Marco van Vulpen
Professor Radiotherapy, in particular Proton Therapy
- Name
- Prof.dr. M. van Vulpen
- Telephone
- +31 71 526 6357
- m.van_vulpen@lumc.nl
- ORCID iD
- null
Marco van Vulpen is a professor of radiotherapy at the Leiden University Medical Center (LUMC). Apart from that he is the medical director of Holland Proton Therapy Center (HollandPTC) in Delft. As a part of Medical Delta, he is also appointed as a professor at Erasmus Medical Center (Erasmus MC) and the Technical University of Delft. Separately, he is professor and faculty member at the department of radiotherapy at the University of Texas MD Anderson Cancer Center in Houston.
More information about Marco van Vulpen
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Marco van Vulpen is a professor of radiotherapy at the Leiden University Medical Center (LUMC). Apart from that he is the medical director of Holland Proton Therapy Center (HollandPTC) in Delft. As a part of Medical Delta, he is also appointed as a professor at Erasmus Medical Center (Erasmus MC) and the Technical University of Delft. Separately, he is professor and faculty member at the department of radiotherapy at the University of Texas MD Anderson Cancer Center in Houston.
Radiotherapy
Approximately 50% of all patients receive radiotherapy as part of their treatment. Radiotherapy has evolved in the previous decennia towards a treatment with a high precision, where the treatment is daily adapted with regard to the position and the movement of tumors and where aggressive areas receive more radiation compared to areas of the tumor which are less aggressive.
Radiotherapy is delivered by a photon beam. Photons are energy packages which damage everything they meet during their travel through the body. By administering these photons from several sites it is possible to deliver the highest dose to the tumor while delivering less dose to the surrounding normal tissues. It is now possible to deliver radiotherapy by a proton beam. Protons are particles that stop completely after delivering the radiation, in contrast to photons. This results in the absence of any radiation behind the proton beam and will spare more of the healthy surrounding tissues. The added value of proton therapy still needs to be determined, also in the light of costs, before this therapy can be standardly applies to more patients.
Academic career
Dr. van Vulpen obtained his M.D. at the University of Amsterdam and his Ph.D. (2003) at the University of Utrecht, both in the Netherlands. The title of his thesis was ‘hyperthermia for prostate cancer’.
In 2011 he was appointed full professor at the university of Utrecht and held his inaugural speech called the ‘End of Radiotherapy’. Since 2013 he was chair of the department of Radiotherapy at the University medical Center Utrecht, the Netherlands, where a 1.5 Tesla MRI linear accelerator was developed. He was clinical chair of the International Consortium, ATLANTIC, on the worldwide clinical introduction of the MRI linear accelerator. He currently serves as adjunct professor and faculty member at the department of Radiotherapy at the University of Texas MD Anderson Cancer Center, Houston, Texas. Since 2016 he is appointed as medical director of the Holland Proton Therapy Center in Delft, the Netherland, and is appointed as professor at the Leiden UMC, Erasmus MC and TU Delft. On October 11, 2019 he presented his second inaugural speech, entitled: “critical mass”. His major research interests include the development, clinical translation off different radiotherapy interventions, like the MRI linac and proton therapy, especially with regard to the value proposition.
Prizes and honourable appointments
Van Vulpen received the ‘Alon Dembo visiting professor’ award at the University of Toronto (2012) and the ‘Donal Hollywood’ award at the European Society of radiotherapy and oncology (ESTRO) (2016). He is honorary member of the Belgian society for radiotherapy (ABRO-BVRO).
Professor Radiotherapy, in particular Proton Therapy
- Faculteit Geneeskunde
- Divisie 4
- Radiotherapie
- Kroesen, M.; Miladinovic, V.; Hutschemaekers, S.A.J.; Jacobs, J.; Vos, C. van der; Wolf, A.L.; Hoogeman, M.S.; Vulpen, M. van; Bloem, J.L.; Dijkstra, S.P.D.S.; Peul, W.C.; Penninkhof, J.J. & Krol, A.D.G. (2022), Single-institution clinical experience using Robust Intensity Modulated Proton Therapy in chordoma and chondrosarcoma of the mobile spine and sacrum: feasibility and need for plan adaptation, Radiotherapy & Oncology 166: 58-64.
