Peter Bredenbeek
- Naam
- Dr. P.J. Bredenbeek
- Telefoon
- +31 71 526 1655
- p.j.bredenbeek@lumc.nl
- Faculteit Geneeskunde
- Divisie 4
- Medische Microbiologie
- Thaler, M.; Wang, Y.; Does, A.M. van der; Faiz, A.; Ninaber, D.K.; Ogando, N.S.; Beckert, H.; Taube, C.; Salgado-Benvindo, C.; Snijder, E.J.; Bredenbeek, P.J.; Hiemstra, P.S. & Hemert, M.J. van (2023), Impact of changes in human airway epithelial cellular composition and differentiation on SARS-CoV-2 infection biology, Journal of Innate Immunity.
- Myeni, S.K.; Bredenbeek, P.J.; Knaap, R.C.M.; Dalebout, T.J.; Morales, S.T.; Sidorov, I.A.; Linger, M.E.; Oreshkova, N.; Zanen-Gerhardt, S. van; Zander, S.A.L.; Enjuanes, L.; Sola, I.; Snijder, E.J. & Kikkert, M. (2023), Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase, Nature Communications 14(1).
- Pardieck, I.N.; Sluis, T.C. van der; Gracht, E.T.I. van der; Veerkamp, D.M.B.; Behr, F.M.; Duikeren, S. van; Beyrend, G.; Rip, J.; Nadafi, R.; Nejad, E.B.; Mulling, N.; Brasem, D.J.; Camps, M.G.M.; Myeni, S.K.; Bredenbeek, P.J.; Kikkert, M.; Kim, Y.; Cicin-Sain, L.; Abdelaal, T.; Gisbergen, K.P.J.M. van; Franken, K.L.M.C.; Drijfhout, J.W.; Melief, C.J.M.; Zondag, G.C.M.; Ossendorp, F. & Arens, R. (2022), A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection, Nature Communications 13(1).
- Oreshkova, N.; Myeni, S.K.; Mishra, N.; Albulescu, I.C.; Dalebout, T.J.; Snijder, E.J.; Bredenbeek, P.J.; Dallmeier, K. & Kikkert, M. (2021), A Yellow Fever 17D virus replicon-based vaccine platform for emerging Coronaviruses, Vaccines 9(12).
- Dilweg, I.W.; Savina, A.; Kothe, S.; Gultyaev, A.P.; Bredenbeek, P.J. & Olsthoorn, R.C.L. (2021), All genera of Flaviviridae host a conserved Xrn1-resistant RNA motif, RNA Biology 18(12): 2321-2329.
- Ogando, N.S.; Zevenhoven-Dobbe, J.C.; Meer, Y. van der; Bredenbeek, P.J.; Posthuma, C.C. & Snijder, E.J. (2020), The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2, Journal of Virology 94(23).
- Sanchez-Velazquez, R.; Lorenzo, G. de; Tandavanitj, R.; Setthapramote, C.; Bredenbeek, P.J.; Bozzacco, L.; MacDonald, M.R.; Clark, J.J.; Rice, C.M.; Patel, A.H.; Kohl, A. & Varjak, M. (2020), Generation of a reporter yellow fever virus for high throughput antiviral assays, Antiviral Research 183.
- Dilweg, I.W.; Bouabda, A.; Dalebout, T.; Gultyaev, A.P.; Bredenbeek, P.J. & Olsthoorn, R.C.L. (2020), Xrn1-resistant RNA structures are well-conserved within the genus flavivirus, RNA Biology 18(5).
- MacFadden, A.; O'Donoghue, Z.; Silva, P.A.G.C.; Chapman, E.G.; Olsthoorn, R.C.; Sterken, M.G.; Pijlman, G.P.; Bredenbeek, P.J. & Kieft, J.S. (2018), Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs, Nature Communications 9.
- Boheemen, S. van; Tas, A.; Anvar, S.Y.; Grootveld, R. van; Albulescu, I.C.; Bauer, M.P.; Feltkamp, M.C.; Bredenbeek, P.J. & Hemert, M.J. van (2017), Quasispecies composition and evolution of a typical Zika virus clinical isolate from Suriname, Scientific Reports 7.
