Gabriel van der Pluijm
- Naam
- Dr. G. van der Pluijm
- Telefoon
- +31 71 526 3082
- g.van.der.pluijm@umail.leidenuniv.nl
- Faculteit Geneeskunde
- Divisie 2
- Interne Geneeskunde
- Endocrinologie
- Pluijm, L.A.K. van der; Koudijs, A.; Stam, W.; Roelofs, J.J.T.H.; Danser, A.H.J.; Rotmans, J.I.; Gross, K.W.; Pieper, M.P.; Zonneveld, A.J. van & Bijkerk, R. (2024), SGLT2 inhibition promotes glomerular repopulation by cells of renin lineage in experimental kidney disease, Acta Physiologica.
- Vrouwe, J.P.M.; Kamerling, I.M.C.; Esdonk, M.J. van; Metselaar, J.M.; Stuurman, F.E.; Pluijm, G. van der; Burggraaf, J. & Osanto, S. (2021), An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer, Pharmacology Research and Perspectives 9(5).
- Merbel, A.F. van de; Horst, G. van der; Mark, M.H. van der; Bots, S.T.F.; Wollenberg, D.J.M. van den; Ridder, C.M.A. de; Stuurman, D.; Aalders, T.; Erkens-Schulz, S.; Montfoort, N. van; Karthaus, W.R.; Mehra, N.; Smits, M.; Schalken, J.A.; Weerden, W.M. van; Hoeben, R.C. & Pluijm, G. van der (2021), Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models, Cancer Gene Therapy.
- Puhr, M.; Eigentler, A.; Handle, F.; Hackl, H.; Ploner, C.; Heidegger, I.; Schaefer, G.; Brandt, M.P.; Hoefer, J.; Pluijm, G. van der & Klocker, H. (2021), Targeting the glucocorticoid receptor signature gene Mono Amine Oxidase-A enhances the efficacy of chemo- and anti-androgen therapy in advanced prostate cancer, Oncogene 40(17): 3087-3100.
- Baart, V.M.; Horst, G. van der; Deken, M.M.; Bhairosingh, S.S.; Schomann, T.; Sier, V.Q.; Mark, M.H. van der; Iamele, L.; Jonge, H. de; Resnati, M.; Mazar, A.P.; Pelger, R.C.M.; Pluijm, G. van der; Kuppen, P.J.K.; Vahrmeijer, A.L. & Sier, C.F.M. (2021), A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma, European Journal of Cancer 146: 11-20.
- Merbel, A.F. van de; Hooij, O. van; Horst, G. van der; Rijt-van de Westerlo, C.C.M. van; Mark, M.H. van der; Cheung, H.; Kroon, J.; Verhaegh, G.W.; Tijhuis, J.; Wellink, A.; Maas, P.; Vietor, H.; Schalken, J.A. & Pluijm, G. van der (2021), The identification of small molecule inhibitors that reduce invasion and metastasis of aggressive cancers, International Journal of Molecular Sciences 22(4).
- Kemp, V.; Lamfers, M.L.M.; Pluijm, G. van der; Hoogen, B.G. van den & Hoeben, R.C. (2020), Developing oncolytic viruses for clinical use: a consortium approach, Cytokine & Growth Factor Reviews 56: 133-140.
- Merbel, A.F. van de; Horst, G. van der & Pluijm, G. van der (2021), Patient-derived tumour models for personalized therapeutics in urological cancers, Nature Reviews Urology 18(1): 33-45.
- Horst, G. van der; Merbel, A.F. van de; Ruigrok, E.; Mark, M.H. van der; Ploeg, E.; Appelman, L.; Tvingsholm, S.; Jaatela, M.; Uhm, J. van; Kruithof-de Julio, M.; Thalmann, G.N.; Pelger, R.C.M.; Bangma, C.H.; Boormans, J.L.; Pluijm, G. van der & Zwarthoff, E.C. (2020), Cationic amphiphilic drugs as potential anticancer therapy for bladder cancer, Molecular Oncology 14(12): 3121-3134.
- Sheybanifard, M.; Beztsinna, N.; Bagheri, M.; Buhl, E.M.; Bresseleers, J.; Varela-Moreira, A.; Shi, Y.; Nostrum, C.F. van; Pluijm, G. van der; Storm, G.; Hennink, W.E.; Lammers, T. & Metselaar, J.M. (2020), Systematic evaluation of design features enables efficient selection of ? electron -stabilized polymeric micelles, International Journal of Pharmaceutics 584.
- Hensbergen, A.W.; Buckle, T.; Willigen, D.M. van; Schottelius, M.; Welling, M.M.; Wijk, F.A. van der; Maurer, T.; Poel, H.G. van der; Pluijm, G. van der; Weerden, W.M. van; Wester, H.J. & Leeuwen, F.W.B. van (2020), Hybrid tracers based on cyanine backbones targeting prostate-specific membrane antigen, Journal of Nuclear Medicine 61(2): 234-241.
- Buijs, J.T.; Laghmani, E.; Akker, R.F.P. van den; Tieken, C.; Vletter, E.M.; Molen, K.M. van der; Crooijmans, J.J.; Kroone, C.; Devedec, S.E. le; Pluijm, G. van der & Versteeg, H.H. (2019), The direct oral anticoagulants rivaroxaban and dabigatran do not inhibit orthotopic growth and metastasis of human breast cancer in mice, Journal of Thrombosis and Haemostasis 17(6): 951-963.
- Zoni, E.; Astrologo, L.; Ng, C.K.Y.; Piscuoglio, S.; Melsen, J.; Grosjean, J.; Klima, I.; Chen, L.P.; Snaar-Jagalska, E.B.; Flanagan, K.; Pluijm, G. van der; Kloen, P.; Cecchini, M.G.; Kruithof-de Julio, M. & Thalmann, G.N. (2019), Therapeutic targeting of CD146/MCAM reduces bone metastasis in prostate cancer, Molecular Cancer Research 17(5): 1049-1062.
