Helle van den Maagdenberg
During my bachelor Bio-Pharmaceutical Sciences at Leiden University (2016-2019), I wrote my thesis on modelling the effect of morphine in pre-verbal children. I discovered I was specifically interested in the computational aspect of modelling. Therefore, I chose to start the master computer science (2019-2021) with a specialization in Bioinformatics to broaden my horizon and learn more on this subject. During the master program I worked on a research project to develop a deep-learning model for cell tracking at LIACS. I finished my master with a thesis project at LAP&P. The topic was to explore and create a framework for determining parameter identifiability for a series of Target Mediated Drug Disposition models with different biomarkers and parameter sets through simulation. I am currently doing my PhD research under the supervision of Prof.Dr. Gerard van Westen, Dr. Coen van Hasselt and Prof.Dr. Piet van der Graaf on the topic of virtual drug discovery. The aim of the project is to couple computational chemistry and pharmacology modelling methods in a single approach to virtual drug discovery. This will be applied to multiple relevant disease areas currently being investigated at Leiden University.
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