- Weide, H.L. van der; Kramer, M.C.A.; Scandurra, D.; Eekers, D.B.P.; Klaver, Y.L.B.; Wiggenraad, R.G.J.; Romero, A.M.; Coremans, I.E.M.; Boersma, L.; Vulpen, M. van; Langendijk, J.A. & Dutch Soc Radiation Oncology NVRO (2021), Proton therapy for selected low grade glioma patients in the Netherlands, Radiotherapy & Oncology 154: 283-290.
- Koetsier, K.S.; Hensen, E.F.; Wiggenraad, R.; Lips, I.M.; Benthem, P.P.G. van; Vulpen, M. van & Shih, H.L.A. (2019), Clinical outcomes and toxicity of proton radiotherapy for vestibular schwannomas: a systematic review, Journal of Radiation Oncology 8(4): 357-368.
- Westhoff, P.G.; Graeff, A. de; Monninkhof, E.M.; Pree, I. de; Vulpen, M. van; Leer, J.W.H.; Marijnen, C.A.M.; Linden, Y.M. van der & Dutch Bone Metastasis Study Grp (2018), Effectiveness and toxicity of radiotherapy treatment for painful spinal metastases, journal of radiation oncology 7(1).
- Langendijk, J.A.; Boersma, L.J.; Rasch, C.R.N.; Vulpen, M. van; Reitsma, J.B.; Schaaf, A. van der & Schuit, E. (2018), Clinical trial strategies to compare protons with photons, Seminars in Radiation Oncology 28(2): 79-87.
- Westhoff, P.G.; Graeff, A. de; Monninkhof, E.M.; Pree, I. de; Vulpen, M. van; Leer, J.W.H.; Marijnen, C.A.M.; Linden, Y.M. van der & Dutch Bone Metastasis Study Grp (2018), Effectiveness and toxicity of conventional radiotherapy treatment for painful spinal metastases: a detailed course of side effects after opposing fields versus a single posterior field technique, Journal of Radiation Oncology 7(1): 17-26.
- Westhoff, P.; Verdam, M.; Oort, F.; Jobsen, J.; Vulpen, M. van; Leer, J.W.; Marijnen, C.; Graeff, A. de & Linden, Y. van der (2016), Course of quality of life after radiotherapy for painful bone metastases, Radiotherapy and Oncology 119: S254-S255.
- Heethuis, S.E.; Rossum, P.S.N. van; Lips, I.M.; Goense, L.; Voncken, F.E.; Reerink, O.; Hillegersberg, R. van; Ruurda, J.P.; Philippens, M.E.; Vulpen, M. van; Meijer, G.J.; Lagendijk, J.J.W. & Lier, A.L.H.M.W. van (2016), Dynamic contrast-enhanced MRI for treatment response assessment in patients with oesophageal cancer receiving neoadjuvant chemoradiotherapy, Radiotherapy and Oncology 120(1): 128-135.
- Goense, L.; Rossum, P.S.N. van; Lips, I.M.; Heethuis, S.E.; Lier, A.H.M.W. van; Lam, M.G.E.H.; Kotte, A.N.; Vulpen, M. van; Hillegersberg, R. van; Ruurda, J.P. & Meijer, G.J. (2016), Correlation between biomarkers derived from PET/CT and diffusion-weighted MRI in esophageal cancer, Radiotherapy and Oncology 119: S872-S873.
- Nowee, M.E.; Voncken, F.E.; Kotte, A.N.; Goense, L.; Rossum, P.S.N. van; Lier, A.L.H.M.W. van; Aleman, B.M.; Vulpen, M. van; Meijer, G.J. & Lips, I.M. (2016), Interobserver variation of CT and FDG-PET based GTV for oesophageal cancer: a Dutch nationwide study, Radiotherapy and Oncology 119: S331-S331.
