van der (2021), Lessons Learned from Setting Up a Prospective, Longitudinal, Multicenter Study with Women at High Risk for Breast Cancer, Cancer Epidemiology, Biomarkers and Prevention 30(3): 441-449.
- Dang, H.; Pelt, G.W. van; Haasnoot, K.J.C.; Backes, Y.; Elias, S.G.; Seerden, T.C.J.; Schwartz, M.P.; Spanier, B.W.M.; Cappel, W.H.D.T.N.; Bergeijk, J.D. van; Kessels, K.; Geesing, J.M.J.; Groen, J.N.; Borg, F. ter; Wolfhagen, F.H.J.; Seldenrijk, C.A.; Raicu, M.G.; Milne, A.N.; Lent, A.U.G. van; Brosens, L.A.A.; Offerhaus, G.J.A.; Siersema, P.D.; Tollenaar, R.A.E.M.; Hardwick, J.C.H.; Hawinkels, L.J.A.C.; Moons, L.M.G.; Lacle, M.M.; Mesker, W.E. & Boonstra, J.J. (2021), Tumour-stroma ratio has poor prognostic value in nonpedunculated T1 colorectal cancer, United European Gastroenterology Journal 9(4).
- Boyaval, F.; Zeijl, R. van; Dalebout, H.; Holst, S.; Pelt, G. van; Farina-Sarasqueta, A.; Mesker, W.; Tollenaar, R.; Morreau, H.; Wuhrer, M. & Heijs, B. (2021), N-glycomic signature of stage II colorectal cancer and its association with the tumor microenvironment, Molecular and Cellular Proteomics 20.
- Zunder, S.M.; Perez-Lopez, R.; Kok, B.M. de; Raciti, M.V.; Pelt, G.W. van; Dienstmann, R.; Garcia-Ruiz, A.; Meijer, C.A.; Gelderblom, H.; Tollenaar, R.A.; Nuciforo, P.; Wasser, M.N. & Mesker, W.E. (2020), Correlation of the tumour-stroma ratio with diffusion weighted MRI in rectal cancer, European Journal of Radiology 133.
- Spek, Y.M. van der; Kroep, J.R.; Tollenaar, R.A.E.M. & Mesker, W.E. (2020), Chemotherapy resistance and stromal targets in breast cancer treatment: a review, Molecular Biology Reports 47(10): 8169-8177.
- Vreeker, G.C.M.; Hanna-Sawires, R.G.; Mohammed, Y.; Bladergroen, M.R.; Nicolardi, S.; Dotz, V.; Nouta, J.; Bonsing, B.A.; Mesker, W.E.; Burgt, Y.E.M. van der; Wuhrer, M. & Tollenaar, R.A.E.M. (2020), Serum N-glycome analysis reveals pancreatic cancer disease signatures, Cancer Medicine 9(22).
- Zunder, S.M.; Gelderblom, H.; Tollenaar, R.A. & Mesker, W.E. (2020), The significance of stromal collagen organization in cancer tissue: an in depth discussion of literature, Critical Reviews in Oncology/Hematology 151.
- Smit, M.A.; Steenhoven, J.E.C. van; Tollenaar, R.A.E.M.; Dalen, T. van; Diest, P.J. van & Mesker, W.E. (2020), 70-Gene Signature and Tumor-Stroma Ratio Select Different Groups of Patients with Breast Cancer at Risk for Recurrence, Journal of Surgery and Research 3(2).
- Zunder, S.M.; Pelt, G.W. van; Vroome, S.W. de; Gelderblom, A.J.; Tollenaar, R.A.E.M. & Mesker, W.E. (2020), Prognostic and predictive value of the tumor-stroma ratio in STAGE II colon cancer, Clinical Oncology and Research 3(4).
- Momcilovic, A.; Haan, N. de; Ederveen, A.L.H.; Bondt, A.; Koeleman, C.A.M.; Falck, D.; Neef, L.A. de; Mesker, W.E.; Tollenaar, R.; Ru, A. de; Veelen, P. van; Wuhrer, M. & Dotz, V. (2020), Simultaneous immunoglobulin A and G glycopeptide profiling for high-throughput applications, Analytical Chemistry 92(6): 4518-4526.
- Liu, S.J.; Gonzalez-Prieto, R.; Zhang, M.D.; Geurink, P.P.; Kooij, R.; Iyengar, P.V.; Dinther, M. van; Bos, E.; Zhang, X.B.; Devedec, S.E. le; Water, B. van de; Koning, R.I.; Zhu, H.J.; Mesker, W.E.; Vertegaal, A.C.O.; Ovaa, H.; Zhang, L.; Martens, J.W.M. & Dijke, P. ten (2020), Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGF beta-induced breast cancer metastasis, Clinical Cancer Research 26(6): 1460-1473.
- Rebello, O.D.; Nicolardi, S.; Lageveen-Kammeijer, G.S.M.; Nouta, J.; Gardner, R.A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Spencer, D.I.R.; Wuhrer, M. & Falck, D. (2020), A matrix-assisted laser desorption/ionization-mass spectrometry assay for the relative quantitation of antennary fucosylated N-glycans in human plasma, Frontiers in Chemistry 8.
- Zunder, S.M.; Gelderblom, H.; Tollenaar, R.A. & Mesker, W.E. (2020), The significance of stromal collagen organization in cancer tissue: an in-depth discussion of literature, Critical Reviews in Oncology/Hematology 151.
- Pelt, G.W. van; Krol, J.A.; Lips, I.M.; Peters, F.P.; Klaveren, D. van; Boonstra, J.J.; Steur, W.O. de; Tollenaar, R.A.E.M.; Sarasqueta, A.F.; Mesker, W.E. & Slingerland, M. (2020), The value of tumor-stroma ratio as predictor of pathologic response after neoadjuvant chemoradiotherapy in esophageal cancer, Clinical and Translational Radiation Oncology 20: 39-44.
- Ouahoud, S.; Voorneveld, P.W.; Burg, L.R.A. van der; Jonge-Muller, E.S.M. de; Schoonderwoerd, M.J.A.; Paauwe, M.; Vos, T. de; Wit, S. de; Pelt, G.W. van; Mesker, W.E.; Hawinkels, L.J.A.C. & Hardwick, J.C.H. (2020), Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer, Oncogene 39.
- Vangangelt, K.M.H.; Green, A.R.; Heemskerk, I.M.F.; Cohen, D.; Pelt, G.W. van; Sobral-Leite, M.; Schmidt, M.K.; Putter, H.; Rakha, E.A.; Tollenaar, R.A.E.M. & Mesker, W.E. (2020), The prognostic value of the tumor-stroma ratio is most discriminative in patients with grade III or triple-negative breast cancer, International Journal of Cancer 146(8).
- Rebello, O.D.; Nicolardi, S.; Lageveen-Kammeijer, G.S.M.; Nouta, J.; Gardner, R.A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Spencer, D.I.R.; Wuhrer, M. & Falck, D. (2020), A matrix-assisted laser desorption/ionization—mass spectrometry assay for the relative quantitation of antennary fucosylated N-glycans in human plasma, Frontiers in Chemistry 8.
