Indira Nederpelt
Promovendus / gast
- Naam
- I. Nederpelt MSc
- Telefoon
- +31 71 527 4266
- i.nederpelt@lacdr.leidenuniv.nl
Promovendus / gast
- Wiskunde en Natuurwetenschappen
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Nederpelt I., Kuzikov M., Witte W.E.A. de, Schnider P., Tuijt B., Gul S., IJzerman A.P., Lange E.C.M. de & Heitman L.H. (2017), From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action, Scientific Reports 7: 14169.
- Nederpelt I. (6 april 2017), Time is of the essence - investigating kinetic interactions between drug, endogenous neuropeptides and receptor (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Science, Leiden University). Promotor(en) en copromotor(en): IJzerman A.P., Heitman L.H.
- Schuetz D.A., Witte W.E.A. de, Wong Y.C, Knasmueller B., Richter L., Kokh D.B., Sadiq S.K., Bosma R., Nederpelt I., Heitman L.H., Segala E., Amaral M., Guo D., Andres D., Georgi V., Stoddart L.A., Hill S., Cooke R.M., Graaf C. de, Leurs R., Frech M., Wade R.C., Lange E.C.M. de, IJzerman A.P., Mueller-Fahrnow A. & Ecker G.F. (2017), Kinetics for Drug Discovery: an industry-driven effort to target drug residence time, Drug Discovery Today 22(6): 896-911.
- Nederpelt I., Bunnik J., IJzerman A.P. & Heitman L.H. (2016), Kinetic profile of neuro-peptide-receptor interactions, Trends in Neurosciences 39: 830.
- Nederpelt I., Bleeker D., Tuijt B., IJzerman A.P. & Heitman L.H. (2016), Kinetic binding and activation profiles of endogenous tachykinins targeting the NK1 receptor, Biochemical Pharmacology 118: 88-95.
- Witte W.E., Wong Y.C., Nederpelt I., Heitman L.H., Danhof M., Graaf P.H. van der, Gilissen R.A. & De Lange E.C. (2016), Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients, Expert Opinion on Drug Discovery 11(1): 45-63.
- Nederpelt I., Vergroesen R.D., IJzerman A.P. & Heitman L.H. (2016), Persistent GnRH receptor activation in pituitary αT3-1 cells analyzed with a label-free technology, Biosensors and Bioelectronics 79: 721-727.
- Nederpelt I., Georgi V., Schiele F., Nowak-Reppel K., Fernández-Montalván A.E., IJzerman A.P. & Heitman L.H. (2016), Characterization of 12 GnRH peptide agonists : a kinetic perspective, British Journal of Pharmacology 173(1): 128-141.
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