Frits Koning
Professor emeritus Immunology, in particular the Protein Chemical Aspects of Immune-mediated Diseases
- Name
- Prof.dr. F. Koning
- Telephone
- +31 71 526 9111
- f.koning@lumc.nl
- ORCID iD
- 0000-0002-4007-5715
Staff member in the department of Immunology, member of the daily management team. Chairman of the Scientific Advisory board of the LUMC. Member of the Biomedical Sciences Program committee. Recipient of a prestigious PIONIER grant from the Netherlands Organization for Scientific Research in 1993. Director of the Celiac Disease Consortium 2004-2014 (11,7 million Euro grant from the Dutch Government).
More information about Frits Koning
Gastrointestinal disorders
My main interest is in gastrointestinal disorders like celiac disease, Crohn and ulcerative colitis. Here we make use of a recent technological innovation, mass cytometry, by which we can unravel the role of the immune system in these disorders. We expect that this will ultimately lead to improved diagnosis and tailored patient-specific therapies.
Academic career
PhD 30-01-1986 (Identification and functional relevance of epitopes on human lymphocytes); Postdoctoral fellow NIH 1986-1988; Researcher LUMC 1988-1993; Associate Professor 1993-2006; Sabbatical La Jolla Institute for Allergy and Immunology 200-2001; full professor 2006-. Title oratie: “Een koekje van ander deeg”.
Prizes and honourable appointments
1986: Nato Science Fellowship; 1987: Fogarty International Fellowship from the National Institutes of Health, Bethesda, MD, U.S.A; 1992: C.J. Kok award (Faculty of Medicine, University of Leiden); 2000: Fulbright Scholar Grant; 2004. Guido-Tytgat laureate (Dutch Society of Gastroenterology); 2010. The Rank Prize for Nutrition (London, UK); 2011. The W.K. Warren Jr. Prize for excellence in Celiac Disease Research (San Diego, USA); 2013. Van Lochem laureate. (Dutch Society for Immunology).
Confidential Adviser on Academic Integrity
Frits Koning is Confidential Adviser on Academic Integrity for staff members of the Faculty of Medicine/LUMC. He is also the confidential advisor for the PhD's of the Faculty of Medicine/LUMC.
Professor emeritus Immunology, in particular the Protein Chemical Aspects of Immune-mediated Diseases
- Faculteit Geneeskunde
- Divisie 4
- Immunologie
- IHB algemeen
Contact
- Doytchinova, I.; Atanasova, M.; Fernandez, A.; Moreno, F.J.; Koning, F. & Dimitrov, I. (2024), Modeling peptide-protein interactions by a logo-based method, Molecules 29(2).
- Atanasova, M.; Dimitrov, I.; Fernandez, A.; Moreno, J.; Koning, F. & Doytchinova, I. (2024), Assessment of novel proteins triggering celiac disease via docking-based approach, Molecules 29(1).
- Tessa Dieckman, Michael Schumann, Hanneke Beaumont, Hetty J Bontkes, Frits Koning, Gerd Bouma & RCDII Tofacitinib Consortium (2024), Enduring clinical remission in refractory celiac disease type II with tofacitinib: an open-label clinical study, Clinical Gastroenterology and Hepatology.
- Ouboter, L.F.; Lindelauf, C.; Jiang, Q.Y.; Schreurs, M.; Abdelaal, T.R.; Luk, S.J.; Barnhoorn, M.C.; Hueting, W.E.; Han-Geurts, I.J.; Peeters, K.C.M.J.; Holman, F.A.; Koning, F.; Jong, A.E.V. & Pascutti, M.F. (2024), Activated HLA-DR+CD38+ Effector Th1/17 cells distinguish Crohn's disease-associated perianal fistulas from cryptoglandular fistulas, Inflammatory Bowel Diseases.
- Hendriks, S.H.; Heidt, S.; Schulz, A.R.; Fijter, J.W. de; Reinders, M.E.J.; Koning, F. & Kooten, C. van (2023), Peripheral blood immune cell composition after autologous MSC infusion in kidney transplantation recipients, Transplant International 36.
- Pool, E.S.; Kooy-Winkelaar, Y.; Unen, V. van; Falkenburg, J.H.F.; Koning, F.; Heemskerk, M.H.M. & Tjon, J.M.L. (2023), Mass cytometric analysis unveils a disease-specific immune cell network in the bone marrow in acquired aplastic anemia, Frontiers in Immunology 14.
- Ouboter, L.F.; Barnhoorn, M.C.; Verspaget, H.W.; Plug, L.; Pool, E.S.; Szuhai, K.; Hawinkels, L.J.A.C.; Pel, M. van; Zwaginga, J.J.; Roelen, D.; Koning, F.; Pascutti, M.F. & Meulen-de Jong, A.E. van der (2023), Local administration of mesenchymal stromal cells is safe and modulates the immune compartment in ulcerative proctitis, JCI Insight 8(9).
- Guo, N.N.; Li, N.; Jia, L.; Jiang, Q.Y.; Schreurs, M.; Unen, V. van; Lopes, S.M.C.D.; Vloemans, A.A.; Eggermont, J.; Lelieveldt, B.; Staal, F.J.T.; Miranda, N.F.C.C. de; Pascutti, M.F. & Koning, F. (2023), Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation, Nature Communications 14(1).
- Krop, J.; Meeren, L.E. van der; Hoorn, M.L.P. van der; Ijsselsteijn, M.E.; Dijkstra, K.L.; Kapsenberg, H.; Keur, C. van der; Cornish, E.F.; Nikkels, P.G.J.; Koning, F.; Claas, F.H.J.; Heidt, S.; Eikmans, M. & Bos, M. (2023), Identification of a unique intervillous cellular signature in chronic histiocytic intervillositis, Placenta 139: 34-42.
- Vries, N.L. de; Haar, J. van de; Veninga, V.; Chalabi, M.; Ijsselsteijn, M.E.; Ploeg, M. van der; Bulk, J. van den; Ruano, D.; Berg, J.G. van den; Haanen, J.B.; Zeverijn, L.J.; Geurts, B.S.; Wit, G.F. de; Battaglia, T.W.; Gelderblom, H.; Verheul, H.M.W.; Schumacher, T.N.; Wessels, L.F.A.; Koning, F.; Miranda, N.F.C.C. de & Voest, E.E. (2023), γδ T cells are effectors of immunotherapy in cancers with HLA class I defects, Nature 613(7945).
- Unen, V. van; Ouboter, L.F.; Li, N.; Schreurs, M.; Abdelaal, T.; Kooy-Winkelaar, Y.; Beyrend, G.; Hoellt, T.; Maljaars, P.W.J.; Mearin, M.L.; Mahfouz, A.; Witte, A.M.C.; Clemens, C.H.M.; Abraham, S.; Escher, J.C.; Lelieveldt, B.P.F.; Pascutti, M.F.; Jong, A.E.V.E. de & Koning, F. (2022), Identification of a disease-associated network of intestinal immune cells in treatment-naive inflammatory bowel disease, Frontiers in Immunology 13.
- Unen, V. van; Ouboter, L.F.; Li, N.; Schreurs, M.; Abdelaal, T.; Kooy-Winkelaar, Y.; Beyrend, G.; Hoellt, T.; Maljaars, P.W.J.; Mearin, M.L.; Mahfouz, A.; Witte, A.M.C.; Clemens, C.H.M.; Abraham, S.; Escher, J.C.; Lelieveldt, B.P.F.; Pascutti, M.F.; Jong, A.E.V.E. de & Koning, F. (2022), Identification of a disease-associated network of intestinal immune cells in treatment-naive inflammatory bowel disease, Frontiers in Immunology 13.
- Dieckman, T.; Koning, F. & Bouma, G. (2022), Celiac disease: new therapies on the horizon, Current Opinion in Pharmacology 66.
- Krop, J.; Zwan, A. van der; Ijsselsteijn, M.E.; Kapsenberg, H.; Luk, S.J.; Hendriks, S.H.; Keur, C. van der; Verleng, L.J.; Somarakis, A.; Meeren, L. van der; Haasnoot, G.; Bos, M.; Miranda, N.F.C.C. de; Lopes, S.M.C.D.; Hoorn, M.L.P. van der; Koning, F.; Claas, F.H.J.; Heidt, S. & Eikmans, M. (2022), Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface, iScience 25(7).
- Dieckman, T.; Schreurs, M.; Mahfouz, A.; Kooy-Winkelaar, Y.; Neefjes-Borst, A.; Bouma, G. & Koning, F. (2022), Single-cell analysis of refractory celiac disease demonstrates inter- and intra-patient aberrant cell heterogeneity, Cellular and Molecular Gastroenterology and Hepatology 14(1): 173-192.
- Guo, N.N.; Jia, L.; Out-Luiting, C.; Miranda, N.F.C.C. de; Willemze, R.; Koning, F.; Vermeer, M. & Quint, K. (2022), Mass cytometric analysis of early-stage mycosis fungoides, Cells 11(7).
- Brouwer, T.P.; Vries, N.L. de; Abdelaal, T.; Krog, R.T.; Li, Z.; Ruano, D.; Farina, A.; Lelieveldt, B.P.F.; Morreau, H.; Bonsing, B.A.; Vahrmeijer, A.L.; Koning, F. & Miranda, N.F.C.C. de (2022), Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry, Journal for ImmunoTherapy of Cancer 10(7).
- Ouboter, L.; Barnhoorn, M.; Plug, L.; Pel, M. van; Zwaginga, J.J.; Roelen, D.; Pascutti, E.; Koning, F.; Hawinkels, L.; Verspaget, H. & Meulen-de Jong, A. van der (2021), Endoscopically injected allogeneic mesenchymal stromal cells alter the mucosal immune cell compartment in patients with ulcerative proctitis, Journal of Crohn's and Colitis 15: S098-S099.
- Gracht, E.T.I. van der; Beyrend, G.; Abdelaal, T.; Pardieck, I.N.; Wesselink, T.H.; Haften, F.J. van; Duikeren, S. van; Koning, F. & Arens, R. (2021), Memory CD8(+) T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment, iScience 24(1).