- Navone, N.M.; Weerden, W.M. van; Vessella, R.L.; Williams, E.D.; Wang, Y.Z.; Isaacs, J.T.; Nguyen, H.M.; Culig, Z.; Pluijm, G. van der; Rentsch, C.A.; Marques, R.B.; Ridder, C.M.A. de; Bubendorf, L.; Thalmann, G.N.; Brennen, W.N.; Santer, F.R.; Moser, P.L.; Shepherd, P.; Efstathiou, E.; Xue, H.; Lin, D.; Buijs, J.; Bosse, T.; Collins, A.; Maitland, N.; Buzza, M.; Kouspou, M.; Achtman, A.; Taylor, R.A.; Risbridger, G. & Corey, E. (2018), Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models, Prostate 78(16): 1262-1282.
- Merbel, A.F. van de; Horst, G. van der; Mark, M.H. van der; Uhm, J.I.M. van; Gennep, E.J. van; Kloen, P.; Beimers, L.; Peiger, R.C.M. & Pluijm, G. van der (2018), An ex vivo Tissue Culture Model for the Assessment of Individualized Drug Responses in Prostate and Bladder Cancer, Frontiers in Oncology.
- Merbel, A.F. van de; Horst, G. van der; Mark, M.H. van der; Uhm, J.I.M. van; Gennep, E.J. van; Kloen, P.; Beimers, L.; Peiger, R.C.M. & Pluijm, G. van der (2018), An ex vivo Tissue Culture Model for the Assessment of Individualized Drug Responses in Prostate and Bladder Cancer, Frontiers in Oncology 8.
- Urbiola, C.; Santer, F.R.; Petersson, M.; Pluijm, G. van der; Horninger, W.; Erlmann, P.; Wollmann, G.; Kimpel, J.; Culig, Z. & Laer, D. von (2018), Oncolytic activity of the rhabdovirus VSV-GP against prostate cancer, International Journal of Cancer 143(7): 1786-1796.
- Puhr, M.; Hoefer, J.; Eigentler, A.; Ploner, C.; Handle, F.; Schaefer, G.; Kroon, J.; Leo, A.; Heidegger, I.; Eder, I.; Culig, Z.; Pluijm, G. van der & Klocker, H. (2018), The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Antiandrogen Therapy, Clinical Cancer Research 24(4): 927-938.
- Astrologo, L.; Zoni, E.; Karkampouna, S.; Gray, P.C.; Klima, I.; Grosjean, J.; Goumans, M.J.; Hawinkels, L.J.A.C.; Pluijm, G. van der; Spahn, M.; Thalmann, G.N.; Dijke, P. ten & Kruithof-de Julio, M. (2017), ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models, Frontiers in Cell and Developmental Biology 5.
- Taurozzi, A.J.; Beekharry, R.; Wantoch, M.; Labarthe, M.C.; Walker, H.F.; Seed, R.I.; Simms, M.; Rodrigues, G.; Bradford, J.; Horst, G. van der; Pluijm, G. van der & Collins, A.T. (2017), Spontaneous development of Epstein-Barr Virus associated human lymphomas in a prostate cancer xenograft program, PLoS ONE 12(11).
- Zoni, E.; Chen, L.; Karkampouna, S.; Granchi, Z.; Verhoef, E.I.; Manna, F. la; Kelber, J.; Pelger, R.C.M.; Henry, M.D.; Snaar-Jagalska, E.; Leenders, G.J.L.H. van; Beimers, L.; Kloen, P.; Gray, P.C.; Pluijm, G. van der & Julio, M.K.D. (2017), CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer, Oncogene 36(33): 4739-4749.
- Chen L., Groenewoud A., Tulotta C., Zoni E., Kruithof-de Julio M., Horst G. van der, Pluijm G. van der & Snaar-Jagalska B.E. (2017), A Zebrafish Xenograft Model for Studying Human Cancer Stem Cells in distant metastasis and therapy response, Methods in Cell Biology 138: 471-494.
- Zoni E., Chen L., Karkampouna S., Granchi Z., Verhoef E.I., La Manna F., Kelber J., Pelger R.C.M., Henry M.D., Snaar-Jagalska B.E., Leenders G.J.L.H. van, Beimers L., Kloen P., Gray P.C., Pluijm G. van der & Kruithof-de Julio M. (2017), CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer, Oncogene 36: 4739-4749.
- Wright, L.E.; Ottewell, P.D.; Rucci, N.; Peyruchaud, O.; Pagnotti, G.M.; Chiechi, A.; Buijs, J.T. & Sterling, J.A. (2016), Murine models of breast cancer bone metastasis, BoneKEy Reports 5.
- Kroon, J.; Puhr, M.; Buijs, J.T.; Horst, G. van der; Hemmer, D.M.; Marijt, K.A.; Hwang, M.S.; Masood, M.; Grimm, S.; Storm, G.; Metselaar, J.M.; Meijer, O.C.; Culig, Z. & Pluijm, G. van der (2016), Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer, Endocrine-Related Cancer 23(1): 35-45.
- Chen L., Groenewoud A., Pluijm G. van der & Snaar-Jagalska B.E. (2016), A zebrafish xenograft model for studying human cancer stem cells in distant metastasis and therapy response, Methods in Cell Biology 138: 471–496.
- Hawinkels, L.J.A.C.; Vinuesa, A.G. de; Paauwe, M.; Kruithof-de Julio, M.; Wiercinska, E.; Pardali, E.; Mezzanotte, L.; Keereweer, S.; Braumuller, T.M.; Heijkants, R.C.; Jonkers, J.; Lowik, C.W.; Goumans, M.J.; Hagen, T.L. ten & Dijke, P. ten (2016), Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors, Clinical Cancer Research 22(1): 96-106.
- Kroon, J.; Buijs, J.T.; Horst, G. van der; Cheung, H.; Mark, M. van der; Bloois, L. van; Rizzo, L.Y.; Lammers, T.; Pelger, R.C.; Storm, G.; Pluijm, G. van der & Metselaar, J.M. (2015), Liposomal Delivery of Dexamethasone Attenuates Prostate Cancer Bone Metastatic Tumor Growth In Vivo, Prostate 75(8): 815-824.
- Zoni, E.; Horst, G. van der; Merbel, A.F. van de; Chen, L.; Rane, J.K.; Pelger, R.C.M.; Collins, A.T.; Visakorpi, T.; Snaar-Jagalska, B.E.; Maitland, N.J. & Pluijm, G. van der (2015), miR-25 Modulates Invasivenessand Dissemination of Human Prostate Cancer Cells via Regulation of alpha(v)- and alpha(6)-Integrin Expression, Cancer Research 75(11): 2326-2336.
