Harm Vrieling
- Naam
- Dr. H. Vrieling
- Telefoon
- +31 71 526 9610
- h.vrieling@lumc.nl
- Faculteit Geneeskunde
- Divisie 4
- Humane Genetica
- Drake, C.; Wehr, M.M.; Zobl, W.; Koschmann, J.; Lucca, D. de; Kuhne, B.A.; Hansen, T.; Knebel, J.; Ritter, D.; Boei, J.; Vrieling, H.; Bitsch, A. & Escher, S.E. (2023), Substantiate a read-across hypothesis by using transcriptome data-A case study on volatile diketones, Frontiers in Toxicology 5.
- Sampadi, B.; Vermeulen, S.; Misovic, B.; Boei, J.J.; Batth, T.S.; Chang, J.G.; Paulsen, M.T.; Magnuson, B.; Schimmel, J.; Kool, H.; Olie, C.S.; Everts, B.; Vertegaal, A.C.O.; Olsen, J.V.; Ljungman, M.; Jeggo, P.A.; Mullenders, L.H.F. & Vrieling, H. (2022), Divergent molecular and cellular responses to low and high-dose Ionizing radiation, Cells 11(23).
- Sampadi, B.; Mullenders, L.H.F. & Vrieling, H. (2022), Low and high doses of ionizing radiation evoke discrete global (phospho) proteome responses, DNA Repair 113.
- Wijk, L.M. van; Kramer, C.J.H.; Vermeulen, S.; Haar, N.T. ter; Jonge, M.M. de; Kroep, J.R.; Kroon, C.D. de; Gaarenstroom, K.N.; Vrieling, H.; Bosse, T. & Vreeswijk, M.P.G. (2021), 'The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks, Cancers 13(12): 2994.
- Wijk, L.M. van; Nilas, A.B.; Vrieling, H. & Vreeswijk, M.P.G. (2022), RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?, Expert Review of Molecular Diagnostics 22(2): 185-199.
- Sampadi, B.; Mullenders, L.H.F. & Vrieling, H. (2021), Phosphoproteomics sample preparation impacts biological interpretation of phosphorylation signaling outcomes, Cells 10(12).
- Wijk, L.M. van; Vermeulen, S.; Meijers, M.; Diest, M.F. van; Haar, N.T. ter; Jonge, M.M. de; Solleveld-Westerink, N.; Wezel, T. van; Gent, D.C. van; Kroep, J.R.; Bosse, T.; Gaarenstroom, K.N.; Vrieling, H. & Vreeswijk, M.P.G. (2020), The RECAP test rapidly and reliably identifies homologous recombination-deficient ovarian carcinomas, Cancers 12(10).
- Krebs, A.; Vugt-Lussenburg, B.M.A. van; Waldmann, T.; Albrecht, W.; Boei, J.; Braak, B. ter; Brajnik, M.; Braunbeck, T.; Brecklinghaus, T.; Busquet, F.; Dinnyes, A.; Dokler, J.; Dolde, X.; Exner, T.E.; Fisher, C.; Fluri, D.; Forsby, A.; Hengstler, J.G.; Holzer, A.K.; Janstova, Z.; Jennings, P.; Kisitu, J.; Kobolak, J.; Kumar, M.; Limonciel, A.; Lundqvist, J.; Mihalik, B.; Moritz, W.; Pallocca, G.; Ulloa, A.P.C.; Pastor, M.; Rovida, C.; Sarkans, U.; Schimming, J.P.; Schmidt, B.Z.; Stober, R.; Strassfeld, T.; Water, B. van de; Wilmes, A.; Burg, B. van der; Verfaillie, C.M.; Hellfeld, R. von; Vrieling, H.; Vrijenhoek, N.G. & Leist, M. (2020), The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods, Archives of Toxicology 94(7): 2435-2461.
- Mesman, R.L.S.; Calleja, F.M.G.R.; Hoya, M. de la; Devilee, P.; Asperen, C.J. van; Vrieling, H. & Vreeswijk, M.P.G. (2020), Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2, Genetics in Medicine 22(8): 1355-1365.