- Rossum, P.S.N. van; Lier, A.L.H.M.W. van; Vulpen, M. van; Reerink, O.; Lagendijk, J.J.W.; Lin, S.H.; Hillegersberg, R. van; Ruurda, J.P.; Meijer, G.J. & Lips, I.M. (2015), Diffusion-weighted magnetic resonance imaging for the prediction of pathologic response to neoadjuvant chemoradiotherapy in esophageal cancer, Radiotherapy and Oncology 115(2): 163-170.
- Rossum, P.S.N. van; Lier, A.L.H. van; Vulpen, M. van; Reerink, O.; Lin, S.H.; Hillegersberg, R. van; Ruurda, J.P.; Meijer, G.J. & Lips, I.M. (2015), Diffusion-weighted MRI for the prediction of response to neoadjuvant chemoradiotherapy in esophageal cancer, Radiotherapy and Oncology 115: S302-S303.
- Rossum, P.S.N. van; Lier, A.L.H.M.W. van; Lips, I.M.; Meijer, G.J.; Reerink, O.; Vulpen, M. van; Lam, M.G.E.H.; Hillegersberg, R. van & Ruurda, J.P. (2015), Imaging of oesophageal cancer with FDG-PET/CT and MRI, Clinical Radiology 70(1): 81-95.
- Heethuis, S.E.; Rossum, P.S.N. van; Lips, I.M.; Vulpen, M. van; Philippens, M.E.P.; Ruurda, J.P.; Meijer, G.J.; Lagendijk, J.J.W. & Lier, A. van (2015), Potential of DCE-MRI for treatment response assessment in esophageal cancer, Radiotherapy and Oncology 115: S33-S34.
- Lever, F.M.; Lips, I.M.; Crijns, S.P.M.; Reerink, O.; Lier, A.L.H.M.W. van; Moerland, M.A.; Vulpen, M. van & Meijer, G.J. (2014), Quantification of Esophageal Tumor Motion on Cine-Magnetic Resonance Imaging, International Journal of Radiation Oncology - Biology - Physics 88(2): 419-424.
- Lier, A. van; Rossum, P.S.N. van; Meijer, J.; Berg, C.A.T. van den; Philippens, M.E.P.; Lagendijk, J.J.W.; Vulpen, M. van & Lips, I.M. (2014), Repeatability of MRI-based diffusion measurements of oesophageal cancer, Radiotherapy and Oncology 111: S106-S107.
- Harder, A.M. den; Gils, C.H. van; Kotte, A.N.T.J.; Vulpen, M. van & Lips, I.M. (2014), Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy. Analysis of a randomized clinical trial, Strahlentherapie und Onkologie 190(8): 758-761.
- Heethuis, S.; Rossum, P. van; Lips, I.; Vulpen, M. van; Meijer, G. & Lier, A. van (2014), Comparison of Image Registration Strategies to Improve DCE-MRI Uptake Curves in Esophageal Cancer, Medical Physics 41(6).
- Harder, A.M. den; Gils, C.H. van; Kotte, A.N.; Vulpen, M. van & Lips, I.M. (2014), Erratum to: Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy: analysis of a randomized clinical trial (vol 190, pg 776, 2014), Strahlentherapie und Onkologie 190(8): 776-776.
- Heethuis, S.; Rossum, P. van; Lips, I.; Vulpen, M. van; Meijer, G.; Lagendijk, J. & Lier, A. van (2014), Comparison of Image Registration Strategies to Improve DCE-MRI Uptake Curves in Esophageal Cancer, Medical Physics 41(6): 529-529.
- Lier, A. van; Rossum, P. van; Lips, I.; Philippens, M.; Meijer, G.; Berg, C. van den; Vulpen, M. van & Lagendijk, J. (2014), Functional MRI of Esophageal Cancer: Repeatability and Inter Observer Reproducibility of Geometrically Corrected ADC Maps, Medical Physics 41(6): 463-463.