- Scherf, K.A.; Catassi, C.; Chirdo, F.G.; Ciclitira, P.J.; Feighery, C.F.; Gianfrani, C.; Koning, F.; Lundin, K.E.A.; Masci, S.; Schuppan, D.; Smulders, M.J.M.; Tranquet, O.; Troncone, R. & Koehler, P. (2021), Statement of the prolamin working group on the determination of gluten in fermented foods containing partially hydrolyzed gluten, Frontiers in Nutrition 7.
- Bakker, O.B.; Ramirez-Sanchez, A.D.; Borek, Z.A.; Klein, N. de; Li, Y.; Modderman, R.; Kooy-Winkelaar, Y.; Johannesen, M.K.; Matarese, F.; Martens, J.H.A.; Kumar, V.; Bergen, J. van; Qiao, S.W.; Lundin, K.E.A.; Sollid, L.M.; Koning, F.; Wijmenga, C.; Withoff, S. & Jonkers, I.H. (2021), Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+T cells, Scientific Reports 11(1).
- Krop, J.; Kapsenberg, H.; Keur, C. van der; Hoorn, M.L. van der; Koning, F.; Claas, F.; Heidt, S. & Eikmans, M. (2021), Are Regulatory T-cells Involved in Attaining an Ongoing Uncomplicated Pregnancy after Unexplained Recurrent Pregnancy Loss?, Reproductive Sciences 28(SUPPL 1): 166A-166A.
- Fernandez, A.; Mills, E.N.C.; Koning, F. & Moreno, F.J. (2021), Allergenicity assessment of novel food proteins: what should be improved?, Trends in Biotechnology 39(1): 4-8.
- Vriz, R.; Moreno, F.J.; Koning, F. & Fernandez, A. (2021), Ranking of immunodominant epitopes in celiac disease: Identification of reliable parameters for the safety assessment of innovative food proteins, Food and Chemical Toxicology 157.
- Drs, L.O.; Barnhoorn, M.; Pel, M. van; Zwaginga, J.J.; Hawinkels, L.; Maljaars, J.; Koning, F.; Verspaget, H. & Meulen-de de Jong, A. van der (2021), Locally injected allogeneic bone marrow-derived mesenchymal stromal cells for the treatment of refractory proctitis: clinical results of a phase IIa trial, Journal of Crohn's and Colitis 15: S381-S381.
- Krop, J.; Hoorn, M.L. van der; Kapsenberg, H.; Keur, C. van der; Koning, F.; Claas, F.; Heidt, S. & Eikmans, M. (2021), INCREASED AMOUNT OF REGULATORY T CELLS MAY BE REQUIRED IN ATTAINING AN ONGOING UNCOMPLICATED PREGNANCY AFTER UNEXPLAINED RECURRENT PREGNANCY LOSS., Placenta 112: E22-E22.
- Jong, S.E. de; Unen, V. van; Manurung, M.D.; Stam, K.A.; Goeman, J.J.; Jochems, S.P.; Hollt, T.; Pezzotti, N.; Mouwenda, Y.D.; Ongwe, M.E.B.; Lorenz, F.R.; Kruize, Y.C.M.; Azimi, S.; Konig, M.H.; Vilanova, A.; Eisemann, E.; Lelieveldt, B.P.F.; Roestenberg, M.; Sim, B.K.L.; Reinders, M.J.T.; Fendel, R.; Hoffman, S.L.; Kremsner, P.G.; Koning, F.; Mordmuller, B.; Lell, B. & Yazdanbakhsh, M. (2021), Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity, Nature Immunology 22(5): 654-+.
- Graaf, A. van der; Zorro, M.M.; Claringbould, A.; Vosa, U.; Aguirre-Gamboa, R.; Li, C.; Mooiweer, J.; Ricano-Ponce, I.; Borek, Z.; Koning, F.; Kooy-Winkelaar, Y.; Sollid, L.M.; Qiao, S.W.; Kumar, V.; Li, Y.; Franke, L.; Withoff, S.; Wijmenga, C.; Sanna, S.; Jonkers, I. & BIOS Consortium (2021), Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFN gamma signaling in Celiac disease, Frontiers in Genetics 11.
- Somarakis, A.; Unen, V. van; Koning, F.; Lelieveldt, B. & Hollt, T. (2021), ImaCytE: visual exploration of cellular micro-environments for imaging mass cytometry data, IEEE Transactions on Visualization and Computer Graphics 27(1): 98-110.
- Khedoe, P.P.S.J.; Li, N.; Jia, L.; Guo, N.N.; Hiemstra, P.S.; Koning, F. & Stolk, J. (2020), High-dimensional mass cytometry analysis of immune cells in emphysematous lung tissue, European Respiratory Journal 56.
- Sollid, L.M.; Tye-Din, J.A.; Qiao, S.W.; Anderson, R.P.; Gianfrani, C. & Koning, F. (2020), Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4(+) T cells, Immunogenetics 72(1-2): 85-88.
- Drs, L.O.; Barnhoorn, M.C.; Hawinkels, L.J.A.C.; Pel, M. van; Zwaginga, J.J.; Verspaget, H.W.; Koning, F.; Pascutti, M.F. & Meulen-de Jong, A.E. van der (2020), High-dimensional mass cytometry after local MSC treatment in patients with refractory proctitis shows an effect on the myeloid compartment: preliminary data, Journal of Crohn's and Colitis 14: S174-S175.
- Groot, N.G. de; Heijmans, C.M.C.; Rue, A.H. de; Otting, N.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2020), Chimpanzees and bonobos have MHC-A allotypes resembling an HLA-A*03-like supertype: implications for controlling retroviral infections , HLA: Immune Response Genetics 95(4): 274-275.
- Vries, N.L. de; Mahfouz, A.; Koning, F. & Miranda, N.F.C.C. de (2020), Unraveling the complexity of the cancer microenvironment with multidimensional genomic and cytometric technologies, Frontiers in Oncology 10.
- Ruiter, K. de; Jochems, S.P.; Tahapary, D.L.; Stam, K.A.; Konig, M.; Unen, V. van; Laban, S.; Hollt, T.; Mbow, M.; Lelieveldt, B.P.F.; Koning, F.; Sartono, E.; Smit, J.W.A.; Supali, T. & Yazdanbakhsh, M. (2020), Helminth infections drive heterogeneity in human type 2 and regulatory cells, Science Translational Medicine 12(524).
- Scherf, K.A.; Catassi, C.; Chirdo, F.; Ciclitira, P.J.; Feighery, C.; Gianfrani, C.; Koning, F.; Lundin, K.E.A.; Schuppan, D.; Smulders, M.J.M.; Tranquet, O.; Troncone, R. & Koehler, P. (2020), Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity, Frontiers in Nutrition 7.
- Sajic, N.; Oplatowska-Stachowiak, M.; Streppel, L.; Drijfhout, J.W.; Salden, M. & Koning, F. (2020), Performance characteristics of a new competitive DQ2.5-glia-alpha 3 gliadin ELISA, Food Control 110.
- Groot, N.G. de; Heijmans, C.M.C.; Ru, A.H. de; Otting, N.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2020), The HLA A03 supertype and several pan species major histocompatibility complex class I A allotypes share a preference for binding positively charged residues in the F pocket, Journal of Virology 94(9).
- Zwan, A. van der; Unen, V. van; Beyrend, G.; Laban, S.; Keur, C. van der; Kapsenberg, H.J.M.; Hollt, T.; Lopes, S.M.C.D.; Hoorn, M.L.P. van der; Koning, F.; Claas, F.H.J.; Eikmans, M. & Heidt, S. (2020), Visualizing dynamic changes at the maternal-fetal interface throughout human pregnancy by mass cytometry, Frontiers in Immunology 11.
- Guo, N.N.; Unen, V. van; Ijsselsteijn, M.E.; Ouboter, L.F.; Meulen, A.E. van der; Lopes, S.M.C.D.; Miranda, N.F.C.C. de; Koning, F. & Li, N. (2020), A 34-marker panel for imaging mass cytometric analysis of human snap-frozen tissue, Frontiers in Immunology 11.
- Vries, N.L. de; Unen, V. van; Ijsselsteijn, M.E.; Abdelaal, T.; Breggen, R. van der; Sarasqueta, A.F.; Mahfouz, A.; Peeters, K.C.M.J.; Hollt, T.; Lelieveldt, B.P.F.; Koning, F. & Miranda, N.F.C.C. de (2020), High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity, Gut 69(4): 691-703.
- Gracht, E.T.I. van der; Schoonderwoerd, M.J.; Duikeren, S. van; Yilmaz, A.N.; Behr, F.M.; Colston, J.M.; Lee, L.N.; Yagita, H.; Gisbergen, K.P.J.M. van; Hawinkels, L.J.A.C.; Koning, F.; Klenerman, P. & Arens, R. (2020), Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer, Journal for ImmunoTherapy of Cancer 8(2).
- Unen, V. van; Li, N.; Abdelaal, T.; Kooy-Winkelaar, Y.; Ouboter, L.; Beyrend, G.; Hollt, T.; Mearin, L.; Witte, A.; Escher, H.; Lelieveldt, B.; Meulen-de Jong, A. van der & Koning, F. (2019), High-dimensional mass cytometry reveals the immune cell landscape in inflammatory bowel disease, Journal of Crohn's and Colitis 13: S20-S20.
- Guo, N.; Li, N.; Out-Luiting, C.; Quint, K.; Vermeer, M. & Koning, F. (2019), High-dimensional analysis of the immune system in mycosis fungoides, European Journal of Immunology 49: 1990-1991.
- Ijsselsteijn, M.E.; Breggen, R. van der; Sarasqueta, A.F.; Koning, F. & Miranda, N.F.C.C. de (2019), A 40-Marker Panel for High Dimensional Characterization of Cancer Immune Microenvironments by Imaging Mass Cytometry, Frontiers in Immunology 10.
- Schinkelshoek, M.; Kooy-Winkelaar, Y.; Triller, A.; Dietmann, A.; Kallweit, U.; Fronczek, R.; Bassetti, C.; Lammers, G.J. & Koning, F. (2019), Mass cytometry-based analysis of the composition of the immune system in narcolepsy type 1, European Journal of Neurology 26: 1004-1005.
- Fergusson, J.R.; Morgan, M.D.; Bruchard, M.; Huitema, L.; Heesters, B.A.; Unen, V. van; Hamburg, J.P. van; Wel, N.N. van der; Picavet, D.; Koning, F.; Tas, S.W.; Anderson, M.S.; Marioni, J.C.; Hollander, G.A. & Spits, H. (2019), Maturing Human CD127+CCR7+PDL1+Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens, Frontiers in Immunology 9.
