Robin Hartman
Hoofd bedrijfshulpverlening
- Naam
- Ing. R.J. Hartman
- Telefoon
- +31 623262 122
- r.hartman@science.leidenuniv.nl
- ORCID iD
- 0000-0002-3078-3814
Hoofd bedrijfshulpverlening
- Wiskunde en Natuurwetenschappen
- Bedrijfsvoering
- Arbo- en milieudienst
- Puris E., Auriola S., Petralla S., Hartman R., Gynther M., Lange E.C.M. de & Fricker G. (2022), Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model, Neurobiology of Disease 169: 105741.
- Brink W.J. van den, Hartman R.J., Berg D.J. van den, Flik G., Gonzalez-Amoros B., Koopman N., Elassais-Schaap J., Graaf P.H. van der, Hankemeier T. & Lange E.C.M. de (2019), Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain, CPT: Pharmacometrics and Systems Pharmacology 8(2): 107-117.
- Wong Y.C., Ilkova T.I., Wijk R.C. van, Hartman R.J. & Lange E.C.M. de (2018), Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in nonanesthetized rat, European Journal of Pharmaceutical Sciences 111: 514–525.
- Brink W.J. van den, Berg D.J. van den, Bonsel F.E.M., Hartman R.J., Wong Y.C., Graaf P.H. van der & Lange E.C.M. de (2018), Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling, British Journal of Pharmacology 175(19): 3832-3843.
- Kervezee L., Berg D.J. van den, Hartman R.J., Meijer J.H. & Lange E.C.M. de (2017), Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite, European Journal of Pharmaceutical Sciences 109: S122-S130.
- Yamamoto Y., Valitalo P.A.J., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Beukers M.W., Berg D.J. van den, Hartman R.J., Wong Y.C., Danhof M., Hasselt J.G.C. van & Lange E.C.M. de (2017), Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model, CPT: Pharmacometrics and Systems Pharmacology 6(11): 765–777.
- Shimizu S., Hoedt S.M. den, Mangas-Sanjuan V., Cristea S., Geuer J.K., Berg D.-J. van den, Hartman R., Bellanti F. & Lange E.C.M. de (2017), Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat, Drug Metabolism and Disposition 45(2): 152-159.
- Yamamoto Y., Välitalo P.A., Berg D.J. van den, Hartman R.J., Brink W. van den, Wong Y.C., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Bakshi S.D., Aranzana-Climent V., Marchand S., Dahyot-Fizelier C., Couet W., Danhof M., Hasselt J.G.C. van & Lange E.C.M. de (2017), A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations, Pharmaceutical Research 34(2): 333–351.
- Kervezee L., Hartman R.J., Berg D.J. van den, Shimizu S., Yamamoto Y., Meijer J.H. & Lange E.C.M. de (2014), Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain, AAPS Journal 16(5): 1029-1037.
- Westerhout J., Van den Berg D.J., Hartman R., Danhof M. & De Lange E.C. (2014), Prediction of methotrexate CNS distribution in different species - influence of disease conditions, European Journal of Pharmaceutical Sciences 2014(Jan 22): 0928-0987.
- Rip J., Chen L., Hartman R., Heuvel A. van den, Reijerkerk A., Kregten J. van, Boom B. van der, Appeldoorn C., Boer M. de, Maussang D., Lange E.C. de & Gaillard P.J. (2014), Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats, Journal of Drug Targeting 22(3): .
- Chakravarthy S., Keck T., Roelandse M., Hartman R.J., Jeromin A., Perry S., Hofer S.B., Mrsic-Flogel T. & Levelt C.N. (2008), Cre-dependent expression of multiple transgenes in isolated neurons of the adult forebrain, PLoS ONE 3(8): 3059.
- Heimel J.A., Hartman R.J., Hermans J.M. & Levelt C.N. (2007), Screening mouse vision with intrinsic signal optical imaging, European Journal of Neuroscience 25(3): 795-804.
- Chakravarthy S., Saiepour M.H., Bence M., Perry S., Hartman R.J., Couey J.J., Mansvelder H.D. & Levelt C.N. (2006), Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus, Proceedings of the National Academy of Sciences 103(4): 1071-1076.
- Abrahamse S.L., Runnard Heimel P. van, Hartman R.J., Chamuleau R.A. & Gulik T.M. van (2003), Induction of necrosis and DNA fragmentation during hypothermic preservation of hepatocytes in UW, HTK, and Celsior solutions, Cell Transplantation 12(1): 59-68.
- Abrahamse S.L., Kerkhove M.P. van de, Sosef M.N., Hartman R., Chamuleau R.A. & Gulik T.M. van (2002), Treatment of acute liver failure in pigs reduces hepatocyte function in a bioartificial liver support system, International Journal of Artificial Organs 25(10): 966-974.
- Sosef M.N., Abrahamse L.S., Kerkhove M.P. van de, Hartman R.J., Chamuleau R.A. & Gulik T.M. van (2002), Assessment of the AMC-bioartificial liver in the anhepatic pig, Transplantation 73(2): 204-209.
- Straatsburg I.H., Abrahamse S.L., Song S.W., Hartman R.J. & Gulik T.M. van (2002), Evaluation of rat liver apoptotic and necrotic cell death after cold storage using UW, HTK, and Celsior, Transplantation 74(4): 458-464.