Marco van Eijk
Assistant professor / director of education
- Name
- Dr. M.C. van Eijk
- Telephone
- +31 71 527 4771
- m.c.van.eijk@lic.leidenuniv.nl
- ORCID iD
- 0000-0001-7751-4112
More information about Marco van Eijk
News
Curriculum Vitae
Personal information
Nationality: Dutch
Date of birth: 24 June 1970
Education
2018 PhD, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands, 21 November 2000. Thesis title: “Regulation of germinal center B cell apoptosis”.
Advisors: Prof. R. van Noorden and Prof. M. Kapsenberg
1994 BSc in Medical Biology, Utrecht University, The Netherlands
Current and previous research positions
2022 – now Director of education BSc Life Science and Technology, Leiden Institute of Chemistry, Leiden University, The Netherlands
2022 – now University Teacher 1, Leiden Institute of Chemistry, Leiden University, The Netherlands
2018 – 2022 University Teacher 2, Leiden Institute of Chemistry, Leiden University, The Netherlands
2015 – 2018 Postdoctoral researcher, Leiden Institute of Chemistry/University of Amsterdam, The Netherlands
2003 – 2015 Postdoctoral researcher, Medical Biochemistry, University of Amsterdam, The Netherlands
2002 – 2003 Macrozyme B.V., Amsterdam, The Netherlands
2000 – 2002 Tanox Pharma, Amsterdam, The Netherlands
Grants, awards, recognitions since 2016
- Nominated teacher of the year by SV LIFE (2020/2021; 2022/2023)
- Nominated teacher of the year by TU Delft category “non-TNW faculty teaching in a TNW programme” (2020/2021)
Contribution to teaching and supervision
- Course for MSc Chemistry at Leiden University: Integrated Cell Biology
- Course for BSc LST at Leiden University/TU Delft: Cell Biology
- Course for BSc LST at Leiden University/TU Delft: Life Sciences
- Course for BSc LST at Leiden University/TU Delft: Molecular Cell Biology and Immunology, including the practical course
- Course for BSc LST at Leiden University/TU Delft: Molecular Genetics and Gene Technology
- Coordinator Pre-University and Pre-class programme at Leiden University
- Teaching in Pre-University and Pre-Class programme at Leiden University
- Supervision of bachelor and master students
Co-promotor of 6 PhD students since 2016. Currently co-supervising 2 PhD students
Other current responsibilities since 2016
- Education committee BSc LST 2020-2022
- Budget holder Bsc LST
- Admission committee BSc LST
- Bi-annual educational director meeting with Dean Prof. H. Bijl
Teaching vision
- Modern life science and technology curriculum
- Programme offers a close connection between theory and practice. Practical programmes allow further development of theoretical components and soft skills
- Up too date teaching programme is guaranteed as top research is integrated
Publication record including five recent representative publications
58 papers, H-index 32 (Web of Science)
Full publication record: Leiden University
- M. van Eijk, J.M.F.G. Aerts. The unique phenotype of lipid-laden macrophages. Int. J. Mol. Sci. 2021, 22, 4039-4054. DOI: 10.3390/ijms22084039
- M. van Eijk, M.J. Ferraz, R.G. Boot, J.M.F.G. Aerts. Lyso-glycosphingolipids: presence and consequences. Essays in Bioch. 2020, 64, 565-578. DOI: 10.1042/EBC20190090
- M.J.C. van der Lienden, P. Gaspar, R. Boot, J.M.F.G. Aerts, M. Van Eijk. Glycoprotein non-metastatic protein B: an emerging biomarker for lysosomal dysfunction in macrophages. Int. J. Mol. Sci. 2019, 20, 66-86. DOI: 10.3390/ijms20010066
- M.J. Tol, M.J.C. van der Lienden, T.L. Gabriel, J.J. Hagen, S. Scheij, T. Veenendaal, J. Klumperman, W.E. Donker-Koopman, A.J. Verhoeven, H. Overkleeft, J.M. Aerts, C.A. Argmann, M. van Eijk. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018, 14, 437-449. DOI: 10.1080/15548627.2017.1419118
- L. Wu, J. Jiang, Y. Jin, W.W. Kallemeijn, C.-L. Kuo, M. Artola, W. Dai, C. van Elk, M. van Eijk, G.A. van der Marel, J.D.C. Codée, B.I. Florea, J.M.F.G. Aerts, H.S. Overkleeft, G.J. Davies. Activity-based probes for functional interrogation of retaining β-glucuronidases. Nat. Chem. Biol. 2017, 13, 867-873. DOI: 10.1038/nchembio.2395
Assistant professor / director of education
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Lienden M.J.C. van der, Aten J., Boot R.G., Eijk M.C. van, Aarts J.M.F.G. & Kuo C.L. (2022), HEPES‐buffering of bicarbonate‐containing culture medium perturbs lysosomal glucocerebrosidase activity, Journal of Cellular Biochemistry 123(5): 893-905.
