Rob van Wijk
Rob van Wijk is a postdoctoral researcher at the Institute of Biology Leiden (Animal Sciences and Health) in collaboration with the Leiden Academic Centre for Drug Research (Systems Biomedicine and Pharmacology).
Rob van Wijk performed his PhD research on ‘Translational pharmacokinetics-pharmacodynamics in zebrafish’ at the Leiden Academic Centre for Drug Research (Systems Biomedicine and Pharmacology) in collaboration with the Institute of Biology Leiden (Animal Sciences and Health), under the supervision of prof. dr. Piet Hein van der Graaf, prof. dr. Herman Spaink, and dr. Elke Krekels. This multi-disciplinary project with collaborators from three different research institutes of Leiden University and two international partners, Uppsala University and Dana Farber Cancer Institute, Harvard University, focussed on the quantification of internal drug exposure over time, and drug effect over it concentration for three different drugs (paracetamol, isoniazid, isotretinoin) in the zebrafish and zebrafish larva.
Currently, Rob is appointed as postdoctoral researcher on the recently started IMI project Respiri-NTM, in which novel therapies against nontuberculous mycobacterial infections will be researched utilizing different animal models, including zebrafish.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Ordas A., Kreling T., Harms A.C., Hankemeier T., Spaink H.P. & Graaf P.H. van der (2019), Mechanistic and quantitative understanding of pharmacokinetics in zebrafish larvae through nanoscale blood sampling and metabolite modelling of paracetamol, Journal of Pharmacology and Experimental Therapeutics 371(1): 15-24.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Harms A.C., Hankemeier T., Graaf P.H. van der & Spaink H.P. (2019), Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae, Scientific Reports 9: 2149.
- Schulthess P., Wijk R.C. van, Krekels E.H.J., Yates J.W.T., Spaink H.P. & Graaf P.H. van der (2018), Outside-in systems pharmacology combines innovative computational methods with high-throughput whole vertebrate studies, CPT: Pharmacometrics & Systems Pharmacology 7(5): 285-287.
- Wong Y.C., Ilkova T.I., Wijk R.C. van, Hartman R.J. & Lange E.C.M. de (2018), Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in nonanesthetized rat, European Journal of Pharmaceutical Sciences 111: 514–525.
- Guo Y., Wijk R.C. van, Krekels E.H.J., Spaink H.P., Graaf P.H. van der & Verbeek F.J. (2017), Multi-modal 3D reconstruction and measurements of zebrafish larvae and its organs using axial-view microscopy. In: 2017 IEEE International Conference on Image Processing (ICIP).: IEEE Xplore. 2194-2198.
- Wijk R.C. van, Krekels E.H.J., Hankemeier T., Spaink H.P. & Graaf P.H. van der (2017), Systems pharmacology of hepatic metabolism in zebrafish larvae, Drug Discovery Today: Disease Models 22: 27-34.
- Kantae V., Krekels E.H.J., Ordas A., Gonzalez O., Wijk R.C. van, Harms A.C., Racz P.I., Graaf P.H. van der, Spaink H.P. & Hankemeier T. (2016), Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude, Zebrafish 13(6): 504-510.
- Bellanti F., Wijk R.C. van, Danhof M. & Della Pasqua O.E. (2015), Integration of PKPD relationships into benefit-risk analysis, British Journal of Clinical Pharmacology 80(5): 979-991.
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