- Lier, A. van; Rossum, P. van; Lips, I.; Philippens, M.; Meijer, G.; Berg, C. van den; Vulpen, M. van & Lagendijk, J. (2014), Functional MRI of Esophageal Cancer: Repeatability and Inter-Observer Reproducibility of Geometrically Corrected ADC Maps, Medical Physics 41(6): 463-+.
- McNair, H.A.; Wedlake, L.; Lips, I.M.; Andreyev, J.; Vulpen, M. van & Dearnaley, D. (2014), A systematic review: Effectiveness of rectal emptying preparation in prostate cancer patients, Practical Radiation Oncology 4(6): 437-447.
- Lier, A. van; Meijer, G.; Moerland, M.; Lever, F.; Reerink, O.; Vulpen, M.; Lagendijk, J.; Lips, I. & Berg, C. van den (2013), Diffusion Weighted MRI of Esophageal Cancer, Medical Physics 40(6).
- Rossum, P.S.N. van; Hillegersberg, R. van; Lever, F.M.; Lips, I.M.; Lier, A.L.H.M.W. van; Meijer, G.J.; Leeuwen, M.S. van; Vulpen, M. van & Ruurda, J.P. (2013), Imaging strategies in the management of oesophageal cancer: what's the role of MRI?, European Radiology 23(7): 1753-1765.
- Westhoff P, de Graeff A, Reyners A, Rodenhuis C, van Vulpen M, Leer J, Marijnen C & van der Linden Y (2013), PD-0533: Response and quality of life in elderly with painful bone metastases: results from a randomized radiotherapy study, Radiotherapy & Oncology 106: S205.
- Lips, I.M.; Gils, C.H. van; Kotte, A.N.T.J.; Leerdam, M.E. van; Franken, S.P.G.; Heide, U.A. van der & Vulpen, M. van (2012), A Double-Blind Placebo-Controlled Randomized Clinical Trial With Magnesium Oxide to Reduce Intrafraction Prostate Motion for Prostate Cancer Radiotherapy, International Journal of Radiation Oncology - Biology - Physics 83(2): 653-660.
- Lips, I.; Lever, F.; Reerink, O.; Moerland, M.; Meijer, G.; Lier, A. van; Berg, C. van den; Philippens, M.; Crijns, S.; Raaymakers, B.; Vulpen, M. van & Lagendijk, J. (2012), MRI-Linac (MRL) Guided Treatment for Esophageal Cancer, Medical Physics 39(6): 3665-3665.
- Lips, I.M.; Heide, U.A. van der; Haustermans, K.; Lin, E.N.J.T. van; Pos, F.; Franken, S.P.G.; Kotte, A.N.T.J.; Gils, C.H. van & Vulpen, M. van (2011), Single blind randomized Phase III trial to investigate the benefit of a focal lesion ablative microboost in prostate cancer (FLAME-trial): study protocol for a randomized controlled trial, Trials 12.
- Lips, I.M.; Kotte, A.N.T.J.; Gils, C.H. van; Leerdam, M.E. van; Heide, U.A. van der & Vulpen, M. van (2011), INFLUENCE OF ANTIFLATULENT DIETARY ADVICE ON INTRAFRACTION MOTION FOR PROSTATE CANCER RADIOTHERAPY, International Journal of Radiation Oncology - Biology - Physics 81(4): E401-E406.
- Lips, I.; Gils, C. van; Kotte, A.; Leerdam, M. van; Heide, U. van der & Vulpen, M. van (2011), A DOUBLE-BLIND PLACEBO-CONTROLLED RANDOMIZED CLINICAL TRIAL WITH MAGNESIUM OXIDE TO REDUCE PROSTATE MOTION FOR PROSTATE CANCER RADIOTHERAPY, Radiotherapy and Oncology 99: S201-S201.