- Miranda, N.F. de; Vries, N.L. de; Unen, V. van; Abdelaal, T.; Ijsselsteijn, M.E.; Breggen, R. van der; Farina-Sarasqueta, A.; Peeters, K.C.M.J.; Hollt, T.; Lelieveldt, B.P.F. & Koning, F. (2019), Multidimensional cytometric analysis of colorectal cancer reveals novel and diverse mediators of antitumor immunity, Cancer Immunology Research 7(2).
- Beyrend, G.; Gracht, E. van der; Yilmaz, A.; Duikeren, S. van; Camps, M.; Hollt, T.; Vilanova, A.; Unen, V. van; Koning, F.; Miranda, N.F.C.C. de; Arens, R. & Ossendorp, F. (2019), PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors, Journal for ImmunoTherapy of Cancer 7(1).
- Petersen, J.; Ciacchi, L.; Tran, M.T.; Loh, K.L.; Kooy-Winkelaar, Y.; Croft, N.P.; Hardy, M.Y.; Chen, Z.J.; McCluskey, J.; Anderson, R.P.; Purcell, A.W.; Tye-Din, J.A.; Koning, F.; Reid, H.H. & Rossjohn, J. (2019), T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease, Nature Structural and Molecular Biology.
- Bassetti, C.L.A.; Adamantidis, A.; Burdakov, D.; Han, F.; Gay, S.; Kallweit, U.; Khatami, R.; Koning, F.; Kornum, B.R.; Lammers, G.J.; Liblau, R.S.; Luppi, P.H.; Mayer, G.; Pollmacher, T.; Sakurai, T.; Sallusto, F.; Scammell, T.E.; Tafti, M. & Dauvilliers, Y. (2019), Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment, Nature Reviews Neurology 15(9): 519-539.
- Unen, V. van; Li, N.; Abdelaal, T.; Ouboter, L.; Kooy-Winkelaar, Y.; Beyrend, G.; Hollt, T.; Mearin, L.; Lelieveldt, B.; Meulen-de Jong, A. van der & Koning, F. (2019), High-dimensional mass cytometry reveals the immune cell landscape in untreated inflammatory bowel disease, European Journal of Immunology 49: 1376-1376.
- Zwan, A. van der; Krop, J.; Unen, V. van; Beyrend, G.; Laban, S.; Kapsenberg, H.; Keur, C. van der; Hollt, T.; Lopes, S.C.D.; Hoorn, M.L. van der; Koning, F.; Claas, F. & Heidt, S. (2019), MAPPING DYNAMIC CHANGES IN THE MATERNAL IMMUNE COMPARTMENT THROUGHOUT PREGNANCY USING MASS CYTOMETRY WITH A SPECIFIC FOCUS ON REGULATORY T CELLS, HLA: Immune Response Genetics 93(5): 264-264.
- Schinkelshoek, M.S.; Fronczek, R.; Kooy-Winkelaar, E.M.C.; Petersen, J.; Reid, H.H.; Heide, A. van der; Drijfhout, J.W.; Rossjohn, J.; Lammers, G.J. & Koning, F. (2019), H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+T cells can be readily detected in narcolepsy type 1 patients and healthy controls, Journal of Neuroimmunology 332: 167-175.
- Li, N.; Unen, V. van; Abdelaal, T.; Guo, N.N.; Kasatskaya, S.A.; Ladell, K.; McLaren, J.E.; Egorov, E.S.; Izraelson, M.; Lopes, S.M.C.D.; Hollt, T.; Britanova, O.V.; Eggermont, J.; Miranda, N.F.C.C. de; Chudakov, D.M.; Price, D.A.; Lelieveldt, B.P.F. & Koning, F. (2019), Memory CD4(+) T cells are generated in the human fetal intestine, Nature Immunology 20(3): 301-+.
- Li, N.; Unen, V. van; Guo, N.; Abdelaal, T.; Somarakis, A.; Eggermont, J.; Mahfouz, A.; Lopes, S.M.C.D.; Lelieveldt, B.P.F. & Koning, F. (2019), Early compartmentalization of immune cells in human fetal tissues revealed by high-dimensional mass cytometry, European Journal of Immunology 49: 1350-1351.
- Li, N.; Unen, V. van; Guo, N.N.; Abdelaal, T.; Somarakis, A.; Eggermont, J.; Mahfouz, A.; Lopes, S.M.C.D.; Lelieveldt, B.P.F. & Koning, F. (2019), Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry, Frontiers in Immunology 10.
- Abdelaal, T.; Hollt, T.; Unen, V. van; Lelieveldt, B.P.F.; Koning, F.; Reinders, M.J.T. & Mahfouz, A. (2019), CyTOFmerge: integrating mass cytometry data across multiple panels, Bioinformatics 35(20): 4063-4071.
- Beyrend, G.; Gracht, E. van der; Yilmaz, A.; Duikeren, S. van; Camps, M.; Hollt, T.; Vilanova, A.; Unen, V. van; Koning, F.; Miranda, N.F.C.C. de; Arens, R. & Ossendorp, F. (2019), PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors, Journal for ImmunoTherapy of Cancer 7(1).
- Abdelaal, T.; Unen, V. van; Hollt, T.; Koning, F.; Reinders, M.J.T. & Mahfouz, A. (2019), Predicting Cell Populations in Single Cell Mass Cytometry Data, Cytometry Part A 95A(7): 769-781.
- Fernandez, A.; Mills, E.N.C.; Koning, F. & Moreno, F.J. (2019), Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins, Trends in Biotechnology 37(8): 796-800.
- Schinkelshoek, M.S.; Fronczek, R.; Kooy-Winkelaar, E.M.C.; Petersen, J.; Reid, H.H.; Heide, A. van der; Drijfhout, J.W.; Rossjohn, J.; Lammers, G.J. & Koning, F. (2019), H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+T cells can be readily detected in narcolepsy type 1 patients and healthy controls, Journal of Neuroimmunology 332: 167-175.
- Lanzoni, A.; Castoldi, A.F.; Kass, G.E.N.; Terron, A.; Seze, G. de; Bal-Price, A.; Bois, F.Y.; Delclos, K.B.; Doerge, D.R.; Fritsche, E.; Halldorsson, T.; Kolossa-Gehring, M.; Bennekou, S.H.; Koning, F.; Lampen, A.; Leist, M.; Mantus, E.; Rousselle, C.; Siegrist, M.; Steinberg, P.; Tritscher, A.; Water, B. van de; Vineis, P.; Walker, N.; Wallace, H.; Whelan, M. & Younes, M. (2019), Advancing human health risk assessment, EFSA 3rd Scientific Conference on Science, Food and Society 17.
- Dam, A.D. van; Beek, L. van; Pronk, A.C.M.; Berg, S.M. van den; Bossche, J. van den; Winther, M.P.J. de; Koning, F.; Kooten, C. van; Rensen, P.C.N.; Boon, M.R.; Verbeek, J.S.; Dijk, K.W. van & Harmelen, V. van (2018), IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fc gamma-receptor or complement, International Journal of Obesity 42(2): 260-269.
- Welters, M.J.P.; Ma, W.B.; Santegoets, S.J.A.M.; Goedemans, R.; Ehsan, I.; Jordanova, E.S.; Ham, V.J. van; Unen, V. van; Koning, F.; Egmond, S.I. van; Charoentong, P.; Trajanoski, Z.; Velden, L.A. van der & Burg, S.H. van der (2018), Intratumoral HPV16-Specific T Cells Constitute a Type I-Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer, Clinical Cancer Research 24(3): 634-647.
- Li, N.; Unen, V. van; Hollt, T.; Thompson, A.; Bergen, J. van; Pezzotti, N.; Eisemann, E.; Vilanova, A.; Lopes, S.M.C.D.; Lelieveldt, B.P.F. & Koning, F. (2018), Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine, Journal of Experimental Medicine 215(5): 1383-1396.
- van der Zwan Anita, van Unen Vincent, Hollt Thomas, Kapsenberg Hanneke J. M., van der Hoorn Marie-Louise P., Uyar-Mercankaya Merve, Lopes Susana M. Chuva de Sousa, Koning Frits, Claas Frans H. J. & Heidt Sebastiaan (2018), UNRAVELLING DYNAMIC CHANGES IN THE MATERNAL IMMUNE COMPARTMENT AT THE MATERNAL-FETAL INTERFACE DURING PREGNANCY BY MASS CYTOMETRY, Hla 91(5): 325-325.
- Li, N.; Unen, V. van; Hollt, T.; Thompson, A.; Bergen, J. van; Pezzotti, N.; Eisemann, E.; Vilanova, A.; Lopes, S.M.C.D.; Lelieveldt, B.P.F. & Koning, F. (2018), Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine, Journal of Experimental Medicine 215(5).
- Goodman R. E., Baumert J. L., Taylor S. L., Ebisawa M., Ferreira F., Bohle B., Van Ree R., Kleine-Tebbe J., Abdelmoteleb M., Koning F. & Amnuaycheewa P. (2018), AllergenOnline.org: Update of comprehensive allergen and celiac protein searchable databases for risk assessment of novel food proteins, Allergy 73: 691-692.
- Redeker, A.; Remmerswaal, E.B.M.; Gracht, E.T.I. van der; Welten, S.P.M.; Hollt, T.; Koning, F.; Cicin-Sain, L.; Nikolich-Zugich, J.; Berge, I.J.M. ten; Lier, R.A.W. van; Unen, V. van & Arens, R. (2018), The contribution of cytomegalovirus infection to immune senescence is set by the infectious Dose, Frontiers in Immunology 8.
- Hollt, T.; Pezzotti, N.; Unen, V. van; Koning, F.; Lelieveldt, B.P.F. & Vilanova, A. (2018), CyteGuide: Visual Guidance for Hierarchical Single-Cell Analysis, IEEE Transactions on Visualization and Computer Graphics 24(1): 739-748.
- Groot, N.G. de; Heijmans, C.M.C.; Ru, A.H. de; Janssen, G.M.C.; Drijfhout, J.W.; Otting, N.; Vangenot, C.; Doxiadis, G.G.M.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2017), THE MACAQUE A2*05 GENE ENCODES FOR SPECIALIST MHC MOLECULES WITH HLA-B*27-LIKE PEPTIDE-BINDING CHARACTERISTICS, Hla 89(6): 356-357.