- Karkampouna, S.; Kloen, P.; Obdeijn, M.C.; Riester, S.M.; Wijnen, A.J. van & Kruithof-de Julio, M. (2015), Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions, Journal of Visualized Experiments.
- Buijs, J.T.; Matula, K.M.; Cheung, H.; Kruithof-de Julio, M.; Mark, M.H. van der; Snoeks, T.J.; Cohen, R.; Corver, W.E.; Mohammad, K.S.; Jonkers, J.; Guise, T.A. & Pluijm, G. van der (2015), Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGF beta receptor I kinase, Journal of Pathology 235(5): 745-759.
- Reeves, K.J.; Hurrell, J.E.; Cecchini, M.; Pluijm, G. van der; Down, J.M.; Eaton, C.L.; Hamdy, F.; Clement-Lacroix, P. & Brown, N.J. (2015), Prostate cancer cells home to bone using a novel in vivo model: Modulation by the integrin antagonist GLPG0187, International Journal of Cancer 136(7): 1731-1740.
- Khedoe, P.P.S.J.; Hoeke, G.; Kooijman, S.; Dijk, W.; Buijs, J.T.; Kersten, S.; Havekes, L.M.; Hiemstra, P.S.; Berbee, J.F.P.; Boon, M.R. & Rensen, P.C.N. (2015), Brown adipose tissue takes up plasma triglycerides mostly after lipolysis, Journal of Lipid Research 56(1): 51-59.
- Zoni, E.; Pluijm, G. van der; Gray, P.C. & Kruithof-de Julio, M. (2015), Epithelial Plasticity in Cancer: Unmasking a MicroRNA Network for TGF-beta-, Notch-, and Wnt-Mediated EMT, Journal of Oncology.
- Zoni, E.; Horst, G. van der; Merbel, A.F. van de; Chen, L.; Rane, J.K.; Pelger, R.C.M.; Collins, A.T.; Visakorpi, T.; Snaar-Jagalska, B.E.; Maitland, N.J. & Pluijm, G. van der (2015), miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression., Cancer Research.
- Ghotra, V.P.S.; He, S.N.; Horst, G. van der; Nijhoff, S.; Bont, H. de; Lekkerkerker, A.; Janssen, R.; Jenster, G.; Leenders, G.J.L.H. van; Hoogland, A.M.M.; Verhoef, E.I.; Baranski, Z.; Xiong, J.L.; Water, B. van de; Pluijm, G. van der; Snaar-Jagalska, B.E. & Danen, E.H.J. (2015), SYK Is a Candidate Kinase Target for the Treatment of Advanced Prostate Cancer, Cancer Research 75(1): 230-240.
- Oezdemir Berna C., Hensel Janine, Secondini Chiara, Wetterwald Antoinette, Schwaninger Ruth, Fleischmann Achim, Raffelsberger Wolfgang, Poch Olivier, Delorenzi Mauro, Temanni Ramzi, Mills Ian G., van der Pluijm Gabri, Thalmann George N. & Cecchini Marco G. (2014), The Molecular Signature of the Stroma Response in Prostate Cancer-Induced Osteoblastic Bone Metastasis Highlights Expansion of Hematopoietic and Prostate Epithelial Stem Cell Niches, PLoS ONE 9(12).
- Zoni, E.; Merbel, A.F. van de; Horst, G. van der; Rane, J.; Visakorpi, T.; Snaar, E.B.; Maitland, N. & Pluijm, G. van der (2014), miR-25 is a key regulator of prostate cancer invasiveness by modulation of the cross-talk between Notch and TGF-beta signaling, European Journal of Cancer 50: 12-13.
- Kroon, J.; in't Veld, L.S.; Buijs, J.T.; Cheung, H.; Horst, G. van der & Pluijm, G. van der (2014), Glycogen synthase kinase-3 beta inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth, Oncotarget 5(19): 8986-8994.
- Horst, G. van der; Bos, L.; Mark, M. van der; Cheung, H.; Heckmann, B.; Clement-Lacroix, P.; Lorenzon, G.; Pelger, R.C.M.; Bevers, R.F.M. & Pluijm, G. van der (2014), Targeting of Alpha-V Integrins Reduces Malignancy of Bladder Carcinoma, PLoS ONE 9(9).
- Bachelier Richard, Confavreux Cyrille B., Peyruchaud Olivier, Croset Martine, Goehrig Delphine, van der Pluijm Gabri & Clezardin Philippe (2014), Combination of anti-angiogenic therapies reduces osteolysis and tumor burden in experimental breast cancer bone metastasis, International Journal of Cancer 135(6): 1319-1329.
- Wissing, M.D.; Morree, E.S. de; Dezentje, V.O.; Buijs, J.T.; Krijger, R.R. de; Smit, V.T.H.B.M.; Weerden, W.M. van; Gelderblom, H. & Pluijm, G. van der (2014), Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness, Oncotarget 5(17): 7357-7367.
- Kroon, J.; Metselaar, J.M.; Storm, G. & Pluijm, G. van der (2014), Liposomal nanomedicines in the treatment of prostate cancer, Cancer Treatment Reviews 40(4): 578-584.
- Hensel Janine, Oezdemir Berna, Secondini Chiara, Wetterwald Antoinette, Schwaninger Ruth, Fleischmann Achim, Raffelsberger Wolfgang, Poch Olivier, Delorenzi Mauro, Temanni Ramzi, van der Pluijm Gabri, Cecchini Marco G. & Thalmann George N. (2014), THE MOLECULAR SIGNATURE OF THE STROMA RESPONSE IN OSTEOBLASTIC BONE METASTASIS REVEALS ENRICHMENT IN HAEMATOPOIETIC STEM CELL NICHE COMPONENTS, Journal of Urology, The 191(4): E326-E326.
- Riplinger, S.M.; Wabnitz, G.H.; Kirchgessner, H.; Jahraus, B.; Lasitschka, F.; Schulte, B.; Pluijm, G. van der; Horst, G. van der; Hammerling, G.J.; Nakchbandi, I. & Samstag, Y. (2014), Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation, Molecular Cancer 13.