- Eijk M.C. van & Aerts J.M.F.G. (2021), The unique phenotype of lipid-laden macrophages, International Journal of Molecular Sciences 22(8): 4039.
- Lienden M.J.C. van der, Aten J., Marques A.R.A., Waas I.S.E., Larsen P.W.B., Claessen N., Wel N.N. van der, Ottenhoff R., Eijk M.C. van & Aerts J.M.F.G. (2021), GCase and LIMP2 abnormalities in the liver of Niemann Pick type C mice, International Journal of Molecular Sciences 22(5): 2532.
- Eijk M. van, Ferraz M.J., Boot R.G. & Aerts J.M.F.G. (2020), Lyso-glycosphingolipids: presence and consequences, Essays in Biochemistry 64(3): 565-578.
- Aerts J.M.F.G., Artola M.E., Eijk M.C. van, Ferraz M.J. & Boot R.G. (2019), Glycosphingolipids and infection. Potential new therapeutic avenues, Frontiers in Cell and Developmental Biology 7: 324.
- Rakhshandehroo M., Eijkeren R.J. van, Gabriel T.L., Haar C. de, Gijzel S.M.W., Hamers N., Ferraz M.J., Aerts J.M.F.G., Schipper H.S., Eijk M.C. van, Boes M. & Kalkhoven E. (2019), Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1864(8): 1157-1167.
- Moro Chao D.H., Wang Y., Foppen E., Ottenhoff R., Roomen C. van, Parlevliet E.T., Eijk M.C. van, Verhoek M., Boot R.G., Marques A.R., Scheij S., Mirzaian M., Kooijman S., Jansen K., Wang D., Mergen C., Seeley R.J., Tschöp M.H., Overkleeft H.S., Rensen P.C.N., Kalsbeek A., Aerts J.M.F.G. & Yi C.X. (2019), The iminosugar AMP-DNM improves satiety and activates brown adipose tissue through GLP1, Diabetes 68(12): 2223-2234.
- Lienden M.J.C. van der, Gaspar P., Boot R.G., Aerts J.M.F.G. & Eijk M.C. van (2018), Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages, International Journal of Molecular Sciences 20(1): 66.
- Tol M.J., Lienden M.J.C. van der, Gabriel T.L., Hagen J.J., Scheij S., Veenendaal T., Klumperman J., Donker-Koopman W.E., Verhoeven A.J., Overkleeft H.S., Aerts J.M.F.G., Argmann C.A. & Eijk M.C. van (2018), HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution, Autophagy 14(3): 437-449.
- Gabriel T.L., Mirzaian M., Hooibrink B., Ottenhof R., Roomen C. van, Aerts J.M.F.G. & Eijk M.C. van (2017), Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival, PLoS ONE 12(7): 0182075.
- Wu L., Jiang J., Jin Y., Kallemeijn W.W., Kuo C.-L., Artola M., Dai W., Elk C. van, Eijk M. van, Marel G.A. van der, Codee J.D.C., Florea B.I., Aerts J.M.F.G., Overkleeft H.S. & Davies G.J. (2017), Activity-based probes for functional interrogation of retaining beta-glucuronidases, Nature Chemical Biology 13(8): 867-873.