- Groot, N.G. de; Heijmans, C.M.C.; Ru, A.H. de; Janssen, G.M.C.; Drijfhout, J.W.; Otting, N.; Vangenot, C.; Doxiadis, G.G.M.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2017), A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics, Journal of Immunology 199(10): 3679-3690.
- Groot, N.G. de; Heijmans, C.M.C.; Ru, A.H. de; Janssen, G.M.C.; Drijfhout, J.W.; Otting, N.; Vangenot, C.; Doxiadis, G.G.M.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2017), THE MACAQUE A2*05 GENE ENCODES FOR SPECIALIST MHC MOLECULES WITH HLA-B*27-LIKE PEPTIDE-BINDING CHARACTERISTICS, Hla 89(6): 356-357.
- Buckle, T.; Wal, S. van der; Malderen, S.J.M. van; Muller, L.; Kuil, J.; Unen, V. van; Peters, R.J.B.; Bemmel, M.E.M. van; McDonnell, L.A.; Velders, A.H.; Koning, F.; Vanhaecke, F. & Leeuwen, F.W.B. van (2017), Hybrid Imaging Labels: Providing the Link Between Mass Spectrometry-Based Molecular Pathology and Theranostics, Theranostics 7(3): 624-633.
- Zwan, A. van der; Li, N.; Keur, C. van der; Koning, F.; Heidt, S.; Claas, F.H.J. & Unen, V. van (2017), VISUALIZING THE PLAYERS OF THE MATERNAL IMMUNE RESPONSE AT THE MATERNAL-FETAL INTERFACE BY HIGH-DIMENSIONAL MASS CYTOMETRY, Hla 89(6): 339-339.
- Zwan, A. van der; Li, N.; Keur, C. van der; Koning, F.; Heidt, S.; Claas, F. & Unen, V. van (2017), VISUALIZING THE PLAYERS OF THE MATERNAL IMMUNE RESPONSE AT THE MATERNAL-FETAL INTERFACE BY HIGH-DIMENSIONAL MASS CYTOMETRY, Placenta 57: 244-245.
- Unen, V. van; Hollt, T.; Pezzotti, N.; Li, N.; Reinders, M.J.T.; Eisemann, E.; Koning, F.; Vilanova, A. & Lelieveldt, B.P.F. (2017), Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types, Nature Communications 8.
- Leeuwen, M.A. van; Costes, L.M.M.; Berkel, L.A. van; Simons-Oosterhuis, Y.; Pre, M.F. du; Kozijn, A.E.; Raatgeep, H.C.; Lindenbergh-Kortleve, D.J.; Rooijen, N. van; Koning, F. & Samsom, J.N. (2017), Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10-and IFN-gamma-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance, Mucosal Immunology 10(3): 635-649.
- Schinkelshoek, M.; Fronczek, R.; Heide, A. van der; Kooy-Winkelaar, Y.; Koning, F. & Lammers, G.J. (2017), H1N1 HA-specific T-cells can be readily detected in patients with narcolepsy, European Journal of Neurology 24: 76-76.
- Sajic, N.; Oplatowska-Stachowiak, M.; Streppel, L.; Drijfhout, J.W.; Salden, M. & Koning, F. (2017), Development and in-house validation of a competitive ELISA for the quantitative detection of gluten in food, Food Control 80: 401-410.
- Kooy-Winkelaar, Y.M.C.; Bouwer, D.; Janssen, G.M.C.; Thompson, A.; Brugman, M.H.; Schmitz, F.; Ru, A.H. de; Gils, T. van; Bouma, G.; Rood, J.J. van; Veelen, P.A. van; Mearin, M.L.; Mulder, C.J.; Koning, F. & Bergen, J. van (2017), CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes, Proceedings of the National Academy of Sciences 114(6): E980-E989.
- Groot, N.G. de; Heijmans, C.M.C.; Ru, A.H. de; Janssen, G.M.C.; Drijfhout, J.W.; Otting, N.; Vangenot, C.; Doxiadis, G.G.M.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2017), A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics, Journal of Immunology 199(10): 3679-3690.
- Zhou, L.; Kooy-Winkelaar, Y.M.C.; Cordfunke, R.A.; Dragan, I.; Thompson, A.; Drijthou, J.W.; Veelen, P.A. van; Chen, H.B. & Koning, F. (2017), Abrogation of Immunogenic Properties of Gliadin Peptides through Transamidation by Microbial Transglutaminase Is Acyl-Acceptor Dependent, Journal of Agricultural and Food Chemistry 65(34): 7542-7552.
- Mariman, R.; Reefman, E.; Tielen, F.; Persoon-Deen, C.; Mark, K. van de; Worms, N.; Koning, F. & Nagelkerken, L. (2016), Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice, Beneficial Microbes 7(2): 215-225.
- Lips, M.A.; Klinken, J.B. van; Pijil, H.; Janssen, I.; Dijk, K.W. van; Koning, F. & Harmelen, V. van (2016), Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass, Metabolism 65(11): 1614-1620.
- Unen, V. van; Li, N.; Molendijk, I.; Temurhan, M.; Hollt, T.; Meulen-de Jong, A.E. van der; Verspaget, H.W.; Mearin, M.L.; Mulder, C.J.; Bergen, J. van; Lelieveldt, B.P.F. & Koning, F. (2016), Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets, Immunity 44(5): 1227-1239.
- Schmitz, F.; Kooy-Winkelaar, Y.; Wiekmeijer, A.S.; Brugman, M.H.; Mearin, M.L.; Mulder, C.; Lopes, S.C.D.; Mummery, C.L.; Staal, F.J.T.; Bergen, J. van & Koning, F. (2016), The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease, Gut 65(8): 1269-1278.
- Hollt, T.; Pezzotti, N.; Unen, V. van; Koning, F.; Eisemann, E.; Lelieveldt, B. & Vilanova, A. (2016), Cytosplore: Interactive Immune Cell Phenotyping for Large Single-Cell Datasets, Computer Graphics Forum 35(3): 171-180.
- Fronczek, R.; Heide, A. van der; Kooy-Winkelaar, Y.; Lammers, G.J. & Koning, F. (2016), H1N1 HA-specific T-cells can be readily detected in narcolepsy type 1, Journal of Sleep Research 25: 98-98.
- Petersen, J.; Kooy-Winkelaar, Y.; Loh, K.L.; Tran, M.; Bergen, J. van; Koning, F.; Rossjohn, J. & Reid, H.H. (2016), Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution, Structure 24(10): 1643-1657.
- Rossjohn, J. & Koning, F. (2016), A biased view toward celiac disease, Mucosal Immunology 9(3): 583-586.
- Wolf, C. de; Zee, R. van der; Braber, I. den; Glant, T.; Maillere, B.; Favry, E.; Lummel, M. van; Koning, F.; Hoek, A.; Ludwig, I.; Eden, W. van & Broere, F. (2016), An Arthritis-Suppressive and Treg Cell-Inducing CD4+T Cell Epitope Is Functional in the Context of HLA-Restricted T Cell Responses, Arthritis and Rheumatology 68(3): 639-647.
- Schmitz, F.; Kooy-Winkelaar, Y.; Wiekmeijer, A.S.; Brugman, M.H.; Mearin, M.L.; Mulder, C.; Lopes, S.C.D.; Mummery, C.L.; Staal, F.J.T.; Bergen, J. van & Koning, F. (2015), The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.
- Salden, B.N.; Monserrat, V.; Troost, F.J.; Bruins, M.J.; Edens, L.; Bartholome, R.; Haenen, G.R.; Winkens, B.; Koning, F. & Masclee, A.A. (2015), Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers, Alimentary Pharmacology and Therapeutics 42(3): 273-285.
- Janssen, G.; Christis, C.; Kooy-Winkelaar, Y.; Edens, L.; Smith, D.; Veelen, P. van & Koning, F. (2015), Ineffective Degradation of Immunogenic Gluten Epitopes by Currently Available Digestive Enzyme Supplements, PLoS ONE 10(6).
- Groot, N. de; Heijmans, C.M.C.; Ru, A.H. de; Janssen, G.M.C.; Drijfhout, J.W.; Otting, N.; Doxiadis, G.G.M.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2015), MHC CLASS I MOLECULE WITH NON-CLASSICAL FEATURES HAS HLA-B*27-LIKE PEPTIDE-BINDING CHARACTERISTICS, Tissue Antigens 85(5): 309-309.
- Montserrat, V.; Bruins, M.J.; Edens, L. & Koning, F. (2015), Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation, Food Chemistry 174: 440-445.
- Koning, F. (2015), Recent insight in the pathophysiology of coeliac disease: relevance to rheumatoid arthritis, Clinical and Experimental Rheumatology 33(4): S8-S10.
- Beek, L. van; Klinken, J.B. van; Pronk, A.C.M.; Dam, A.D. van; Dirven, E.; Rensen, P.C.N.; Koning, F.; Dijk, K.W. van & Harmelen, V. van (2015), The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice, Diabetologia 58(7): 1601-1609.
- Beek, L. van; Vroegrijk, I.O.C.M.; Katiraei, S.; Heemskerk, M.M.; Dam, A.D. van; Kooijman, S.; Rensen, P.C.N.; Koning, F.; Verbeek, J.S.; Dijk, K.W. van & Harmelen, V. van (2015), FcR gamma-Chain Deficiency Reduces the Development of Diet-Induced Obesity, Obesity 23(12): 2435-2444.
- Salden, B.N.; Monserrat, V.; Troost, F.J.; Bruins, M.J.; Edens, L.; Bartholome, R.; Haenen, G.R.; Winkens, B.; Koning, F. & Masclee, A.A. (2015), enhancing gluten digestion in the stomach - a further help to minimise unintentional ingestion? Authors' reply, Alimentary Pharmacology and Therapeutics 42(4): 485-485.
- Petersen, J.; Bergen, J. van; Loh, K.L.; Kooy-Winkelaar, Y.; Beringer, D.X.; Thompson, A.; Bakker, S.F.; Mulder, C.J.J.; Ladell, K.; McLaren, J.E.; Price, D.A.; Rossjohn, J.; Reid, H.H. & Koning, F. (2015), Determinants of Gliadin-Specific T Cell Selection in Celiac Disease, Journal of Immunology 194(12): 6112-6122.