- Meulemans, L.; Mesman, R.L.S.; Caputo, S.M.; Krieger, S.; Guillaud-Bataille, M.; Caux-Moncoutier, V.; Leone, M.; Boutry-Kryza, N.; Sokolowska, J.; Revillion, F.; Delnatte, C.; Tubeuf, H.; Soukarieh, O.; Bonnet-Dorion, F.; Guibert, V.; Bronner, M.; Bourdon, V.; Lizard, S.; Vilquin, P.; Privat, M.; Drouet, A.; Grout, C.; Calleja, F.M.G.R.; Golmard, L.; Vrieling, H.; Stoppa-Lyonnet, D.; Houdayer, C.; Frebourg, T.; Vreeswijk, M.P.G.; Martins, A. & Gaildrat, P. (2020), Skipping Nonsense to Maintain Function: The Paradigm of BRCA2 Exon 12, Cancer Research 80(7): 1374-1386.
- Sampadi, B.; Pines, A.; Munk, S.; Misovic, B.; Groot, A.J. de; Water, B. van de; Olsen, J.V.; Mullenders, L.H.F. & Vrieling, H. (2020), Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action, Archives of Toxicology 94(5): 1655-1671.
- Kopper, O.; Witte, C.J. de; Lohmussaar, K.; Valle-Inclan, J.E.; Hami, N.; Kester, L.; Balgobind, A.V.; Korving, J.; Proost, N.; Begthel, H.; Wijk, L.M. van; Revilla, S.A.; Theeuwsen, R.; Ven, M. van de; Roosmalen, M.J. van; Ponsioen, B.; Ho, V.W.H.; Neel, B.G.; Bosse, T.; Gaarenstroom, K.N.; Vrieling, H.; Vreeswijk, M.P.G.; Diest, P.J. van; Witteveen, P.O.; Jonges, T.; Bos, J.L.; Oudenaarden, A. van; Zweemer, R.P.; Snippert, H.J.G.; Kloosterman, W.P. & Clevers, H. (2019), An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity, Nature Medicine 25(5): 838-+.
- Mesman, R.L.S.; Calleja, F.M.G.R.; Hendriks, G.; Morolli, B.; Misovic, B.; Devilee, P.; Asperen, C.J. van; Vrieling, H. & Vreeswijk, M.P.G. (2019), The functional impact of variants of uncertain significance in BRCA2, Genetics in Medicine 21(2): 293-302.
- Jonge, M.M. de; Auguste, A.; Wijk, L.M. van; Schouten, P.C.; Meijers, M.; Haar, N.T. ter; Smit, V.T.H.B.M.; Nout, R.A.; Glaire, M.A.; Church, D.N.; Vrieling, H.; Job, B.; Boursin, Y.; Kroon, C.D. de; Rouleau, E.; Leary, A.; Vreeswijk, M.P.G. & Bosse, T. (2019), Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas, Clinical Cancer Research 25(3): 1087-1097.
- Leist, M.; Ghallab, A.; Graepel, R.; Marchan, R.; Hassan, R.; Bennekou, S.H.; Limonciel, A.; Vinken, M.; Schildknecht, S.; Waldmann, T.; Danen, E.; Ravenzwaay, B. van; Kamp, H.; Gardner, I.; Godoy, P.; Bois, F.Y.; Braeuning, A.; Reif, R.; Oesch, F.; Drasdo, D.; Hohme, S.; Schwarz, M.; Hartung, T.; Braunbeck, T.; Beltman, J.; Vrieling, H.; Sanz, F.; Forsby, A.; Gadaleta, D.; Fisher, C.; Kelm, J.; Fluri, D.; Ecker, G.; Zdrazil, B.; Terron, A.; Jennings, P.; Burg, B. van der; Dooley, S.; Meijer, A.H.; Willighagen, E.; Martens, M.; Evelo, C.; Mombelli, E.; Taboureau, O.; Mantovani, A.; Hardy, B.; Koch, B.; Escher, S.; Thriel, C. van; Cadenas, C.; Kroese, D.; Water, B. van de & Hengstler, J.G. (2017), Adverse outcome pathways: opportunities, limitations and open questions, Archives of Toxicology 91(11): 3477-3505.