- Aerts J.M.F.G., Guimaraes da Lomba Ferraz M.J., Mirzaian M., Gaspar P., Oussoren S.V., Wisse P., Kuo C.L., Lelieveld L.T., Kytidou K., Hazeu M.D., Boer D.E.C., Meijer R., Lienden M.J.C. van der, Herrera D., Gabriel T.L., Aten J., Overkleeft H.S., Eijk M.C. van, Boot R.G. & Rosa Alcalde Marques A. (2017), Lysosomal Storage Diseases. For Better or Worse: Adapting to Defective Lysosomal Glycosphingolipid Breakdown. In: , eLS. eLS: John Wiley & Sons, Ltd.. 1-13.
- Herrera Moro Chao D., Argmann C., Eijk M. van, Boot R.G., Ottenhoff R., Roomen C. van, Foppen E., Siljee J.E., Unmehopa U.A., Kalsbeek A. & Aerts J.M.F.G. (2016), Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem, Scientific Reports 6: 29094.
- Marques A.R., Gabriel T.L., Aten J., Roomen C.P. van, Ottenhoff R., Claessen N., Alfonso P., Irún P., Giraldo P., Aerts J.M.F.G. & Eijk M.C. van (2016), Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease, PLoS ONE 11(1): e0147208.
- Marques A.R., Mirzaian M., Akiyama H., Wisse P., Ferraz M.J., Gaspar P., Ghauharali-Van der Vlugt K., Meijer R., Giraldo P., Alfonso P., Irún P., Dahl M., Karlsson S., Pavlova E.V., Cox T.M., Scheij S., Verhoek M., Ottenhoff R., Roomen C.P. van, Pannu N.S., Van Eijk M., Dekker N., Boot R.G., Overkleeft H.S., Blommaart E., Hirabayashi Y. & Aerts J.M. (2016), Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases, 57: 451-463.
- Tol M.J., Ottenhoff R., Eijk M. van, Zelcer N., Aten J., Houten S.M., Geerts D., Roomen C. van, Bierlaagh M.C., Scheij S., Hoeksema M.A., Aerts J.M., Bogan J.S., Dorn G.W., Argmann C.A. & Verhoeven A.J. (2016), A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity, Diabetes 65(9): 2591-605.
- Kramer G., Wegdam W., Donker-Koopman W., Ottenhoff R., Gaspar P., Verhoek M., Nelson J., Gabriel T., Kallemeijn W.W., Boot R.G., Laman J.D., Vissers J.P., Cox T., Pavlova E., Moran M.T., Aerts J.M.F.G. & Eijk M.C. van (2016), Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models, FEBS Open Bio 6(9): 902-913.
- Mirzaian M., Wisse P., Ferraz M.J., Marques A.R., Gabriel T.L., Roomen C.P. van, Ottenhoff R., Eijk M. van, Codée J.D., Marel G.A. van der, Overkleeft H.S. & Aerts J.M. (2016), Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard, Clinica Chimica Acta 459: 36-44.
- Kurakula K., Vos M., Eijk M. van, Smits H.H. & Vries C.J.M. de (2015), LIM-only protein FHL2 regulates experimental pulmonary Schistosoma mansoni egg granuloma formation, European Journal of Immunology 45(11): 3098-3106.
- Chao D.H.M., Kallemeijn W.W., Marques A.R.A., Orre M., Ottenhoff R., Roomen C. van, Foppen E., Renner M.C., Moeton M., Eijk M. van, Boot R.G., Kamphuis W., Hol E.M., Aten J., Overkleeft H.S., Kalsbeek A. & Aerts J.M.F.G. (2015), Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes, PLoS ONE 10(9): e0138107.
- Virtue S., Masoodi M., Weijer B.A.M. de, Eijk M. van, Mok C.Y.L., Eiden M., Dale M., Pirraco A., Serlie M.J., Griffin J.L. & Vidal-Puig A. (2015), Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans, International Journal of Obesity 39(7): 1151-1160.
- Dessing M.C., Tammaro A., Pulskens W.P., Teske G.J., Butter L.M., Claessen N., Eijk M. van, Poll T. van der, Vogl T., Roth J., Florquin S. & Leemans J.C. (2015), The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion, Kidney International 87(1): 85-94.
- Franken R., Radonic T., Hartog A.W. den, Groenink M., Pals G., Eijk M. van, Lutter R., Mulder B.J., Zwinderman A.H. & Waard V. de (2015), The revised role of TGF-β in aortic aneurysms in Marfan syndrome, Netherlands Heart Journal 23(2): 116-21.