- Heemst, J. van; Jansen, D.T.S.L.; Polydorides, S.; Moustakas, A.K.; Bax, M.; Feitsma, A.L.; Bontrop-Elferink, D.G.; Baarse, M.; Woude, D. van der; Wolbink, G.J.; Rispens, T.; Koning, F.; Vries, R.R.P. de; Papadopoulos, G.K.; Archontis, G.; Huizinga, T.W. & Toes, R.E. (2015), Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis, Nature Communications 6.
- Koning, F.; Thomas, R.; Rossjohn, J. & Toes, R.E. (2015), Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens, Nature Reviews Rheumatology 11(8): 450-461.
- Vriezinga, S.L.; Schweizer, J.J.; Koning, F. & Mearin, M.L. (2015), Coeliac disease and gluten-related disorders in childhood, Nature Reviews Gastroenterology and Hepatology 12(9): 527-536.
- Koning, F. (2015), Celiac disease: latest developments and future perspectives Preface.
- Koning, F. (2015), Adverse Effects of Wheat Gluten, Annals of Nutrition and Metabolism 67: 8-14.
- Nijeboer, P.; Malamut, G.; Bouma, G.; Cerf-Bensussan, N.; Koning, F.; Bergen, J. van; Cellier, C. & Mulder, C.J.J. (2015), Therapy in RCDII: Rationale for Combination Strategies?, Digestive Diseases 33(2): 227-230.
- Mariman, R.; Tielen, F.; Koning, F. & Nagelkerken, L. (2015), The Probiotic Mixture VSL#3 Has Differential Effects on Intestinal Immune Parameters in Healthy Female BALB/c and C57BL/6 Mice, Journal of Nutrition 145(6): 1354-1361.
- Salden, B.N.; Montserrat, V.; Troost, F.J.; Bruins, M.J.; Edens, L.; Bartholome, R.; Haenen, G.R.; Winkens, B.; Koning, F. & Masclee, A.A. (2015), Letter: gluten digestion in the stomach and duodenum by Aspergillus niger-derived enzyme - things to ponder. Authors' reply, Alimentary Pharmacology and Therapeutics 42(7): 946-947.
- Bergen, J. van; Mulder, C.J.; Mearin, M.L. & Koning, F. (2015), Local Communication Among Mucosal Immune Cells in Patients With Celiac Disease.
- Vriezinga, S.L.; Auricchio, R.; Bravi, E.; Castillejo, G.; Chmielewska, A.; Escobar, P.C.; Kolacek, S.; Koletzko, S.; Korponay-Szabo, I.R.; Mummert, E.; Polanco, I.; Putter, H.; Ribes-Koninckx, C.; Shamir, R.; Szajewska, H.; Werkstetter, K.; Greco, L.; Gyimesi, J.; Hartman, C.; Esch, C.H.; Hopman, E.; Ivarsson, A.; Koltai, T.; Koning, F.; Martinez-Ojinaga, E.; Marvelde, C. te; Pavic, A.M.; Romanos, J.; Stoopman, E.; Villanacci, V.; Wijmenga, C.; Troncone, R. & Mearin, M.L. (2014), Randomized Feeding Intervention in Infants at High Risk for Celiac Disease, New England Journal of Medicine 371(14): 1304-1315.
- Shamir, R.; Heyman, M.B.; Koning, F.; Wijimenga, C.; Gutierrez-Achury, J.; Catassi, C.; Gatti, S.; Fasano, A.; Discepolo, V.; Korponay-Szabo, I.R.; Zevit, N.; Maki, M.; Schaart, M.W.; Mearin, M.L. & Troncone, R. (2014), Celiac Disease: Past, Present, and Future Challenges Dedicated to the Memory of Our Friend and Colleague, Prof David Branski (1944-2013), Journal of Pediatric Gastroenterology and Nutrition 59: S1-S1.
- Bouazzaoui, F. el; Henneman, P.; Thijssen, P.; Visser, A.; Koning, F.; Lips, M.A.; Janssen, I.; Pijl, H.; Dijk, K.W. van & Harmelen, V. van (2014), Adipocyte telomere length associates negatively with adipocyte size, whereas adipose tissue telomere length associates negatively with the extent of fibrosis in severely obese women, International Journal of Obesity 38(5): 746-749.
- Beek, L. van; Lips, M.A.; Visser, A.; Pijl, H.; Ioan-Facsinay, A.; Toes, R.; Berends, F.J.; Dijk, K.W. van; Koning, F. & Harmelen, V. van (2014), Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance, Metabolism 63(4): 492-501.
- Mariman, R.; Kremer, B.; Koning, F. & Nagelkerken, L. (2014), The probiotic mixture VSL#3 mediates both pro- and anti-inflammatory responses in bone marrow-derived dendritic cells from C57BL/6 and BALB/c mice, British Journal of Nutrition 112(7): 1088-1097.
- Mariman, R.; Tielen, F.; Koning, F. & Nagelkerken, L. (2014), The Probiotic Mixture VSL#3 Dampens LPS-Induced Chemokine Expression in Human Dendritic Cells by Inhibition of STAT-1 Phosphorylation, PLoS ONE 9(12).
- Koning, F. (2014), Pathophysiology of Celiac Disease, Journal of Pediatric Gastroenterology and Nutrition 59: S1-S4.
- Schmitz, F.; Tjon, J.M.L.; Bergen, J. van & Koning, F. (2014), Dendritic cells promote expansion and survival of aberrant TCR-negative intraepithelial lymphocyte lines from refractory celiac disease type II patients, Molecular Immunology 58(1): 10-16.
- Petersen, J.; Montserrat, V.; Mujico, J.R.; Loh, K.L.; Beringer, D.X.; Lummel, M. van; Thompson, A.; Mearin, M.L.; Schweizer, J.; Kooy-Winkelaar, Y.; Bergen, J. van; Drijfhout, J.W.; Kan, W.T.; Gruta, N.L. la; Anderson, R.P.; Reid, H.H.; Koning, F. & Rossjohn, J. (2014), T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.
- Koning, F.; Mol, M. & Mearin, M.L. (2013), The million-dollar question: is "gluten-free" food safe for patients with celiac disease?, American Journal of Clinical Nutrition 97(1): 3-4.
- Groot, N.G. de; Heijmans, C.M.C.; Ru, A.H. de; Hassan, C.; Otting, N.; Doxiadis, G.G.M.; Koning, F.; Veelen, P.A. van & Bontrop, R.E. (2013), Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques, Immunogenetics 65(12): 897-900.
- Bergen, J. van; Thompson, A.; Pel, M. van; Retiere, C.; Salvatori, D.; Raulet, D.H.; Trowsdale, J. & Koning, F. (2013), HLA Reduces Killer Cell Ig-like Receptor Expression Level and Frequency in a Humanized Mouse Model, Journal of Immunology 190(6): 2880-2885.
- Tack, G.J.; Water, J.M.W. van de; Bruins, M.J.; Kooy-Winkelaar, E.M.C.; Bergen, J. van; Bonnet, P.; Vreugdenhil, A.C.E.; Korponay-Szabo, I.; Edens, L.; Blomberg, B.M.E. von; Schreurs, M.W.J.; Mulder, C.J. & Koning, F. (2013), Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study, World Journal of Gastroenterology 19(35): 5837-5847.
- Pozo-Rubio, T.; Marcos, A.; Koning, F.; Mujico, J.R.; Sanz, Y. & Nova, E. (2013), Bacterial immune modulation of the cytokine response elicited by gliadin in an in vitro model ofceliac disease, Proceedings of the Nutrition Society 72(OCE1): E71-E71.
- Schmitz, F.; Tjon, J.M.L.; Lai, Y.C.; Thompson, A.; Kooy-Winkelaar, Y.; Lemmers, R.J.L.F.; Verspaget, H.W.; Mearin, M.L.; Staal, F.J.; Schreurs, M.W.; Cupedo, T.; Langerak, A.W.; Mulder, C.J.; Bergen, J. van & Koning, F. (2013), Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II, Gut 62(4): 509-519.
- Bergen, J. van; Gaalen, F.A. van; Dongen, H. van; Huizinga, T.W.J.; Feltkamp, M.C.W.; Toes, R.E.M. & Koning, F. (2012), Anticytomegalovirus seropositivity in rheumatoid arthritis is not associated with the presence of severe extraarticular complications: Comment on the article by Pierer et al, Arthritis and Rheumatism 64(8): 2803-2804.
- Salentijn, E.M.J.; Mitea, D.C.; Goryunova, S.V.; Meer, I.M. van der; Padioleau, I.; Gilissen, L.J.W.J.; Koning, F. & Smulders, M.J.M. (2012), Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation, BMC Genomics 13: -.
- Broughton, S.E.; Petersen, J.; Theodossis, A.; Scally, S.W.; Loh, K.L.; Thompson, A.; Bergen, J. van; Kooy-Winkelaar, Y.; Henderson, K.N.; Beddoe, T.; Tye-Din, J.A.; Mannering, S.I.; Purcell, A.W.; McCluskey, J.; Anderson, R.P.; Koning, F.; Reid, H.H. & Rossjohn, J. (2012), Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease, Immunity 37(4): 611-621.
- Koning, F. (2012), Celiac disease: quantity matters, Seminars in Immunopathology 34(4): 541-549.
- Mariman, R.; Kremer, B.; Erk, M. van; Lagerweij, T.; Koning, F. & Nagelkerken, L. (2012), Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics, Inflammatory Bowel Diseases 18(8): 1424-1433.
- Mariman, R.; Kremer, B.; Erk, M. van; Koning, F. & Nagelkerken, L. (2012), MODULATION OF DENDRITIC CELLS AND COLITIS BY PROBIOTIC BACTERIA, Inflammation Research 61: S21-S21.
- Sollid, L.M.; Qiao, S.W.; Anderson, R.P.; Gianfrani, C. & Koning, F. (2012), Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules, Immunogenetics 64(6): 455-460.
- Mujico, J.R.; Dekking, L.; Kooy-Winkelaar, Y.; Verheijen, R.; Wichen, P. van; Streppel, L.; Sajic, N.; Drijfhout, J.W. & Koning, F. (2012), Validation of a New Enzyme-Linked Immunosorbent Assay to Detect the Triggering Proteins and Peptides for Celiac Disease: Interlaboratory Study, Journal of AOAC INTERNATIONAL 95(1): 206-215.