- Shimelis, H.; Mesman, R.L.S.; Nicolai, C. von; Ehlen, A.; Guidugli, L.; Martin, C.; Calleja, F.M.G.R.; Meeks, H.; Hallberg, E.; Hinton, J.; Lilyquist, J.; Hu, C.L.; Aalfs, C.M.; Aittomaki, K.; Andrulis, I.; Anton-Culver, H.; Arndt, V.; Beckmann, M.W.; Benitez, J.; Bogdanova, N.V.; Bojesen, S.E.; Bolla, M.K.; Borresen-Dale, A.L.; Brauch, H.; Brennan, P.; Brenner, H.; Broeks, A.; Brouwers, B.; Bruning, T.; Burwinkel, B.; Chang-Claude, J.; Chenevix-Trench, G.; Cheng, C.Y.; Choi, J.Y.; Collee, J.M.; Cox, A.; Cross, S.S.; Czene, K.; Darabi, H.; Dennis, J.; Dork, T.; Dos-Santos-Silva, I.; Dunning, A.M.; Fasching, P.A.; Figueroa, J.; Flyger, H.; Garcia-Closas, M.; Giles, G.G.; Glendon, G.; Guenel, P.; Haiman, C.A.; Hall, P.; Hamann, U.; Hartman, M.; Hogervorst, F.B.; Hollestelle, A.; Hopper, J.L.; Ito, H.; Jakubowska, A.; Kang, D.; Kosma, V.M.; Kristensen, V.; Lai, K.N.; Lambrechts, D.; Marchand, L. le; Li, J.M.; Lindblom, A.; Lophatananon, A.; Lubinski, J.; Machackova, E.; Mannermaa, A.; Margolin, S.; Marme, F.; Matsuo, K.; Miao, H.; Michailidou, K.; Milne, R.L.; Muir, K.; Neuhausen, S.L.; Nevanlinna, H.; Olson, J.E.; Olswold, C.; Oosterwijk, J.J.C.; Osorio, A.; Peterlongo, P.; Peto, J.; Pharoah, P.D.P.; Pylkas, K.; Radice, P.; Rashid, M.U.; Rhenius, V.; Rudolph, A.; Sangrajrang, S.; Sawyer, E.J.; Schmidt, M.K.; Schoemaker, M.J.; Seynaeve, C.; Shah, M.; Shen, C.Y.; Shrubsole, M.; Shu, X.O.; Slager, S.; Southey, M.C.; Stram, D.O.; Swerdlow, A.; Teo, S.H.; Tomlinson, I.; Torres, D.; Truong, T.; Asperen, C.J. van; Kolk, L.E. van der; Wang, Q.; Winqvist, R.; Wu, A.H.; Yu, J.C.; Zheng, W.; Zheng, Y.; Leary, J.; Walker, L.; Foretova, L.; Fostira, F.; Claes, K.B.M.; Varesco, L.; Moghadasi, S.; Easton, D.F.; Spurdle, A.; Devilee, P.; Vrieling, H.; Monteiro, A.N.A.; Goldgar, D.E.; Carreira, A.; Vreeswijk, M.P.G.; Couch, F.J.; KConFab AOCS Investigators & NBCS Collaborators (2017), BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer, Cancer Research 77(11): 2789-2799.