- Wissing, M.D.; Leeuwen, F.W.B. van; Pluijm, G. van der & Gelderblom, H. (2013), Radium-223 Chloride: Extending Life in Prostate Cancer Patients by Treating Bone Metastases, Clinical Cancer Research 19(21): 5822-5827.
- Boon, M.R.; Berg, S.A.A. van den; Wang, Y.N.; Bossche, J. van den; Karkampouna, S.; Bauwens, M.; Saint-Hubert, M. de; Horst, G. van der; Vukicevic, S.; Winther, M.P.J. de; Havekes, L.M.; Jukema, J.W.; Tamsma, J.T.; Pluijm, G. van der; Dijk, K.W. van & Rensen, P.C.N. (2013), BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality, PLoS ONE 8(9).
- van der Horst G & van der Pluijm G (2012), Preclinical models that illuminate the bone metastasis cascade., Recent Results in Cancer Research == 192: 1-31.
- Horst, G. van der; Bos, L. & Pluijm, G. van der (2012), Epithelial Plasticity, Cancer Stem Cells, and the Tumor-Supportive Stroma in Bladder Carcinoma, Molecular Cancer Research 10(8): 995-1009.
- Germann, M.; Wetterwald, A.; Guzman-Ramirez, N.; Pluijm, G. van der; Culig, Z.; Cecchini, M.G.; Williams, E.D. & Thalmann, G.N. (2012), Stem-Like Cells with Luminal Progenitor Phenotype Survive Castration in Human Prostate Cancer, STEM CELLS 30(6): 1076-1086.
- Colombel, M.; Eaton, C.L.; Hamdy, F.; Ricci, E.; Pluijm, G. van der; Cecchini, M.; Mege-Lechevallier, F.; Clezardin, P. & Thalmann, G. (2012), Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases, Prostate 72(7): 713-720.
- Horst, G. van der & Pluijm, G. van der (2012), Preclinical imaging of the cellular and molecular events in the multistep process of bone metastasis, Future Oncology 8(4): 415-430.
- Hensel, J.; Wetterwald, A.; Pluijm, G. van der; Temanni, R.; Cecchini, M.G. & Thalmann, G.N. (2012), PROFILING THE BONE MICROENVIRONMENT TRANSCRIPTOME DURING THE DEVELOPMENT OF OSTEOLYTIC BONE METASTASIS, Journal of Urology, The 187(4): E529-E530.
- Buijs, J.T.; Horst, G. van der; Hoogen, C. van den; Cheung, H.; Rooij, B. de; Kroon, J.; Petersen, M.; Overveld, P.G.M. van; Pelger, R.C.M. & Pluijm, G. van der (2012), The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation, Oncogene 31(17): 2164-2174.
- Naber, H.P.H.; Wiercinska, E.; Pardali, E.; Laar, T. van; Nirmala, E.; Sundqvist, A.; Dam, H. van; Horst, G. van der; Pluijm, G. van der; Heckmann, B.; Danen, E.H.J. & Dijke, P. ten (2012), BMP-7 inhibits TGF-beta-induced invasion of breast cancer cells through inhibition of integrin beta(3) expression, Cellular Oncology 35(1): 19-28.
- Naber, H.P.H.; Wiercinska, E.; Pardali, E.; Laar, T. van; Nirmala, E.; Sundqvist, A.; Dam, H. van; Horst, G. van der; Pluijm, G. van der; Heckmann, B.; Danen, E.H.J. & Dijke, P. ten (2012), BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression.
- Hensel, J.; Wetterwald, A.; Pluijm, G. van der; Temanni, R.; Cecchini, M.G. & Thalmann, G.N. (2012), Transcriptome profiling of the bone microenvironment during the development of osteolytic bone metastasis, European Urology Supplements 11(1): E645-U383.
- Naber H.P.H., Wiercinska E., Pardali E., Laar T. van, Nirmala E., Sundqvist A., Dam H. van, Horst G. van der, Pluijm G. van der, Heckmann B., Danen E.H.J. & Dijke P. ten (2012), BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression, Cellular Oncology 35(1): 19-28.
- Hoogen, C. van den; Horst, G. van der; Cheung, H.; Buijs, J.T.; Pelger, R.C.M. & Pluijm, G. van der (2011), Integrin alpha v Expression Is Required for the Acquisition of a Metastatic Stem/Progenitor Cell Phenotype in Human Prostate Cancer, American Journal of Pathology 179(5): 2559-2568.
- Hoogen, C. van den; Horst, G. van der; Cheung, H.; Buijs, J.T.; Pelger, R.C.M. & Pluijm, G. van der (2011), Integrin αv expression is required for the acquisition of a metastatic stem/progenitor cell phenotype in human prostate cancer.
- Hoogen, C. van den; Horst, G. van der; Cheung, H.; Buijs, J.T.; Pelger, R.C.M. & Pluijm, G. van der (2011), The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis, Clinical and Experimental Metastasis 28(7): 615-625.
- Boon, M.R.; Horst, G. van der; Pluijm, G. van der; Tamsma, J.T.; Smit, J.W.A. & Rensen, P.C.N. (2011), Bone morphogenetic protein 7: A broad-spectrum growth factor with multiple target therapeutic potency, Cytokine and Growth Factor Reviews 22(4): 221-229.
- Horst, G. van der; Asten, J.J. van; Figdor, A.; Hoogen, C. van den; Cheung, H.; Bevers, R.F.M.; Pelger, R.C.M. & Pluijm, G. van der (2011), Real-Time Cancer Cell Tracking by Bioluminescence in a Preclinical Model of Human Bladder Cancer Growth and Metastasis, European Urology 60(2): 337-343.
- Wiercinska, E.; Naber, H.P.H.; Pardali, E.; Pluijm, G. van der; Dam, H. van & Dijke, P. ten (2011), The TGF-beta/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system, Breast Cancer Research and Treatment 128(3): 657-666.
- Horst, G. van der; Hoogen, C. van den; Buijs, J.T.; Cheung, H.; Bloys, H.; Pelger, R.C.M.; Lorenzon, G.; Heckmann, B.; Feyen, J.; Pujuguet, P.; Blanque, R.; Clement-Lacroix, P. & Pluijm, G. van der (2011), Targeting of alpha(v)-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer, Neoplasia 13(6): 516-525.