- Vangangelt, K.M.H.; Kramer, C.J.H.; Bastiaannet, E.; Putter, H.; Cohen, D.; Pelt, G.W. van; Rakha, E.A.; Green, A.R.; Tollenaar, R.A.E.M. & Mesker, W.E. (2020), The intra-tumoural stroma in patients with breast cancer increases with age, Breast Cancer Research and Treatment 179(1): 37-45.
- Vreeker, G.C.M.; Bladergroen, M.R.; Nicolardi, S.; Mesker, W.E.; Tollenaar, R.A.E.M.; Burgt, Y.E.M. van der & Wuhrer, M. (2019), Dried blood spot N-glycome analysis by MALDI mass spectrometry, Talanta 205.
- Zunder, S.; Wilk, P. van der; Gelderblom, H.; Dekker, T.; Mancao, C.; Kiialainen, A.; Putter, H.; Tollenaar, R. & Mesker, W. (2019), Stromal organization as predictive biomarker for the treatment of colon cancer with adjuvant bevacizumab; a post-hoc analysis of the AVANT trial, Cellular Oncology 42(5): 717-725.
- Geessink, O.G.F.; Baidoshvili, A.; Klaase, J.M.; Bejnordi, B.E.; Litjens, G.J.S.; Pelt, G.W. van; Mesker, W.E.; Nagtegaal, I.D.; Ciompi, F. & Laak, J.A.W.M. van der (2019), Computer aided quantification of intratumoral stroma yields an independent prognosticator in rectal cancer, Cellular Oncology 42(3): 331-341.
- Sandberg, T.P.; Sweere, I.; Pelt, G.W. van; Putter, H.; Vermeulen, L.; Kuppen, P.J.; Tollenaar, R.A.E.M. & Mesker, W.E. (2019), Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content - a short report, Cellular Oncology 42(3): 397-403.
- Smit, M.; Pelt, G. van; Roodvoets, A.; Kranenbarg, E.M.K.; Putter, H.; Tollenaar, R.; Krieken, J.H. van & Mesker, W. (2019), Uniform Noting for International Application of the Tumor-Stroma Ratio as an Easy Diagnostic Tool: Protocol for a Multicenter Prospective Cohort Study, JMIR Research Protocols 8(6).
- Hanna-Sawires, R.G.; Groen, J.V.; Klok, F.A.; Tollenaar, R.A.E.M.; Mesker, W.E.; Swijnenburg, R.J.; Vahrmeijer, A.L.; Bonsing, B.A. & Mieog, J.S.D. (2019), Outcomes following pancreatic surgery using three different thromboprophylaxis regimens, British Journal of Surgery 106(6): 765-773.
- Sandberg, T.P.; Stuart, M.P.M.E.; Oosting, J.; Tollenaar, R.A.E.M.; Sier, C.F.M. & Mesker, W.E. (2019), Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer, BMC Cancer 19.
- Kramer, C.J.H.; Vangangelt, K.M.H.; Pelt, G.W. van; Dekker, T.J.A.; Tollenaar, R.A.E.M. & Mesker, W.E. (2019), The prognostic value of tumour-stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review, Breast Cancer Research and Treatment 173(1): 55-64.
- Vangangelt, K.M.H.; Kramer, C.J.H.; Bastiaannet, E.; Putter, H.; Cohen, D.; Pelt, G.W. van; Rakha, E.A.; Green, A.R.; Tollenaar, R.A.E.M. & Mesker, W.E. (2019), The intra-tumoural stroma in patients with breast cancer increases with age, Breast Cancer Research and Treatment.
- Vangangelt, K.M.H.; Tollenaar, L.S.A.; Pelt, G.W. van; Kruijf, E.M. de; Dekker, T.J.A.; Kuppen, P.J.K.; Tollenaar, R.A.E.M. & Mesker, W.E. (2018), The prognostic value of tumor-stroma ratio in tumor-positive axillary lymph nodes of breast cancer patients, International Journal of Cancer 143(12): 3194-3200.
- Pelt, G.W. van; Kjaer-Frifeldt, S.; Krieken, J.H.J.M. van; Dieri, R. al; Morreau, H.; Tollenaar, R.A.E.M.; Sorensen, F.B. & Mesker, W.E. (2018), Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations, Virchows Archiv 473(4): 405-412.
- Vreeker, G.C.M.; Nicolardi, S.; Bladergroen, M.R.; Plas, C.J. van der; Mesker, W.E.; Tollenaar, R.A.E.M.; Burgt, Y.E.M. van der & Wuhrer, M. (2018), Automated Plasma Glycomics with Linkage-Specific Sialic Acid Esterification and Ultrahigh Resolution MS, Analytical Chemistry 90(20): 11955-11961.
- Pelt, G.W. van; Sandberg, T.P.; Morreau, H.; Gelderblom, H.; Krieken, J.H.J.M. van; Tollenaar, R.A.E.M. & Mesker, W.E. (2018), The tumour-stroma ratio in colon cancer: the biological role and its prognostic impact, Histopathology 73(2): 197-206.
- Zunder, S.M.; Pelt, G.W. van; Gelderblom, H.J.; Mancao, C.; Putter, H.; Tollenaar, R.A. & Mesker, W.E. (2018), Predictive potential of tumour-stroma ratio on benefit from adjuvant bevacizumab in high-risk stage II and stage III colon cancer, British Journal of Cancer 119(2): 164-169.
- Vangangelt, K.M.H.; Tollenaar, L.S.A.; Pelt, G.W. van; Kruijf, E.M. de; Dekker, T.J.A.; Kuppen, P.J.K.; Tollenaar, R.A.E.M. & Mesker, W.E. (2018), The prognostic value of tumor-stroma ratio in tumor-positive axillary lymph nodes of breast cancer patients, International Journal of Cancer.
- Vangangelt, K.M.H.; Pelt, G.W. van; Engels, C.C.; Putter, H.; Liefers, G.J.; Smit, V.T.H.B.M.; Tollenaar, R.A.E.M.; Kuppen, P.J.K. & Mesker, W.E. (2018), Prognostic value of tumor-stroma ratio combined with the immune status of tumors in invasive breast carcinoma, Breast Cancer Research and Treatment 168(3): 601-612.
- Huijbers, A.; Pelt, G.W. van; Kerr, R.S.; Johnstone, E.C.; Tollenaar, R.A.E.M.; Kerr, D.J. & Mesker, W.E. (2018), The value of additional bevacizumab in patients with high-risk stroma-high colon cancer. A study within the QUASAR2 trial, an open-label randomized phase 3 trial, Journal of Surgical Oncology 117(5): 1043-1048.
- Pelt, G.W. van; Huijbers, A.; Tollenaar, R.A.E.M. & Mesker, W.E. (2018), In reply to Hynes et al.: "Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stages II/III colon cancer in a large population-based study', Histopathology 72(3): 531-532.
- Guo, J.M.; Fung, B.C.M.; Iqbal, F.; Kuppen, P.J.K.; Tollenaar, R.A.E.M.; Mesker, W.E. & Lebrun, J.J. (2017), Revealing determinant factors for early breast cancer recurrence by decision tree, Information Systems Frontiers 19(6): 1233-1241.