- Shimelis, H.; Mesman, R.L.S.; Nicolai, C. von; Ehlen, A.; Guidugli, L.; Martin, C.; Calleja, F.M.G.R.; Meeks, H.; Hallberg, E.; Hinton, J.; Lilyquist, J.; Hu, C.L.; Aalfs, C.M.; Aittomaki, K.; Andrulis, I.; Anton-Culver, H.; Arndt, V.; Beckmann, M.W.; Benitez, J.; Bogdanova, N.V.; Bojesen, S.E.; Bolla, M.K.; Borresen-Dale, A.L.; Brauch, H.; Brennan, P.; Brenner, H.; Broeks, A.; Brouwers, B.; Bruning, T.; Burwinkel, B.; Chang-Claude, J.; Chenevix-Trench, G.; Cheng, C.Y.; Choi, J.Y.; Collee, J.M.; Cox, A.; Cross, S.S.; Czene, K.; Darabi, H.; Dennis, J.; Dork, T.; Dos-Santos-Silva, I.; Dunning, A.M.; Fasching, P.A.; Figueroa, J.; Flyger, H.; Garcia-Closas, M.; Giles, G.G.; Glendon, G.; Guenel, P.; Haiman, C.A.; Hall, P.; Hamann, U.; Hartman, M.; Hogervorst, F.B.; Hollestelle, A.; Hopper, J.L.; Ito, H.; Jakubowska, A.; Kang, D.; Kosma, V.M.; Kristensen, V.; Lai, K.N.; Lambrechts, D.; Marchand, L. le; Li, J.M.; Lindblom, A.; Lophatananon, A.; Lubinski, J.; Machackova, E.; Mannermaa, A.; Margolin, S.; Marme, F.; Matsuo, K.; Miao, H.; Michailidou, K.; Milne, R.L.; Muir, K.; Neuhausen, S.L.; Nevanlinna, H.; Olson, J.E.; Olswold, C.; Oosterwijk, J.J.C.; Osorio, A.; Peterlongo, P.; Peto, J.; Pharoah, P.D.P.; Pylkas, K.; Radice, P.; Rashid, M.U.; Rhenius, V.; Rudolph, A.; Sangrajrang, S.; Sawyer, E.J.; Schmidt, M.K.; Schoemaker, M.J.; Seynaeve, C.; Shah, M.; Shen, C.Y.; Shrubsole, M.; Shu, X.O.; Slager, S.; Southey, M.C.; Stram, D.O.; Swerdlow, A.; Teo, S.H.; Tomlinson, I.; Torres, D.; Truong, T.; Asperen, C.J. van; Kolk, L.E. van der; Wang, Q.; Winqvist, R.; Wu, A.H.; Yu, J.C.; Zheng, W.; Zheng, Y.; Leary, J.; Walker, L.; Foretova, L.; Fostira, F.; Claes, K.B.M.; Varesco, L.; Moghadasi, S.; Easton, D.F.; Spurdle, A.; Devilee, P.; Vrieling, H.; Monteiro, A.N.A.; Goldgar, D.E.; Carreira, A.; Vreeswijk, M.P.G.; Couch, F.J.; KConFab AOCS Investigators & NBCS Collaborators (2017), BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer., Cancer Research.
- Boei, J.J.W.A.; Vermeulen, S.; Klein, B.; Hiemstra, P.S.; Verhoosel, R.M.; Jennen, D.G.J.; Lahoz, A.; Gmuender, H. & Vrieling, H. (2017), Xenobiotic metabolism in differentiated human bronchial epithelial cells, Archives of Toxicology 91(5): 2093-2105.
- Oorschot, B. van; Uitterhoeve, L.; Oomen, I.; Cate, R. ten; Medema, J.P.; Vrieling, H.; Stalpers, L.J.A.; Moerland, P.D. & Franken, N.A.P. (2017), Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination, Cancer Research 77(6): 1485-1491.
- Herpers, B.; Wink, S.; Fredriksson, L.; , Z. di; Hendriks, G.; Vrieling, H.; Bont, H. de & Water, B. van de (2016), Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-kappa B activation and sensitizes toward TNF alpha-induced cytotoxicity, Archives of Toxicology 90(5): 1163-1179.
- Hendriks, G.; Derr, R.S.; Misovic, B.; Morolli, B.; Calleja, F.M.G.R. & Vrieling, H. (2016), The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding, Toxicological Sciences 150(1): 190-203.