- Schmitz, F.; Tjon, J.M.L.; Lai, Y.C.; Thompson, A.; Kooy-Winkelaar, Y.; Lemmers, R.J.L.F.; Verspaget, H.W.; Mearin, M.L.; Staal, F.J.; Schreurs, M.W.; Cupedo, T.; Langerak, A.W.; Mulder, C.J.; Bergen, J. van & Koning, F. (2012), Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II., Gut.
- Tack, G.J.; Wanrooij, R.L.J. van; Langerak, A.W.; Tjon, J.M.L.; Blomberg, B.M.E. von; Heideman, D.A.M.; Bergen, J. van; Koning, F.; Bouma, G.; Mulder, C.J.J. & Schreurs, M.W.J. (2012), Origin and immunophenotype of aberrant IEL in RCDII patients, Molecular Immunology 50(4): 262-270.
- Lummel, M. van; Veelen, P.A. van; Zaldumbide, A.; Ru, A. de; Janssen, G.M.C.; Moustakas, A.K.; Papadopoulos, G.K.; Drijfhout, J.W.; Roep, B.O. & Koning, F. (2012), Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire, Journal of Biological Chemistry 287(12): 9514-9524.
- Bergen, J. van; Thompson, A.; Haasnoot, G.W.; Roodnat, J.I.; Fijter, J.W. de; Claas, F.H.J.; Koning, F. & Doxiadis, I.I.N. (2011), KIR-ligand mismatches are associated with reduced long-term graft survival in HLA-compatible kidney transplantation., American Journal of Transplantation 11(9): 1959-64.
- Nagelkerken, L.; Mariman, R.; Kremer, B.; Erk, M. van & Koning, F. (2011), PROBIOTICS INHIBIT THE DEVELOPMENT OF INFLAMMATORY PROCESSES IN RECURRENT TNBS-COLITIS: INSIGHTS FROM INTESTINAL TRANSCRIPTOME ANALYSIS, Inflammation Research 60: 241-241.
- Pre, M.F. du; Kozijn, A.E.; Berkel, L.A. van; Borg, M.N.D. ter; Lindenbergh-Kortleve, D.; Jensen, L.T.; Kooy-Winkelaar, Y.; Koning, F.; Boon, L.; Nieuwenhuis, E.E.S.; Sollid, L.M.; Fugger, L. & Samsom, J.N. (2011), Tolerance to Ingested Deamidated Gliadin in Mice is Maintained by Splenic, Type 1 Regulatory T Cells, Gastroenterology 141(2): 610-U714.
- Mujico, J.R.; Mitea, C.; Gilissen, L.J.W.J.; Ru, A. de; Veelen, P. van; Smulders, M.J.M. & Koning, F. (2011), Natural variation in avenin epitopes among oat varieties: Implications for celiac disease, Journal of Cereal Science 54(1): 8-12.
- Tjon, J.M.L.; Kooy-Winkelaar, Y.M.C.; Tack, G.J.; Mommaas, A.M.; Schreurs, M.W.J.; Schilham, M.W.; Mulder, C.J.; Bergen, J. van & Koning, F. (2011), DNAM-1 Mediates Epithelial Cell-Specific Cytotoxicity of Aberrant Intraepithelial Lymphocyte Lines from Refractory Celiac Disease Type II Patients, Journal of Immunology 186(11): 6304-6312.
- Mariman, R.; Kremer, B.; Erk, M. van; Lagerweij, T.; Koning, F. & Nagelkerken, L. (2011), Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics., Inflammatory Bowel Diseases.
- Kooy-Winkelaar, Y.; Lummel, M. van; Moustakas, A.K.; Schweizer, J.; Mearin, M.L.; Mulder, C.J.; Roep, B.O.; Drijfhout, J.W.; Papadopoulos, G.K.; Bergen, J. van & Koning, F. (2011), Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer.
- Esch, C.E.H.; Rijssen, M.J.L. van; Roos, A.; Koning, F.; Dekker, F.W.; Mearin, M.L.; Helmerhorst, F.M. & Schweizer, J.J. (2011), Screening for unrecognized coeliac disease in subfertile couples., Scandinavian Journal of Gastroenterology 46(12): 1423-8.
- Lummel, M. van; Veelen, P.A. van; Zaldumbide, A.; Ru, A. de; Janssen, G.M.C.; Moustakas, A.K.; Papadopoulos, G.K.; Drijfhout, J.W.; Roep, B.O. & Koning, F. (2011), The type 1 diabetes associated HLA-DQ8-trans dimer accomodates a unique peptide repertoire., Journal of Biological Chemistry.
- Kooy-Winkelaar, Y.; Lummel, M. van; Moustakas, A.K.; Schweizer, J.; Mearin, M.L.; Mulder, C.J.; Roep, B.O.; Drijfhout, J.W.; Papadopoulos, G.K.; Bergen, J. van & Koning, F. (2011), Gluten-Specific T Cells Cross-React between HLA-DQ8 and the HLA-DQ2 alpha/DQ8 beta Transdimer, Journal of Immunology 187(10): 5123-5129.
- Groot, N.G. de; Heijmans, C.M.C.; Zoet, Y.M.; Ru, A.H. de; Verreck, F.A.; Veelen, P.A. van; Drijfhout, J.W.; Doxiadis, G.G.M.; Remarque, E.J.; Doxiadis, I.I.N.; Koning, F. & Bontrop, R.E. (2011), CONTROL OF HIV-1 REPLICATION: HUMAN LONG-TERM NON-PROGRESSORS AND CHIMPANZEES SHARE MHC CLASS I MOLECULES WITH SIMILAR FUNCTIONAL PROPERTIES, Human Immunology 72: S173-S173.
- Bergen, J. van; Thompson, A.; Haasnoot, G.W.; Roodnat, J.J.; Fijter, J.W. de; Claas, F.H.J.; Koning, F. & Doxiadis, I.I.N. (2011), KIR-LIGAND MISMATCHES ARE ASSOCIATED WITH REDUCED LONG-TERM GRAFT SURVIVAL IN HLA FULLY COMPATIBLE KIDNEY TRANSPLANTATION., Human Immunology 72: S192-S192.
- Bergen, J. van; Thompson, A.; Haasnoot, G.W.; Roodnat, J.I.; Fijter, J.W. de; Claas, F.H.J.; Koning, F. & Doxiadis, I.I.N. (2011), KIR-Ligand Mismatches Are Associated With Reduced Long-Term Graft Survival in HLA-Compatible Kidney Transplantation, American Journal of Transplantation 11(9): 1959-1964.
- Tjon, J.M.L.; Kooy-Winkelaar, Y.M.C.; Tack, G.J.; Mommaas, A.M.; Schreurs, M.W.J.; Schilham, M.W.; Mulder, C.J.; Bergen, J. van & Koning, F. (2011), DNAM-1 mediates epithelial cell-specific cytotoxicity of aberrant intraepithelial lymphocyte lines from refractory celiac disease type II patients.
- Esch, C.E.H.; Rijssen, M.J.L. van; Roos, A.; Koning, F.; Dekker, F.W.; Mearin, M.L.; Helmerhorst, F.M. & Schweizer, J.J. (2011), Screening for unrecognized coeliac disease in subfertile couples, Scandinavian Journal of Gastroenterology 46(12): 1423-1428.
- Doxiadis, I.I.N.; Thompson, A.; Haasnot, G.W.; Roodnat, J.I.; Fijter, J.W. de; Claas, F.H.J.; Koning, F. & Bergen, J. van (2010), EVIDENCE FOR NATURAL KILLER CELL INDUCED GRAFT LOSS IN HLA FULL COMPATIBLE KIDNEY TRANSPLANTATION., Human Immunology 71: S139S139.
- Bergen, J. van & Koning, F. (2010), The tortoise and the hare: slowly evolving T-cell responses take hastily evolving KIR, Immunology 131(3): 301-309.
- Mitea, C.; Salentijn, E.M.J.; Veelen, P. van; Goryunova, S.V.; Meer, I.M. van der; Broeck, H.C. van den; Mujico, J.R.; Monserrat, V.; Gilissen, L.J.W.J.; Drijfhout, J.W.; Dekking, L.; Koning, F. & Smulders, M.J.M. (2010), A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease, PLoS ONE 5(12).
- Duijvestein, M.; Vos, A.C.W.; Roelofs, H.; Wildenberg, M.E.; Wendrich, B.B.; Verspaget, H.W.; Kooy-Winkelaar, E.M.C.; Koning, F.; Zwaginga, J.J.; Fidder, H.H.; Verhaar, A.P.; Fibbe, W.E.; Brink, G.R. van den & Hommes, D.W. (2010), Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study, Gut 59(12): 1662-1669.
- Groot, N.G. de; Heijmans, C.M.C.; Zoet, Y.M.; Ru, A.H. de; Verreck, F.A.; Veelen, P.A. van; Drijfhout, J.W.; Doxiadis, G.G.M.; Remarque, E.J.; Doxiadis, I.I.N.; Rood, J.J. van; Koning, F. & Bontrop, R.E. (2010), AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz, Proceedings of the National Academy of Sciences 107(34): 15175-15180.
- Groot, N.G. de; Heijmans, C.M.C.; Zoet, Y.M.; Ru, A.H. de; Verreck, F.A.; Veelen, P.A. van; Drijfhout, J.W.; Doxiadis, G.G.M.; Remarque, E.J.; Doxiadis, I.I.N.; Koning, F. & Bontrop, R.E. (2010), Control of HIV-1 replication: human long-term non-progressors and chimpanzees share MHC class I molecules with similar functional properties, Tissue Antigens 75(5): 485-485.
- Kapoerchan, V.V.; Wiesner, M.; Hillaert, U.; Drijfhout, J.W.; Overhand, M.; Alard, P.; Marel, G.A. van der; Overkleeft, H.S. & Koning, F. (2010), Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule.
- Tjon, J.M.L.; Bergen, J. van & Koning, F. (2010), Celiac disease: how complicated can it get?, Immunogenetics 62(10): 641-651.
- Juse, U.; Wal, Y. van de; Koning, F.; Sollid, L.M. & Fleckenstein, B. (2010), Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library, Human Immunology 71(5): 475-481.
