Universiteit Leiden

nl en

Robert Hoeben

Name
Prof.dr. R.C. Hoeben
Telephone
+31 71 526 9241
E-mail
r.c.hoeben@lumc.nl

Rob C. Hoeben is professor of Gene Transfer and active in the field of Gene Therapy. He heads the section Virus and Stem Cell Biology of the department of Cell and Chemical Biology at the Leiden University Medical Center.

More information about Robert Hoeben

Rob C. Hoeben is professor of Gene Transfer and active in the field of Gene Therapy. He heads the section Virus and Stem Cell Biology of the department of Cell and Chemical Biology at the Leiden University Medical Center.

Gene Transfer

The prospect of using gene therapy for the treatment of patients is an appealing one. Gene therapy offers the perspective of permanent cures also in those patients with diseases for which there is no effective treatment available to date. The transfer of functional genes into cells of the patient is a key ingredient of every gene therapy protocol. My research is devoted to designing and testing new gene-transfer technology. Viruses are well suited as gene-transfer vehicles and we develop new virus-derived gene-therapy vehicles and test these in collaboration with clinical partners in models for human disease. Our applications are found in a wide variety of diseases such as diabetes, cancer, muscular dystrophy, and immune-deficiencies.

Academic Career

Rob C. Hoeben performed his doctoral research at Leiden University. The title of his thesis (1991) is ‘Toward gene therapy of haemophilia A: vectors for the expression of factor VIII in vivo’. Subsequently his work in Leiden focussed on cancer gene therapy in colorectal cancer, and on improving adenovirus vectors for hepatic gene transfer. In March 2000 he was appointed Professor on  Gene Transfer of the  Leiden University Medical Center. The title of his inaugural lecture was ‘Viruses: From Villains to Friends’. Professor Hoeben has been actively pursuing research on gene therapy vectors and applications. He is author of over 165 scientific publications, several book chapters, and  named as inventor 13 patents granted by the USPTO covering the adenovirus-transformed PER.C6 cell line and associated technology, and a gene-therapy technology for prosthesis refixation. Prof. Hoeben was on the board of the Dutch Society of Gene Therapy (1999 - 2015), and Member of COGEM (Committee on Genetic Modification; 2000 onward), which advises the Ministry of Infrastructure and Water Management on the use of Genetically Modified Organisms.

  • Faculteit Geneeskunde
  • Divisie 4
  • Cel en Chemische biologie

Work address

LUMC Research Building
Einthovenweg 20
2333 ZC Leiden
Room number S1-P

Contact

  • Cogem Lid commissie Genetische Modificatie
  • Erasmus Medisch Centrum Gastdocent
  • Technische Universiteit Delft Gastdocent
  • Universiteit Utrecht Gastdocent
  • Wageningen Universiteit Gastdocent
  • ZonMW Lid Translationele Gentherapie Commissie

This website uses cookies. More information