- Horst, G. van der; Hoogen, C. van den; Buijs, J.T.; Cheung, H.; Bloys, H.; Pelger, R.C.M.; Lorenzon, G.; Heckmann, B.; Feyen, J.; Pujuguet, P.; Blanque, R.; Clement-Lacroix, P. & Pluijm, G. van der (2011), Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer., Neoplasia 13(6): 516-25.
- Miclea, R.L.; Horst, G. van der; Robanus-Maandag, E.C.; Lowik, C.W.G.M.; Oostdijk, W.; Wit, J.M. & Karperien, M. (2011), Apc bridges Wnt/beta-catenin and BMP signaling during osteoblast differentiation of 16483 cells, Experimental Cell Research 317(10): 1411-1421.
- Pluijm, G. van der (2011), CANCER Breast cancer bone metastases: denosumab or zoledronic acid?, Nature Reviews Endocrinology 7(3): 134-135.
- Pluijm, G. van der (2011), Epithelial plasticity, cancer stem cells and bone metastasis formation., BONE 48(1): 37-43.
- Pluijm, G. van der (2011), Epithelial plasticity, cancer stem cells and bone metastasis formation, BONE 48(1): 37-43.
- Ozdemir, B.; Secondini, C.; Wetterwald, A.; Schwaninger, R.; Raffelsberger, W.; Poch, O.; Delorenzi, M.; Pluijm, G. van der; Thalmann, G.N. & Cecchini, M.G. (2011), Molecular characterization of the stromal response to osteoblastic bone metastasis by tissue-compartment specific transcriptional profiling, BONE 48(1): S41-S41.
- Reeves, K.J.; Cecchini, M.G.; Pluijm, G. van der; Eaton, C.L.; Hamdy, F.C. & Brown, N.J. (2011), The homing of prostate cancer to bone in vivo is modulated by Zoledronic acid, BONE 48(1): S45-S46.
- Buijs, J.T.; Kuijpers, C.C.H.J. & Pluijm, G. van der (2010), Targeted Therapy Options for Treatment of Bone Metastases; Beyond Bisphosphonates, Current Pharmaceutical Design 16(27): 3015-3027.
- Buijs, J.T.; Kuijpers, C.C.H.J. & Pluijm, G. van der (2010), Targeted therapy options for treatment of bone metastases; beyond bisphosphonates., Current Pharmaceutical Design 16(27): 3015-27.
- Buijs, J.T.; Cheung, H.; Doumont, G.; Derksen, P.W.B.; Jonkers, J. & Pluijm, G. van der (2010), A new mouse model of invasive lobular carcinoma of the breast representative of the multi-step process of bone metastasis and minimal residual disease (micrometastasis)., BONE 47: S298-S298.
- Horst, G. van der; Hoogen, C. van den; Buijs, J.T.; Cheung, H.; Feyen, J.H.M.; Pujuguet, P.; Heckmann, B.; Pelger, R.C.M.; Clement-Lacroix, P. & Pluijm, G. van der (2010), Targeting of alpha(v) Integrins, a potential marker for tumor-initiating cells, in Prostate Cancer and Bone Stroma Inhibits Bone Metastasis Formation, BONE 47: S320-S320.
- Hoogen, C. van den; Horst, G. van der; Cheung, H.; Buijs, J.T.; Lippitt, J.M.; Guzman-Ramirez, N.; Hamdy, F.C.; Eaton, C.L.; Thalmann, G.N.; Cecchini, M.G.; Pelger, R.C.M. & Pluijm, G. van der (2010), High Aldehyde Dehydrogenase Activity Identifies Tumor-Initiating and Metastasis-Initiating Cells in Human Prostate Cancer, Cancer Research 70(12): 5163-5173.
- Eaton, C.L.; Colombel, M.; Pluijm, G. van der; Cecchini, M.; Wetterwald, A.; Lippitt, J.; Rehman, I.; Hamdy, F. & Thalman, G. (2010), Evaluation of the Frequency of Putative Prostate Cancer Stem Cells in Primary and Metastatic Prostate Cancer, Prostate 70(8): 875-882.
- Buijs, J.T.; Petersen, M.; Horst, G. van der & Pluijm, G. van der (2010), Bone Morphogenetic Proteins and its Receptors; Therapeutic Targets in Cancer Progression and Bone Metastasis?, Current Pharmaceutical Design 16(11): 1291-1300.
- Petersen, M.; Pardali, E.; Horst, G. van der; Cheung, H.; Hoogen, C. van den; Pluijm, G. van der & Dijke, P. ten (2010), Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis, Oncogene 29(9): 1351-1361.
- Petersen, M.; Pardali, E.; Horst, G. van der; Cheung, H.; Hoogen, C. van den; Pluijm, G. van der & Dijke, P. ten (2010), Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis., Oncogene 29(9): 1351-61.
- Kaijzel EL, Snoeks TJ, Buijs JT, van der Pluijm G & Löwik CW (2009), Multimodal imaging and treatment of bone metastasis., Clinical and Experimental Metastasis 26(4): 371-9.
- Kaijzel EL, Snoeks TJA, Buijs JT, van der Pluijm G & Lowik CWGM (2009), Multimodal imaging and treatment of bone metastasis, Clinical and Experimental Metastasis 26(4): 371-379.
- Reeves Kimberley Jayne, van der Pluijm Gabri, Cecchini Marco G., Eaton Colby L., Hamdy Freddie C. & Brown Nicola J. (2009), Prostate cancer cells home to bone in a new in vivo model of bone metastasis, FASEB Journal 23.
- Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akcakaya P & Lowik CWGM (2009), Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors, BMC Developmental Biology 9.
- Buijs JT, Que I, Lowik CWGM, Papapoulos SE & van der Pluijm G (2009), Inhibition of bone resorption and growth of breast cancer in the bone microenvironment, BONE 44(2): 380-386.
- Buijs JT & van der Pluijm G (2009), Osteotropic cancers: from primary tumor to bone.
- Buijs JT & van der Pluijm G (2009), Osteotropic cancers: From primary tumor to bone, Cancer Letters 273(2): 177-193.