- Lips, I.; Moman, M.; Kotte, A.; Heide, U. van der & Vulpen, M. van (2010), THE INFLUENCE OF A DIET ON THE INTRAFRACTION MOTION DURING IMRT FOR PROSTATE CANCER, Radiotherapy and Oncology 96: S87-S87.
- Roeloffzen, E.M.A.; Lips, I.M.; Gellekom, M.P.R. van; Roermund, J. van; Frank, S.J.; Battermann, J.J. & Vulpen, M. van (2010), HEALTH-RELATED QUALITY OF LIFE UP TO SIX YEARS AFTER I-125 BRACHYTHERAPY FOR EARLY-STAGE PROSTATE CANCER, International Journal of Radiation Oncology - Biology - Physics 76(4): 1054-1060.
- Lips, I.M.; Heide, U.A. van der; Kotte, A.N.T.J.; Vulpen, M. van & Bel, A. (2009), EFFECT OF TRANSLATIONAL AND ROTATIONAL ERRORS ON COMPLEX DOSE DISTRIBUTIONS WITH OFF-LINE AND ON-LINE POSITION VERIFICATION, International Journal of Radiation Oncology - Biology - Physics 74(5): 1600-1608.
- Lips, I.M.; Gils, C.H. van; Heide, U.A. van der; Kruger, A.E.B. & Vulpen, M. van (2009), Health-related quality of life 3 years after high-dose intensity-modulated radiotherapy with gold fiducial marker-based position verification, BJU International 103(6): 762-767.
- Lips, I.M.; Dehnad, H.; Gils, C.H. van; Kruger, A.E.B.; Heide, U.A. van der & Vulpen, M. van (2008), High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-based position verification: acute and late toxicity in 331 patients, Radiotherapy and Oncology 3.
- Bosch, M.R. van den; Lips, I.M.; Lagerburg, V.; Vulpen, M. van; Lagendijk, J.J.W. & Moertand, M.A. (2008), Feasibility of adequate dose coverage in permanent prostate brachytherapy using divergent needle insertion methods, Radiotherapy and Oncology 86(1): 120-125.
- Lips, I.; Heide, U. van der; Kruger, A.B.; Gils, C. van & Vulpen, M. van (2008), HIGH-DOSE IMRT FOR PROSTATE CANCER WITHOUT CLINICALLY RELEVANT DETERIORATION IN LONG-TERM QUALITY OF LIFE, Radiotherapy and Oncology 88: S326-S326.
- Klein, S.; Heide, U.A. van der; Lips, I.M.; Vulpen, M. van; Staring, M. & Pluim, J.P.W. (2008), Automatic segmentation of the prostate in 3D MR images by atlas matching using localized mutual information, Medical Physics 35(4): 1407-1417.
- Bosch, M.R. van den; Lips, I.; Lagerburg, V.; Vulpen, M. van; Lagendijk, J. & Moerland, M. (2007), Feasibility of adequate dose coverage in permanent prostate brachytherapy using a MR guided implant robot and inverse planning based on simulated annealing, Radiotherapy and Oncology 84: S34-S34.
- Lips, I.; Dehnad, H.; Kruger, A.B.; Moorselaar, J. van; Heide, U. van der; Battermann, J. & Vulpen, M. van (2007), Health-related quality of life in patients with locally advanced prostate cancer after 76 GY intensity-modulated radiotherapy vs. 70 GY conformal radiotherapy in a prospective and longitudinal study, International Journal of Radiation Oncology - Biology - Physics 69(3): 656-661.
- Lips, I.; Kotte, A.N.T.; Heide, U. van; Vulpen, M. van & Bel, A. (2007), Impact of random position variations on complex dose distributions for prostate IMRT using different margins, Radiotherapy and Oncology 84: S302-S303.
- Vulpen, M. van; Lips, I.; Jeukens, C.; Hofman, P.; Raaymakers, B.W.; Battermann, J.J.; Lagendijk, J.J.W. & Heide, U.A. van der (2006), Prostate dose escalation: Blind versus GTV-assured boost., Radiotherapy and Oncology 81: S378-S379.
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