- Rabouw, H.H.; Langereis, M.A.; Knaap, R.C.M.; Dalebout, T.J.; Canton, J.; Sola, I.; Enjuanes, L.; Bredenbeek, P.J.; Kikkert, M.; Groot, R.J. de & Kuppeveld, F.J.M. van (2016), Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses, PLoS Pathogens 12(10).
- Jiang, X.; Dalebout, T.J.; Lukashevich, I.S.; Bredenbeek, P.J. & Franco, D. (2015), Molecular and immunological characterization of a DNA-launched yellow fever virus 17D infectious clone, Journal of General Virology 96: 804-814.
- Bailey-Elkin, B.A.; Knaap, R.C.M.; Johnson, G.G.; Dalebout, T.J.; Ninaber, D.K.; Kasteren, P.B. van; Bredenbeek, P.J.; Snijder, E.J.; Kikkert, M. & Mark, B.L. (2014), Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression, Journal of Biological Chemistry 289(50): 34667-34682.
- Saiyasombat, R.; Carrillo-Tripp, J.; Miller, W.A.; Bredenbeek, P.J. & Blitvich, B.J. (2014), Substitution of the premembrane and envelope protein genes of Modoc virus with the homologous sequences of West Nile virus generates a chimeric virus that replicates in vertebrate but not mosquito cells, Virology Journal 11.
- Belgnaoui, S.M.; Paz, S.; Samuel, S.; Goulet, M.L.; Sun, Q.; Kikkert, M.; Iwai, K.; Dikic, I.; Hiscott, J. & Lin, R.T. (2012), Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex, Cell Host and Microbe 12(2): 211-222.
- Kasteren, P.B. van; Beugeling, C.; Ninaber, D.K.; Frias-Staheli, N.; Boheemen, S. van; Garcia-Sastre, A.; Snijder, E.J. & Kikkert, M. (2012), Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling, Journal of Virology 86(2): 773-785.
- Roukens, A.H.; Soonawala, D.; Joosten, S.A.; Visser, A.W. de; Jiang, X.H.; Dirksen, K.; Gruijter, M. de; Dissel, J.T. van; Bredenbeek, P.J. & Visser, L.G. (2011), Elderly Subjects Have a Delayed Antibody Response and Prolonged Viraemia following Yellow Fever Vaccination: A Prospective Controlled Cohort Study, PLoS ONE 6(12): -.
- Jiang, X.H.; Dalebout, T.J.; Bredenbeek, P.J.; Carrion, R.; Brasky, K.; Patterson, J.; Goicochea, M.; Bryant, J.; Salvato, M.S. & Lukashevich, I.S. (2011), Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs, Vaccine 29(6): 1248-1257.
- Yi, Z.G.; Sperzel, L.; Nurnberger, C.; Bredenbeek, P.J.; Lubick, K.J.; Best, S.M.; Stoyanov, C.T.; Law, L.M.J.; Yuan, Z.H.; Rice, C.M. & MacDonald, M.R. (2011), Identification and Characterization of the Host Protein DNAJC14 as a Broadly Active Flavivirus Replication Modulator, PLoS Pathogens 7(1).
- Silva, P.A.G.C.; Pereira, C.F.; Dalebout, T.J.; Spaan, W.J.M. & Bredenbeek, P.J. (2010), An RNA Pseudoknot Is Required for Production of Yellow Fever Virus Subgenomic RNA by the Host Nuclease XRN1, Journal of Virology 84(21): 11395-11406.
- Roukens AH, Vossen AC, Bredenbeek PJ, van Dissel JT & Visser LG (2008), Intradermally Administered Yellow Fever Vaccine at Reduced Dose Induces a Protective Immune Response: A Randomized Controlled Non-Inferiority Trial, PLoS ONE 3(4).
- Versteeg GA, van de Nes PS, Bredenbeek PJ & Spaan WJM (2007), The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations, Journal of Virology 81(20).
- Silva PAGC, Molenkamp R, Dalebout TJ, Charlier N, Neyts JH, Spaan WJM & Bredenbeek PJ (2007), Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3 ' stem-loop structure is not required for replication, Journal of General Virology 88.
- Versteeg GA, Bredenbeek PJ, van den Worm SHE & Spaan WJM (2007), Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition, Virology 361(1).