- Derks, K.W.J.; Misovic, B.; Hout, M.C.G.N. van den; Kockx, C.E.M.; Gomez, C.P.; Brouwer, R.W.W.; Vrieling, H.; Hoeijmakers, J.H.J.; IJcken, W.F.J. van & Pothof, J. (2015), Deciphering the RNA landscape by RNAome sequencing, RNA Biology 12(1): 30-42.
- Hendriks, G.; Derr, R.S.; Misovic, B.; Morolli, B.; Calleja, F.M.G.R. & Vrieling, H. (2015), The extended ToxTracker assay discriminates between induction of DNA damage, oxidative stress and protein misfolding., Toxicological Sciences.
- Herpers, B; Wink, S; Fredriksson L, Di Z; Hendriks, G; Vrieling, H, de Bont, H, van de Water & B (2015), Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity., Archives of Toxicology.
- Stechow, L. von; Typas, D.; Puigvert, J.C.; Oort, L.; Siddappa, R.; Pines, A.; Vrieling, H.; Water, B. van de; Mullenders, L.H.F. & Danen, E.H.J. (2015), The E3 Ubiquitin Ligase ARIH1 Protects against Genotoxic Stress by Initiating a 4EHP-Mediated mRNA Translation Arrest, Molecular and Cellular Biology 35(7): 1254-1268.
- Hendriks, G.; Morolli, B.; Calleja, F.M.G.R.; Plomp, A.; Mesman, R.L.S.; Meijers, M.; Sharan, S.K.; Vreeswijk, M.P.G. & Vrieling, H. (2014), An Efficient Pipeline for the Generation and Functional Analysis of Human BRCA2 Variants of Uncertain Significance, Human Mutation 35(11): 1382-1391.
- Kraan Heleen, Vrieling Hilde, Czerkinsky Cecil, Jiskoot Wim, Kersten Gideon & Amorij Jean-Pierre (2014), Buccal and sublingual vaccine delivery, JOURNAL OF CONTROLLED RELEASE 190: 580-592.
- Naipal, K.A.T.; Verkaik, N.S.; Ameziane, N.; Deurzen, C.H.M. van; Brugge, P. ter; Meijers, M.; Sieuwerts, A.M.; Martens, J.W.; O'Connor, M.J.; Vrieling, H.; Hoeijmakers, J.H.J.; Jonkers, J.; Kanaar, R.; Winter, J.P. de; Vreeswijk, M.P.; Jager, A. & Gent, D.C. van (2014), Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment, Clinical Cancer Research 20(18): 4816-4826.
- Karlsson, H.L.; Gliga, A.R.; Calleja, F.M.G.R.; Goncalves, C.S.A.G.; Wallinder, I.O.; Vrieling, H.; Fadeel, B. & Hendriks, G. (2014), Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines, Particle and Fibre Toxicology 11.
- Wink, S.; Hiemstra, S.; Huppelschoten, S.; Danen, E.; Niemeijer, M.; Hendriks, G.; Vrieling, H.; Herpers, B. & Water, B. van de (2014), Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment, Chemical Research in Toxicology 27(3): 338-355.
- Oorschot, B. van; Hovingh, S.E.; Moerland, P.D.; Medema, J.P.; Stalpers, L.J.A.; Vrieling, H. & Franken, N.A.P. (2014), Reduced Activity of Double-Strand Break Repair Genes in Prostate Cancer Patients With Late Normal Tissue Radiation Toxicity, International Journal of Radiation Oncology - Biology - Physics 88(3): 664-670.
- Oorschot, B. van; Moerland, P.D.; Medema, J.P.; Stalpers, L.J.A.; Vrieling, H. & Franken, N.A.P. (2013), Reduced expression of DSB repair genes in prostate cancer patients with late normal tissue radiation-toxicity, International Journal of Molecular Medicine 32: S9-S9.
- Hendriks, G.; Gliga, A.; Vrieling, H. & Karlsson, H. (2013), The ToxTracker assay provides mechanistic insight into the (geno)toxic properties of metal oxide nanoparticles, Toxicology Letters 221: S245-S245.