- Esch, C.E.H.; Rosen, A.; Auricchio, R.; Romanos, J.; Chmielewska, A.; Putter, H.; Ivarsson, A.; Szajewska, H.; Koning, F.; Wijmenga, C.; Troncone, R.; Mearin, M.L. & PreventCD Study Grp (2010), The PreventCD Study design: towards new strategies for the prevention of coeliac disease, European Journal of Gastroenterology and Hepatology 22(12): 1424-1430.
- de Groot NG, Heijmans CMC, Zoet YM, Verreck FA, van Veelen PA, Drijfhout JW, Doxiadis GGM, Doxiadis IIN, Koning F & Bontrop RE (2009), Chimpanzee MHC class I and HLA-B*27/57 molecules target the same conserved epitope areas of HIV-1: a clue to understanding AIDS resistance, Tissue Antigens 73(5): 408-408.
- van Bergen J, Thompson A, Retiere C, Trowsdale J & Koning F (2009), Cutting Edge: Killer Ig-Like Receptors Mediate "Missing Self" Recognition In Vivo, Journal of Immunology 182(5): 2569-2572.
- Dekking L, Koning F, Hosek D, Ondrak TD, Taylor SL, Schroeder JW & Bauer M (2009), Intolerance of celiac disease patients to bovine milk is not due to the presence of T-cell stimulatory epitopes of gluten, Nutrition 25(1): 122-123.
- Maat W, van der Slik AR, Verhoeven DHJ, Alizadeh BZ, Ly LV, Verduijn W, Luyten GPM, Mulder A, van Hall T & Koning F (2009), Evidence for Natural Killer Cell-Mediated Protection from Metastasis Formation in Uveal Melanoma Patients, Investigative Ophthalmology & Visual Science 50(6): 2888-2895.
- Vermeulen BAN, Esch CEH, Yuksel Z, Koning F, Verduijn W, Doxiadis IIN, Schreuder GMT & Mearin ML (2009), Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect, Scandinavian Journal of Gastroenterology 44(1): 40-45.
- Huibregtse IL, Marietta EV, Rashtak S, Koning F, Rottiers P, David CS, van Deventer SJH & Murray JA (2009), Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab degrees Dq8 Transgenic Mice, Journal of Immunology 183(4): 2390-2396.
- van Bergen J, Kooy-Winkelaar EMC, van Dongen H, van Gaalen FA, Thompson A, Huizinga TWJ, Feltkamp MCW, Toes REM & Koning F (2009), Functional Killer Ig-Like Receptors on Human Memory CD4(+) T Cells Specific for Cytomegalovirus, Journal of Immunology 182(7): 4175-4182.
- van Bergen J, Thompson A, Haasnoot GW, Roodnat JI, de Fijter JW, Claas FHJ, Koning F & Doxiadis II (2009), COMBINED KIR/HLA GENOTYPING INDICATES A ROLE FOR ALLOREACTIVE NATURAL KILLER CELLS IN KIDNEY TRANSPLANTATION, Transplant International 22: 354-354.
- Kel JM, Slutter B, Drijfhout JW, Koning F & Nagelkerken L (2008), Mannosylated self-peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells, Journal of Leukocyte Biology 84(1).
- Hopman E, Dekking L, Blokland ML, Wuisman M, Zuijderduin W, Koning F & Schweizer J (2008), Tef in the diet of celiac patients in The Netherlands, Scandinavian Journal of Gastroenterology 43(3).
- Kapoerchan VV, Wiesner M, Overhand M, van der Marel GA, Koning F & Overkleeft HS (2008), Design of azidoproline containing gluten peptides to suppress CD4(+) T-cell responses associated with Celiac disease, Bioorganic and Medicinal Chemistry 16(4).
- Kel JM, de Geus ED, van Stipdonk MJ, Drijfhout JW, Koning F & Nagelkerken L (2008), Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation, International Immunology 20(1).
- Hovhannisyan Z, Weiss A, Martin A, Wiesner M, Tollefsen S, Yoshida K, Ciszewski C, Curran SA, Murray JA, David CS, Sollid LM, Koning F, Teyton L & Jabri B (2008), The role of HLA-DQ8 beta 57 polymorphism in the anti-gluten T-cell response in coeliac disease, Nature 456(7221).
- Tjon JML, Verbeek WHM, Kooy-Winkelaar YMC, Nguyen BH, van der Slik AR, Thompson A, Heemskerk MHM, Schreurs MWJ, Dekking LHA, Mulder CJ, van Bergen J & Koning F (2008), Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma, Blood 112(13).
- Stepniak D, Wiesner M, de Ru AH, Moustakas AK, Drijfhout JW, Papadopoulos GK, van Veelen PA & Koning F (2008), Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2, Journal of Immunology 180(5).
- Mitea C, Havenaar R, Drijfhout JW, Edens L, Dekking L & Koning F (2008), Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease, Gut 57(1).
- Huibregtse IL, Marietta EV, Rashtak S, Koning F, Rottiers R, David C, van Deventer SJH & Murray JA (2008), Tolerance to gliadin peptides can be restored by enteral administration of Lactococcus lactis bioengineered to deliver the immunodominant antigen to sensitized NOD ABO DQ8 transgenic mice, European Journal of Gastroenterology and Hepatology 20(7).
- Wiesner M, Stepniak D, de Ru AH, Moustakis AK, Drijfhout JW, Papadopoulos GK, van Veelen PA & Koning F (2008), Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule, Immunogenetics 60(9).
- Hopman EGD, von Blomberg ME, Batstra MR, Morreau H, Dekker FW, Koning F, Lamers CBHW & Mearin ML (2008), Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?, European Journal of Gastroenterology and Hepatology 20(5).
- Dekking EHA, Van Veelen PA, de Ru A, Kooy-Winkelaar EMC, Groneveld T, Nieuwenhuizen WF & Koning F (2008), Microbial transglutaminases generate T cell stimulatory epitopes involved in celiac disease, Journal of Cereal Science 47(2).
- Mitea C, Kooy-Winkelaar Y, van Veelen P, de Ru A, Drijfhout JW, Koning F & Dekking L (2008), Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteome, American Journal of Clinical Nutrition 88(4).
- Dekking L, Hopman E, Beelen F, Smoltsak N, De Vries S, Dogger L, Mearin L & Koning F (2007), Presence of T cell stimulatory epitopes of gluten in breast milk: Implications for the development of celiac disease, Journal of Pediatric Gastroenterology and Nutrition 44.
- Koning F (2007), A tertiary twist to the transglutaminase tale, PLoS Biology 5(12).
- Hopman GD, Dekking EHA, Blokland ML, Wuisman MC, Zuijderduin WM, Koning F & Schweizer JJ (2007), TEFF use in the diet of celiac disease patients in the Netherlands, Journal of Pediatric Gastroenterology and Nutrition 44.
- Kel J, Oldenampsen J, Luca M, Drijfhout JW, Koning F & Nagelkerken L (2007), Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis, American Journal of Pathology 170(1).
- Monsuur AJ, Stepniak D, Diosdado B, Wapenaar MC, Mearin ML, Koning F & Wijmenga C (2006), Genetic and functional analysis of pyroglutamyl-peptidase I in coeliac disease, European Journal of Gastroenterology and Hepatology 18(6).
- Stepniak D, Spaenij-Dekking L, Mitea C, Moester M, de Ru A, Baak-Pablo R, van Veelen P, Edens L & Koning F (2006), Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease, AJP - Gastrointestinal and Liver Physiology 291(4).
- Kel J, Drijfhout JW, van Stipdonk M, Koning F & Nagelkerken L (2006), Targeting of C type lectins inhibits the effector functions of Th1 cells in experimental autoimmune encephalomyelitis, Inflammation Research 55.
- Stepniak D & Koning F (2006), Enzymatic gluten detoxification: the proof of the pudding is in the eating!, Trends in Biotechnology 24(10).
- Thompson A, van der Slik AR, Koning F & van Bergen J (2006), An improved RT-PCR method for the detection of killer-cell immunoglobulin-like receptor (KIR) transcripts, Immunogenetics 58(11).
- van Herpen TWJM, Goryunova SV, van der Schoot J, Mitreva M, Salentijn E, Vorst O, Schenk MF, van Veelen PA, Koning F, van Soest LJM, Vosman B, Bosch D, Hamer RJ, Gilissen LJWJ & Smulders MJM (2006), Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes, BMC Genomics 7.
- Thomassen, E.A.J.; Dekking, E.H.A.; Thompson, A.; Franken, K.L.; Sanal, O.; Abrahams, J.P.; Tol, M.J.D. van & Koning, F. (2006), The impact of single amino acid substitutions in CD3 gamma on the CD3 epsilon gamma interaction and T-cell receptor-CD3 complex formation, Human Immunology 67(8).
- Hall, T. van; Wolpert, E.Z.; Veelen, P. van; Laban, S.; Veer, M. van der; Roseboom, M.; Bres, S.; Grufman, P.; Ru, A. de; Meiring, H.; Jong, A. de; Franken, K.; Teixeira, A.; Valentijn, R.; Drijfhout, J.W.; Koning, F.; Camps, M.; Ossendorp, F.; Karre, K.; Ljunggren, H.G.; Melief, C.J.M. & Offringa, R. (2006), Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants, Nature Medicine 12(4).
- Stepniak D & Koning F (2006), Celiac disease- Sandwiched between innate and adaptive immunity, Human Immunology 67(6).
- Mulder A, Eijsink C, Kester MGD, Franke MEI, Kardol MJ, Heemskerk MHM, van Kooten C, Verreck FA, Drijfhout JW, Koning F, Doxiadis IIN & Claas FHJ (2005), Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies, Journal of Immunology 175(9).
- Stepniak D, Vader LW, Kooy Y, van Veelen PA, Moustakas A, Papandreou NA, Eliopoulos E, Drijfhout JW, Papadopoulos GK & Koning F (2005), T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1, Immunogenetics 57(1-2).
- Spaenij-Dekking L, Kooy-Winkelaar Y & Koning F (2005), The ethiopian cereal tef in celiac disease, New England Journal of Medicine 353(16).
- Schulze A, Standera S, Buerger E, Kikkert M, van Voorden S, Wiertz E, Koning F, Kloetzel PM & Seeger M (2005), The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway, Journal of Molecular Biology 354(5).