- Vangangelt, K.M.H.; Pelt, G.W. van; Engels, C.C.; Putter, H.; Liefers, G.J.; Smit, V.T.H.B.M.; Tollenaar, R.A.E.M.; Kuppen, P.J.K. & Mesker, W.E. (2017), Prognostic value of tumor-stroma ratio combined with the immune status of tumors in invasive breast carcinoma., Breast Cancer Research and Treatment.
- Roeke, T.; Sobral-Leite, M.; Dekker, T.J.A.; Wesseling, J.; Smit, V.T.H.B.M.; Tollenaar, R.A.E.M.; Schmidt, M.K. & Mesker, W.E. (2017), The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study, Breast Cancer Research and Treatment 166(2): 435-445.
- Mesker, W.; Pelt, G. van; Laak, J. van der; Dequeker, E.; Flejou, J.F.; Dieri, R. al; Krieken, H. van & Tollenaar, R. (2017), Chemotherapy or not? Practice changing approach for the accurate selection of patients for chemotherapy treatment after colon cancer diagnosis. The Tumour-Stroma-Ratio (TSR) as addition to the TNM classification, Virchows Archiv 471: S184-S184.
- Mesker, W.; Pelt, G. van; Huijbers, A.; Laak, J. van der; Dequeker, E.; Flejou, J.F.; Dieri, R. al; Kerr, D.; Krieken, J. van & Tollenaar, R. (2017), Improving treatment decisions in colon cancer: The tumor-stroma ratio (TSR) additional to the TNM classification, Annals of Oncology 28.
- Sandberg, T.; Oosting, J.; Pelt, G. van; Putter, H.; Wezel, J.T. van; Tollenaar, R.; Morreau, J. & Mesker, W. (2017), Molecular profiling of colorectal tumors stratified by the histological tumor-stroma ratio, Annals of Oncology 28.
- Zunder, S.; Pelt, G. van; Gelderblom, H.; Tollenaar, R.; Mancao, C. & Mesker, W. (2017), Predictive potential of tumour-stroma ratio on benefit from adjuvant bevacizumab in high-risk stage II and stage III colon cancer, Annals of Oncology 28.
- Pelt, G. van; Huijbers, A.; Kerr, R.; Johnstone, E.; Tollenaar, R.; Kerr, D. & Mesker, W. (2017), Tumour-stroma ratio combined with vascular invasion improves survival prediction for colon cancer patients, Virchows Archiv 471: S34-S34.
- Vogelaar, F.J.; Pelt, G.W. van; Leeuwen, A.M. van; Willems, J.M.; Tollenaar, R.A.E.M.; Liefers, G.J. & Mesker, W.E. (2016), Are disseminated tumor cells in bone marrow and tumor-stroma ratio clinically applicable for patients undergoing surgical resection of primary colorectal cancer? The Leiden MRD study, Cellular Oncology 39(6): 537-544.
- Sijp, M.P.L. van der; Bastiaannet, E.; Mesker, W.E.; Geest, L.G.M. van der; Breugom, A.J.; Steup, W.H.; Marinelli, A.W.K.S.; Tseng, L.N.L.; Tollenaar, R.A.E.M.; Velde, C.J.H. van de & Dekker, J.W.T. (2016), Differences between colon and rectal cancer in complications, short-term survival and recurrences, International Journal of Colorectal Disease 31(10): 1683-1691.
- Breugom, A.J.; Dongen, D.T. van; Bastiaannet, E.; Dekker, F.W.; Geest, L.G.M. van der; Liefers, G.J.; Marinelli, A.W.K.S.; Mesker, W.E.; Portielje, J.E.A.; Steup, W.H.; Tseng, L.N.L.; Velde, C.J.H. van de & Dekker, J.W.T. (2016), Association Between the Most Frequent Complications After Surgery for Stage I-III Colon Cancer and Short-Term Survival, Long-Term Survival, and Recurrences, Annals of Surgical Oncology 23(9): 2858-2865.
- Heijs, B.; Holst, S.; Briaire-de Bruijn, I.H.; Pelt, G.W. van; Ru, A.H. de; Veelen, P.A. van; Drake, R.R.; Mehta, A.S.; Mesker, W.E.; Tollenaar, R.A.; Bovee, J.V.M.G.; Wuhrer, M. & McDonnell, L.A. (2016), Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section, Analytical Chemistry 88(15): 7745-7753.
- Holst, S.; Heijs, B.; Haan, N. de; Zeijl, R.J.M. van; Briaire-de Bruijn, I.H.; Pelt, G.W. van; Mehta, A.S.; Angel, P.M.; Mesker, W.E.; Tollenaar, R.A.; Drake, R.R.; Bovee, J.V.M.G.; McDonnell, L.A. & Wuhrer, M. (2016), Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues, Analytical Chemistry 88(11): 5904-5913.
- Potjer, T.P.; Mertens, B.J.; Nicolardi, S.; Burgt, Y.E.M. van der; Bonsing, B.A.; Mesker, W.E.; Tollenaar, R.A.E.M. & Vasen, H.F.A. (2016), Application of a Serum Protein Signature for Pancreatic Cancer to Separate Cases from Controls in a Pancreatic Surveillance Cohort, Translational Oncology 9(3): 242-247.
- Li, Y.H.; Jin, K.; Pelt, G.W. van; Dam, H. van; Yu, X.; Mesker, W.E.; Dijke, P. ten; Zhou, F.F. & Zhang, L. (2016), c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway, Cancer Research 76(11): 3364-3375.
- Gabi W. van Pelt, Torben F. Hansen, Esther Bastiaannet, Sanne Kjær-Frifeldt, J. Han J.M. van Krieken, Rob A.E.M. Tollenaar, Flemming B. Sørensen & Wilma E. Mesker (2016), Stroma-high lymph node involvement predicts poor survival more accurately for patients with stage III colon cancer, Journal of Medical And Surgical Pathology 1(2).
- Holst, S.; Deuss, A.J.M.; Pelt, G.W. van; Vliet, S.J. van; Garcia-Vallejo, J.J.; Koeleman, C.A.M.; Deelder, A.M.; Mesker, W.E.; Tollenaar, R.A.; Rombouts, Y. & Wuhrer, M. (2016), N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression, Molecular and Cellular Proteomics 15(1): 124-140.
- Boonstra Martin C., Prakash Jai, Van De Velde Cornelis J. H., Mesker Wilma E., Kuppen Peter J. K., Vahrmeijer Alexander L. & Sier Cornelis F. M. (2015), Stromal Targets for Fluorescent-Guided Oncologic Surgery, Frontiers in Oncology 5.
- Dekker, T.J.A.; Borg, S. ter; Hooijer, G.K.J.; Meijer, S.L.; Wesseling, J.; Boers, J.E.; Schuuring, E.; Bart, J.; Gorp, J. van; Bult, P.; Riemersma, S.A.; Deurzen, C.H.M. van; Sleddens, H.F.B.M.; Mesker, W.E.; Kroep, J.R.; Smit, V.T.H.B.M. & Vijver, M.J. van de (2015), Quality assessment of estrogen receptor and progesterone receptor testing in breast cancer using a tissue microarray-based approach, Breast Cancer Research and Treatment 152(2): 247-252.