- Henriquez NV, van Overveld PG, Que I, Buijs JT, Bachelier R, Kaijzel EL, Löwik CW, Clezardin P & van der Pluijm G (2007), Advances in optical imaging and novel model systems for cancer metastasis research., Clinical and Experimental Metastasis 24(8): 699-705.
- Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, ten Dijke P & van der Pluijm G (2007), TGF-beta and BMP7 interactions in tumour progression and bone metastasis., Clinical and Experimental Metastasis 24(8): 609-17.
- Henriquez NV, van Overveld PGM, Que I, Buijs JT, Bachelier R, Kaijzel EL, Lowik CWGM, Clezardin P & van der Pluijm G (2007), Advances in optical imaging and novel model systems for cancer metastasis research, Clinical and Experimental Metastasis 24(8).
- Notting, I.; Buijs, J.; Mintardjo, R.; Horst, G. van der; Vukicevic, S.; Lowik, C.; Schalij-Delfos, N.; Keunen, J. & Pluijm, G. van der (2007), Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo, Investigative Ophthalmology & Visual Science 48(11).
- Gomes, C.M.F.; Welling, M.; Que, I.; Henriquez, N.V.; Pluijm, G. van der; Romeo, S.; Abrunhosa, A.J.; Botelho, M.F.; Hogendoorn, P.C.W.; Pauwels, E.K.J. & Cleton-Jansen, A.M. (2007), Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using Tc-99m-sestamibi, European Journal of Nuclear Medicine and Molecular Imaging 34(11).
- Buijs JT, Henriquez NV, van Overveld PGM, van der Horst G, ten Dijke P & van der Pluijm G (2007), TGF-beta and BMP7 interactions in tumour progression and bone metastasis, Clinical and Experimental Metastasis 24(8).
- Gomes CM, Welling M, Que I, Henriquez NV, van der Pluijm G, Romeo S, Abrunhosa AJ, Botelho MF, Hogendoorn PC, Pauwels EK & Cleton-Jansen AM (2007), Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi., European Journal of Nuclear Medicine and Molecular Imaging 34(11): 1793-803.
- Buijs JT, Rentsch CA, van der Horst G, van Civerveld PGM, Wetterwald A, Schwaninger R, Henriquez NV, ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RCM, Vukicevic S, Cecchini MG, Lowik CWGM & van der Pluijm G (2007), BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo, American Journal of Pathology 171(3).
- Buijs JT, Rentsch CA, van der Horst G, van Overveld PG, Wetterwald A, Schwaninger R, Henriquez NV, Ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RC, Vukicevic S, Cecchini MG, Löwik CW & van der Pluijm G (2007), BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo., American Journal of Pathology 171(3): 1047-57.
- Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clézardin P, Papapoulos SE, Cecchini MG, Löwik CW & van der Pluijm G (2007), Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer., Cancer Research 67(18): 8742-51.
- Buijs JT, Henriquez NV, Van Overveld PGM, Van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clezardin P, Papapoulos SE, Cecchini MG, Lowik CWGM & Van der Pluijm G (2007), Bone morphogenetic protein 7 in the development and treatment of bone Metastases from breast cancer, Cancer Research 67(18).
- Kaijzel EL, van der Pluijm G & Löwik CW (2007), Whole-body optical imaging in animal models to assess cancer development and progression., Clinical Cancer Research 13(12): 3490-7.
- Kaijzel EL, van der Pluijm G & Lowik CWGM (2007), Whole-body optical Imaging in animal models to assess cancer development and progression, Clinical Cancer Research 13(12).
- van Wijngaarden J, van Beek E, van Rossum G, van der Bent C, Hoekman K, van der Pluijm G, van der Pol MA, Broxterman HJ, van Hinsbergh VWM & Lowik CWGM (2007), Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappa B-mediated increase of intracellular doxorubicin accumulation, European Journal of Cancer 43(2).
- Schwaninger R, Rentsch CA, Wetterwald A, van der Horst G, van Bezooijen RL, van der Pluijm G, Lowik CWGM, Ackermann K, Pyerin W, Hamdy FC, Thalmann GN & Cecchini MG (2007), Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases, American Journal of Pathology 170(1).
- van Wijngaarden J, van Beek E, van Rossum G, van der Bent C, Hoekman K, van der Pluijm G, van der Pol MA, Broxterman HJ, van Hinsbergh VW & Löwik CW (2007), Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappaB-mediated increase of intracellular doxorubicin accumulation., European Journal of Cancer 43(2): 433-42.
- Notting IC, Missotten GSOA, Sijmons B, Boonman ZFHM, Keunen JEE & van der Pluijm G (2006), Angiogenic profile of uveal melanoma, Current Eye Research 31(9).
- Liu YY, van der Pluijm G, Karperien M, Stokkel MPM, Pereira AM, Morreau J, Kievit J, Romijn JA & Smit JWA (2006), Lithium as adjuvant to radioiodine therapy in differentiated thyroid carcinoma: clinical and in vitro studies, Clinical Endocrinology 64(6).
- van der Horst G, Farih-Sips H, Lowik CWGM & Karperien M (2006), Full length or fragments in hormone studies? Reply, Journal of Bone and Mineral Research 21(5).
- Hovens GCJ, Buiting AMJ, Karperien M, Ballieux BEPB, van der Pluijm G, Pereira AM, Romijn JA & Smit JWA (2006), A bioluminescence assay for thyrotropin receptor antibodies predicts serum thyroid hormone levels in patients with de novo Graves' disease, Clinical Endocrinology 64(4).
- Rentsch CA, Buijs J, Van der Horst G, Van Overveld P, Wetterwald A, Schwaninger R, Henriquez N, Ten Dyke P, Borovecki F, Thalmann GN, Pelger R, Vukicevic S, Cecchini MG, Lowik C & Van der Pluijm G (2006), BMP-7 is a potent inhibitor of prostate cancer bone metastasis in vivo, Journal of Urology, The 175(4): 255-256.
- Schwaninger R, Rentsch CA, Wetterwald A, Klima I, Van der Pluijm G, Van Bezooijen R, Lowik C, Studer UE, Thalmann GN & Cecchini MG (2006), Noggin blocks the osteoinductive properties of human prostate cancer cell lines, Journal of Urology, The 175(4): 258-258.