- Hendriks, G.; Calleja, F.; Morolli, B.; Water, B. van de & Vrieling, H. (2013), The ToxTracker assay: Unveiling the carcinogenic properties of chemicals, Toxicology Letters 221: S132-S132.
- Hendriks, G.; Water, B. van de; Schoonen, W. & Vrieling, H. (2013), Cellular-signaling pathways unveil the carcinogenic potential of chemicals, Journal of Applied Toxicology 33(6): 399-409.
- Hameetman, L.; Commandeur, S.; Bavinck, J.N.B.; Wisgerhof, H.C.; Gruijl, F.R. de; Willemze, R.; Mullenders, L.; Tensen, C.P. & Vrieling, H. (2013), Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients, BMC Cancer 13.
- Puigvert, J.C.; Stechow, L. von; Siddappa, R.; Pines, A.; Bahjat, M.; Haazen, L.C.J.M.; Olsen, J.V.; Vrieling, H.; Meerman, J.H.N.; Mullenders, L.H.F.; Water, B. van de & Danen, E.H.J. (2013), Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells.
- Pines, A.; Vrouwe, M.G.; Marteijn, J.A.; Typas, D.; Luijsterburg, M.S.; Cansoy, M.; Hensbergen, P.; Deelder, A.; Groot, A. de; Matsumoto, S.; Sugasawa, K.; Thoma, N.; Vermeulen, W.; Vrieling, H. & Mullenders, L. (2012), PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1.
- Vrieling, H.; Hendriks, G. & Water, B. van de (2012), Toxtracker Assays: Advanced Mechanism-Based GFP Reporter Systems for Toxicity Profiling of Chemicals, Environmental and Molecular Mutagenesis 53: S20-S20.
- Boei, J.J.W.A.; Vermeulen, S.; Skubakova, M.M.; Meijers, M.; Loenen, W.A.M.; Wolterbeek, R.; Mullenders, L.H.F.; Vrieling, H. & Giphart-Gassler, M. (2012), No Threshold for the Induction of Chromosomal Damage at Clinically Relevant Low Doses of X Rays, Radiation Research 177(5): 602-613.
- Hendriks G., Atallah M., Morolli B., Calléja F., Ras-Verloop N., Huijskens I., Raamsman M., Water B. van de & Vrieling H. (2012), The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals, Toxicological Sciences 125(1): 285-298.
- Hendriks, G.; Atallah, M.; Morolli, B.; Calleja, F.; Ras-Verloop, N.; Huijskens, I.; Raamsman, M.; Water, B. van de & Vrieling, H. (2012), The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals.
- Pines, A.; Kelstrup, C.D.; Vrouwe, M.G.; Puigvert, J.C.; Typas, D.; Misovic, B.; Groot, A. de; Stechow, L. von; Water, B. van de; Danen, E.H.J.; Vrieling, H.; Mullenders, L.H.F. & Olsen, J.V. (2011), Global Phosphoproteome Profiling Reveals Unanticipated Networks Responsive to Cisplatin Treatment of Embryonic Stem Cells, Molecular and Cellular Biology 31(24): 4964-4977.
- Hendriks, G.; Atallah, M.; Raamsman, M.; Morolli, B.; Putten, H. van der; Jaadar, H.; Tijdens, I.; Esveldt-van Lange, R.; Mullenders, L.; Water, B. van de & Vrieling, H. (2011), Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment.
- Pines, A.; Hameetman, L.; Wilde, J. de; Alekseev, S.; Gruijl, F.R. de; Vrieling, H. & Mullenders, L.H.F. (2010), Enhanced Global Genome Nucleotide Excision Repair Reduces UV Carcinogenesis and Nullifies Strand Bias in p53 Mutations in Csb(-/-) Mice, Journal of Investigative Dermatology 130(6): 1746-1749.
- Hendriks, G.; Calleja, F.; Besaratinia, A.; Vrieling, H.; Pfeifer, G.P.; Mullenders, L.H.F.; Jansen, J.G. & Wind, N. de (2010), Transcription-Dependent Cytosine Deamination Is a Novel Mechanism in Ultraviolet Light-Induced Mutagenesis, Current Biology 20(2): 170-175.