- Dekker, T.J.A.; Borg, S. ter; Hooijer, G.K.J.; Meijer, S.L.; Wesseling, J.; Boers, J.E.; Schuuring, E.; Bart, J.; Gorp, J. van; Bult, P.; Riemersma, S.A.; Deurzen, C.H.M. van; Sleddens, H.F.B.M.; Mesker, W.E.; Kroep, J.R.; Smit, V.T.H.B.M. & Vijver, M.J. van de (2015), Quality assessment of estrogen receptor and progesterone receptor testing in breast cancer using a tissue microarray-based approach (vol 152, pg 247, 2015), Breast Cancer Research and Treatment 152(2): 253-253.
- Dekker, T.J.A.; Charehbili, A.; Smit, V.T.H.B.M.; Dijke, P. ten; Kranenbarg, E.M.K.; Velde, C.J.H. van de; Nortier, J.W.R.; Tollenaar, R.A.E.M.; Mesker, W.E. & Kroep, J.R. (2015), Disorganised stroma determined on pre-treatment breast cancer biopsies is associated with poor response to neoadjuvant chemotherapy: Results from the NEOZOTAC trial, Molecular Oncology 9(6): 1120-1128.
- Mesker, W.E.; Dekker, T.J.A.; Kruijf, E.M. de; Engels, C.C.; Pelt, G.W. van; Smit, V.T.H.B.M. & Tollenaar, R.A.E.M. (2015), Comment on: The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer, British Journal of Cancer 112(11): 1832-1833.
- Velstra, B.; Vonk, M.A.; Bonsing, B.A.; Mertens, B.J.; Nicolardi, S.; Huijbers, A.; Vasen, H.; Deelder, A.M.; Mesker, W.E.; Burgt, Y.E.M. van der & Tollenaar, R.A.E.M. (2015), Serum peptide signatures for pancreatic cancer based on mass spectrometry: a comparison to CA19-9 levels and routine imaging techniques, Journal of Cancer Research and Clinical Oncology 141(3): 531-541.
- Nicolardi, S.; Bladergroen, M.R.; Deelder, A.M.; Tollenaar, R.A.E.M.; Palmblad, M.; Mesker, W. & Burgt, Y.E.M. van der (2015), SPE-MALDI Profiling of Serum Peptides and Proteins by Ultrahigh Resolution FTICR-MS, Chromatographia 78(5-6): 445-449.
- Dekker, T.J.A.; Jones, E.A.; Corver, W.E.; Zeijl, R.J.M. van; Deelder, A.M.; Tollenaar, R.A.E.M.; Mesker, W.E.; Morreau, H. & McDonnell, L.A. (2015), Towards imaging metabolic pathways in tissues, Analytical and Bioanalytical Chemistry 407(8): 2167-2176.
- Voorneveld, P.W.; Kodach, L.L.; Jacobs, R.J.; Noesel, C.J.M. van; Peppelenbosch, M.P.; Korkmaz, K.S.; Molendijk, I.; Dekker, E.; Morreau, H.; Pelt, G.W. van; Tollenaar, R.A.E.M.; Mesker, W.; Hawinkels, L.J.A.C.; Paauwe, M.; Verspaget, H.W.; Geraets, D.T.; Hommes, D.W.; Offerhaus, G.J.A.; Brink, G.R. van den; Dijke, P. ten & Hardwick, J.C.H. (2015), The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC, British Journal of Cancer 112(1): 122-130.
- Huijbers, A.; Mesker, W.E.; Mertens, B.J.; Bladergroen, M.R.; Deelder, A.M.; Burgt, Y.E.M. van der & Tollenaar, R.A.E.M. (2014), Case-controlled identification of colorectal cancer based on proteomic profiles and the potential for screening, Colorectal Disease 16(11): 907-913.
- Dekker, T.J.A.; Balluff, B.D.; Jones, E.A.; Schone, C.D.; Schmitt, M.; Aubele, M.; Kroep, J.R.; Smit, V.T.H.B.M.; Tollenaar, R.A.E.M.; Mesker, W.E.; Walch, A. & McDonnell, L.A. (2014), Multicenter Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) Identifies Proteomic Differences in Breast-Cancer-Associated Stroma, Journal of Proteome Research 13(11): 4730-4738.
- Roeke, T.; Bommel, A.C.M. van; Gaillard-Hemmink, M.P.; Hartgrink, H.H.; Mesker, W.E. & Tollenaar, R.A.E.M. (2014), The additional cancer yield of clinical breast examination in screening of women at hereditary increased risk of breast cancer: a systematic review, Breast Cancer Research and Treatment 147(1): 15-23.
- Braat, A.E.; Pol, R.A.; Oosterhuis, J.W.A.; Vries, J.E. de; Mesker, W.E. & Tollenaar, R.A.E.M. (2014), Excellent prognosis of node negative patients after sentinel node procedure in colon carcinoma: A 5-year follow-up study, EJSO - European Journal of Surgical Oncology 40(6): 747-755.
- Zhou, F.F.; Drabsch, Y.; Dekker, T.J.A.; Vinuesa, A.G. de; Li, Y.H.; Hawinkels, L.J.A.C.; Sheppard, K.A.; Goumans, M.J.; Luwor, R.B.; Vries, C.J. de; Mesker, W.E.; Tollenaar, R.A.E.M.; Devilee, P.; Lu, C.X.; Zhu, H.J.; Zhang, L. & Dijke, P. ten (2014), Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-beta signalling, Nature Communications 5.
- Broersen, L.H.A.; Pelt, G.W. van; Tollenaar, R.A.E.M. & Mesker, W.E. (2014), Clinical application of circulating tumor cells in breast cancer.
- Hawinkels, L.J.A.C.; Paauwe, M.; Verspaget, H.W.; Wiercinska, E.; Zon, J.M. van der; Ploeg, K. van der; Koelink, P.J.; Lindeman, J.H.N.; Mesker, W.; Dijke, P. ten & Sier, C.F.M. (2014), Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts, Oncogene 33(1): 97-107.
- No authors listed (2014), Ultrahigh resolution profiles lead to more detailed serum peptidome signatures of pancreatic cancer, Translational Proteomics.
- Dekker, T.J.A.; Velde, C.J.H. van de; Bruggen, D. van; Mesker, W.E.; Hoeven, J.J.M. van der; Kroep, J.R.; Tollenaar, R.A.E.M. & Smit, V.T.H.B.M. (2013), Quantitative assessment of lymph vascular space invasion (LVSI) provides important prognostic information in node-negative breast cancer, Annals of Oncology 24(12): 2994-2998.
- Dekker, T.J.A.; Charehbili, A.; Smit, V.T.H.B.M.; Wasser, M.N.J.M.; Heijns, J.B.; Warmerdam, L.J. van; Kessels, L.; Dercksen, W.; Pepels, M.; Maartense, E.; Laarhoven, H.W.M. van; Vriens, B.; Kranenbarg, E.M.K.; Velde, C.J.H. van de; Liefers, G.J.; Nortier, H.W.R.; Tollenaar, R.A.E.M.; Mesker, W.E. & Kroep, J.R. (2013), The predictive value of tumor-stroma ratio for radiological and pathological response to neoadjuvant chemotherapy in breast cancer (BC): A Dutch breast cancer trialists' group (BOOG) side-study.