- Rentsch CA, Cecchini MG, Schwaninger R, Germann M, Markwalder R, Heller M, van der Pluijm G, Thalmann GN & Wetterwald A (2006), Differential expression of TGF beta-stimulated clone 22 in normal prostate and prostate cancer, International Journal of Cancer 118(4).
- Deckers M, van Dinther M, Buijs J, Que N, Lowik C, van der Pluijm G & ten Dijke P (2006), The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells, Cancer Research 66(4).
- Rentsch C.A., Cecchini M.G., Schwaninger R., Germann M., Markwalder R., Heller M., Pluijm G. van der, Thalmann G.N. & Wetterwald A. (2006), Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer, INTERNATIONAL JOURNAL OF CANCER : .
- Steenvoorden MMC, Tolboom TCA, van der Pluijm G, Lowik C, Visser CPJ, DeGroot J, Gittenberger-DeGroot AC, DeRuiter MC, Wisse BJ, Huizinga TWJ & Toes REM (2006), Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics, Arthritis Research and Therapy 8(6).
- van der Horst G, Farih-Sips H, Lowik CWGM & Karperien M (2005), Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 cells, Journal of Bone and Mineral Research 20(12).
- Lowik CW, Cecchini MG, Maggi A & van der Pluijm G (2005), Noninvasive real-time in vivo bioluminescent imaging of gene expression and of tumor progression and metastasis., Ernst Schering Research Foundation workshop: 193-227.
- van der Horst G, van der Wert SM, Farih-Sips H, van Bezooijen RL, Lowik CWGM & Karperien M (2005), Downregulation of Wnt signaling by increased expression of Dickkopf-1 and-2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells, Journal of Bone and Mineral Research 20(10).
- van der Pluijm G, Que I, Sijmons B, Buijs JT, Lowik CWGM, Wetterwald A, Thalmann GN, Papapoulos SE & Cecchini MG (2005), Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo, Cancer Research 65(17).
- van der Pluijm G, Que I, Sijmons B, Buijs JT, Löwik CW, Wetterwald A, Thalmann GN, Papapoulos SE & Cecchini MG (2005), Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo., Cancer Research 65(17): 7682-90.
- Notting IC, Buijs JT, Que I, Mintardjo RE, van der Horst G, Karperien M, Missotten GSOA, Schalij-Delfos NE, Keunen JEE & van der Pluijm G (2005), Whole-body bioluminescent Imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis, Investigative Ophthalmology & Visual Science 46(5).
- Ponec M, El Ghalbzouri A, Dijkman R, Kempenaar J, van der Pluijm G & Koolwijk P (2004), Endothelial network formed with human dermal microvascular endothelial cells in autologous multicellular skin substitutes., Angiogenesis 7(4): 295-305.
- Sehwaninger R, Rentsch CA, Geissbuhler F, Wetterwald A, Van der Pluijm G, Lowik CW, Studer UE, Thalmann GN & Cecchini MG (2004), Does expression of BMP antagonists noggin and SOST determine the bone metastatic phenotype in prostate cancer?, Journal of Urology, The 171(4): 159-159.
- van der Pluijm G, Wetterwald A, Thalmann GN, Nijeholt GLA, Pelger R & Cecchini MG (2004), Whole body optical imaging of skeletal metastases: Pathogenic relationship with bone turnover and therapeutic rationale, Journal of Urology, The 171(4): 289-289.
- Buijs, J.T.; Cleton, A.M.; Smit, V.T.H.B.M.; Lowik, C.W.G.M.; Papapoulos, S.E. & Pluijm, G. van der (2004), Prognostic significance of periodic acid-Schiff-positive patterns in primary breast cancer and its lymph node metastases, Breast Cancer Research and Treatment 84(2).
- van der Horst G, Farih-Sips H, Lowik CWGM & Karperien M (2003), Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells, BONE 33(6).
- van der Pluijm G, Deckers M, Sijmons B, de Groot H, Bird J, Wills R, Papapoulos S, Baxter A & Lowik C (2003), In vitro and in vivo endochondral bone formation models allow identification of anti-angiogenic compounds, American Journal of Pathology 163(1).
- Deckers MML, Van Beek ER, Van Der Pluijm G, Wetterwald A, Van Der Wee-Pals L, Cecchini MG, Papapoulos SE & Lowik CWGM (2002), Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice, Journal of Bone and Mineral Research 17(6).
- Notting I, Sijmons B, Hurks HMH, van der Pluijm G & Jager MJ (2002), Expression of the Vegf family and its receptors of 12 uveal melanoma cell lines with per in vitro, Investigative Ophthalmology & Visual Science 43: U245-U245.
- Heikkila P, Teronen O, Moilanen M, Konttinen YT, Hanemaaijer R, Laitinen M, Maisi P, van der Pluijm G, Bartlett JD, Salo T & Sorsa T (2002), Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines, Anti-Cancer Drugs 13(3).
- Wetterwald, A.; Pluijm, G. van der; Que, I.; Sijmons, B.; Buijs, J.; Karperien, M.; Lowik, C.W.G.M.; Gautschi, E.; Thalmann, G.N. & Cecchini, M.G. (2002), Optical Imaging of cancer metastasis to bone marrow - A mouse model of minimal residual disease, American Journal of Pathology 160(3).
- Wetterwald A, Gautschi E, van der Pluijm G, Buijs J, Karperien M, Sijmons K, Lowik C, Thalmann G & Cecchini M (2001), Bioluminescent reporter imaging of cancer metastasis to bone marrow and bone: A mouse model of minimal residual disease.
- Deckers MML, van der Pluijm G, van Beek ER, Wetterwald A, van der Wee-Pals L, Cecchini M, Papapoulos SE & Lowik CWG (2001), Dissociation of angiogenesis and osteoclastic resorption during endochondral bone formation in neonatal mice.
- van der Pluijm G, Sijmons B, Vloedgraven H, van der Bent C, Drijfhout JW, Verheijen J, Quax P, Karperien M, Papapoulos S & Lowik C (2001), Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo, American Journal of Pathology 159(3).
- Van der Pluijm G, Sijmons B, Vloedgraven H, Deckers M, Papapoulos S & Lowik C (2001), Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: Elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases, Journal of Bone and Mineral Research 16(6).
