Johan Meerman
Onderzoeker / gast
- Naam
- Dr. J.H.N. Meerman
- Telefoon
- +31 71 527 6270
- j.h.n.meerman@lacdr.leidenuniv.nl
Onderzoeker / gast
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Wester L., Venneker S., Hazenoot M., Pont C.M., Koedoot E., Timmermans A.M., Martens J.W.M., Jansen M.P.H.M., Kockx C.E.M., IJcken W.F.J. van, Meerman J.H.N., Zhang Y. & Water B. van de (2022), A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer, Biochemical Pharmacology 204: 115233.
- Hiemstra S., Ramaiahgari S.C., Wink S., Callegaro G., Coonen M., Meerman J., Jennen D., Nieuwendijk K. van den, Dankers A., Snoeys J., Bont H. de, Price L. & Water B. van de (2019), High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability, Archives of Toxicology 93(10): 2895-2911.
- Fredriksson L., Wink S., Herpers B.H.A., Benedetti G., Hadi M., Bont H.J.G.M. de, Groothuis G., Luijten M., Danen E.H.J., Graauw M. de, Meerman J.H.N. & Water B. van de (2014), Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity, Toxicological Sciences 140(1): 144-159.
- Truong H.H., Xiong J., Ghotra V.P, Nirmala .E, Haazen L.C.J.M., Dévédec S.E. le, Balcioğlu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H. (2014), β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer, Science Signaling 7(312): ra15.
- Di Z., Klop M.J.D., Rogkoti V.M., Le Dèvèdec S.E., Water B. van de, Verbeek F.J., Price L.S. & Meerman J.H.N. (2014), Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues, PLoS ONE 9(10): e109688.
- Moerkens M., Zhang Y., Wester L., Water B. van de & Meerman J.H.N. (2014), Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation, BMC Cancer 14: 283.
- Truong H.H., Xiong J., Ghotra V.P.S., Nirmala E., Haazen L., Le Dévédec S.E., Balcioglu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H.J. (2014), beta(1) Integrin Inhibition Elicits a Prometastatic Switch Through the TGF beta-miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer, Science Signaling 7(312): ra15.
- Benedetti G., Fredriksson L., Herpers B., Meerman J., Water B. van de & Graauw M. de (2013), TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells, Biochemical Pharmacology 85(2): 274-86.
- Benedetti G., Fokkelman M., Yan K., Fredriksson L., Herpers B., Meerman J., Water B. van de & Graauw M. de (2013), The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch, Molecular Pharmacology 84(1): 128-38.
- Di Z., Herpers B.H.A., Fredriksson L., Yan K., Water B. van de, Verbeek F.J. & Meerman J.H.N. (2012), Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening, PLoS ONE 7(12): e52337.
- Zhang Y., Moerkens M., Ramaiahgari S., Bont H.J.G.M. de, Price L., Meerman J.H.N. & Water B. van de (2011), Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes, Breast cancer research 13(3): R52.
- Verissimo C.S., Molenaar J.J., Meerman J.H.N., Puigvert J.C., Lamers F., Koster J., Danen E.H., Water B. van de, Versteeg R., Fitzsimons C.P. & Vreugdenhil E.H.J. (2010), Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells, Endocrine-Related Cancer 17(2): 399-414.
- Dijkmans T.F., Hooijdonk L.C. van, Schouten T.G., Kamphorst J.T., Verhoeven A.C., Meerman J.H.N. & et al (2008), Temporal and functional dynamics of the transcriptome during Nerve Growth Factor-induced differentiation, Journal of Neurochemistry 105(6): 2388-2403.
- Liempd S.M. van, Kool J., Meerman J.H.N., Irth H. & Vermeulen N.P. (2007), Metabolic Profiling of Endocrine-Disrupting Compounds by On-Line Cytochrome P450 Bioreaction Coupled to On-Line Receptor Affinity Screening, Chemical Research in Toxicology : .
- Kool J., Eggink M., Rossum H. van, Liempd S.M. van, Elswijk D.A. van, Irth H., Commandeur J.N.M., Meerman J.H.N. & Vermeulen N.P. (2007), Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures, J. Biomol. Screen. 12(3): 396-405.