- Holst, S.; Stavenhagen, K.; Balog, C.I.A.; Koeleman, C.A.M.; McDonnell, L.M.; Mayboroda, O.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2013), Investigations on Aberrant Glycosylation of Glycosphingolipids in Colorectal Cancer Tissues Using Liquid Chromatography and Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF-MS), Molecular and Cellular Proteomics 12(11): 3081-3093.
- Dekker, T.J.A.; Velde, C.J.H. van de; Bruggen, D. van; Mesker, W.E.; Hoeven, J.J.M. van der; Tollenaar, R.A.E.M.; Kroep, J.R. & Smit, V. (2013), Quantitative assessment of lymph vascular space invasion (LVSI) provides important prognostic information in node-negative breast cancer patients, European Journal of Cancer 49: S210-S210.
- Dekker, T.J.A.; Charehbili, A.; Smit, V.T.; Kranenbarg, E.M.M.K.; Tollenaar, R.A.E.M.; Velde, C.J.H. van de; Liefers, G.J.; Nortier, J.W.R.; Mesker, W.E. & Kroep, J.R. (2013), Tumor stroma ratio as a predictor for response to neoadjuvant chemotherapy (TAC) in breast cancer (BC): A Dutch Breast Cancer Trialists' Group (BOOG) side-study, European Journal of Cancer 49: S204-S204.
- Zhang, L.; Zhou, F.F.; Vinuesa, A.G. de; Kruijf, E.M. de; Mesker, W.E.; Hui, L.; Drabsch, Y.; Li, Y.H.; Bauer, A.; Rousseau, A.; Sheppard, K.A.; Mickanin, C.; Kuppen, P.J.K.; Lu, C.X. & Dijke, P. ten (2013), TRAF4 Promotes TGF-beta Receptor Signaling and Drives Breast Cancer Metastasis, Molecular Cell 51(5): 559-572.
- Velstra, B.; Bonsing, B.A.; Mertens, B.J.; Burgt, Y.E.M. van der; Huijbers, A.; Vasen, H.; Mesker, W.E.; Deelder, A.M. & Tollenaar, R.A.E.M. (2013), Detection of pancreatic cancer using serum protein profiling, HPB 15(8): 602-610.
- Dekker, T.J.A.; Velde, C.J.H. van de; Pelt, G.W. van; Kroep, J.R.; Julien, J.P.; Smit, V.T.H.B.M.; Tollenaar, R.A.E.M. & Mesker, W.E. (2013), Prognostic significance of the tumor-stroma ratio: validation study in node-negative premenopausal breast cancer patients from the EORTC perioperative chemotherapy (POP) trial (10854), Breast Cancer Research and Treatment 139(2): 371-379.
- Dekker, T.J.A.; Smit, V.T.H.B.M.; Hooijer, G.K.J.; Vijver, M.J. van de; Mesker, W.E.; Tollenaar, R.A.E.M.; Nortier, J.W.R. & Kroep, J.R. (2013), Reliability of core needle biopsy for determining ER and HER2 status in breast cancer, Annals of Oncology 24(4): 931-937.
- Kruijf, E.M. de; Dekker, T.J.A.; Hawinkels, L.J.A.C.; Putter, H.; Smit, V.T.H.B.M.; Kroep, J.R.; Kuppen, P.J.K.; Velde, C.J.H. van de; Dijke, P. ten; Tollenaar, R.A.E.M. & Mesker, W.E. (2013), The prognostic role of TGF-beta signaling pathway in breast cancer patients, Annals of Oncology 24(2): 384-390.
- Kruijf, E.M. de; Dekker, T.J.A.; Hawinkels, L.J.A.C.; Putter, H.; Smit, V.T.H.B.M.; Kroep, J.R.; Kuppen, P.J.K.; Velde, C.J.H. van de; Dijke, P. ten; Tollenaar, R.A.E.M. & Mesker, W.E. (2013), The prognostic role of TGF-beta signaling pathway in breast cancer patients, Annals of Oncology 24(2): 384-390.
- Huijbers, A.; Tollenaar, R.A.E.M.; Pelt, G.W. van; Zeestraten, E.C.M.; Dutton, S.; McConkey, C.C.; Domingo, E.; Smit, V.T.H.B.M.; Midgley, R.; Warren, B.F.; Johnstone, E.C.; Kerr, D.J. & Mesker, W.E. (2013), The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial, Annals of Oncology 24(1): 179-185.
- Huijbers, A.; Tollenaar, R.A.E.M.; Pelt, G.W. van; Zeestraten, E.C.M.; Dutton, S.; McConkey, C.C.; Domingo, E.; Smit, V.T.H.B.M.; Midgley, R.; Warren, B.F.; Johnstone, E.C.; Kerr, D.J. & Mesker, W.E. (2013), The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial.
- Tian, S.; Roepman, P.; Popovici, V.; Michaut, M.; Majewski, I.; Salazar, R.; Santos, C.; Rosenberg, R.; Nitsche, U.; Mesker, W.E.; Bruin, S.; Tejpar, S.; Delorenzi, M.; Bernards, R. & Simon, I. (2012), A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency, Journal of Pathology 228(4): 586-595.
- Dekker, T.J.A.; Borg, S. ter; Hooijer, G.K.J.; Meijer, S.L.; Wesseling, J.; Boers, J.E.; Schuuring, E.; Bart, J.; Gorp, J. van; Mesker, W.E.; Kroep, J.R.; Smit, V.T.H.B.M. & Vijver, M.J. van de (2012), Determining sensitivity and specificity of HER2 testing in breast cancer using a tissue micro-array approach, Breast Cancer Research 14(3): -.
- Velstra Berit, van der Burgt Yuri E. M., Mertens Bart J., Mesker Wilma E., Deelder Andre M. & Tollenaar Rob A. E. M. (2012), Improved classification of breast cancer peptide and protein profiles by combining two serum workup procedures, Journal of Cancer Research and Clinical Oncology 138(12): 1983-1992.
- Nicolardi S, Dalebout H, Bladergroen MR, Mesker WE, Tollenaar RA, Deelder AM & van der Burgt YE (2012), Identification of human serum peptides in fourier transform ion cyclotron resonance precision profiles., International Journal of Proteomics 2012: 804036.
- Velstra, B.; Burgt, Y.E.M. van der; Mertens, B.J.; Mesker, W.E.; Deelder, A.M. & Tollenaar, R.A.E.M. (2012), Improved classification of breast cancer peptide and protein profiles by combining two serum workup procedures., Journal of Cancer Research and Clinical Oncology 138(12): 1983-92.
- Graveland, A.P.; Braakhuis, B.J.M.; Eerenstein, S.E.J.; Bree, R. de; Bloemena, E.; Maaker, M. de; Brekel, M.W.M. van den; Dijk, F.; Mesker, W.E.; Tanke, H.J.; Leemans, C.R. & Brakenhoff, R.H. (2012), Molecular diagnosis of minimal residual disease in head and neck cancer patients, Cellular Oncology 35(5): 367-375.