- van der Pluijm G, Wetterwald A, Buijs J, Sijmons B, Gautschi E, Que I, Stadler B, Cecchini M & Lowik C (2001), Monitoring metastatic behavior of human breast cancer cells in mice with species-specific PCR and bioluminescent reporter imaging, BONE 28(5): S135-S135.
- Deckers M, van der Pluijm G, Dooijewaard S, Kroon M, van Hinsbergh V, Papapoulos S & Lowik C (2001), Effect of angiogenic and antiangiogenic compounds on the outgrowth of capillary structures from fetal mouse bone explants.
- Havekes B, van der Elst JPS, van der Pluijm G, Goslings BM, Morreau J, Romijn JA & Smit JWA (2000), Beneficial effects of retinoic acid on extracellular matrix degradation and attachment behaviour in follicular thyroid carcinoma cell lines, Journal of Endocrinology 167(2).
- Smit JWA, Schroder-van der Elst JP, Karperien M, Que I, van der Pluijm G, Goslings B, Romijn JA & van der Heide D (2000), Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line, Thyroid 10(11).
- Lowik CWG, Deckers M, Que I, Papapoulos SE, Berndsen H, van der Kogel B & van der Pluijm G (2000), The natural anti-angiogenic agents Endostatin and Kringle-5 peptide inhibit tumor progression and even induce tumor regression. Possible mechanism of action.
- Papapoulos SE, Hamdy NA & van der Pluijm G (2000), Bisphosphonates in the management of prostate carcinoma metastatic to the skeleton., Cancer 88(12 Suppl): 3047-53.
- van der Pluijm G, Lowik C & Papapoulos S (2000), Tumour progression and angiogenesis in bone metastasis from breast cancer: new approaches to an old problem.
- Smit JWA, Van der Pluijm G, Romijn HA, Lowik CWGM, Morreau H & Goslings BM (1999), Degradation of extracellular matrix by metastatic follicular thyroid carcinoma cell lines: Role of the plasmin activation system, Thyroid 9(9): 913-919.
- Kroon ME, Koolwijk P, van Goor H, Weidle UH, Collen A, van der Pluijm G & van Hinsbergh VWM (1999), Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matrices, American Journal of Pathology 154(6): 1731-1742.
- van Beek E, Lowik C, van der Pluijm G & Papapoulos S (1999), The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates.
- Smit JWA, van der Pluijm G, Vloedgraven HJM, Lowik CWGM & Goslings BM (1998), Role of integrins in the attachment of metastatic follicular thyroid carcinoma cell lines to bone, Thyroid 8(1): 29-36.
- van der Pluijm G, Vloedgraven H, Papapoulos S, Lowik C, Grzesik W, Kerr J & Robey PG (1997), Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components.
- vanderPluijm, G.; Drijfhout, J.W.; Papapoulos, S. & Lowik, C. (1997), The urokinase receptor acts as an adhesion receptor in metastatic breast cancer cells and regulates integrin function., Journal of Bone and Mineral Research 12: 103-103.
- Ronday HK, Smits HH, Quax PHA, vanderPluijm G, Lowik CWGM, Breedveld FC & Verheijen JH (1997), Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis, British journal of rheumatology 36(1): 9-15.
- Ronday HK, Smits HH, Quax PH, van der Pluijm G, Löwik CW, Breedveld FC & Verheijen JH (1997), Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis., British journal of rheumatology 36(1): 9-15.
- van der Pluijm G, Vloedgraven H, van Beek E, van der Wee-Pals L, Löwik C & Papapoulos S (1996), Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro., Journal of Clinical Investigation 98(3): 698-705.
- van der Pluijm G, Vloedgraven HJ, Ivanov B, Robey FA, Grzesik WJ, Robey PG, Papapoulos SE & Lowik CW (1996), Bone sialoprotein peptides are potent inhibitors of breast cancer cell adhesion to bone., Cancer Research 56(8): 1948-55.
- RONDAY HK, SMITS HH, QUAX PHA, VANDERPLUIJM G, LOWIK CWGM, BREEDVELD FC & VERHEIJEN JH (1995), UROKINASE MEDIATED, PLASMIN DEPENDENT DEGRADATION OF BONE-LIKE MATRIX, Arthritis and Rheumatism 38(9): 1237-1237.
- Schweitzer DH, Oostendorp-van de Ruit M, Van der Pluijm G, Löwik CW & Papapoulos SE (1995), Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate., Journal of Bone and Mineral Research 10(6): 956-62.
- van der Pluijm G, Mouthaan H, Baas C, de Groot H, Papapoulos S & Löwik C (1994), Integrins and osteoclastic resorption in three bone organ cultures: differential sensitivity to synthetic Arg-Gly-Asp peptides during osteoclast formation., Journal of Bone and Mineral Research 9(7): 1021-8.
- Löwik CW, Alblas MJ, van de Ruit M, Papapoulos SE & van der Pluijm G (1993), Quantification of adherent and nonadherent cells cultured in 96-well plates using the supravital stain neutral red., Analytical Biochemistry 213(2): 426-33.
- van der Pluijm G, Binderup L, Bramm E, van der Wee-Pals L, De Groot H, Binderup E, Löwik C & Papapoulos S (1992), Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo., Journal of Bone and Mineral Research 7(8): 981-6.
- van der Pluijm G, Löwik CW, de Groot H, Alblas MJ, van der Wee-Pals LJ, Bijvoet OL & Papapoulos SE (1991), Modulation of PTH-stimulated osteoclastic resorption by bisphosphonates in fetal mouse bone explants., Journal of Bone and Mineral Research 6(11): 1203-10.
- van der Pluijm G, Most W, van der Wee-Pals L, de Groot H, Papapoulos S & Löwik C (1991), Two distinct effects of recombinant human tumor necrosis factor-alpha on osteoclast development and subsequent resorption of mineralized matrix., Endocrinology 129(3): 1596-604.
- Löwik CW, van der Pluijm G, Bloys H, Hoekman K, Bijvoet OL, Aarden LA & Papapoulos SE (1989), Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis., Biochemical and Biophysical Research Communications 162(3): 1546-52.
- Löwik CW, van der Pluijm G, van der Wee-Pals LJ, van Treslong-De Groot HB & Bijvoet OL (1988), Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: the effect of a bisphosphonate., Journal of Bone and Mineral Research 3(2): 185-92.