- Hendriks, G.; Calleja, F.; Besaratinia, A.; Vrieling, H.; Pfeifer, G.P.; Mullenders, L.H.F.; Jansen, J.G. & Wind, N. de (2010), Transcription-Dependent Cytosine Deamination Is a Novel Mechanism in Ultraviolet Light-Induced Mutagenesis, Current Biology 20(2): 170-175.
- Silva FP, Almeida I, Morolli B, Brouwer-Mandema G, Wessels H, Vossen R, Vrieling H, Marijt EW, Valk PJ, Kluin-Nelemans HC, Sperr WR, Ludwig WD & Giphart-Gassler M (2009), Genome wide molecular analysis of minimally differentiated acute myeloid leukemia.
- Silva FPG, Almeida I, Morolli B, Brouwer-Mandema G, Wessels H, Vossen R, Vrieling H, Marijt EWA, Valk PJM, Kluin-Nelemans HC, Sperr WR, Ludwig WD & Giphart-Gassler M (2009), Genome wide molecular analysis of minimally differentiated acute myeloid leukemia, Haematologica 94(11): 1546-1554.
- Jonker MJ, Bruning O, van Iterson M, Schaap MM, van der Hoeven TV, Vrieling H, Beems RB, de Vries A, van Steeg H & Breit TM (2009), Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models, Carcinogenesis 30(10): 1805-1812.
- Silva FPG, Swagemakers SMA, Erpelinck-Verschueren C, Wouters BJ, Delwel R, Vrieling H, van der Spek P, Valk PJM & Giphart-Gassler M (2009), Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status, Blood 114(14): 3001-3007.
- Silva FP, Swagemakers SM, Erpelinck-Verschueren C, Wouters BJ, Delwel R, Vrieling H, van der Spek P, Valk PJ & Giphart-Gassler M (2009), Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status., Blood 114(14): 3001-7.
- Vreeswijk MPG, Meijers CM, Giphart-Gassler M, Vrieling H, van Zeeland AA, Mullenders LHF & Loenen WAM (2009), Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 663(1-2): 7-14.
- Vreeswijk MP, Meijers CM, Giphart-Gassler M, Vrieling H, van Zeeland AA, Mullenders LH & Loenen WA (2009), Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra., Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 663(1-2): 7-14.
- Pines A, Backendorf C, Alekseev S, Jansen JG, de Gruijl FR, Vrieling H & Mullenders LH (2009), Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer., DNA Repair 8(2): 153-61.
- Pines A, Backendorf C, Alekseev S, Jansen JG, de Gruij FR, Vrieling H & Mullenders LHF (2009), Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: Impact on DNA repair and UV-induced skin cancer, DNA Repair 8(2): 153-161.
- de Waard H, Sonneveld E, de Wit J, Esveldt-van Lange R, Hoeijmakers JHJ, Vrieling H & van der Horst GTJ (2008), Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts, DNA Repair 7(10).
- Silva FPG, Morolli B, Storlazzi CT, Zagaria A, Impera L, Klein B, Vrieling H, Kluin-Nelemans HC & Giphart-Gassler M (2008), ETV6 mutations and loss in AML-MO, Leukemia 22(8).
- Hendriks G, Calleja F, Vrieling H, Mullenders LHF, Jansen JG & de Wind N (2008), Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells, DNA Repair 7(8).
- Hendriks G, Calléja F, Vrieling H, Mullenders LH, Jansen JG & de Wind N (2008), Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells., DNA Repair 7(8): 1330-9.
- Kruse JJCM, Svensson JP, Huigsloot M, Giphart-Gassler M, Schoonen WGEJ, Polman JEM, Horbach GJ, van de Water B & Vrieling H (2007), A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 617(1-2).
- van Bezooijen RL, Svensson JP, Eefting D, Visser A, van der Horst G, Karperien M, Quax PH, Vrieling H, Papapoulos SE, ten Dijke P & Lowik CW (2007), Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation, Journal of Bone and Mineral Research 22(1).