- Graveland A. Peggy, Braakhuis Boudewijn J. M., Eerenstein Simone E. J., de Bree Remco, Bloemena Elisabeth, de Maaker Michiel, van den Brekel Michiel W. M., Dijk Frederike, Mesker Wilma E., Tanke Hans J., Leemans C. Rene & Brakenhoff Ruud H. (2012), Molecular diagnosis of minimal residual disease in head and neck cancer patients, Cellular Oncology 35(5): 367-375.
- Balog, C.I.A.; Stavenhagen, K.; Fung, W.L.J.; Koeleman, C.A.; McDonnell, L.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2012), N-glycosylation of Colorectal Cancer Tissues.
- Balog, C.I.A.; Stavenhagen, K.; Fung, W.L.J.; Koeleman, C.A.; McDonnell, L.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2012), N-glycosylation of Colorectal Cancer Tissues, Molecular and Cellular Proteomics 11(9): 571-585.
- Mesker, W.; Pelt, V.G.; Gelderblom, H.; Krieken, V.H.; Kerr, D.J. & Tollenaar, R. (2012), THE INTRA-TUMOR STROMA MICROENVIRONMENT IN THERAPY MANAGEMENT FOR COLON CANCER PATIENTS, Annals of Oncology 23: 184-184.
- Balog, C.I.A.; Stavenhagen, K.; Fung, W.L.J.; Koeleman, C.A.; McDonnell, L.A.; Verhoeven, A.; Mesker, W.E.; Tollenaar, R.A.E.M.; Deelder, A.M. & Wuhrer, M. (2012), N-glycosylation of colorectal cancer tissues: a liquid chromatography and mass spectrometry-based investigation.
- Velstra, B.; Mesker, W.E.; Burgt, Y.E.M. van der; Huijbers, A.; Mertens, B.J.; Deelder, A.M. & Tollenaar, R.A.E.M. (2012), Improved sensitivity and specificity for early detection of breast, pancreatic and colorectal cancer using mass spectrometry based serum protein profiles.
- Velstra B., Mesker W. E., van der Burgt Y. E. M., Huijbers A., Mertens B. J., Deelder A. M. & Tollenaar R. A. E. M. (2012), Improved sensitivity and specificity for early detection of breast, pancreatic and colorectal cancer using mass spectrometry based serum protein profiles, British Journal of Surgery 99: S1-S1.
- Huijbers, A.; Pin, E.; Pierobon, M.; Pelt, G.W. van; Belluco, C.; Silvestri, A.; Liotta, L.A.; Tollenaar, R.A.; Petricoin, E. & Mesker, W.E. (2012), Correlation of VEGFR activation within the tumor-associated stroma with an aggressive colon cancer phenotype, Journal of Clinical Oncology 30(15).
- Mesker, W.; Pelt, G. van; Huijbers, A.; Smit; Gelderblom; Johnstone; Krieken van; Kerr & Tollenaar (2012), The intra-tumor stroma microenvironment as a strong prognosticator for colon cancer, European Journal of Cancer 48: S15-S15.
- Huijts, P.E.A.; Dongen, M. van; Goeij, M.C.M. de; Moolenbroek, A.J. van; Blanken, F.; Vreeswijk, M.P.G.; Kruijf, E.M. de; Mesker, W.E.; Zwet, E.W. van; Tollenaar, R.A.E.M.; Smit, V.T.H.B.M.; Asperen, C.J. van & Devilee, P. (2011), Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10, Breast Cancer Research 13(4): -.
- Mesker, W.; Huijbers, A.; Johnstone, E.; Pelt, G. van; Midgley, R.; Morreau, H.; Kerr, D. & Tollenaar, R. (2011), Stroma production within the primary tumor correlates with poor survival for stage 1-11 colon cancer patients, European Journal of Cancer 47: S24-S24.
- Mesker, W.E.; Huijbers, A.; Johnstone, E.C.; Pelt, G.W. van; Midgley, R.; Liefers, G.J.; Morreau, J.; Kerr, D.J. & Tollenaar, R.A.E.M. (2011), Stroma Production Within the Primary Tumour Correlates With Poor Survival for Stage I-II Colon Cancer Patients, European Journal of Cancer 47: S415-S415.
- Mertens, B.J.A.; Burgt, Y.E.M. van der; Velstra, B.; Mesker, W.E.; Tollenaar, R.A.E.M. & Deelder, A.M. (2011), On the use of double cross-validation for the combination of proteomic mass spectral data for enhanced diagnosis and prediction, Statistics and Probability Letters 81(7): 759-766.
- Mesker, W.; Huijbers, A.; Johnstone, E.C.; Pelt, G. van; Midgley, R.; Liefers, G.J.; Morreau, J.; Kerr, D. & Tollenaar, R. (2011), STROMA PRODUCTION WITHIN THE PRIMARY TUMOR CORRELATES WITH POOR SURVIVAL FOR STAGE I-II COLON CANCER PATIENTS, Annals of Oncology 22: v16-v16.
- Staal, E.F.W.C.; Smit, V.T.H.B.M.; Velthuysen, M.L.F. van; Spitzer-Naaykens, J.M.J.; Wouters, M.W.J.M.; Mesker, W.E.; Tollenaar, R.A.E.M. & Sandick, J.W. van (2011), Reproducibility and validation of tumour stroma ratio scoring on oesophageal adenocarcinoma biopsies, European Journal of Cancer 47(3): 375-382.
- Kruijf, E.M. de; Nes, J.G.H. van; Velde, C.J.H.V. de; Putter, H.; Smit, V.T.H.B.M.; Liefers, G.J.; Kuppen, P.J.K.; Tollenaar, R.A.E.M. & Mesker, W.E. (2011), Tumor-stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients.
- Vogelaar, F.J.; Mesker, W.E.; Rijken, A.M.; Pelt, G.W. van; Leeuwen, A.M. van; Tanke, H.J.; Tollenaar, R.A. & Liefers, G.J. (2010), Clinical impact of different detection methods for disseminated tumor cells in bone marrow of patients undergoing surgical resection of colorectal liver metastases: a prospective follow-up study., BMC Cancer 10: 153.
- Huijbers, A.; Velstra, B.; Dekker, T.J.A.; Mesker, W.E.; Burgt, Y.E.M. van der; Mertens, B.J.; Deelder, A.M. & Tollenaar, R.A.E.M. (2010), Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs, International Journal of Molecular Sciences 11(11): 4175-4193.
- Mesker, W.; Johnstone, E.; Huijbers, A.; Pelt, G. van; Midgley, R.; Morreau, H.; Kerr, D. & Tollenaar, R. (2010), STROMA PRODUCTION WITHIN THE PRIMARY TUMOR CORRELATES WITH POOR SURVIVAL FOR STAGE I-II COLON CANCER PATIENTS., Annals of Oncology 21: 207-208.
- Velstra, B.; Mesker, W.E.; Burgt, Y.E.M. van der; Mertens, B.J.; Deelder, A.M. & Tollenaar, R.A.E.M. (2010), Mass spectrometry based serum protein profiling for the early detection of breast cancer: Taking the steps towards clinical implementation., British Journal of Surgery 97: S5-S5.