- Versteeg G.A., Nes P. van de, Bredenbeek P.J. & Spaan W.J.M. (2007), The coronavirus spike protein induces Endoplasmic Reticulum Stress and upregulation of intracellular chemokine mRNA concentrations, Journal of Virology 81(20): 10981-10990.
- Bredenbeek PJ, Molenkamp R, Spaan WJM, Deubel V, Marianneau P, Salvato MS, Moshkoff D, Zapata J, Tikhonov C, Patterson J, Carrion R, Ticer A, Brasky K & Lukashevich IS (2006), A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins, Virology 345(2).
- Charlier N, Molenkamp R, Leyssen P, Paeshuyse J, Drosten C, Panning M, De Clercq E, Bredenbeek PJ & Neyts J (2004), Exchanging the yellow fever virus envelope proteins with modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice, Journal of Virology 78(14).
- Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LLM, Guan Y, Rozanov M, Spaan WJM & Gorbalenya AE (2003), Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage, Journal of Molecular Biology 331(5): 991-1004.
- Reusken CBEM, Dalebout TJ, Eerligh P, Bredenbeek PJ & Spaan WJM (2003), Analysis of hepatitis C virus/classical swine fever virus chimeric 5 ' NTRs: sequences within the hepatitis C virus IRES are required for viral RNA replication, Journal of General Virology 84.
- Bredenbeek PJ, Kooi EA, Lindenbach B, Huijkman N, Rice CM & Spaan WJM (2003), A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication, Journal of General Virology 84.
- Charlier N, Molenkamp R, Leyssen P, Vandamme AM, De Clercq E, Bredenbeek P & Neyts J (2003), A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses, Journal of Virological Methods 108(1).
- De Beeck AO, Molenkamp R, Caron M, Ben Younes A, Bredenbeek P & Dubuisson J (2003), Role of the transmembrane domains of prM and E proteins in the formation of yellow fever virus envelope, Journal of Virology 77(2).
- Molenkamp R, Kooi EA, Lucassen MA, Greve S, Thijssen JCP, Spaan WJM & Bredenbeek PJ (2003), Yellow fever virus replicons as an expression system for hepatitis C virus structural proteins, Journal of Virology 77(2).
- Rijnbrand R, Bredenbeek PJ, Haasnoot PC, Keift JS, Spaan WJM & Lemon SM (2001), The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs, RNA 7(4).
- Rijnbrand R, vanderStraaten T, vanRijn PA, Spaan WJM & Bredenbeek PJ (1997), Internal entry of ribosomes is directed by the 5' noncoding region of classical swine fever virus and is dependent on the presence of an RNA pseudoknot upstream of the initiation codon, Journal of Virology 71(1): 451-457.
- Rijnbrand RCA, Abbink TEM, Haasnoot PCJ, Spaan WJM & Bredenbeek PJ (1996), The influence of AUG codons in the hepatitis C virus 5' nontranslated region on translation and mapping of the translation initiation window, Virology 226(1): 47-56.
- RIJNBRAND R, BREDENBEEK P, VANDERSTRAATEN T, WHETTER L, INCHAUSPE G, LEMON S & SPAAN W (1995), ALMOST THE ENTIRE 5' NON-TRANSLATED REGION OF HEPATITIS-C VIRUS IS REQUIRED FOR CAP-INDEPENDENT TRANSLATION, FEBS Letters 365(2-3): 115-119.
- VANDERMOST RG, BREDENBEEK PJ & SPAAN WJM (1991), A DOMAIN AT THE 3' END OF THE POLYMERASE GENE IS ESSENTIAL FOR ENCAPSIDATION OF CORONAVIRUS DEFECTIVE INTERFERING RNAS, Journal of Virology 65(6): 3219-3226.
- Snijder EJ, den Boon JA, Bredenbeek PJ, Horzinek MC, Rijnbrand R & Spaan WJM (1990), The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro-viruses and coronaviruses are evolutionarily related, Nucleic Acids Research 18(15): 4535-4542.
- DEVRIES AAF, CHIRNSIDE ED, BREDENBEEK PJ, GRAVESTEIN LA, HORZINEK MC & SPAAN WJM (1990), ALL SUBGENOMIC MESSENGER-RNAS OF EQUINE ARTERITIS VIRUS CONTAIN A COMMON LEADER SEQUENCE, Nucleic Acids Research 18(11): 3241-3247.