- Gabriel Tanit L., Tol Marc J., Ottenhof Roelof, Van Roomen Cindy, Aten Jan, Claessen Nike, Hooibrink Berend, De Weijer Barbara, Serlie Mireille J., Argmann Carmen, Van Elsenburg Leonie, Aerts Johannes M.P.G. & Van Eijk Marco (2014), Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction, Diabetes 63(10): 3310-3323.
- Gaspar P., Kallemeijn W.W., Strijland A., Scheij S., Eijk M. van, Aten J., Overkleeft H.S., Balreira A., Zunke F., Schwake M., Sa Miranda M.C. & Aerts J.M.F.G. (2014), Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis, 55(1): 138-145.
- Xu X., Grijalva A., Skowronski A., Eijk M. van, Serlie M.J. & Ferrante A.W.Jr. (2013), Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation, Cell Metabolism 18(6): 816-830.
- Melief J., Schuurman K.G., Garde M.D.B. van de, Smolders J., Eijk M. van, Hamann J. & Huitinga I. (2013), Microglia in Normal Appearing White Matter of Multiple Sclerosis are Alerted but Immunosuppressed, Glia 61(11): 1848-1861.
- Melief J., Koning N., Schuurman K.G., Garde M.D.B. van de, Smolders J., Hoek R.M., Eijk M. van, Hamann J. & Huitinga I. (2012), Phenotyping primary human microglia: Tight regulation of LPS responsiveness, Glia 60(10): 1506-1517.
- Ambarus C.A., Krausz S., Eijk M. van, Hamann J., Radstake T.R.D.J., Reedquist K.A., Tak P.P. & Baeten D.L.P. (2012), Systematic validation of specific phenotypic markers for in vitro polarized human macrophages, Journal of Immunological Methods 375(1-2): 196-206.
- Radonic T., Witte P. de, Groenink M., Waard V. de, Lutter R., Eijk M. van, Jansen M., Timmermans J., Kempers M., Scholte A.J., Hilhorst-Hofstee Y., Berg M.P. van den, Tintelen J.P. van, Pals G., Baars M.J.H., Mulder B.J.M. & Zwinderman A.H. (2012), Inflammation Aggravates Disease Severity in Marfan Syndrome Patients, PLOS ONE 7(3): e0032963.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance, Advances in Experimental Medicine and Biology 721: 99-119.
- Reuwer A.Q., Eijk M. van, Houttuijn-Bloemendaal F.M., Loos C.M. van der, Claessen N., Teeling P., Kastelein J.J.P., Hamann J., Goffin V., Thusen J.H. von der, Twickler M.T.B. & Aten J. (2011), The prolactin receptor is expressed in macrophages within human carotid atherosclerotic plaques: a role for prolactin in atherogenesis?, Journal of Endocrinology 208(2): 107-117.
- Aerts J.M.F.G., Boot R.G., Eijk M.C. van, Groener J., Bijl N., Lombardo E., Bietrix F.M., Dekker N., Groen A.K., Ottenhoff R., Roomen C. van, Aten J., Serlie M., Langeveld M., Wennekes T. & Overkleeft H.S. (2011), Glycosphingolipids and insulin resistance. In: Cowart L.A. (Ed.), Sphingolipids and Metabolic Disease. Advances in Experimental Medicine and Biology no. 721. New York, NY, U.S.A.: Springer. 20-41.
- Pols T.W.H., Bonta P.I., Pires N.M.M., Otermin I., Vos M., Vries M.R. de, Eijk M. van, Roelofsen J., Havekes L.M., Quax P.H.A., Kuilenburg A.B.P. van, Waard V. de, Pannekoek H. & Vries C.J.M. de (2010), 6-Mercaptopurine Inhibits Atherosclerosis in Apolipoprotein E*3-Leiden Transgenic Mice Through Atheroprotective Actions on Monocytes and Macrophages, Arteriosclerosis, Thrombosis, and Vascular Biology 30(8): 1591-U184.
- Eijk M.C. van, Voorn-Brouwer T., Scheij S.S., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2010), Curdlan-mediated regulation of human phagocyte-specific chitotriosidase, FEBS Letters 584(14): 3165-3169.