- Mesker, W.E.; Johnstone, E.C.; Pelt, G.W. van; Midgley, R.; Liefers, G.J.; Morreau, J.; Kerr, D.J. & Tollenaar, R.A.E.M. (2010), Stroma production within the primary tumour correlates with poor survival for stage I-II colon cancer patients, EJC Supplements 8(5): 33-33.
- Doekhie, F.S.; Mesker, W.E.; Kuppen, P.J.; Leeuwen, G.A. van; Morreau, H.; Bock, G.H. de; Putter, H.; Tanke, H.J.; Velde, C.J. van de & Tollenaar, R.A. (2010), Detailed examination of lymph nodes improves prognostication in colorectal cancer, International Journal of Cancer 126(11): 2644-2652.
- Vogelaar, F.J.; Mesker, W.E.; Rijken, A.M.; Pelt, G.W. van; Leeuwen, A.M. van; Tanke, H.J.; Tollenaar, R.A. & Liefers, G.J. (2010), Clinical impact of different detection methods for disseminated tumor cells in bone marrow of patients undergoing surgical resection of colorectal liver metastases: a prospective follow-up study, BMC Cancer 10.
- Staal, E.F.W.C.; Wouters, M.W.J.M.; Sandick, J.W. van; Takkenberg, M.M.; Smit, V.T.H.B.M.; Junggeburt, J.M.C.; Spitzer-Naaykens, J.M.J.; Karsten, T.; Hartgrink, H.H.; Mesker, W.E. & Tollenaar, R.A.E.M. (2010), The stromal part of adenocarcinomas of the oesophagus: Does it conceal targets for therapy?, European Journal of Cancer 46(4): 720-728.
- Mesker WE, Liefers GJ, Junggeburt JMC, van Pelt GW, Alberici P, Kuppen PJK, Miranda NF, van Leeuwen KAM, Morreau H & Szuhai K (2009), Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients, Analytical Cellular Pathology / Cellular Oncology 31(3): 169-178.
- Mesker WE, Junggeburt JMC, Szuhai K, de Heer P, Morreau H, Tanke HJ & Tollenaar RAEM (2007), The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage, Analytical Cellular Pathology / Cellular Oncology 29(5).
- Doekhie FS, Kuppen PJK, Peeters KCMJ, Mesker WE, van Soest RA, Morreau H, de Velde CJH, Tanke HJ & Tollenaar RAEM (2006), Prognostic relevance of occult tumour cells in lymph nodes in colorectal cancer, EJSO - European Journal of Surgical Oncology 32(3).
- Pelikan DM, Kanhai HH, De Groot-Swings GM, Mesker WE, Tanke HJ & Scherjon SA (2006), Fetomaternal hemorrhage in relation to chorionic villus sampling revisited, Prenatal Diagnosis 26(3).
- Mesker WE, Vrolijk H, Sloos WCR, Tollenaar RAEM & Tanke HJ (2006), Detection of tumor cells in bone marrow, peripheral blood and lymph nodes by automated imaging devices, Analytical Cellular Pathology / Cellular Oncology 28(4).
- Doekhie FS, Peeters KCMJ, Kuppen PJK, Mesker WE, Tanke HJ, Morreau H, van de Velde CJH & Tollenaar RAEM (2005), The feasibility and reliability of sentinel node mapping in colorectal cancer, EJSO - European Journal of Surgical Oncology 31(8).
- Doekhie TS, Mesker WE, van Krieken JHJM, Kok NFM, Hartgrink HH, Kranenbarg EK, Putter H, Kuppen PJK, Tanke HJ, Tollenaar RAEM & van de Velde CJH (2005), Clinical relevance of occult tumor cells in lymph nodes from gastric cancer patients, American Journal of Surgical Pathology 29(9).
- Pelikan D, Scherjon S, Mesker W, de Groot-Swings G, Tanke H & Kanhai H (2005), Chorionic villus sampling increases the alpha-fetoprotein level but not the number of fetal erythrocytes in maternal blood., Journal of the Society for Gynecologic Investigation 12(2): 314A-314A.
- Pelikan D, Scherjon S, Mesker W, Groot-Swings G, Tanke H & Kanhai H (2004), Chorionic villus sampling increases the alpha-fetoprotein level but not the numberof fetal erythrocytes in maternal blood, American Journal of Obstetrics and Gynecology 191(6): S72-S72.
- Mesker WE, Torrenga H, Sloos WCR, Vrolijk H, Tollenaar RAEM, de Bruin PC, van Diest PJ & Tanke HJ (2004), Supervised automated microscopy increases sensitivity and efficiency of detection of sentinel node micrometastases in patients with breast cancer, Journal of Clinical Pathology 57(9).
- Pelikan Denise M., Scherjon Sicco A., Mesker Wilma E., de Groot-Swings Godelieve M., Brouwer-Mandema Geeske G., Tanke Hans J. & Kanhai Humphrey H. (2004), Quantification of fetomaternal hemorrhage: A comparative study of the manual and automated microscopic Kleihauer-Betke tests and flow cytometry in clinical samples, American Journal of Obstetrics and Gynecology 191(2): 551-557.
- Tanke HJ, Mesker W, Sloos W, Vrolijk H, Tollenaar R, De Bruin P & Van Diest P (2004), Supervised automated microscopy increases sensitivity and efficiency of detection of sentinel node micrometastases in breast cancer patients, Cytometry Part A 59A(1): 104-104.
- Mesker WE, Torrenga H, Borthwick D, van Diest PJ & Tanke HJ (2003), Improvement of the sensitivity of detecting immunohistochemically stained tumor cells in breast cancer sentinel nodes by supervised automated microscopy., Breast Cancer Research and Treatment 82: S168-S168.
- Mesker WE, Doekhie FS, Vrolijk H, Keyzer R, Sloos WCR, Morreau H, O'Kelly PS, de Bock GH, Tollenaar RAEM & Tanke HJ (2003), Automated analysis of multiple sections for the detection of occult cells in lymph nodes, Clinical Cancer Research 9(13).
- Vrolijk H, Sloos W, Mesker W, Franken P, Fodde R, Morreau H & Tanke H (2003), Automated acquisition of stained tissue microarrays for high-throughput evaluation of molecular targets, Journal of Molecular Diagnostics 5(3).
- Pelikan DMV, Mesker WE, Scherjon SA, Kanhai HHH & Tanke HJ (2003), Improvement of the Kleihauer-Betke test by automated detection of fetal erythrocytes in maternal blood, Cytometry 54B(1).
- Darroudi F, Bezrookove V, Fomina J, Mesker WE, Wiegant JCAG, Raap AK & Tanke HJ (2002), Insights into the sites of X ray and neutron induced chromosomal aberrations in human lymphocytes using COBRA-MFISH, Radiation Protection Dosimetry 99(1-4).
- Oosterwijk JC, Mesker WE, Ouwerkerk-van Velzen MCM, Knepfle CFHM, Wiesmeijer CC, Beverstock GC, van Ommen GJB, Tanke HJ & Kanhai HHH (1998), Fetal cell detection in maternal blood: A multiparameter study in 236 samples using erythroblast morphology, DAB and HbF staining and FISH analysis, European Journal of Human Genetics 6: 82-82.