- Gurer-Orhan H., Orhan H., Vermeulen N.P. & Meerman J.H.N. (2006), Screening the oxidative potential of several mono- and di-halogenated biphenyls and biphenyl ethers in rat hepatocytes, Combinatorial Chemistry & High Throughput Screening 9(6): 449-454.
- Kool J., Ramautar J.R., Liempd S.M. van, Beckman J., Kanter F.J.J. de, Meerman J.H.N., Schenk T., Irth H., Commandeur J.N.M. & Vermeulen N.P. (2006), Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen, Journal of Medicinal Chemistry 49(11): 3287-3292.
- Orhan H., Gurer-Orhan H., Vriese E., Vermeulen N.P. & Meerman J.H.N. (2006), Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes, Toxicology In Vitro 20(6): 1005-1013.
- Lipzig M.M.H. van, Laak A.M. ter, Jongejan A., Vermeulen N.P.E., Wamelink M., Geerke D. & Meerman J.H.N. (2004), Prediction of ligand binding affinity and orientation of (xeno) estrogens to the estrogen receptor (Era) by molecular dynamics simulations and the linear interaction energy (LIE) mtehod, Journal of Medicinal Chemistry 47: 1018-1030.
- Orhan H., Holland B. van, Krab B., Moeken J., Vermeulen N.P.E., Hollander P. den & Meerman J.H.N. (2004), One hour of exercise increases urinary excetion of lipid, protein, and DNA oxidation products in man as determined by a comprehensive multiparameter biomarker set, Free Radical Research 38(12): 1269-1279.
- Orhan H., Holland B. van, Krab B., Moeken J., Vermeulen N.P.E., Hollander P. den & Meerman J.H.N. (2004), Evaluation of a multi-parameter biomarker set for oxidative damage in man: increased urinary excretion of lipid, protein and DNA-oxidation products after one hour of exercise, Free Radical Research 38: 1269-1279.
- Murk A.J., Legler J., Lipzig M.M.H. van, Meerman J.H.N., Belfroid A.C., Spenkelink A., Burg B. van der, Rijs G.B. & Vethaak D. (2002), Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays, Environmental Toxicology and Chemistry 21(1): 16-23.
- Vermeulen N.P.E., Groot M.J. de, Meerman J.H.N. & Venhorst J. (1998), Modeling the active sites of cytochrome P450s, one of the most important biotransformation enzymes. In: , Proceedings XVth EFMC International Symposium on Medicinal Chemistry. Edinburgh, UK.
- Vermeulen N.P.E., Groot M.J. de, Meerman J.H.N. & Venhorst J. (1998), Modeling the active sites of cytochrome P450s, one of the most important biotransformation enzymes. In: , Proceedings 7th SETAC-Europe Annual Meting COST. Liege, Frankrijk.
- Zwart L.L. de, Meerman J.H.N., Commandeur J.N.M. & Vermeulen N.P.E. (1998), Biomarkers of free radical damage. Applications in experimental animals and in humans, Free Radical Biology and Medicine 26: 202-226.
- Zwart L.L. de, Hermanns R.C.A., Meerman J.H.N., Commandeur J.N.M., Salemink P.J.M. & Vermeulen N.P.E. (1998), Excretion of multiple urinary biomarkers for radical-induced damage in rats treated with three different nephrotoxic compounds, Biomarkers 3(4/5): 347-365.
- Zwart L.L. de, Hermanns R.C.A., Meerman J.H.N., Commandeur J.N.M., Salemink P.J.M. & Vermeulen N.P.E. (1998), Evaluation of urinary biomarkers for radical-induced liver damage in rats treated with carbon tetrachloride, Toxicology and Applied Pharmacology 148(1): 71-82.
- Gijssel H.E. van, Gijlswijk R.P.M. van, Haas R.R., Stark C., Mulder G.J. & Meerman J.H.N. (1998), Immunohistochemical visualisation of wildtype p53 protein in paraffin-embedded rat liver using tyramine amplification: zonal distribution of p53 protein after N-hydroxy-2-acetylaminofluorene administration, Carcinogenesis 19: 219-222.
- Beerendonk G.J.M. van, Klein J.C., Tijdens R.B., Lichtenauer-Kaligis E.G.R., Tasseron-de Jong J.G. & Meerman J.H.N. (1998), Lack of mammalian mutagenicity of the potent bacterial mutagen tris (2,3-dibromopropyl) phosphate and its metabolite 2-bromoacrolein, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 415: 201-211.