- Luca ME, Kel JM, van Rijs W, Drijfhout JW, Koning F & Nagelkerken L (2005), Mannosylated PLP139-151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis, Journal of Neuroimmunology 160(1-2).
- Koning F, Schuppan D, Cerf-Bensussan N & Sollid LM (2005), Pathomechanisms in celiac disease, Best Practice and Research: Clinical Gastroenterology 19(3).
- Koning F, Gilissen L & Wijmenga C (2005), Gluten: a two-edged sword. Immunopathogenesis of celiac disease, Springer Seminars in Immunopathology 27(2).
- Koning F (2005), Celiac disease: Caught between a rock and a hard place, Gastroenterology 129(4).
- Diosdado B, Stepniak DT, Monsuur AJ, Franke L, Wapenaar MC, Mearin ML, Koning F & Wijmenga C (2005), No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population, AJP - Gastrointestinal and Liver Physiology 289(3).
- Spaenij-Dekking L & Koning F (2005), Natural variation in toxicity of wheat - Reply, Gastroenterology 129(6).
- Spaenij-Dekking L, Kooy-Winkelaar Y, Van Veelen P, Drijfhout JW, Jonker H, Van Soest L, Smulders MJM, Bosch D, Gilissen LJWJ & Koning F (2005), Natural variation in toxicity of wheat: Potential for selection of nontoxic varieties for celiac disease patients, Gastroenterology 129(3).
- Mulder A, Eijsink C, Kester M, Kardol M, Franke M, Drijfhout JW, Koning F, Doxiadis I & Claas F (2004), The impact of peptides on the recognition of HLA class I molecules by human HLA antibodies, Genes and Immunity 5.
- Arentz-Hansen H, Fleckenstein B, Molberg O, Scott H, Koning F, Jung G, Roepstorff P, Lundin KEA & Sollid LM (2004), The molecular basis for oat intolerance in patients with Celiac disease, PLoS Medicine 1(1).
- van Bergen J, Thompson A, van der Slik A, Ottenhoff THM, Gussekloo J & Koning F (2004), Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors, Journal of Immunology 173(11).
- Kel JM, Luca M, Drijfhout JW, Koning F & Nagelkerken L (2004), Tolerance to experimental autoimmune encephalomyelitis: targeting of C-type lectins, Journal of Neuroimmunology 154(1-2).
- Verdijk P, van Veelen PA, de Ru AH, Hensbergen PJ, Mizuno K, Koerten HK, Koning F, Tensen CP & Mommaas AM (2004), Morphological changes during dendritic cell maturation correlate with cofilin activation and translocation to the cell membrane, European Journal of Immunology 34(1).
- Muntasell A, Carrascal M, Alvarez I, Serradell L, van Veelen P, Verreck FAW, Koning F, Abian J & Jaraquemada D (2004), Dissection of the HLA-DR4 peptide repertoire in endocrine epithelial cells: Strong influence of invariant chain and HLA-DM expression on the nature of ligands, Journal of Immunology 173(2).
- Spaenij-Dekking EHA, Kooy-Winkelaar EMC, Nieuwenhuizen WF, Drijfhout JW & Koning F (2004), A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin, Gut 53(9).
- Vader LW, Stepniak DT, Bunnik EM, Kooy YMC, De Haan W, Drijfhout JW, Van Veelen PA & Koning F (2003), Characterization of cereal toxicity for celiac disease patients based on protein homology in grains, Gastroenterology 125(4).
- Vader W, Stepniak D, Kooy Y, Mearin L, Thompson A, van Rood JJ, Spaenij L & Koning F (2003), The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses, Proceedings of the National Academy of Sciences 100(21).
- Mearin ML & Koning F (2003), Tissue transglutaminase: Master regulator of celiac disease?, Journal of Pediatric Gastroenterology and Nutrition 36(1).
- Gamerdinger K, Moulon C, Karp DR, van Bergen J, Koning F, Wild D, Pflugfelder U & Weltzien HU (2003), A new type of metal recognition by human T cells: Contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel, Journal of Experimental Medicine 197(10).
- Mazzarella G, Maglio M, Paparo F, Nardone G, Stefanile R, Greco L, van de Wal Y, Kooy Y, Koning F, Auricchio S & Troncone R (2003), An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients, Gut 52(1).
- Spaenij-Dekking EHA, Van Delft J, Van der Meijden E, Hiemstra HS, Falkenburg JHF, Koning F, Drijfhout JW & Kluin-Nelemans JC (2003), Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells, Leukemia 17(12).
- Koning F & Vader W (2003), Gluten peptides and celiac disease, Science 299(5606).
- Koning F (2003), The molecular basis of Celiac disease, Journal of Molecular Recognition 16(5).
- Vader W, Kooy Y, Spaenij L, van Veelen P, de Ru A, Harris D, Benckhuijsen W, Pena S, Mearin L, Drijfhout JW & Koning F (2003), The identification of toxic T cell stimulatory gluten peptides.
- Muntasesll A, Carrascal M, Serradell L, van Veelen P, Verreck F, Koning F, Raposo G, Abian J & Jaraquemada D (2002), HLA-DR4 molecules in neuroendocrine epithelial cells associate to a heterogeneous repertoire of cytoplasmic and surface self peptides, Journal of Immunology 169(9).
- Vader LW, de Ru A, van der Wal Y, Kooy YMC, Benckhuijsen W, Mearin ML, Drijfhout JW, van Veelen P & Koning F (2002), Specificity of tissue transglutaminase explains cereal toxicity in celiac disease, Journal of Experimental Medicine 195(5).
- Kita H, Naidenko OV, Kronenberg M, Ansari AA, Rogers P, He XS, Koning F, Mikayama T, Van de Water J, Coppel RL, Kaplan M & Gershwin ME (2002), Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human mid tetramer, Gastroenterology 123(4).
- Koning F (2002), Immunotherapy of celiac disease: Fact or fallacy?, Netherlands Journal of Medicine 60(7).
- Vader W, Kooy Y, Van Veelen P, De Ru A, Harris D, Benckhuijsen W, Pena S, Mearin L, Drijfhout JW & Koning F (2002), The gluten response in children with Celiac disease is directed toward multiple gliadin and glutenin peptides, Gastroenterology 122(7).
- van Bergen J, Kooy Y & Koning F (2001), CD4-independent T cells impair TCR triggering of CD4-dependent T cells: a putative mechanism for T cell affinity maturation, European Journal of Immunology 31(2).
- van Tienhoven EAE, ten Brink CTB, van Bergen J, Koning F, van Eden W & Broeren CPM (2001), Induction of antigen specific CD4+T cell responses by invariant chain based DNA vaccines, Vaccine 19(11-12).
- Heemskerk MHM, de Paus RA, Lurvink EGA, Koning F, Mulder A, Willemze R, van Rood JJ & Falkenburg JHF (2001), Dual HLA class I and class II restricted recognition of alloreactive T lymphocytes mediated by a single T cell receptor complex, Proceedings of the National Academy of Sciences 98(12).
- Papadopoulos GK, Wijmenga C & Koning F (2001), Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life, Journal of Clinical Investigation 108(9).
- Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, Chang HC, Reinherz E, Kronenberg M & Cheroutre H (2001), T cell responses modulated through interaction between CD8 alpha alpha and the nonclassical MHC class I molecule, TL, Science 294(5548).
- Moustakas AK, van de Wal Y, Routsias J, Kooy YMC, van Veelen P, Drijfhout JW, Koning F & Papadopoulos GK (2000), Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.
- Arentz-Hansen H, Korner R, Molberg O, Quarsten H, Vader W, Kooy YMC, Lundin KEA, Koning F, Roepstorff P, Sollid LM & McAdam SN (2000), The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase.
- van Bergen J, Camps M, Offringa R, Melief CJM, Ossendorp F & Koning F (2000), Superior tumor protection induced by a cellular vaccine carrying a tumor-specific T helper epitope by genetic exchange of the class II-associated invariant chain peptide, Cancer Research 60(22).
- Van de Wal Y, Kooy Y, Van Veelen P, Vader W, Koning F & Pena S (2000), Coeliac disease: it takes three to tango!
- Moustakas AK, van de Wal Y, Kooy YMC, van Veelen P, Drifthout JW, Koning F & Papadopoulos GK (2000), Antigen recognition in HLA-DQ8-restricted T cell clones from celiac disease patients, Diabetologia 43.
- Maasho K, Satti I, Nylen S, Guzman G, Koning F & Akuffo H (2000), A Leishmania homologue of receptors for activated C-kinase (LACK) induces both interferon-gamma and interleukin-10 in natural killer cells of healthy blood donors.
- van Hall T, van Bergen J, van Veelen PA, Kraakman M, Henkamp LC, Koning F, Melief CJM, Ossendorp F & Offringa R (2000), Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin.
- van den Biggelaar AHJ, Grogan JL, Filie Y, Jordens R, Kremsner PG, Koning F & Yazdanbakhsh M (2000), Chronic schistosomiasis: Dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness.
- van Bergen J, Ossendorp F, Jordens R, Mommaas AM, Drijfhout JW & Koning F (1999), Get into the groove! Targeting antigens to MHC class II.
- Wal, Y. van de; Kooy, Y.M.C.; Veelen, P. van; Vader, W.; August, S.A.; Drijfhout, J.W.; Pena, S.A. & Koning, F. (1999), Glutenin is involved in the gluten-driven mucosal T cell response, European Journal of Immunology 29(10): 3133-3139.
- Wal, Y. van de; Kooy, Y.M.C.; Veelen, P.A. van; Pena, S.A.; Mearin, L.M.; Molberg, O.; Lundin, K.E.A.; Sollid, L.M.; Mutis, T.; Benckhuijsen, W.E.; Drijfhout, J.W. & Koning, F. (1998), Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin, Proceedings of the National Academy of Sciences 95(17): 10050-10054.
- Wal, Y. van de; Kooy, Y.; Veelen, P. van; Pena, S.; Mearin, L.; Papadopoulos, G. & Koning, F. (1998), Cutting edge: Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity, Journal of Immunology 161(4): 1585-1588.
- van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, Molberg O, Lundin K, Sollid L, Mutis T, Benckhuijsen W, Drijfhout JW & Koning F (1998), T cells from the small intestinal mucosa of coeliac disease patients recognize a unique peptide sequence of gliadin.
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