- van der Wees C, Jansen J, Vrieling H, van der Laarse A, Van Zeeland A & Mullenders L (2007), Nucleotide excision repair in differentiated cells, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 614(1-2).
- Alekseev S, Kool H, Rebel H, Fousteri M, Moser J, Backendorf C, de Gruijl FR, Vrieling H & Mullenders LHF (2005), Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation, Cancer Research 65(22).
- van Zeeland AA, Vreeswijk MPG, de Gruijl FR, van Kranen HJ, Vrieling H & Mullenders LFH (2005), Transcription-coupled repair: Impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 577(1-2).
- Moser J, Volker M, Kool H, Alekseev S, Vrieling H, Yasui A, van Zeeland AA & Mullenders LHF (2005), The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions, DNA Repair 4(5).
- Boerma M, van der Wees CGC, Vrieling H, Svensson JP, Wondergem J, van der Laarse A, Mullenders LHF & van Zeeland AA (2005), Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress, ionising or ultraviolet radiation, BMC Genomics 6.
- Lemmers RJLF, van Overveld PGM, Sandkuijl LA, Vrieling H, Padberg GW, Frants RR & van der Maarel SM (2004), Mechanism and timing of mitotic rearrangements in the subtelomeric D4Z4 repeat involved in facioscapulohumeral muscular dystrophy, American Journal of Human Genetics 75(1).
- Ng JMY, Vermeulen W, van der Horst GTJ, Bergink S, Sugasawa K, Vrieling H & Hoeijmakers JHJ (2003), A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein, Genes and Development 17(13).
- Wijnhoven SWP, Sonneveld E, Kool HJM, van Teijlingen CMM & Vrieling H (2003), Chemical carcinogens induce varying patterns of LOH in mouse T-lymphocytes, Carcinogenesis 24(1).
- Ng JMY, Vrieling H, Sugasawa K, Ooms MP, Grootegoed JA, Vreeburg JTM, Visser P, Beems RB, Gorgels TGMF, Hanaoka F, Hoeijmakers JHJ & van der Horst GTJ (2002), Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B, Molecular and Cellular Biology 22(4).
- Wijnhoven SWP, Kool HJM, Mullenders LHF, Slater R, van Zeeland AA & Vrieling H (2001), DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice, Carcinogenesis 22(7).
- Turner SD, Wijnhoven SWP, Tinwell H, Lashford LS, Rafferty JA, Ashby J, Vrieling H & Fairbairn LJ (2001), Assays to predict the genotoxicity of the chromosomal mutagen etoposide - focussing on the best assay, Mutation Research - Genetic Toxicology and Environmental Mutagenesis 493(1-2).
- van Zeeland AA, Mullenders LHF & Vrieling H (2001), Gene and sequence specificity of DNA damage induction and repair: consequences for mutagenesis, Mutation Research-DNA Repair 485(1).
- Wijnhoven SWP, Kool HJM, van Teijlingen CMM, van Zeeland AA & Vrieling H (2001), Loss of heterozygosity in somatic cells of the mouse - An important step in cancer initiation?, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 473(1).
- Sonneveld E, Vrieling H, Mullenders LHF & van Hoffen A (2001), Mouse mismatch repair gene Msh2 is not essential for transcription-coupled repair of UV-induced cyclobutane pyrimidine dimers, Oncogene 20(4).
- Wijnhoven SWP, Kool HJM, van Oostrom CTM, Beems RB, Mullenders LHF, van Zeeland AA, van der Horst GTJ, Vrieling H & van Steeg H (2000), The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient cockayne syndrome group B mice, Cancer Research 60(20).
- Wijnhoven SWP, Kool HJM, Mullenders LHF, van Zeeland AA, Friedberg EC, van der Horst GTJ, van Steeg H & Vrieling H (2000), Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair, Oncogene 19(43).
- Rockx DAP, Mason R, van Hoffen A, Barton MC, Citterio E, Bregman DB, van Zeeland AA, Vrieling H & Mullenders LHF (2000), UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II, Proceedings of the National Academy of Sciences 97(19).