- Eijk M.C. van, Aust G., Brouwer M.S.M., Meurs M. van, Voerman J.S.A., Dijke I.E., Pouwels W., Saendig I., Wandel E., Aerts J.M.F.G., Boot R.G., Laman J.D. & Hamann J. (2010), Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease, Immunology Letters 129(2): 64-71.
- Koning N., Eijk M. van, Pouwels W., Brouwer M.S.M., Voehringer D., Huitinga I., Hoek R.M., Raes G. & Hamann J. (2010), Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation, Journal of Innate Immunity 2(2): 195-200.
- Wennekes T., Meijer A.J., Groen A.K., Boot R.G., Groener J.E., Eijk M.C. van, Ottenhoff R., Bijl N., Ghauharali K., Song H., O'Shea T.J., Liu H., Yew N., Copeland D., Berg R.J.B.H.N. van den, Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry 53(2): 689-698.
- Bijl N., Roomen C.P.A.A. van, Triantis V., Sokolovic M., Ottenhoff R., Scheij S., Eijk M. van, Boot R.G., Aerts J.M.F.G. & Groen A.K. (2009), Reduction of Glycosphingolipid Biosynthesis Stimulates Biliary Lipid Secretion In Mice, Hepatology 49(2): 637-645.
- Bijl N., Sokolovic M., Vrins C., Langeveld M., Moerland P.D., Ottenhoff R., Roomen C.P.A.A. van, Claessen N., Boot R.G., Aten J., Groen A.K., Aerts J.M.F.G. & Eijk M.C. van (2009), Modulation of Glycosphingolipid Metabolism Significantly Improves Hepatic Insulin Sensitivity and Reverses Hepatic Steatosis in Mice, Hepatology 50(5): 1431-1441.
- Iyer A., Eijk M. van, Silva E., Hatta M., Faber W., Aerts J.M.F.G. & Das P.K. (2009), Increased chitotriosidase activity in serum of leprosy patients: Association with bacillary leprosy, Clinical Immunology 131(3): 501-509.
- Eijk M.C. van, Aten J., Bijl N., Ottenhoff R., Roomen C.P.A.A. van, Dubbelhuis P.F., Seeman I., Ghauharali-Vlugt van der K., Overkleeft H.S., Arbeeny C., Groen A.K. & Aerts J.M.F.G. (2009), Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation, PLoS ONE 4(3): e4723.
- Hamann J., Koning N., Pouwels W., Ulfman L.H., Eijk M. van, Stacey M., Lin H.-H., Gordon S. & Kwakkenbos M.J. (2007), EMR1, the human homolog of F4/80, is an eosinophil-specific receptor, European Journal of Immunology 37(10): 2797-2802.
- Eijk M.C. van, Scheij S.S., Roomen C.P.A.A. van, Speijer D., Boot R.G. & Aerts J.M.F.G. (2007), TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase, FEBS Letters 581(28): 5389-5395.
- Bussink A.P., Swieten P.F. van, Ghauharali K., Scheij S., Eijk M.C. van, Wennekes T., Marel G.A. van der, Boot R.G., Aerts J.M.F.G. & Overkleeft H.S. (2007), N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides, Journal of Lipid Research 48(6): 1417-1421.
- Aerts J.M.F.G., Ottenhoff R., Powlson A.S., Grefhorst A., Eijk M. van, Dubbelhuis P.F., Aten J., Kuipers F., Serlie M.J., Wennekes T., Sethi J.K., O'Rahilly S. & Overkleeft H.S. (2007), Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity, Diabetes 56(5): 1341-1349.
- Nierop K. van, Muller F.J.M., Stap J., Noorden C.J.F. van, Eijk M. van & Groot C. de (2006), Lysosomal destabilization contributes to apoptosis of germinal center B-lymphocytes, Journal of Histochemistry and Cytochemistry 54(12): 1425-1435.
- Eijk M.C. van, Roomen C.P.A.A. van, Renkema G.H., Bussink A.P., Andrews L., Blommaart E.F.C., Sugar A., Verhoeven A.J., Boot R.G. & Aerts J.M.F.G. (2005), Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity, International Immunology 17(11): 1505-1512.