- Oosterwijk JC, Knepfle CFHM, Mesker WE, Vrolijk H, Sloos WCR, Pattenier H, Ravkin I, van Ommen GJB, Kanhai HHH & Tanke HJ (1998), Strategies for rare-event detection: An approach for automated fetal cell detection in maternal blood, American Journal of Human Genetics 63(6): 1783-1792.
- Oosterwijk JC, Mesker WE, Ouwerkerk-Van Velzen MCM, Knepfle CFHM, Wiesmeijer KC, Beverstock GC, Van Ommen GJB, Tanke HJ & Kanhai HHH (1998), Prenatal diagnosis of trisomy 13 on fetal cells obtained from maternal blood after minor enrichment, Prenatal Diagnosis 18(10): 1082-1085.
- Oosterwijk JC, Mesker WE, Ouwerkerk-van Velzen MCM, Knepfle CFHM, Wiesmeijer KC, van den Burg MJM, Beverstock GC, Bernini LF, van Ommen GJB, Kanhai HHH & Tanke HJ (1998), Development of a preparation and staining method for fetal erythroblasts in maternal blood: Simultaneous immunocytochemical staining and FISH analysis, Cytometry 32(3): 170-177.
- Oosterwijk JC, Mesker WE, Ouwerkerk-van Velzen MCM, Knepfle CFHM, Wiesmeijer KC, Beverstock GC, van Ommen GJB, Kanhai HHH & Tanke HJ (1998), Fetal cell detection in maternal blood: A study in 236 samples using erythroblast morphology, DAB and HbF staining, and FISH analysis, Cytometry 32(3): 178-185.
- van Tol MJD, van den Bergh RL, Mesker W, Ouwerkerk-van Velzen MCM, Vossen JM & Tanke HJ (1998), Simultaneous detection of X and Y chromosomes by two-colour fluorescence in situ hybridization in combination with immunophenotyping of single cells to document chimaerism after sex-mismatched bone marrow transplantation, Bone Marrow Transplantation 21(5): 497-503.
- Oosterwijk JC, Mesker WE, Ouwerkerk MCM, Knepfle CFHM, vanderBurg MJM, Wiesmeijer CC, Beverstock GC, Losekoot M, Bernini LF, vanOmmen GJB, vandeKamp JJP, Kanhai HHH & Tanke HJ (1996), Detection of fetal erythroblasts in maternal blood by onestep gradient enrichment and immunocytochemical recognition, Early Human Development 47: S95-S97.
- Tanke HJ, Oosterwijk JC, Mesker WE, vonVelzen MCMO, Knepfle CM, Wiesmeyer CC, vonOmmen GJB, Kanhai HHH & Vrolijk J (1996), Detection of 'rare event' fetal erythroblasts in maternal blood using automated microscopy, Early Human Development 47: S89-S93.
- Mesker WE, Alers JC, Sloos WCR, Vrolijk H, Raap AK, Dekken HV & Tanke HJ (1996), Automated assessment of numerical chromosomal aberrations in paraffin embedded prostate tumor cells stained by in situ hybridization, Cytometry 26(4): 298-304.
- Vrolijk H, Sloos WCR, vandeRijke FM, Mesker WE, Netten H, Young IT, Raap AK & Tanke HJ (1996), Automation of spot counting in interphase cytogenetics using brightfield microscopy, Cytometry 24(2): 158-166.
- BOLAND GJ, MESKER WE, DOORN R, PLOEMZAAIJER JJ, TANK HJ & DEGAST GC (1995), DETECTION IMPROVEMENT OF CYTOMEGALOVIRUS ANTIGEN IN HUMAN PERIPHERAL-BLOOD USING MONOCLONAL-ANTIBODIES AND AUTOMATED READING OF CELL PREPARATIONS, European Journal of Clinical Investigation 25(9): 639-646.
- MESKER WE, KNEPFLE CFHM, PLOEMZAAIJER JJ, SCHIPPER NW, BOLAND GJ & TANKE HJ (1995), AUTOMATED SCREENING FOR CYTOMEGALOVIRUS-INFECTED CELLS USING IMAGE-ANALYSIS - COMPARISON OF 2 IMMUNOENZYMATIC STAINING METHODS WITH RESPECT TO COLOR SEGMENTATION, Analytical Cellular Pathology 8(1): 27-37.
- MESKER WE, VANDERBURG MJM, OUD PS, KNEPFLE CFHM, OUWERKERKVONVELZEN MCM, SCHIPPER NW & TANKE HJ (1994), DETECTION OF IMMUNOCYTOCHEMICALLY STAINED RARE EVENTS USING IMAGE-ANALYSIS, Cytometry 17(3): 209-215.
- JIWA NM, MESKER WE, PLOEMZAAIJER JJ, VANDORP W, THE TH & RAAP AK (1994), QUANTIFICATION OF LOW-FREQUENCY WHITE BLOOD-CELLS EXPRESSING HUMAN CYTOMEGALOVIRUS ANTIGEN BY IMAGE CYTOMETRY, Cytometry 16(1): 69-73.
- PLOEMZAAIJER JJ, MESKER WE, BOLAND GJ, SLOOS WCR, VANDERIJKE FM, JIWA M & RAAP AK (1994), AUTOMATED IMAGE CYTOMETRY FOR DETECTION OF RARE, VIRAL ANTIGEN-POSITIVE CELLS IN PERIPHERAL-BLOOD, Cytometry 15(3): 199-206.
- GILCHRIST KW, GRAY R, VANDRIELKULKER AMJ, MESKER WE, PLOEMZAAIJER JJ, PLOEM JS, TAYLOR SG & TORMEY DC (1993), HIGH DNA CONTENT AND PROGNOSIS IN LYMPH-NODE POSITIVE BREAST-CANCER - A CASE-CONTROL STUDY BY THE UNIVERSITY OF LEIDEN AND ECOG, Breast Cancer Research and Treatment 28(1): 1-8.
- MANSI JL, MESKER WE, MCDONNELL T, VANDRIELKULKER AMJ, PLOEM JS & COOMBES RC (1988), AUTOMATED SCREENING FOR MICRO-METASTESES IN BONE-MARROW SMEARS, Journal of Immunological Methods 112(1): 105-111.
- STOCKLE M, TANKE HJ, MESKER WE, PLOEM JS, JONAS U & HOHENFELLNER R (1987), AUTOMATED DNA-IMAGE CYTOMETRY - A PROGNOSTIC TOOL IN INFILTRATING BLADDER-CARCINOMA.
- RODENBURG CJ, PLOEMZAAIJER JJ, CORNELISSE CJ, MESKER WE, HERMANS J, HEINTZ PAM, PLOEM JS & FLEUREN GJ (1987), USE OF DNA IMAGE CYTOMETRY IN ADDITION TO FLOW-CYTOMETRY FOR THE STUDY OF PATIENTS WITH ADVANCED OVARIAN-CANCER, Cancer Research 47(15): 3938-3941.
- VANDRIELKULKER AMJ, MESKER WE, VANVELZEN I, TANKE HJ, FEICHTINGER J & PLOEM JS (1985), PREPARATION OF MONOLAYER SMEARS FROM PARAFFIN-EMBEDDED TISSUE FOR IMAGE CYTOMETRY, Cytometry 6(3): 268-272.